한려해상국립공원 계단형 등산로에서 등산의 운동생리학적 연구 -금산지구를 중심으로-

이준우 ( Joon Woo Lee ),박범진 ( Bum Jin Park ),최윤호 ( Yeon Ho Choi ),김재수 ( Je Su Kim ) 한국환경생태학회 1999 한국환경생태학회지 Vol.12 No.4

운동강도 평가를 이용한 국립공원 등산로의 관리대책 -설악산국립공원과 계룡산국립공원을 대상으로-

이준우 ( Joon Woo Lee ),박범진 ( Bum Jin Park ) 한국환경생태학회 1998 한국환경생태학회지 Vol.11 No.4

각종 소화성질환에서의 Campylobacter Pylori의 검출에 관하여

허정욱,강영우,박준호,박승국,하경임,김재룡,안성훈,박선우 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Peptic disorders are among the most common maladies in korea as the world. In most cases their etiologies not be established and their pathophysioolgy remain obscure. Although the persence of fastric bacteria has been logn established, recently campylobacter pylori seems to be etiologic agent of peptic disorders. Campylobacter pylori is visualized in most cases of peptic disorders and not visualized after treatment of bctericidal agents, bismuth compound or metronidazole. We had a following results for identification of campylocacter pylori in stomach and duodenal mcuosa via endoscipc biopsy. 1. We studied 54 patients who had dyspeptic symptoms, 29 males. 2. Most patients are in 5th decades, next in 3rd and 6th in order. 3. Ptients were composed of 27 peptic ulcer, 22 gastitis and 5 gastric carcinoma. 4. Campylobacter pylori was identified in 69% of total patients, peptic ulcer 63%, gastritis 77%, stomach carcinoma leastly.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

DBS STB의 스마트 카드 인터페이스 설계

박준호,윤영우 嶺南大學校 工業技術硏究所 2001 工業技術硏究所論文集 Vol.29 No.2

In this paper, we design a Smartcard interface of DBS(Direct Broadcasting by Satellite) receiver that manages resource and subscriber management system by Mugunghwa satellite broadcasting system. The smartcard is used for subscribers selecting TV programs or various services. It must follow ISO/IEC 7816 standard for smartcard and observe Mugunghwa satellite DBS system regulations. Simulation is performed with virtual smartcard through personal computer serial communication. From the simulation results, the designed method is adequate to function of DBS regulations and shows good performance.

완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

의류제품 단서 차이에 따른 소비자 평가 가격대

박준우,김정원 한국의류산업학회 2002 한국의류산업학회지 Vol.4 No.5

This study examines whether there are differences in consumer's evaluation price zone according to clothing clue (the type of clothing, brand, time of fashion, place of origin, material, submaterial, place for sale). Therefore the ultimate goal is to offer help in fixing price when establishing marketing of the clothing industry by grasping the actual price set by consumers under the IMF system. The female consumers of 20s and 30s were chosen as study subjects for their sensitivity to the purchase of clothing. The tests carried out in this research are: SPSS/PC+ is used for frequency Analysis. The Results of this study are showed as the following : The clothing goods of made in Italy, the brand of Georgio Armani, the material of leather, the button with leather, sold in department store was evaluated with the highest price zone. On the other hand, the clothing goods of made in Indonesia, the brand of VIKI, the material of plastic, the button with plastic, sold in market was evaluated with the lowest price zone.

Pristinamycin(Pyostacine®)의 methicillin-resistant Staphylococcus aureus,Penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae 임상균주에 대한 시험관내 항균력

박정원,송준영,김철현,정희진,김우주,김민자,박승철 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

