젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

청소년 도덕적 품성화 검사 도구 개정 연구(2차년도)

류숙희 ( Sook Hee Ryue ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),홍성훈 ( Seong Hoon Hong ),전종희 ( Jong Hee Jeon ),윤영돈 ( Young Don Yoon ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 한국 청소년들의 도덕적 품성화 능력을 측정하기 위한 검사 도구를 개발하기 위한 것으로 2011년도에 개발된 검사 도구를 수정 및 보완한 것이다. 즉, J. Rest가 주장한 도덕성의 제4요소인 도덕적 품성화에 관한 선행연구들을 체계적으로 분석하여 도덕적 품성화의 개념을 보다 명확히 하였고, 1차년도에 설정한 도덕적 품성화의 구성 요소를 개인품성과 관계품성의 두 항목으로 재설정하였다. 또한 검사의 신뢰도와 타당도를 높이기 위해 기존의 스토리와 문항을 수정하였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사는 전국 중학교 2학년생 409명을 대상으로 실시되었고, 본조사는 전국 6,216명의 중학교 2학년생을 대상으로 실시되었다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 확보하기 위해 요인분석을 실시했는데, 도덕적 품성화 능력 검사는 1개 문항을 제외하고 모든 문항이 예정된 요인으로 묶였다. 그리하여 2차년도 연구를 통한 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 10개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 29개 문항으로 확정되었다. 2차년도 연구결과 개정된 검사 도구는 2011년 검사 도구에 비해 더 안정된 검사도구로서 향후 청소년의 도덕적 품성화 측정을 위한 연구와 실무에 활용될 수 있을 것이다. The study aims to revise Moral Character Test I which was set for adolescents based on Rest`s four components model in 2011 and make standardized final morality test. In theory, this study is based on the four components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The four components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral character. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral character, research team used personal character and interpersonal character. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral character, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “on going to park”, the factor analysis shows a little bit limitation result. Even though, 1st and 2nd researches have common weak point which is highly dependent upon not factor but story. Through these processes, to test moral motivation, this study shows 3 stories and 29 questions. And this recommends that just one simple story might be developed for one component(moral character).

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

청소년 도덕적 동기화 검사 도구 개정 연구(2차년도)

전종희 ( Jong Hee Jeon ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),윤영돈 ( Young Don Yoon ),류숙희 ( Sook Hee Ryue ),홍성훈 ( Seong Hoon Hong ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 J. Rest의 4구성요소 모형을 바탕으로 1차년도(2011년)에 개발된 도덕적 동기화 검사를 보다 신뢰롭고 타당한 도구로 개정하는 것이다. 따라서 선행연구를 보완하여 도덕 동기화의 구성 요소를 도덕지향성과 도덕적 정서귀인 등 두 항목으로 재설정하고, 스토리와 문항을 수정하였다. 개발된 세 개의 스토리(과제, 놀이공원, 작품) 별로 신뢰도를 분석한 결과, 전반적으로 .90 내외의 높고 수치를 보였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사를 위해서는 전국 중학교 2학년생 409명을 대상으로 했고, 본조사를 위해서는 전국 6,216명의 중학교 2학년생을 대상으로 실시하였다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 검증하기 위하여 요인분석을 실시한 결과, 과제 스토리와 놀이공원 스토리의 일부 문항이 가정한 요인으로 잘 묶이지 않았는데 이 문항들을 제거하고 요인분석을 다시 실시해본 결과 기대하는 바를 충족했다. 그리하여 2차년도 연구를 통해 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 9개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 28개 문항으로 확정되었다. 본 연구를 통해 수정 확정된 도덕적 동기화 검사도구는 상당히 안정적인 신뢰도와 타당도를 확보하였기에, 향후 우리나라 청소년의 도덕적 동기화 능력을 측정하기 위한 검사도구로 활용되기에 적절할 것으로 판단된다. The study aims to revise Moral Motivation Test I which was set for adolescents based on Rest`s four component model in 2011 and make standardized final morality test. In theory, this study is based on 4 components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The 4 components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral motivation. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral motivation, research team used moral orientation, moral emotion attributions. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral motivation, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “homework inspect”and “on going to park”, the factor analysis shows a little bit limitation result. Eliminated those questions, the result of factor analysis was more stable and reliable. Through these processes, to test moral motivation, this study shows 3 stories and 28 questions. And this recommends that just one simple story might be developed for one component(moral motivation).

