Predicting the potential geographic distribution of Thrips palmi in Korea, using the CLIMEX model

Jung-Joon Park,Gwan-Seok Lee,Joon-Ho Lee,Kijong Cho 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Thrips palmi Karny was introduced and first recorded in 1993 in Korea. This species has become a serious pest of vegetable and ornamental crops. CLIMEX simulation was applied to T. palmi to predict the potential geographic distribution in Korea under the Representative Concentration Pathway (RCP) 8.5 climate change scenario. In the CLIMEX simulation, ecoclimatic index (EI) was calculated, and compared in each simulated year and each simulated location. The map comparisons showed a good agreement between simulated and present distributions of T. palmi, indicating that the CLIMEX model was well explained and appropriate for prediction of future distributions of this species in Korea. In near future, until a year of 2020, all the western and eastern parts of Korea showed favorable to marginal suitability for T. palmi populations in fields. After the year of 2040, the potential distributions are shifted from no persistent to favorable for establishment and persistence from coastal to interior of the Korean peninsula except a north-eastern interior region which is the northernmost part of high mountains (Baekdu-Daegan) area in South Korea. Based on simulation results, T. palmi would overcome its weather restriction in near future under a severe climate change scenario, thus, pest management measures and strategies should be re-constructed in Korea, with further studies including interspecific competition and understanding ecosystem change due to climate change.

Intensity-modulated radiotherapy for stage I glottic cancer: a short-term outcomes compared with three-dimensional conformal radiotherapy

Cho, Ick Joon,Chung, Woong-Ki,Lee, Joon Kyoo,Lee, Min-Cheol,Paek, Jayeong,Kim, Yong-Hyub,Jeong, Jae-Uk,Yoon, Mee Sun,Song, Ju-Young,Nam, Taek-Keun,Ahn, Sung-Ja,Lee, Dong Hoon,Yoon, Tae Mi,Lim, Sang-Ch The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.4

Purpose: To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT). Materials and Methods: We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot technique (1 patient), respectively. The 3DCRT was performed with bilateral parallel opposing fields. The median follow-up duration was 30 months (range, 31 to 42 months) in the IMRT group and 65 months (range, 20 to 143 months) in the 3DCRT group. Results: The 5-year overall survival and 3-year local control rates of the 160 patients were 95.7% and 91.4%, respectively. There was no significant difference in 3-year local control rates between the IMRT and 3DCRT groups (94.4% vs. 91.0%; p = 0.587). Thirteen of 137 patients in the 3DCRT group had recurrences. In the IMRT group, one patient had a recurrence at the true vocal cord. Patients treated with IMRT had less grade 2 skin reaction than the 3DCRT group, but this had no statistical significance (4.3% vs. 21.2%; p = 0.080). Conclusion: IMRT had comparable outcomes with 3DCRT, and a trend of less acute skin reaction in stage I glottic cancer patients.

Cost Efficient Sampling Method for Management of Aphis Gossypii (Hemiptera: Aphididae) in Greenhouse Cultivation of Cucumbers

Taek Jun Kang,Myoung Rae Cho,Joon Ho Lee,Kijong Cho,Jung-Joon Park 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

The cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae), is one of the major insect pests of cucumber, Cucumis sativus L. The spatial distribution and occurrence of Aphis gossypii Glover on greenhouse cucumber, Cucumis sativus L., were studied to provide an efficient and reliable sampling plan for its control. A highly clumped pattern was observed among plants (TPL b = 1.63) within a greenhouse. To develop a sampling plan for visual enumeration, leaves within plants were selected by different percentages of leaves (eg., 3rd and 6th, 6th and 9th leaf,…from the bottom of the plant) and then compared the accuracies and efficiencies by relative net precision (RNP). The results indicated that selecting leaves from the bottom of the plant by systemic sampling methods were relatively high as other sampling methods.

Use of a Baculovirus-Expressed Structural Protein for the Detection of Antibodies to Foot-and-Mouth Disease Virus Type A by a Blocking Enzyme-Linked Immunosorbent Assay

Ko, Young-Joon,Lee, Hyang-Sim,Jeoung, Hye-Young,Heo, Eun-Jeong,Ko, Hyo-Rim,Chang, Byung-Sik,Joo, Hoo-Don,Gerelmaa, U.,Dashzeveg, B.,Tserendorj, S.,Sodnomdarjaa, R.,Park, Jong-Hyeon,Kweon, Chang-Hee,Ch American Society for Microbiology 2010 CLINICAL AND VACCINE IMMUNOLOGY Vol.17 No.1

