바이오필터에 의한 VOCs의 제거에 대한 연구

김장호,김옥택,안종수,김종수 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Biofiltration was successfully applied to treat amixture of volatile organic compounds(Benzene, Xylene) from contaminated air stream. Immobilized Ps.oleovorans biofilter was evaluated for its value in simultaneous removal of B.X from waste air stream. The variety of operating conditions were tested to evaluated important factors such as space velocity, PH, water content, ect. In the loading rate(1,000ppmv) and space velocity(l,200hr), the average removal efficiencies of B.X. were 39.3% and 30.5% and CO₂ production rate were 6.72 mg/hr, 4.65mg/hr, respectively. Removal efficiency of B.X. mixture was lower than it's each individual at same loading rate. When the concentrations of B.X. mixture were controlled 300ppmv and 900ppmv at two stages reactor, the average outlet concentration were 7.lppmv, 184.5ppmv and CO₂ production rate were 6.04mg/hr, 12.6mg/hr, respectively.

아미노글리코사이드 사용제한에 따른 병원성 균혈증 유발 그람음성간균의 내성변화 및 임상적 의의

오종택,김신우,손종원,도병훈,한승우,신병철,박지현,이종명,김능수 대한감염학회 2003 감염과 화학요법 Vol.35 No.4

목적 : 항균제 오남용으로 인한 내성균의 출현, 약물부작용의 발생 및 약제 비용의 증가는 환자 개인뿐만 아니라 사회적으로 문제가 되고 있다. 본 연구는 항생제의 오남용을 막기 위한 제도의 일환으로 시행한 아미노글리코사이드 사용 제한정책의 비용 효과적인 측면을 조사하고 그람음성간균에 의해 병원성 균혈증이 발생한 환자들을 대상으로 이 정책이 항생제 내성률과 환자 사망률에 미치는 영향을 연구하였다. 방법 : 930병상 규모의 3차 병원인 일개 대학병원에서 아미노글리코사이드 사용제한정책이 시행된 직후인 2002년 3월에서 9월 사이에 그람음성간균(Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Stenotrophomonas maltophilia, Burkholderia cepacia)에 의해 발생한 병원성 균혈증 환자 60명(실험군)과, 이 정책이 시행되기 전에 입원한 환자들 중 균주별로 같은 수만큼 선별한 병원성 균혈증 환자 60명(대조군)의 의무기록을 후향적으로 조사하였다. 결과 : 아미노글리코사이드 사용제한정책이 시행된 시기인 2002년 3월에서 9월 사이에 처방된 아미노글리코사이드 사용량 및 비용을 이 정책이 시행되기 전인 2001년 3월에서 9월 사이와 비교한 결과, 아미노글리코사이드의 사용량(antimicrobial utilization density)은 사용제한 후 225.2에서 130.3으로 42% 감소하였고 약제 비용은 44% 감소하였다. 아미노글리코사이드 사용제한 후 병원성 균혈증을 유발한 그람 음성간균의 이 항생제에 대한 내성률은 유의한 변화를 보이지 않았으며 균혈증과 직접 연관된 사망률도 환자의 나이, 성별, 기저질환 및 원발병소 등을 보정할 경우 유의한 차이를 보이지 않았다(40.4% vs. 24.1%, P=0.11). 결론 : 아미노글리코사이드를 5일을 초과한 사용 시 감염전문가의 사전 승인을 필요로 하는 사용제한정책은 아미노글리코사이드의 사용량과 비용을 유의하게 감소시켰다. 또한 이 정책 시행 후 그람음성간균에 의한 균혈증 환자에서 균혈증으로 인한 사망률과 아미노글리코사이드에 대한 내성률은 유의한 차이가 없었다. Objective : To evaluate the effects of an aminoglycoside restriction policy on expenditures for aminoglycosides, antimicrobial resistance rates and clinical outcome of nosocomial bacteremia caused by Gram-negative bacilli (GNB). Methods : Starting in February, 2002, a prior consultation with an infectious disease specialist for using aminoglycoside antibiotics over 5 days was required in a 930-bed university hospital. In retrospective analysis of medical records 7 months after initiation of the aminoglycoside restriction policy, sixty cases of clinically relevant nosocomial bacteremia caused by GNB were found. These bacteremic patients were compared with sixty, species-matched, control patients with nosocomial Gramnegative bacteremia before the policy for total expenditures for aminoglycosides, susceptibility to antibiotics and clinical outcomes of bacteremia. Results : During the same period of 7 months before and after the restriction policy, total expenditures for aminoglycosides decreased by 44% in cost (from 465,030,841 Won to 259,618,337 Won) and the antimicrobial utilization density of aminoglycosides decreased by 42% (from 225,2 to 130.3). On the other hand, the patterns of antibiotic susceptibility and bacteremia-related in-hospital mortality rates after the policy did not show a significant change, compared with those before the policy. Conclusion : Antibiotic restrictions are among the most popular methods to diminish the practice of antibiotic overuse in hospitals. In this study, requirement for prior approval of aminoglycoside use over 5 days led to a significant decrease in the amount and cost of total aminoglycosides without a significant change in susceptibility patterns and bacteremia-related mortality rates.

