신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

두부외상에 의한 기질성 정신장애환자의 단축형 K-WAIS

강종구,오상우 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.1

The purpose of this study was to make an short form of K-WAIS for patients with organic mental disorder due to head trauma. The patients were 215 brain damage patients with organic mental disorder whose sex were composed of 160 male and 55 female. The new form consisted of comprehension, vocabulary, picture completion, and picture arrangement. Multiple correlation coefficient(R=.81) with Full IQ was higher than that of the existing short-form and could explain 66%. This result suggested that K-WAIS short-form was enable to estimate IQ for patients with organic mental disorder due to head trauma.

마우스간염바이러스(MHV-2) 변이주 감염마우스에 있어서의 간염 및 뇌병변

강종구 충북대학교 농업과학기술연구소 1991 農業科學硏究 Vol.9 No.2

For the analysis of the phenotypical lesions of fulminant hepatitis, three plaque purified mutant strains were isolated from early releasing virus of MHV-2 infected DBT cells. In the present study I investigated the histopathological lesions, virus titrations and viral antigen distribution produced by the inoculation of various routes of three mutants. The results obtained were as follows. 1.The Mortality was 60% in mice inoculated with MHV-2S, 40% in mice inoculated with MHV-2M, and 0% in mice inoculated with MHV-2L. 2.In corticosteroid treatment, all mice inoculated with MHV-2S and -2M also died but 33% of mice died in those inoculated with MHV-2L. 3.Viral antigens by immunofluorescence were distributed in a spotty pattern for MHV-2L, unifocal for MHV-2M, and diffused or massive for MHV-2S and MHV-2. 4.Liver lesions in mice infected with MHV-2L were characterized by small inflammatory foci, MHV-2M caused spotty necrosis and focal cell infiltration. Likewise, MHV-2S5 led to zonal necrosis and cell infiltration and MHV-2 was found to produce massive hepatic necrosis. 5.At an early stage of intracerebral infection of three mutants, moderate inflammation was produced in the cerebral cortex, whereas severe demyelination became distinct after subsidence of degenerative and necrotic changes. The magnitude of these lesions were the highest in the MHV-2L infected mice.

알루미나가 3Y-TZP의 소결에 미치는 영향

강종봉,정재욱,양성구 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.2

본 연구에서는 3Y-TZP(3mol Yttria-Tetragonal Zirconia Polycrystal)의 기계적 물성과 미세구조를 관찰하기 위하여 소결조제로 알루미나를 1 2 wt%까지 첨가하고 1390%부터 1510℃부터 1510℃까지 열처리하였다. 소결 시료의 밀도는 온도와 알루미나의 첨가량이 증가할수록 저하되었으며, 경도는 1470℃ 이상에서 감소하는 경향을 보였다. 결정상 분석은 고온에서 Monclinic-ZrO_2가 검출되었으며, 열처리 온도가 증가함에 따라 결정입자의 성장을 나타내었다. To investigate the mechanical properties and microstructure of 3Y-TZP composition, alumina was added up to 1.2 wt% into the 3Y-TZP composition and sintered from 1390℃ to 1510℃ The density of specimen was decreased as increasing the alumina content and the hardness was also decreased at the above 1470℃ Monclinic ZrO_2 Phase was found for the specimen sintered at the above 1470℃. The grain size of specimen without alumina was increased rapidly as increasing the sintering temperature.