<B>ABSTRACT</B><P>A blocking enzyme-linked immunosorbent assay (ELISA) with a baculovirus-expressed structural protein was developed for the detection of antibodies to foot-and-mouth disease virus type A. It exhibited 99% specificity with a cutoff of 53% inhibition. Its sensitivity was comparable to the sensitivities of the virus neutralization test and the liquid-phase blocking ELISA, indicating its potential as an alternative assay.</P>

장기적인 우심실 첨부 조율 시 좌심실 기능부전의 발생에 관여하는 인자

홍영준(Young Joon Hong),정명호(Myung Ho Jeong),이승현(Seung Hyun Lee),박옥영(Ok Young Park),김주한(Ju Han Kim),김원(Weon Kim),류제영(Jay Young Rhew),안영근(Young Keun Ahn),조정관(Jeong Gwan Cho),박종춘(Jong Chun Park),강정채(Jung Ch 대한내과학회 2002 대한내과학회지 Vol.63 No.2

배경: 12유도 심전도상 QRS파 폭(QRSd)의 연장은 좌심실 수축기 기능의 감소와 관계가 있고, 확장형 심근증에서 QRS파 폭은 좌심실 기능 이상 정도 및 예후와 밀접한 관계가 있다고 알려져 있다. 우심실 첨부를 조율하는 영구형 심박조율기 시술 후 QRSd의 과도한 연장이 관찰되는데 심박조율기 시술 환자에서 QRSd 연장의 의미는 아직까지 명확하게 밝혀져 있지 않다. 본 연구는 우심실 첨부를 조율하는 영구형 심박조율기 시술 후 QRSd 증가의 의미를 규명하고 좌심실 기능부전에 관여하는 인자를 알아보기 위하여 시행되었다. 방법: 전남대학교병원 순환기내과에서 영구형 심박조율기(DDD형 15, VDD형 18, VVI형 31)를 시술 받은 후 1년 이상 경과된 환자 64명(남:녀=27:37, 시술 시 나이=57.6±15.4세)을 대상으로 하였다. 시술 전 기저질환을 평가하고, 시술 전, 시술 직후 및 최종 추적 시(추적기간 68.2±44.0개월) 심전도와 심초음파도를 시행하여 QRSd와 좌심실 구혈률(LVEF)과의 관계를 분석하고, 최종 추적 시 좌심실 기능부전(LVEF-FU<50%)에 관여하는 인자를 분석하였다. 결과: 심박조율기 시술 전 LVEF는 64.9±10.1%이었고, 최종 추적 시 LVEF (LVEF-FU)은 59.3±11.5%로 유의하게 감소하였고(p<0.001), 11명(17.2%)에서는 LVEF- FU가 50% 미만으로 감소하였다. LVEF-FU<50%는 시술 전 당뇨병의 존재 및 최종 추적 시 QRSd와 관련이 있었다(R2=0.302, p<0.001). 심박조율기 시술 전 및 직후 QRSd와 LVEF-FU은 유의한 상관관계가 없었으나, 최종 추적 시 QRSd는 LVEF-FU와 유의한 음의 상관관계가 있었고(r=-0.451, p<0.01), 추적 기간 동안 QRSd의 변화량과 LVEF의 변화량 사이에 유의한 음의 상관관계가 있었다(r=-0.419, p<0.01). LVEF-FU는 QRSd가 180 ms 이상일 때 180 ms 이하일 때에 비해 유의하게 낮았다(44.4±12.0% vs. 61.7±9.5%, p<0.001). QRSd 180 ms로 좌심실 기능부전을 예측할 때 예민도는 60.0%, 특이도는 88.7%, 양성 예측도는 50.0%, 음성 예측도 99.2%이었다. 시술 직후 QRSd는 최종 추적 시 QRSd과 유의한 양의 상관관계가 있었다(r=0.542, p<0.01). 결론: 우심실 첨부를 조율하는 심박조율기 시술 후 좌심실 기능부전이 17.4%에서 발생하였고 좌심실 기능부전은 추적 심전도에서 QRSd가 180 ms 이상 연장되는 것으로 예측할 수 있었다. 심실 심박조율기 시술 후 발생할 수 있는 좌심실 기능부전을 예방하기 위해서 심박조율기 시술 후 QRSd의 변화를 극소화할 수 있는 기술에 대한 연구가 필요할 것으로 생각되었다. Background It is known that prolonged QRS duration (QRSd) in a 12-lead ECG is associated with decreased left ventricular (LV) systolic function in patients with dilated cardiomyopathy. Development of LV systolic dysfunction and prolongation of paced QRSd are often observed in patients with permanent pacemakers (PPM). However, the significance of prolonged paced QRSd in patients with PPM is not determined. Methods We studied sixty-four patients (male:female=27:37, mean age=57.6±15.4 years) who had been on PPM (DDD: 15, VDD: 18, VVI: 31) for more than one year (mean: 68.2±44.0 months). LV function was normal before implantation of PPM. The 12-lead ECG and echocardiography were recorded prior to implantation, immediately after implantation and at the last follow-up. Results Paced QRSd did not significantly increase during the follow-up period. LVEF at the last follow-up (LVEF-FU) was significantly lower than that prior to implantation (59.3±11.5% vs. 64.9±10.1%, p<0.001). Eleven (17.2%) patients developed LV systolic dysfunction (LVEF<50%) during the follow-up period. Paced QRSd at the last follow-up and diabetes mellitus were correlated with LV systolic dysfunction (R2=0.302, p<0.001). There was a significant negative correlation between the paced QRSd and LVEF-FU (r=-0.451, p<0.01) and between change of paced QRSd and that of LVEF during follow-up (r=-0.419, p<0.01). LVEF-FU was reduced more in patients with paced QRSd ≥180 ms than in patients without (44.4±12.0% vs. 61.7±9.5%, p<0.001). In predicting LV systolic dysfunction with the paced QRSd (cut-off value: 180 ms), sensitivity, specificity, positive and negative predictive values were 60.0%, 88.7%, 50.0% and 99.2%, respectively. The paced QRSd at the last follow-up was significantly correlated with paced QRSd immediately after implantation (r=0.542, p<0.01). Conclusion LV systolic dysfunction after long-term right ventricular apical pacing may develop. Prolongation of paced QRSd ≥180 ms during follow-up may suggest development of LV systolic dysfunction. New technologies to minimize prolongation of paced QRSd should be investigated to prevent LV systolic dysfunction after permanent ventricular pacing. (Korean J Med 63:169-176, 2002)