목적 : 국내 및 전세계적으로 methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae(PRSP), β-lactamase 생성 H. influenzae 등의 항균제 내성 감염증이 증가되고, 이에 대한 효과적인 항생제 요법에 대한 필요성이 증가되고 있다. Streptogramin 계열의 경구 항생제인 pristinamycin의 임상검체에서 분리된 균주에 대한 시험관내 항균력을 검사함으로서 이러한 감염증에 대한 임상적 사용의 유용성여부를 알아보고자 하였다. 방법 : 1999년 8월1일부터 2000년 1월 1일까지 호흡기 감염, 피부 및 연조직 감염환자로부터 분리된 MRSA 60주, PRSP 50주, H. influenzae 40주를 대상으로 pristinamycin을 비롯한 8-9종 항생제의 시험관내 항균제 감수성을 측정하였다. 결과 : Pristinamycin은 MRSA에 대한 MIC 범위가 0.125-1㎎/L로서 100%의 감수성을, PRSP에 대한 MIC 범위가 0.125-1㎎/L로서 100%의 감수성을, β-lactamase를 생성하는 H. influenzae에 대해서도 MIC 범위가 0.25-2㎎/L, 96% 감수성으로서 다른 항생제들에 비하여 우수한 시험관내 항균력을 나타내었다. 결론 : 국내에서 문제가 되고 있는 MRSA, PRSP, β-lactamase 생성 H. influenzae에 대하여 pristinamycin은 우수한 시험관내 항균력을 나타내어, 이들 항생제 내성균들에 의한 감염증의 치료에 효과적으로 사용될 수 있을 것으로 생각된다. Background: Pristinamycin(Pyostacine®) is a natural antibacterial combination of compounds Produced by Streptomyces pristinaespiralis. It has been marketed in European countries over 30 years as an oral anti-stphyhcoocal agent. Because of the increasing prevalence microorganisms that are resistant to multiple antimicrobial agents in Korea. there are demand of noble antibiotics like pristinamycin against these resistant organissms. Methods The one-hundred and fifity bacterial strains which were collected from Korea University Guro hospital included sixty methicillin-resistant S. aurous (MRSA) , fifty penicillin-resistant S. pneumoniae (PRSP) and forty H. infuenzae clinical isolates. Using an microbroth dilution or agar dilution technique, we compared the antimicrobial activities of pristinamycin and other usual antibiotics against the studmicroorganisms. Results: All sixty MRSA strains were multiply resistant to other antimicrobial agents, but 100% of MRSA strains were susceptible to pristinamycin (MIC range: 0.125-1㎎/L). All of fifty PRSP strains were multiple resistant to other antimicrobial agents but 100% PRSP strains were susceptible to pristinamycin (MIC range: 0.125-1㎎/L). Twenty-seven strains of forty H. influenzae strains were β-lactamase positive, and 95% (38/40) of H. influenzae strains were susceptible to prisitinamycin (MICrange : 0.015-4㎎/L) . Conclusion : Pristinamycin demonstrated the highly active. in vitro antimicrobial activities against MRSA. PRSP. and H.influenzae isolated so it might be an effective oral therapeutic agent for treating patients with mild infection due to those organisms or on the outpatient setting.

사업전략·제조구조·생산자동화기술의 유형에 관한 연구

朴愚東,白埈尙 漢陽大學校 産業經營硏究所 1991 産業經營硏究 Vol.3 No.-

병원과 지역사회에서 메티실린 내성 황색 포도상구균(methicillin-resistant Staphylococcus aureus) 감염의 임상 분자역학 연구

박정원,이종섭,송준영,김철현,엄중식,정희진,김우주,박승철 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.2

