담낭암의 발생에서 담췌관합류이상의 역할 규명과 암화과정에 관한 연구

한기준,송시영,정재복,이세준,김호근,강진경 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.4

담낭암 발생에서 담췌관합류이상의 역할 규명과 암화과정에 관한 연구

강진경,한기준,이세준,송시영,정재복,김호근 대한소화기학회 1998 대한소화기학회지 Vol.32 No.4

Baekground/Aims: To clarify the careinogenesis of gallbladder cancer (GBC) in patients with anomalous pancreaticobiliary ductal union (APBDU), we investigated the expression of mutated p53 protein and c-erbB2, the cell proliferation indices of Ki-67 and the histopathologic changes in gallbladder carcinoma and noncaneeraus mucosa which are associated with APBDU. Methods: In the clinical review, we analysed 62 patients (27 patients of GBC with APBDU and 35 patients of GBC without APBDU) who were diagnosed in Sevrance Hospital from January, 1992 to December, 1994. Immunohistochemical staining and histologic examination were performed on the specimens obtained from surgically resected gallbladders from the patients. For comparative study, the specimens were grogped as follows: 5 cases of carcinoma with APBDU, 4 eases of noneancerous mucosa with APBDU associated with GBC, 11 cases of noncancerous mucosa with APBDU not associated with GBC, 19 cases of carcinoma without APBDU and 7 cases of chronic inflammatory mucosa of gallbladder stones as controls. Results, GBC developed in 33.3% of patients with APBDU (especially, 66.7% of PC type) and showed no gallbladder stones. The frequency of papillary carcinoma was higher and depth of invasion was less in GBC with APBDU than in GBC without APBDU. Among 15 cases of noncancerous mucosa with APBDU, isolated dysplasia and adenomyomatous hyperplasia were noted in 10 cases and 4 cases, respectively. In one case of APBDU with GBC, the expression of p53 protein was noted in the focal area of low grade dysplasia. Cell proliferation indices of Ki-67 were stepwise increased with the progression of histologic findings from inflammation, papiUary hyperplasia, metaplasia and adenomyomatous hyperplasia to dysplasia. Particularly, remarkable increase was observed in adenomyomatous hyperplasia and dysplasia. Conclusions: The high incidence of isolated dysplasia and adenomyoma accompanying with increased cell proliferative indices seems to be closely related to th carcinogenesis of GBC in patients with APBDU. Additionally, the mutation of p53 may contribute to early event of carcinogenesis in some patients with APBDU.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

밀링가공에서 절삭유를 이용한 AE 신호의 검출

정준기,맹민재 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

In order to achieve the automation and untended system of manufacturing process, it is necessary that the monitoring system check up the disorder of machine tool. In this study, the method which uses acoustic emission(AE) signal is proposed to monitor the tool fracture in the milling process. In order to detect the AE-signal from the cutting zone directly, the AE-sensor is installed in the cutting oil supply device. Due to the tool fracture, the amplitude level of AE-signal at the beginning of tool-workpiece contact increases with the progressing cutting time. Using this phenomena, a practical monitoring algorithm has been developed. The practical method was also proposed to detect the tool fracture.

수술후 경막외강에 주입한 ketamine의 진통효과에 관한 연구

정기호,조남수,임경준,유병식,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Author divided 60 patients who got lower abdomen or lower extremity surgical operation into three groups. Each group consisted of 20 patients. We injected ketamine 10㎎, 20㎎, and 30㎎ respectively into the epidural space when the patient complained of pain postoperatively and observed the postoperative analgesic effect of ketamine. Finally, we concluded the following : 1) The onset time of analgesic effect. : The analgesic effect appeared within 10 minutes in 3 groups and the significant difference among them was not seen. 2) The duration of analgesic effect : The duration of analgesia was relatively short with less than 1 hour on an average in all 3 groups and was not constant. 3) Cardiopulmonary system. : The significant change of blood pressure, pulse and respiratory rate was not seen in all three groups and and the difference among them also was not seen. 4) Side effects. : Sedative action(16%), nausea(10%), dizziness(5%), headache(3.3%) From above results, the epidural administration of ketamine is not suitable for postoperative pain management because of a lot of side effects as well as short and inconstant duration of analgesic effeet.