뇌실외 배액술 시행과 관련된 뇌실염 : 원인균주와 경험적 치료약제의 적절성

도병훈,김신우,오종택,손종원,하상우,이응갑,장현하,이종명,김능수 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 본 연구는 뇌실외 배액술을 시행한 신경외과 환자들에서 뇌실염 발생 빈도, 원인균주와 감수성 추이 및 경험적 치료로 사용되는 항생제인 ceftazidime과 vancomycin의 적절성 여부에 대하여 조사하였다. 재료 및 방법 : 2000년 12월부터 2003년 10월까지 EVD를 시행한 경북대학교병원 신경외과 입원환자 340명 중 뇌실염이 발생한 39명을 대상으로 후향적으로 조사하였다. 결과 : 340명 중 39예 (11.5%)에서 뇌실염이 발생하였고 이들 가운데 4명이 뇌실염과 연관하여 사망하였다(10.3%). EVD 시행일로부터 뇌실염 발생까지는 평균 8.4일이었다. 원인균은 33예(87.1%)에서 확인되었으며 Aci-netobacter (19예, 45%), methicillin-resistant coagulase negative Staphylococcus (9예, 22%), methicillin-resistant Staphylococcus aureus (9예, 22%) 등의 순이었다. 가장 많이 동정된 Acinetobacter 19예 중에서 8예(42.1%)가 ceftriaxone에 내성을 보였으며 현재 경험적으로 널리 사용되는 ceftazidime에 대해서는 11예중 3예(27%)가 내성을 보였다. 결론 : 최근 EVD 시행과 관련된 뇌실염 뇌실염 최근 그람음성 non-fermenter 특히 Acinetobacter에 의한 경우가 증가하고 있으며, 이들 그람음성 non-fermenter는 현재까지 경험적으로 사용되는 ceftazidime에 점차 내성을 보이고 있다. 경험적 치료제에 대한 성공률을 높이기 위해서는 각 병원별 내실염의 원인균주의 감수성에 대한 검사가 필요하겠다. Purpose : To investigate the etiologic microorganisms of external ventricular drain (EVD)-related ventriculitis and the appropriateness of using ceftazidime and vancomycin as an empiric therapy in neurosurgical patients with EVD-related ventriculitis. Materials and Methods : Retrospective analysis of 39 patients with EVD-related ventriculitis among 340 neurosurgical patients to whom EVD had been placed during December 2000 and October 2003 at Kyungpook National University Hospital. Results : Thirty-nine EVD-related infections (39/340, 11.5%) occurred and the attributable mortality rate was 10.3% (4/39). The average duration from the ventricular catheter placement to the development of ventriculitis was 8.4 days. All patients with EVD infection had fever and 89.7% (35/39) of the patients showed nuchal rigidity. The positive culture rate in CSF was 87.1% (34/39) and the frequency of individual organism is as follows : Acinetobacter 45% (19 cases), methicillin-resistant coagulase negative Staphylococcus 22% (9 cases), methicillin-resistant Staphylococcus aureus 22% (9 cases), Enterococcus 5% (2 cases), Streptococcus pneumoniae 3% (1 case), non-fermenting gram-negative bacilli 3% (1 case). The polymicrobial infection rate was 15.4% (6/39). Among 19 cases of Acinetobacter infection, 42.1% (8/19) of the strains showed resistance to ceftriaxone and 15.7% (3/11) to ceftazidime. However, all cases were sensitive to meropenem. Conclusion : These findings show that the major etiologic organisms causing EVD-related ventriculitis have recently changed to Gram-negative non-fermenters, especially Acinetobacter. Because Gram-negative non-fermenting rods resistant to ceftazidime are increasing, an immediate change from ceftazidime plus vancomycin, the widely accepted empiric antibiotic therapy, to meropenem plus vancomycin should be considered when clinical symptoms and signs show no improvement or even deterioration.

개스크로마토그래피 패턴과 官能檢査 成績을 利用한 韓國 在來式 간장 香氣으 主成分 分析

金鍾奎,金洙澤 慶尙大學校 1984 論文集 Vol.23 No.2

韓國 在來式 간장의 香氣에 대한 44개의 PEAK들 中에 含有되어 있는 香氣의 有效因子를 찾아내고자 主成分 分析 및 단계별 重回歸 分析을 한 結果는 다음과 같다. 간장 香氣의 有意的으로 영향을 미치는 有效因子로써의 중요 PC들은 8,20,9,4,38,15,28,3,7,36 및 33번이었고 이들의 性質에 크게 관계하는 GC peak는 전부 空明이 되었으나 앞으로 各 GC peak의 構成 物質들의 構造가 더 자세히 밝혀지면 이 PC들의 자세한 性質과 간장 香氣의 특징이 解明되리라 보며 그러나 前報1)에서 밝혀진 주요 peak인 10번 peak는 8번 PC에 positive로, 12번 peak는 4번 및 20번 PC에 negative로 밀접한 相關을 나타내었다. 또 官能檢査値의 총 變動에 대한 33.87%에 해당하는 부분은 4번, 8번, 20번 PC에 의하여 영향을 받았다고 추정할 수 있었다. 여기서 밝혀진 重要 PC의 性質을 좌우할 중요 GC peak는 앞으로 간장香을 위한 微生物 育種等에 지표로 利用 可能하리라 본다. The relationship between percent transf ormed GC data and sensory score of the Korean ordinary soy sauce flavor were analyzed by principal component analysis and multiple regression analysis. Peak 10 showed the closest correlation to the 8th principal (PC) in the positive factor loading. And peak 12 showed the closest correlation to the 4th PC and the 20th PC in the negative factor loading. The 4th, the 8th and the 20th PC can explain 33.87% of the variation among total variation contained in the sensory score.