Generalized Tonic-Clonic Seizures after Self-Limited Epilepsy with Centrotemporal Spikes: A Case Series

Hye Jin Kim(Hye Jin Kim),Young Joon Ko(Young Joon Ko),Soo Yeon Kim(Soo Yeon Kim),Anna Cho(Anna Cho),Hunmin Kim(Hunmin Kim),Byung Chan Lim(Byung Chan Lim),Hee Hwang(Hee Hwang),Jong-Hee Chae(Jong-Hee Ch 대한소아신경학회 2022 대한소아신경학회지 Vol.30 No.4

Purpose: Patients with self-limited epilepsy with centrotemporal spikes (SLECTS) rarely experience generalized tonic-clonic seizures (GTCS) after remission, and post-remission GTCS has not been thoroughly described in earlier studies. Herein, we describe the clinical and electrographic features of GTCS after a substantial period of seizure freedom in patients with SLECTS. Methods: This study included six patients (three boys and three girls) diagnosed with SLECTS who later developed GTCS after or near remission. Medical records, including clinical data and serial electroencephalography (EEG) recordings, were retrospectively reviewed for all patients. Results: Patients’ age at SLECTS onset ranged from 5.2 to 10.2 years (mean, 8.4 years), while seizure cessation was achieved between 8 and 12.2 years. During SLECTS, typical centrotemporal spikes were observed in all patients, and generalized spike-and-wave discharges were observed in three patients. The age at the first episode of subsequent GTCS ranged from 14.4 to 17.3 years (mean, 15.8 years), constituting an average interval of 5.6 years after the last episode of seizures (range, 4.1 to 8.1 years). EEG at subsequent episodes of GTCS revealed generalized discharges in two patients, focal discharges in two other patients, and normal discharges in the remaining two patients. Two patients had multiple episodes of GTCS. Conclusion: Although rare, GTCS may occur near or after remission in patients with SLECTS, and clinicians should be aware of this. Subsequent GTCS may be a manifestation of idiopathic generalized epilepsy. However, large-scale studies are needed to determine the nature of such episodes of GTCS and their associated risk factors.

