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관계형 DBMS 사용 환경을 위한 SQL - SDE의 구현
이준호(Joonho Lee),안태호(Taeho Ahn),이윤숙(Yoonsuk Lee),이윤준(Yoonjoon Lee) 한국정보과학회 1988 한국정보과학회 학술발표논문집 Vol.15 No.2
사용자가 단말기에서 대화식으로 질의를 작성하여 데이타베이스에 접근하려면 DBMS가 제공하는 질의어의 구문에 알맞도록 질의를 작성해야 한다. 일반적으로 질의어는 많은 수의 예약어를 포함하는 복잡한 구조의 국문도 제공하기 때문에 일반 사용자들이 질의어를 술달하기에는 오랜 시간이 필요하다. 본 논문에서는 사용자가 SQL 언어로 질의를 작성할 때, 문법적 오류가 없는 질의를 쉽게 작성할 수 있도록, DBMS 사용 환경에 적합한 SQL syntax directed 에디터를 구현하였다. 이 시스템은 사용자가 DBMS가 제공하는 SQL 언어의 구문에 구애받지 않고, 문법적 오류가 없는 질의를 쉽게 작성할 수 있도록 도와준다.
Lee, JoonHo,Kim, Chong Jai,Kim, Jung‐,Sun,Lee, Deug‐,Chan,Ahn, Sejin,Yoon, Bo Hyun John Wiley and Sons Inc. 2018 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.22 No.2
<P><B>Abstract</B></P><P>Acute chorioamnionitis, frequently observed in preterm placentas, is a major risk factor for the development of infection and non‐infection‐related adverse perinatal outcomes. MicroRNAs play important roles in immune cell development and function as well as in the development of cancers and neurologic diseases. We sought to investigate the changes in microRNA‐223 (miR‐223) expression and the functional significance of the changes in miR‐223 expression in foetal organs in the presence of acute chorioamnionitis. Using formalin‐fixed, paraffin‐embedded (FFPE) tissue samples from foetal or neonatal autopsy cases, which are the most practical option to study the changes in several organs simultaneously, miR‐223 expression profiles in foetal thymus, lung and liver were compared between cases with and without acute chorioamnionitis. Total RNA was extracted from FFPE specimens and qRT‐PCR was conducted. miR‐223‐3p expression levels in foetal thymus (2.55‐fold), lung (1.93‐fold) and liver (1.70‐fold) were significantly higher in cases with acute chorioamnionitis than in those without. Transfection of pre‐miR‐223‐3p in Jurkat cells and luciferase assay and ribonucleoprotein immunoprecipitation followed by qRT‐PCR analysis confirmed the binding of miR‐223 to the 3′ untranslated region (3′UTR) of forkhead box O1 (FoxO1) mRNA and the regulation of FoxO1 by miR‐223. We report for the first time that foetuses with inflammation in the chorioamniotic membranes show increased expression of miR‐223 in the thymus, lung and liver. Furthermore, FoxO1 is a target of miR‐223. These findings suggest that post‐transcriptional regulation of genes by miR‐223 is a component of the foetal inflammatory response, which has systemic consequences in the foetus.</P>
Lee, Joonho,Cheng, Hao,Garrick, Dorian,Golden, Bruce,Dekkers, Jack,Park, Kyungdo,Lee, Deukhwan,Fernando, Rohan BioMed Central 2017 Genetics, selection, evolution Vol.49 No.-
<P><B>Background</B></P><P>Genomic predictions from BayesA and BayesB use training data that include animals with both phenotypes and genotypes. Single-step methodologies allow additional information from non-genotyped relatives to be included in the analysis. The single-step genomic best linear unbiased prediction (SSGBLUP) method uses a relationship matrix computed from marker and pedigree information, in which missing genotypes are imputed implicitly. Single-step Bayesian regression (SSBR) extends SSGBLUP to BayesB-like models using explicitly imputed genotypes for non-genotyped individuals.</P><P><B>Methods</B></P><P>Carcass records included 988 genotyped Hanwoo steers with 35,882 SNPs and 1438 non-genotyped steers that were measured for back-fat thickness (BFT), carcass weight (CWT), eye-muscle area, and marbling score (MAR). Single-trait pedigree-based BLUP, Bayesian methods using only genotyped individuals, SSGBLUP and SSBR methods were compared using cross-validation.</P><P><B>Results</B></P><P>Methods using genomic information always outperformed pedigree-based BLUP when the same phenotypic data were modeled from either genotyped individuals only or both genotyped and non-genotyped individuals. For BFT and MAR, accuracies were higher with single-step methods than with BayesB, BayesC and BayesC<I>π</I>. Gains in accuracy with the single-step methods ranged from +0.06 to +0.09 for BFT and from +0.05 to +0.07 for MAR. For CWT, SSBR always outperformed the corresponding Bayesian methods that used only genotyped individuals. However, although SSGBLUP incorporated information from non-genotyped individuals, prediction accuracies were lower with SSGBLUP than with BayesC (<I>π</I> = 0.9999) and BayesB (<I>π</I> = 0.98) for CWT because, for this particular trait, there was a benefit from the mixture priors of the effects of the single nucleotide polymorphisms.</P><P><B>Conclusions</B></P><P>Single-step methods are the preferred approaches for prediction combining genotyped and non-genotyped animals. Alternative priors allow SSBR to outperform SSGBLUP in some cases.</P>
Effects of Porcine Seminal Plasma in In Vitro Culture of Embryos
JoonHo Moon,SuJin Kim,JungTaek Kang,SolJi Park,JiYei Choi,JiHyun Lee,Islam M. Saadeldin,HyunJu Oh,JungEun Park,MinJung Kim,GeonA Kim,Eun Jung Park,Jin Choi,Goo Jang,Byeong Chun Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Semen can be divided into two parts. One is cellular part which contains sperms the other is liquid part which is called by seminal plasma. The seminal plasma is a nutritive and protective medium for the sperms. Fructose, which is major energy source, is supplied to sperms swim to female oocyte. Alkalic property protects sperms from hostile environment of female reproductive organ. Also, seminal plasma induces tolerance to preexisted immune cells, and changes intra-uterine environment to better conditions for fertilized embryos to implant. However, the effects of seminal plasma in in vitro culture of fertilized embryos are unclear. Second fraction of fresh semen was obtained from a normal farm pig. The semen was centrifuged to remove sperms, and then supernatant was filtrated. The filtered seminal plasma was stored in - 30℃. In this study, electrically activated and chemically activated porcine embryos were employed to investigate the developmental rate after 2 hours treatment of none, 0.1%, 0.5%, and 1% seminal plasma in culture media by two days of activation. Both electrically and chemically activated embryos, cleavage rate and cell numbers of blastocysts were not significant difference within four groups. Blastocyst formation rate of electrically activated embryos also did not show significant difference within any groups. However 0.1% seminal plasma treatment group showed significantly increase of blastocyst formation rate in chemically activated group (None; 24.8%, 0.1%; 31.7%, 0.5%; 19.4, and 1%; 16.5%, respectively. p<0.05).
Effects of Porcine Seminal Plasma in In Vitro Culture of Embryos
JoonHo Moon,SuJin Kim,JungTaek Kang,SolJi Park,JiYei Choi,JiHyun Lee,Islam M. Saadeldin,HyunJu Oh,JungEun Park,MinJung Kim,GeonA Kim,Eun Jung Park,Jin Choi,Goo Jang,Byeong Chun Lee 한국동물번식학회 2012 Reproductive & developmental biology Vol.36 No.2