1 自由度系로 모델化한 旋削系의 安定性 硏究

鄭準基 弘益大學校 1987 弘大論叢 Vol.19 No.2

Chatter vibration is considered as a linear single degree of freedom spring mass damper system 'with forces acting upon it. The effects of the equivalent spring constant, mass and damping ratio of the system an the amplitude of the chatter vibration are qualitatively investigated in relation to the cutting prccess which provides the system with the exciting forces. Cutting experiments have been carried out to evaluate the validity of the theoritical considerations using the modified toolpost. The comparison between the theoretical predictions and the experimental results shows a good qualitative agreement. In the present study, the following conclusions are made. The modified tool-post model for chatter vibration can be quantified as a linear single degree of freedom vibration system. Chatter frequency is higher than the natural frequency of the tool-post. And increase in the equivalent damping ratio and the equivalent spring constant causes the decrease in the gain of the frequency response of the tool-post at the chatter frequency, which reduces the amplitude of the chatter vibration.

공구진단을 위한 엔드밀 변위에 인프로세스 측정

鄭準基 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1

Milling operations with endmill are performed to investigate the characteristics of laser beam signals due to tool deflection and fracture. The laser beam signals are obtained with adapt focusing of tool. Tool conditions are identified with scanning electron microscopy and optical microscopy. It is demonstrated that the laser beam signals provide reliable informations about the cutting processes and tool conditions. Moreover, tool fracture can be detected successfully using the coefficient of variation.

로타리 공구의 절삭특성

鄭準基,沈昇天 弘益大學校 科學技術硏究所 2004 科學技術硏究論文集 Vol.15 No.-

The feasibility of application of the rotary carbide tools in the machining of aluminium alloys is studied in this paper. For the experiment, a new rotary tool holder has been designed and manufactured. Experiments were performed using Taguchi methods and regression analysis to analyse the influence of various factors and their interactions on the cutting characteristics of rotary carbide tools during machining. It turns out that the inclination angle has the greatest influence on the cutting force and the depth of cut has a clear effect on the surface roughness. The cutting force and surface roughness can be estimated using an equation proposed in this paper, which will be well matched to the data of physical experiments.

旋削加工에서 衝擊댐퍼가 채터發生抑制에 주는 效果에 關한 硏究

鄭準基 弘益大學校 1985 弘大論叢 Vol.17 No.2

In metal cutting, there often exist violent vibration, called chatter, between tool and workpiece. Chatter is an undesirable phenomenon and affects the surface finish, dimensional accuracy, tool life, and machine tool life itself. In this study, the chatter suppression effect of impact damper installed on the tool post of a lathe was investigated. It was found here that the impact damper has a chatter suppression effect and there are optimum values in massr atio and gap ratio. In this experiment, the optimum values of mass ratio and gap ratio were 0.06, 30 respectively, and on the optimum condition there was a 5 times increase in chatter free depth of cut with respect to the case without the impact damper.

Chatter 解析에 對한 非線形 理論

鄭準基 弘益大學校 1983 弘大論叢 Vol.15 No.2

The chatter analysis has been studied by many authors using non-linear theory. In this study, the stability chart was obtained experimentally in lathe turning, and was compared with the result of chatter analysis by non-linear theory qualitatively. From experimental results, it was verified that the stability of cutting process is affected by the depth of cut in the following manner. Keeping the rotational speed of workpiece constant, as the chip thickness is increased from zero, the stability can be distinguished by three ranges; (a) unconditionally stable range, (b) conditionally stable range, (c) unstable range. In the conditionally stable range the system is stable for small disturbances but unstable when these exceed a certain level. When the chatter occurs, the amplitude initially increases and stabilized itself at a finite level. This phenomenon agree well with the analysis of non-linear theory qualitatively.