Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

ATmega128을 이용한 4족 보행로봇의 제어

이준모 關東大學校 産業技術開發硏究所 2008 산업기술논문집 Vol.- No.25

In this paper, the control algorithm of a quadruped walking robot with three degree of freedom is studied and the walking robot is implemented experimentally For obtaining the walking algorithm D-H transformation is used The angle and the coordinate of each step is calcualated by using the derived algorithm Experimental software program is implemented by C language compiler EzAVR and the hardware of the experiment is controled by using the ATmega128.

坡州郡 廣灘面에 있어서의 肺吸蟲症의 疫學的 推移

李駿商,鄭然郁,林漢鍾,朴永模 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.3

Paragonimiasis is a common trematodiasis of medical importance and one of public health problems in many areas of southern part of Korea. During the last sixty years, several surveys on the prevalence among the Korean population have been carried out by various investigators, although the general distribution and prevalence of paragonimiasis are not yet clearly determined. This study was undertaken to compare the status of human paragonimiasis in Kwang-Tan Myun, Pa Joo Gun by the use of intradermal screening test with Veronal buffered saline antigen. 1. In 1969, 27.9 per cent of the inhabitant examiners showed positive reaction, with sexual difference of 38.7 per cent in male and 8.3 per cent in female. 2. In 1977, 19.8 per cent of the inhabitant examiners showed positive reaction, with sexual difference of 31.9 per cent in male and 3.8 per cent in female. 3. In 1977, 1.9 per cent of the student examiners showed positive reaction. 4. In the inhabitant examiners, relarively higher positive rate was shown from the age group of 10 years in 1969, but it was shown from the age group of 40 years in 1977.

스위칭 파형을 사용한 동조 N-Path Filter에 관한 연구

李俊模 관동대학교 1983 關大論文集 Vol.11 No.1

In this paper, a method based on N-Path principle is presented to design bandpass filters tunable over a fairly wide tuning range. The design represents a compromise between the complexity of the switching waveform and that of the auxiliary output filter. Broad tuning range has been made possible by use of switched band-limiting networks. The system transfer function of a switched N-Path Filter with a very general switching waveform is derived and the results are applies to a variety of practical situations. We know that the losses in the shift register degrades the amplitude characteristics and lowers the center frequency gain. The realization of this class N-Path Filter using time-multiplexing of the basic analog network is discussed.

Analog형 PLL을 사용한 Pull-In Range와 주파수 체배 회로에 관한 연구

李俊模,金聖珞 관동대학교 1984 關大論文集 Vol.12 No.2

In this paper, Lock range, Capture range, frequency stability of the VCO by source voltage variation of the frequency multiplier are experimented and frequency multiplier is composed by the PLL and the frequency divider. Because multiplication rate passes the reference output to the VCO through R and C, it is possible to multiply about ten times the maximum free running frequency of VCO, 500KHz. The capture range has no concern with the multiplication constant and it has about 70KHz to 80KHz bandwidth when the input voltage is 50mV/div but lock range is decreased as much the frequency divider rate as multiplication constant. Though the frequency variation of the VCO has no concern with source voltage, a amplitude varition happened.

Bit-slice Devices에 의한 Processor Elements의 평가

李俊模 관동대학교 1993 關大論文集 Vol.21 No.2

Designing with a byte-oriented metal-oxide-semiconductor microprocessor, after all, consists mainly of programming a system made up of components hooked together according to the manufactuer's specifications. But bit-slice processor design involves critical hardware decisions and the creation of an instruction set as well and only then comes the programing. Morever, since bit-slice processor patrs of different manufactures can be mixed in one the same design, consideration must be given individually to each of them. The complexity of bit-slice processor parts, compounded by minimal support from their manufacturers, has won them a poorer welcome than they deserve from designers. Although processors built with bit slices can be extremely powerful, the design flexibility of the parts in both hardware and instruction sets demands an intimate familiarity with a particular family before a designer can be confident of success. In this paper, each slice is illustrated with two diagrams : a diagram of its physical lay out and a diagram of its external connections. The same notation will be used for each slice to ease the transition from slice to slice. However, because of this, these diagrams differ from those used by the manufacturers of the slice. Hence, the manufacturers' diagram are also included to ease the transition to the manufacturer's detailed specifications.

2차 구간을 이용한 능동 RC 대역통과 Filter

李俊模 관동대학교 1988 關大論文集 Vol.16 No.2

Since it is not necessary to adjust the active RC filter after it`s manufacturing, it is the filter easy to adjust that will be well suited to practical use and mass production. Even more it is needed a lot of things to be done for the relatively easy-adjusted cascade connection and it can not be well suited to mass production without the other adjustment each biquad sections at sometimes. In this paper presents, as solution to these problems, a synthesis of the active RC bandpass filter that used biquad section which requires the value of elements and the identical circuit structure. To begin with, two synthesis methods of fourth-order bandpass filter are presented. Next, an experiment are made on it, and then investigation on sensitivity, dynamic range is described. Finally, based on the synthesis method of fourth-order bandpass filter, the expension method of the realization of high-order bandpass filter is described.