Simple Tests to Predict Hepatic Fibrosis in Nonalcoholic Chronic Liver Diseases

( Woon Geon Shin ),( Sang Hoon Park ),( Sun Young Jun ),( Jae One Jung ),( Joon Ho Moon ),( Jong Pyo Kim ),( Kyoung Oh Kim ),( Cheol Hee Park ),( Tai Ho Hahn ),( Kyo Sang Yoo ),( Jong Hyeok Kim ),( Ch 대한소화기기능성질환·운동학회 2007 Gut and Liver Vol.1 No.2

Background/Aims: Several simple tests for hepatic fibrosis employ indirect markers. However, the efficacy of using direct and indirect serum markers to predict significant fibrosis in clinical practice is inconclusive. We analyzed the efficacy of a previously reported indirect marker of hepatic fibrosis - the aspartate aminotransferase to platelet ratio index (APRI) - in patients with nonalcoholic chronic liver diseases (CLDs). Methods: A total of 134 patients who underwent a percutaneous liver biopsy with a final diagnosis of chronic hepatitis B (n=93), chronic hepatitis C (n=18), or nonalcoholic fatty liver disease (n=23) were enrolled. A single-blinded pathologist staged fibrosis from F0 to F4 according to the METAVIR system, with significant hepatic fibrosis defined as a METAVIR fibrosis score of ≥2. Results: The mean area under the receiver operating characteristic curve (AUROC) of APRI for predicting significant fibrosis in nonalcoholic CLDs was 0.84 [95% confidence interval (CI), 0.78-0.91]. APRI yielded the highest mean AUROC in the patients with chronic hepatitis B (0.85; 95% CI, 0.771-0.926). The positive predictive value of APRI ≥ 1.5 for predicting significant fibrosis was 89%. The negative predictive value of APRI <0.5 for excluding significant fibrosis was 80%. Conclusions: APRI might be a simple and noninvasive index for predicting significant fibrosis in nonalcoholic CLDs. (Gut and Liver 2007;1:145-150)

Rural Systems Visioneering: Paradigm Shift from Flux Measurement to Sustainability Science

김준,강민석,타이칸 오끼,박은우,카즈히토 이치이,요하나 마리아 인드라와티,조성식,문지현,유완철,이지영,이협승,카롤리 은자우,안성훈,Kim, Joon,Kang, Minseok,Oki, Taikan,Park, Eun Woo,Ichii, Kazuhito,Indrawati, Yohana Maria,Cho, Sungsik,Moon, Jihyun,Yoo, Wan Ch Korean Society of Agricultural and Forest Meteorol 2018 한국농림기상학회지 Vol.20 No.1

지속가능성과학은 다양한 학문 배경과 관심을 가진 과학자, 전문직 종사자 및 이해당사자들 간의 소통과 협력뿐 아니라 결정론적 환원주의적 접근에서 오래전 기본으로의 패러다임 전환이 요구되는 떠오르는 초학문적 연구다. 생태-사회시스템은 많은 구성성분(또는 행위자)들로 이루어져 이들의 국지 규모의 무작위 상호작용이 자연스럽게 시스템 전체 규모의 질서를 만들어내는 공진화하는 복잡계다. 여기서, 시스템과 주변환경 간의 에너지와 물질과 정보의 흐름이 중요한 역할을 한다. 본 통신에서는 이렇게 계속 변화하는 역동적 시스템, 즉 '자기-조직화하는 계층구조의 열린 시스템(SOHOs)'의 개념적 틀을 소개한다. 먼저 SOHOs의 구조와 기능성을 이해하기 위해 물리학의 두 기본 법칙을 다시 논의한다. 두 법칙의 재해석을 통해 시스템의 운명과 지속가능성을 향한 보다 나은 경로, 또한 생태계의 온전함과 사회의 비전/가치 추구를 어떻게 조화시킬 것인가에 대한 이해를 돕고자한다. 그 다음에 소위 '비저니어링(V)'이라는 틀을 되먹임/전방급전(feedback/feedforward) 루프로 SOHOs 틀에 통합시켜서, '슬쩍 찌르는(nudged) 자기-조직화'가 시스템을 구성하는 행위자들이 합력하여 지속가능한 생태-사회 시스템을 이루어 가도록 유도한다. 마지막으로, SOHOs-V의 적용사례로서, 현재 탄자니아의 농촌마을에서 진행되고 있는 미래지구의 지속가능발전목표 연구실(SDG Lab)인 '농촌시스템 비저니어링(Rural Systems Visioneering)'을 예로 제시하였다. Sustainability science is an emerging transdisciplinary research which necessitates not only the communication and collaboration of scientists, practitioners and stakeholders from different disciplines and interests, but also the paradigm shift from deterministic and reductionist approaches to the old basic. Ecological-societal systems (ESS) are co-evolving complex systems having many interacting parts (or agents) whose random interactions at local scale give rise to spontaneous emerging order at global scale (i.e., self-organization). Here, the flows of energy, matter and information between the systems and their surroundings play a key role. We introduce a conceptual framework for such continually morphing dynamical systems, i.e. self-organizing hierarchical open systems (SOHOs). To understand the structure and functionality of SOHOs, we revisit the two fundamental laws of physics. Re-interpretation of these principles helps understand the destiny and better path toward sustainability, and how to reconcile ecosystem integrity with societal vision and value. We then integrate the so-called visioneering (V) framework with that of SOHOs as feedback/feedforward loops so that 'a nudged self-organization' may guide systems' agents to work together toward sustainable ESS. Finally, example is given with newly endorsed Sustainable Development Goals (SDG) Lab (i.e., 'Rural systems visioneering') by Future Earth, which is now underway in rural villages in Tanzania.