통역사의 정보처리능력과 Note-Taking

박숙종 한국국제회의통역학회 2002 통역과 번역 Vol.4 No.1

Interpretation is a special procedure of information processing distinct from other forms of general information processing. Here, a special procedure of information processing is related to the role of interpreter. Interpreter does not deliver only a part of message. In order to understand the message in its entirety, an interpreter must consciously analyze the entire message, relying on the ability that surpasses the bounds of natural and automatic understanding. Hence the message must be analyzed very quickly, using a more intuitive analysis rather than a linguistic analysis. This is because the interpreter, unlike the audience, has the responsibility to deliver the whole message to the audience, however trivial the message seems or indifferent the interpreter may feel toward the message. However, it is not easy to clarify the cognitive process applied to interpretation, a special form of information processing, when general information processing and cognitive process have not been fully identified yet. Having attached excessive importance on the theorization, the currently available consecutive interpretation models and theories are somewhat distant from the consecutive interpretation observed on site. For example, the stage of consecutive interpretation in which linguistic transformation (linguistic transformation from the source language to the target language) takes place differs from theory to real life. There is a study that examined the correlation between the location of linguistic transformation and the note-taking language (whether to take notes in the source language or the target language). The reality is that there is a difference between this study and the note-taking method actually employed by interpreters. I believe that this is expected, considering that the relationship between interpretation and cognitive action to enhance the interpretation efficiency has not been fully investigated. A study of relationship between the information processing capacity of interpreter and note-taking would make an interesting study theme, particularly in the consecutive interpretation, in which interpreters information processing capacity is clearly revealed.

카리스마적 리더십에 관한 연구

박종태,최영곤,한남익,박철용,표내숙,조춘호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

In the early decades of this century, Charisma which originally means endowment with the gift of grace, has been introduced to social sciences by German sociologist, Max Weber. It quickly became interested in the field of sociology and politics. But, into the 1970s, charismatic leadership still had not became a subject for empirical or experimental research related to organizational theory. Recently, much attention has been paid to charismatic leadership as the prototype of leadership that people have in mind when they describe their ideal leader and is more likely to provide a role model with which subordinates want to identify. As a result, in will perform further study related to Charisma leadership which developing various kind of measurement and instrument. Finally, it should identify lost of possibility and phenomenon through the study of charisma leadership.

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

감각통합기능장애에 대한 집중치료프로그램의 효과 : 사례보고

박지훈,노종수,이향숙,차정진 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.2

목적: 본 연구는 감각통합기능장애를 가진 아동을 대상으로 주간에 걸친 집중치료프로그램을 제공하였을 때 미치는 효과를 알아보기 위한 것이며, 사후 평가를 통하여 감각통합기능의 유지 여부를 알아보았다. 연구방법: 단일사례연구로써 2주간 9회기 1회기에 40분씩 치료접근을 실시하고, 가정에서 Sensory diet와 더불어 Wilbarger Protocol을 실시하였다. 초기평가와 1차 재평가 사이의 시간은 15일이며, 5개월 후 2차 재평가를 실시하였다. 결과: 집중치료프로그램 적용 후, 아동은 전반적인 감각영역에서 감각방어가 감소되었고 자기조절 (수면, 각성)이 향상되었다. 또한 실행과 시-지각에서도 향상을 보였으며, 정서적 안정과 일상생활에서도 향상을 보였다. 프로그램 적용 5개월 후 감각조절능력, 안정적인 수면은 유지되고 시-지각에서도 지속적인 발달을 보였지만 정서적인 안정은 지속되지 않았다. 결론: 집중치료프로그램이 긍정적인 효과가 있음을 알 수 있었고, 집중치료프로그램 적용 후 치료적 접근이 없어도 대부분의 감각영역에서 감각조절능력을 유지할 수 있음을 알 수 있었다. Objective : The purpose of this study was to identify effects of intensive sensory integration (SI) treatment and home-program for a child who has a sensory integration disorder. This study also examined wheth­er the positive effect is long-lasting by a follow-up test. Method : A boy with sensory integration dysfunction underwent an intensive SI treatment for 2 weeks. The intervention was consisted of 9 sessions and duration of the each session was 40 minutes. Sensory diet and Wilbarger protocol was provided as home program. The child's sensory function was evaluated be­fore and after the SI intervention. Five month later, re-evaluation was executed for follow-up purpose. Results : In the evaluation after the Si intervention, the child's sensory defensiveness was decreased. Praxis, visual perception, sensory regulation dysfunction (sleep function), affective stabilization and performance of activities of daily living are also improved. In the re-evaluation after the 5 month later, the self-reg­ulation ability, especially sleep function, has been maintained and the visual perception was developing continually. However, the child showed some affective regulation such as bothering his mother and los­ing his temper. Conclusions : The intensive SI intervention showed positive effects in terms of SI function improvement and the effect lasted long without any additional therapeutic intervention.