범게, Orithyia sinica 유생의 생존과 성장에 미치는 암모니아와 아질산의 영향

구자근,김종만,장차환,지정훈,강주찬 한국어병학회 2004 한국어병학회지 Vol.17 No.1

범게, Orithyia sinica 유생을 대상으로 암모니아와 아질산에 대한 생존 및 성장에 관한 실험을 실시하였다. 암모니아 노출 실험구에서 zoea기 유생은 노출 20일후, 대조구가 80%의 생존율을 나타내었지만 10㎎/L 이상의 실험구에서는 37-45%의 생존율을 나타내었고, megalopa기 유생에서도 유사한 경향을 나타내었다. 암모니아가 범게 유생의 성장에 미치는 영향을 조사한 결과, zoea기 유생은 20㎎/L 이상의 농도에서 megaloparl 유생은 50㎎/L 이상의 농도에서 유의한 차이를 나타내었다. (P<0.05). 아질산 노출 실험에서는 zoea기 유생과 meglaopa기 유생에서 농도와 노출기간에 비례하여 생존율이 감소하였으며, 특히 150㎎/L 이상의 아질산 농도에 노출된 zoea기 유생가 megalopa기 유생은 대조구와 비교하여 유의한 성장 지연을 나타내었다(P<0.05). This study investigates the influence of waterborne ammonia and nitrite on the zoea and megalopa stage larvae of tiger crab, Orithyiu sinicu under laboratory condition, focusing on the effects on survival and growth as deleterious responses of toxicant. Survival rate of zoea stage larvae exposed to control levels, and to 5, 10,20 and 50 ㎎/L total ammonia-N, using a continuous flow system for 20 days was 80, 77, 45, 40 and 37%, respectively. Growth rate of zoea stage larvae exposed to 20 and 50 ㎎/L total ammonia was significantly lower than in controls after 20 days (P< 0.05). Survival rate and growth rate of megalopa stage larvae exposed to ammonia also decreased at greater than 10 and 50 ㎎/L, respectively. In the nitrite exposure experiment with zoea and megalopa stage larvae of tiger crab, survival rate was decreased in a concentration and exposure period-dependent way. The growth rate of zoea and megalopa stage larvae of tiger crab exposed to nitrite decreased at greater than 150 ㎎/L nitrite concentration.

신부전증과 폐에 Pseudolyrmphorma를 동만한 원발성 Sjogren 증후군 : Cyclophosphamide와 Prednisolone에 의한 성공적인 치료

강민규,구영선,황평주,김종학,나기량,서광선,이강욱,신영태 대한신장학회 2000 대한신장학회잡지 Vol.19 No.4

우리나라 중소제조기업의 수출활성화 방안에 관한 연구

구종순,강성찬 충남대학교 경상대학부설 경영경제연구소 1999 경영논집 Vol.15 No.1

IMF구제금융 등 외채 상환을 위해서 수출증대를 통한 무역수지 흑자가 가장 중요한데 수출시장은 축소되고 선진 수입국들의 수입규제는 더욱 강화되고 있는 현실에서는 대기업보다 수출경쟁력이 높은 중소기업 특히 중소제조기업의 수출활성화가 무엇보다도 중요하다. 이를 위하여 개별 중소제조기업들은 기업간 협력을 통한 연계화 추진, 바이어와의 신뢰 확보, 전략적 소수품목 집중, 수출상품은 중간재에 전문화, 시장국의 다변화, 대기업과의 협력방안 모색, 간접수출경로의 이용 등을 추진해야 하며 정부도 수출지원 network 구축을 통한 해외마케팅활동 지원, 대·중소기업 협력관계 적극 장려, 불필요한 각종 규제 철폐, 통상마찰 제거를 위한 적극적인 통상외교활동 수행 등을 통해 중소제조기업에게 실질적 도움이 될 수 있는 방안을 강구해야 한다.

글래스비드 방법과 분말프레스 방법을 이용한 지르코니아 분말시편의 반정량 엑스선형광분석

강종봉,조범래,양성구 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-

XRF는 시편의 종류에 따라 벌크, 분말 등 여러 가지 형태의 시료를 간단한 전처리 조작에 의해 빠른 시간에 분석할 수 있다는 장점으로 파인세라믹스의 원소분석으로 이용되고 있다. 그러나 시편들의 전처리 방법에 따라 분석의 결과가 달리 나타나고 있어, 본 실험험에서는 분말프페스형 시편과 글래스비드형 시편에서의 분석결과 차이를 밝히고자 하였으며, 분석결과에 미치는 영향들을 살펴보고자 하였다. 글래스비드형 시편인 경우 첨가하는 10배 이상의 플럭스 때문에 측정시편에 포함된 실제 분석하고자하는 시료의 양이 적어 오차의 범위가 크게 나타났다. 미량원소의 분석일 경우 글래스비드형 시편이 분말프레스형 시편의 시편보다 측정결과에서 많은 오차를 나타낸다. 이것은 X-선이 조사되는 영역에서 실제 시편내의 시료의 양이 미량 원소 분석의 오차를 나타냄을 알 수 있었다. XRF(X-ray Fluorescence Spectrometer) is one of the element analyzing instruments. which can be used to analyze ceramic materials of bulk, powder and various forms. The advantage of XRF is rapid analysis of elements in ceramics with simple sample preparation. In this study, the difference in results between pressed powder method and glass bead method were evaluated and the effects of sample preparation the final results were examined. The flux included in glass bead method, which is more than 10 times of samples, affected the final analyzing result. Trace element analysis in XRF could be affected by the sample amount because the region of X-ray beam is related the sample amount.