PD 제어기를 이용한 회전시스템의 동특성에 관한 연구

김택현,김종태,김재경 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1

기계 회전 시스템을 통하여 응답특성 및 제어효과에 대한 연구를 목적으로 하여 PD제어기를 사용하여 응답특성을 확인하였는데 제어기를 사용함은 얻고자하는 대상 플랜트의 출력 특성을 제어하는데 목적이 있다. 우선, 실험으로 들어가 시스템의 관성 (inertia), 스프링 강성(spring stiffness), 감쇠계수(damping coefficient) 등의 매개변수 값들을 측정하고, 하드웨어 게인 값을 정의한다. 다음으로 PD제어기의 설계를 하는데 우선 강체로 모델링된 시스템에서의 step 응답, ramp 응답, parabolic 응답과 sinusoidal 응답에서의 비례게인, 미분게인 값이 시스템에 미치는 영향을 통하여 제어특성과 효과를 알아보고, 2자유도(two degree of freedom) 기계 회전 시스템에 대하여 PD제어실험을 통하여 회전 시스템의 상승시간(rising time), 정착시간 (settling time) 등의 응답속도 개선, 그리고 오버슈트(overshoot), 언더슈트(undershoot) 등의 응답성능의 향상을 꾀한다. The mechanical rotation system is made up of belts, mass disks and gears. This precise piece of equipment is controlled electro-mechanically by the motor and operation program. The control strategy of the system can be changed by belts' stiffness and change of the mass and gear. This system can be modeled as a rigid body, and also finds broad application in such diverse fields as machine tools, the cruise control system in automobiles, and control in the attitude and gimbals of spacecraft. This system proves the necessity and effect of a closed loop control. The study of the mechanical rotation system excited by its base motion is not only able to predict the rotational performance, but obtain the fundamental data for vibration isolation. In this thesis, we studied the response abilities such as steady overshoot, undershoot and ect. and the response velocities such as rising time, settling time, and ect. in the mechanical rotation system. through PD control experiment..

證券市場의 情報效率性 測定모델과 주요 市場의 效率性

金鍾斗,공정택 효성여자대학교 산업경영연구소 1990 경영경제 Vol.7 No.-

대칭형 보강재 간격에 따른 주기구조물의 음향방사에 관한 연구

김종태,김택현 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.2

The purpose of this research is to study the vibration and acoustic pressure radiation from a thin isotropic flat plate stiffened by a rectangular array of beams, and excited by a point harmonic force. Periodic constructions on aircraft and ship structures are often subjected to frequency dependent pressure fluctuations and forces. For example, the forces exerted by the wing attachments on the fuselage may be modeled as concentrated static forces arising from the dead weight of the attachments and dynamic forces from the engine moving parts, while a random acoustic pressure variation over the structure is realized around a jet efflux. Fluctuating pressure excitations are also caused by boundary layer pressure fields. These excitations induce structural vibrations in a wide range of frequencies, which may cause such things as acoustic fatigue and internal cabin noise in the aircraft. It is thus important that the response characteristics and vibration modes of such periodic structures be known. From this theoretical model, the sound pressure levels in a semi-infinite fluid(water) bounded by the plate with the variation in the locations of an external time harmonic point force on the plate can be calculated efficiently using three numerical tools such as the Gauss-Jordan method, the LU decomposition method and the IMSL numerical package.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

박람회 관광객의 만족요인 및 행동의도 결정요인에 관한 연구 : 안면도 국제 꽃 박람회를 중심으로 Focused on Korea Floritopia 2002

김종택 문화관광연구학회 2003 문화관광연구 Vol.5 No.2

The research on the factors determining the satisfaction which exhibition tourists feel after their touring is expected to provide an important material to tourist businesses planning exhibitions in understanding the determining factors of customer satisfaction. Putting together the above-stated results of empirical analysis, it shows that tourist service business has some satisfaction-determining factors different from those of general services or products due to its unique characteristics, and the determining factors may have influence on the behavioral intent of tourists after their touring. Among the satisfaction-determining factors on the side of non-suppliers, "empirical characteristics" was especially disclosed as the variable that influences on both the general satisfaction and behavioral intent, thus implying the necessity of the succeeding research on it.

李人稙小說 <雉岳山>의 談論 特性

김영택,최종순 牧園大學校 2000 論文集 - 牧園大學校 Vol.38 No.-