목적 : 국내에서 1990년대 이후 중요한 병원균으로 대두되고 있는 methicillin-resistant S. ureus(MRSA)는 주로 입원환자에서만 분리되는 것으로 알려져 있으나, 최근들어 지역사회에서도 퍼져있는 것으로 알려지기 시작하였다. 이에 병원획득 및 지역사회획득 MRSA의 임상역학 및 분자역학적 연구를 통하여 획득요인, 병원과 지역사회 획득 균주간의 교류 양상등을 규명하고자 하였다. 방법 : 1998년 1월부터 12월까지 고려대 부속 구로병원에서 임상검체로부터 분리된 S. aureus 균주중에서 MRSA 균주의 빈도를 구하였고, 이중 1998년 10월 1개월 동안 분리되었던 42균주에 대하여 지역사회획득 균주와 병원획득 균주로 나누고, 임상역학적 조사를 하였다. 지역사회 획득 18주와 병원획득 22주에 대하여 PCR 방법으로 mecA 유전자를 확인하였고, PFGE를 시행하여 균주의 클론형(clonal type)을 결정하고 이 결과에 준하여 덴드로그램 분석을 시행하여 분자적 친밀도를 결정하였다. 결과 : 1998년 1년간 분리된 총 1,587주의 S. aeureus 균주중 73.8%(1,163주)가 MRSA 였다. 1998년 10월 1개월 동안 임상자료의 고찰이 가능하였던 MRSA 감염환자 42명 중 20명이 지역사회획득 환자였고, 병원획득 환자가 지역사회획득 환자보다 항생제사용 과거력(17 vs 5, p=0.001), 기저질환의 존재(18 vs 8, p=0.002) 등이 통계적으로 의미있게 높았다. 지역사회획득환자가 이루(7/20[35.0%] vs 2/22[9.1%] ; p=0.041)와 밀접한 관계가 있음도 확인하였다. 분자생물학적연구가 진행된 40주의 MRSA 균주는 모두 mecA 유전자 양성이었고, 18주의 지역사회획득 균주에서 총 8가지의 PFGE 클론형이 존재하였으며 A형이 가장 많았다(7/18, 38.8%). 22주의 병원획득균주에서는 6가지의 클론형이 존재하고 A형이 가장 많았으며(15/22, 68%), 15주의 지역사회획득 균주(83.3%)가 21주의 병원획득균주와 공통적인 클론형을 공유하고 있었다. 결론 : 지역사회 획득 MRSA는 주로 이루나 창상부위에서 많이 분리되는 반면 병원획득 MRSA는 객담에서 많이 분리되고 또한 당뇨병을 가진 환자에서 감염을 잘 일으키는 것으로 밝혀졌다. PFGE 분석 결과 원내감염은 단일균주에 의한 유행양상을 보였고, 지역사회에서도 같은 형의 균주에 의한 감염빈도가 가장 높음을 보여 MRSA 균주가 지역사회로 유입되어 지역사회내 MRSA 감염의 발생에 기여했을 것으로 사료된다. Background : Until recently, methicillin-resistant Staphylococcus aureus (MRSA) infection has been acquired primarily in hospital settings. During the late 1990s, the incidence of community-acquired MRSA infections has been increased in this university hospital. This retrospective study evaluated the clinical features and risk factors for community-acquired MRSA infection compared with hospital-acquired MRSA infection; and molecular relatedness of MRSA strains determined by pulsed-field gel electrophoresis(PFGE). Method: MRSA isolates collected from patients during October of 1998 were classified as community-acquired("community') or hospital-acquired("hospital") cases. MRSA infections were defined as hospital-acquired if organisms were isolated > 48 hours after admission to the hospital or isolated from patients with a history of admission to a hospital within the last 3 months. A comparative analysis of risk factors for community MRSA compared with hospital MRSA was performed. mecA gene PCR and PFGE of MRSA isolated was used as a tool of strain identification and molecular typing. Result : During one month, there were 42 patients with MRSA infection or colonization. Of 42 patients with MRSA isolates, 22(52%) were hospital cases and 20(48%) were community cases. Previous exposure to antibiotics(17 vs 5, p = 0.001) and presence of underlying diseases (18 vs 8, p = 0.002) were more common in hospital cases than in community cases. MRSA were more frequently isolated in otorrhea specimens from patients with otitis media in community cases compared with hospital cases. Of the 40 MRSA isolates subjected for PFGE typing, 18 were community isolates and 22 were hospital isolates. There were 8 distinct PFGE types among the 18 community isolates and type A was the most common clonal type (7/18, 38.8%). 22 hospital isolates were of 6 distinct PFGE types, and type A was dominant clonal type (15/22, 68%). PGFE subtyping indicated that 15(83.3%) of 18 community MRSA strains were clonally related with that of 21 hospital MRSA strains. Conclusion : Our results suggest that hospital MRSA strains may have disseminated in the community setting. PFGE subtyping support the finding that MRSA is circulating beyond nosocomial settings in the regional community.