Immittance 함수 확장에 의한 고차능동 RC 회로망

李俊模 관동대학교 1986 關大論文集 Vol.14 No.2

In active RC networks, GIC inductor and FDNR is realized as an immittance elements. Using these elements, a new networks design method with high-order elements can be considered. In this paper, the fundamental circuit is designed as unilateral circuits. Immittance function of arbitrary order is realized by expanding the fundamental circuit, and is implemented by active RC networks. Inverse L type circuit using this RC circuit is considered. The network design method in this paper is relatively easy and parameter of circuit is calculated simply. 5th order lowpass filter using this active RC networks is implemented and what its operation characteristic is approximately same that of theory is proved through experiment, and its dynamic range is studied.

기능성 소화불량증환자에서 Winstal® 투여에 관한 임상경험

이창형,김영탁,금민수,권중구,안병철,윤영미,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.3

목적 : 기능성 소화불량증은 소화, 흡수등 장관의 기능적인 이상과 관련되어 있을 것으로 생각되며 복합소화효소제(Winstal®)를 투여하여 그 임상효과를 평가하고자 본 연구를 실시하였다. 대상 및 방법 : 1994년 3월 부터 6월까지 경북대학교병원 내과를 방문한 기능성 소화불량증을 호소하는 환자 20명을 대상으로 Winstal®을 1회 1정씩, 1일 3회 식후 30분내에 경구로 2주간 투여하였다. 결과 : 소화불량증의 증상은 복부불쾌감, 복부팽만감, 식욕부진 및 오심, 복부동통, 공기연하증, 고창 및 구토순이었으며, 증상의 개선은 복부불쾌감이 76.4%(13/17)로 가장 높았으며, 그 다음으로 복부팽만감 및 공기연하증이 66.5%(10/15, 6/9)이었고, 오심 61.5%(8/13), 식욕부진 53.8%(7/13), 복부동통 41.6%(5/12), 고창 37.5%(3/8)이었다. 각 환자별 종합적인 증상의 개선도는 현저한 개선이 2예(10%), 중등도 개선이 3예(15%), 약간개선이 11예(55%), 불변이 4예(20%)이었으며 종합적인 유효율은 80%(16/20)이었다. 부작용은 한 예에서도 관찰되지 않았다. 결론 : 본 제제는 기능성 소화불량증 환자의 증상개선에 추천할 만한 유효한 약제로 생각된다. Dyspepsia is a common symptom in gastroenterologic practice and trigger for numerous consultations with physician. The treatment of chronic functional dyspesia is unsatisfactory. This study was performed to evaluate the efficacy of the digestive compound (Winstal®) on 20 functional dyspepsia patients. On open trial, all patients were given 6 tablets daily for 2 weeks and we evaluated the efficacy of this preparation according to the degree of the improvement. The improvement of symptoms was 76.4%(13/17) in abdominal discomfort, 66.5%(10/15, 6/9) in abdominal distension and aerophagia, 61.5%(8/13) in nausea, 53.8%(7/13) in abdominal pain, and 37.5% (5/12) in flatulence, respectively. Overall effectiveness of subjective symptoms was 80% (16/20) and there were no untoward effects of the preparations during this study. As a result, We think that this preparation is an effective one to relieve symptoms of functional dyspepsia.

김일의 일생에 관한 연구

이준호,이근모 釜山大學校 附設 體育科學硏究所 2013 體育科學硏究所 論文集 Vol.29 No.-

본 연구는 김일의 일생과 업적을 재조명 하는데 그 목적을 두었다. 이를 위해 김일의 회고록, 다큐멘터리, 신문, 잡지, 기사, 동영상 등을 자료로 설정하여 '김일의 일생'과 '김일의 일생이 한국민의 정서에 미친 영향', 그리고 '김일의 스포츠 외교'에 중점을 두고 문헌 고찰하였다. 그 결과는 다음과 같다. 첫째, 김일은 WWA 세계 태그타이틀을 비롯하여 각종 세계 대회의 타이틀을 거머쥐었으며, 그 공로를 인정받아 국가로부터 국민훈장 석류장, 체육훈장 맹호장, 체육훈장 청룡장을 수상하였다. 둘째, 일본과 서양열강들로부터 끊임없는 간섭과 지배를 받아 실의에 빠져있던 우리 국민들은 김일이 경기에서 일본선수들을 강력한 박치기로 쓰러트리고, 서양열강 소속의 선수들을 발차기로 쓰러트리는 모습에 일제에 대한 복수감과 같은 대리만족을 느꼈을 것으로 해석된다. 셋째, 스포츠외교가 활발하지 않은 시점에서 김일이 일본과 한국을 비롯한 여러 국가를 돌아다니며 경기를 하였다. 특히 일본과의 교류를 활발히 가짐으로서 대한민국 엘리트스포츠발전의 일부요인이라고 할 수 있는 일본과의 체육 교류의 물꼬를 틀었다. 본 결과는 김일의 일생과 업적이 대한민국 사회에 일부 영향을 주었다는 것을 시사한다.