탱자(Poncirus tripoliata RAF)잎으로부터 Mitochondrial DNA의 분리

박종필,전홍성,김연순,이숙영,김성준 조선대학교 부설 유전생물공학연구소 1992 유전생물공학연구지 Vol.2 No.-

Differaitial centrifugation, sucrose(30%, 60%) and percoll(13.5%, 21% and 45%) density gradient centrifugation were used to effectively isolate mitochondria and mitochondrial DNA (mt DNA) from the leaves of the genus Poncirus (Pondrus trifoliata RAF.) The results showed that percoll density gradient centrifugation provided a convinient and effective method for the preparation of clean mitochondria. The purity of prepared mt DNA was increased by the removal of the nuclear DNA by DNase treatment to the crude mitochondrial suspension mt DNA on the agarose gel was shown extra fluorescent background in case of isolation by differential centrifugation and more cleared band included slightly smeared patterns for sucrose density gradient, and highly paint band from percoll density gradient was appeared to the best results of the above three methods. In addition to chromosomal mt DNAs, two short mt plasmid-like elements were detected in the genus Poncirus. These elements consistently co-purified with the chromosomal mt DNAs and is widely distributed among natrual Poncirus trifoliata RAF. populations. But these elements required proteinase K treatment for mobility in agarose gels.

肝炎試藥의 程度管理 Microplate法과 MEIA法의 比較

박종우,송인숙 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Background : The authors investigated HBsAg and anti-HBsAb EIA detection kits in 1,500 cases, which contained 500 cases of HBsAg positive confirmed by first screening test and comparison with HBV nested PCR and anti-HBV RIA methods. Methods At first, authors performed screening tests which EIA detection kits (Behring) were run by ELISA process II(Behringwerke® AG, German) and one detection kit(Abbotts) was run by IMx(Abbott Park® USA). And then the samples which were discrepant results investigsted by RIA method and HBV DT A nested PCR. Results : By examination, the following results were obtained: 1. Serum HBsAg was detected in 43.5%, 43.9% of 1500 cases for Behring, Abbotts respectively. Anti-HBsAb was detected in 45.7% for Behring and 49.9% for Abbotts. 2. The discrepancy rate of 1500 cases between Behring® and Abbotts® EIA kits was 6.9% on HBsAg detection kits. In case of anti-HBsAb detection kits, the discrepancy rate was 14.0%. 3. The sensitivity, specificity, positive predictive value and negative predictive value for anti-HBs was 95.7%, 94.3%, 93.8%, 96% and for HBs Ag, the sensitivity, specificity, positive predictive value and negative predictive value 98.0%, 98.2%, 97.9%, 98.4% in Behring. In Abbotts, 97.1%, 91.2%. 91.2%, 97.1% for Anti-HBs and 98.8%, 98.2%, 98.3%, 99.1% for HBs Ag. Conclusions : The difference in sensitivity and specificity between three EIA kits may have been the results of different cut-off value of positive control and negative control. There was no difference between three HBsAg aid anti-HBsAb diagnostic EIA kits.