Maintenance Therapy of Facial Seborrheic Dermatitis with 0.1% Tacrolimus Ointment

( Hye One Kim ),( Yoon Seok Yang ),( Hyun Chang Ko ),( Gyung Moon Kim ),( Sang Hyun Cho ),( Young Joon Seo ),( Sang Wook Son ),( Jong Rok Lee ),( Joong Sun Lee ),( Sung Eun Chang ),( Jae We Che ),( Ch 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5

Background: Topical calcineurin inhibitors (TCIs) have been successfully used to treat seborrheic dermatitis (SD) patients. Meanwhile, treatment of atopic dermatitis (AD) with lowdose, intermittent TCI has been proved to reduce disease flare-ups. This regimen is known as a maintenance treatment. Objective: The aim of this trial was to investigate the efficacy and tolerability of a maintenance treatment with tacrolimus ointment in patients with facial SD. Methods: During the initial stabilization period, patients with facial SD or AD applied 0.1% tacrolimus ointment twice daily for up to 4 weeks. Clinical measurements were evaluated on either in the whole face or on separate facial regions. When an investigator global assessment score 1 was achieved, the patient applied tacrolimus twice weekly for 20 weeks. We also compared our results with recent published data of placebo controlled study to allow an estimation of the placebo effect. Results: The time to the first relapse during phase II was similar in both groups otherwise significantly longer than the placebo group. The recurrence-free curves of two groups were not significantly different from each other; otherwise the curve of the placebo group was significantly different. There were no significant differences between the 2 groups in the number of DEs, and treatment days for disease exacerbations (DEs). The adverse event profile was also similar between the 2 groups. During the 20 weeks of treatment, the study population tolerated tacrolimus ointment well. Conclusion: The results of this study suggest that maintenance treatment with tacrolimus may be effective in preventing the occurrence of facial SD exacerbations. (Ann Dermatol 27(5) 523∼530, 2015)

슬관절 골관절염 환자에 대한 Meloxicam의 유효성 및 안전성 평가를 위한 Diclofenac과의 공개 비교 무작위 다기관 임상 시험

송정식 ( Jung Sik Song ),박용범 ( Yong Beom Park ),이수곤 ( Soo Kon Lee ),안홍준 ( Hong Joon Ahn ),이윤우 ( Yun Woo Lee ),이창근 ( Chang Keun Lee ),고재현 ( Jae Hyun Koh ),고은미 ( Eun Mi Koh ),이은영 ( Eun Young Lee ),이충기 ( Ch 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4

Objective: To assess the clinical efficacy and safety of meloxicam 7.5mg versus diclofenac 100mg slow release (SR) in the Korean patients with osteoarthritis of the knee. Methods: Ninety-one patients of four university hospitals in 1999 were randomized to receive once daily oral meloxicam 7.5mg (N=45) or diclofenac 100mg SR (N=46) for 8 weeks. Clinical efficacy was evaluated using 100mm Visual Analogue Scale (VAS) for pain, Lequesne index after 4, 8 weeks of treatment as well as the physician`s and patient`s global assessment at the end of treatment. Evaluations for clinical safety were performed using the incidence of adverse events, physical examinations, laboratory finding and total ingestion of antacid during the treatment. Results: After 8 weeks of therapy, both groups had significant improvement in 100mm VAS and Lequesne index than baseline although the difference between two groups did not reach statistical significance. The physician`s and patient`s global assessment were similar in two groups. The incidence of gastrointestinal adverse events was significantly lower in meloxicam group (24.4%) than diclofenac group (50.0%) (p<0.05). Conclusion: Meloxicam 7.5mg is comparable to diclofenac 100mg SR in the treatment of Korean patients with osteoarthritis of the knee. Furthermore meloxicam 7.5mg was well tolerated for 8 weeks and has safe advantage of a significantly lower incidence of gastrointestinal adverse events.