성인 급성 신부전의 원인 및 예후인자 분석

구영선,장윤경,양종오,강민규,황평주,김종학,나기량,이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Acute renal failure is a frequent complication in hospitalized patients and is strongly related to the mortality. The Clinical outcome and prognostic factors of acute renal failure(ARF) have been analyzed by many authors. The present study describes the etiologic and clinical aspects, as well as other factors related to mortality. All the patients suffering from acute renal failure admitted during the period of January 1993 - August 1998 were included in the study. The average age of the patients was 52±17 years and mortality rate was 24%. The causes of acute renal failure were hemorrhagic fever with renal syndrome(HFRS), sepsis, renal hypoperfusion, urinary tract obstruction, acute tubular necrosis, etc. The etiology of ARF was a significant prognostic factor on mortality in ARF. Other significant prognostic factors were oliguria, organ failure, use of vasoconstrictors, hypotension, serum bicarbonate, premorbid conditions, sepsis, neurologic complications, gastrointestinal bleeding. On the other hands, operation, sex, anemia, thrombocytopenia, hypoalbuminemia, BUN, serum creatinine, and hyperkalemia were not significant factors for the mortality. We conclude that major prognostic factors of acute renal failure arc premorbid conditions, sepsis and multiorgan failure, and they are responsible for persistent high mortality of acute renal failure despite of advances of medical care.

고상-기상 반응에 의한 질화 알루미늄 휘스커 합성

강종봉,양성구,이성우,정승화 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.2

질화알루미늄 휘스커 합성을 위하여, Al원으로는 Al_2O_3, Al(OH)_3, AlOOH를 사용하였고, 환원제로는 카본블랙, 기상반응을 유도하기 위하여 AlF_3, NH_4F, CaF_2를 사용하여 고순도 질소분위기에서 실험을 행하였다. 또한 액상반응 시 미세구조상의 변화를 확인하기 위하여 금속 알루미늄을 첨가하여 실험을 행하였다. 질화알루미늄의 생성과 침상형 휘스커상의 형상은 1600℃의 온도에서 가장 잘 나타났으며 열처리 온도의 상승은 오히려 휘스커상의 형성을 방해하고 있음을 보여주었다. 침상형 휘스커의 합성에 가장 큰 영향을 주는 것은 기상반응을 일으키는 AlF_3 첨가이며, AlF_3 첨가량이 증가함에 따라 침상형 휘스커상의 증가를 확인할 수 있었다. 액상 반응을 위한 금속 알루미늄 첨가는 전체의 15 wt%까지는 침상형 휘스커가 증가하였으나 15 wt%이상으로 첨가하는 경우 오히려 침상형 휘스커가 감소하는 것으로 나타났다. To synthesize aluminium nitride whisker, Al_2O_3, Al(OH)_3, and AlOOH were used for aluminium element. Experiment was done under the high purity nitrogen atmosphere with carbon black as deoxidation agent and AlF_3, NH_4F and CaF as gas phase reactants. Metallic aluminium was used for liquid phase reaction in which microstructural change occured. The AlN with whiskered Phase was formed at 1600℃ and the increase of temperature inhibited the formation of whiskered phase. AlF_3 was the main factor for the formation of needle-shaped whiskers, and the amount of whisker increased with AlF_3 contents. The amount of needle-shaped AlN whiskers increased with the addition of metallic aluminium up to 15 wt% but decreased with aluminium of above 15 wt%.