조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

발레 푸에떼 앙뚜루낭 앙드오르 동작의 운동학적 분석

유봉준,박계순,임규찬,박종진 한국운동역학회 1999 한국운동역학회지 Vol.9 No.1

The study aimed to analyse and compare the various kinematic variables of Croise´ motion with A la seconde motion in order to provide improve-ment of understanding in the technique of ballet. And Fouett´ motion was divided into LSI(i.e., Leg-Stretching motion: A la seconde in French), LBI(i.e., Leg-Banding motion: Coupe´ in French), LS2 and LB2. To achieve of such the purpose, six ballerina were sampled as subjects with 5-year career at university and the motions were required to be performed as quickly and stably as possible. The motions were analysed using the DLT method of three-dimensional cinematography. The principal kinematic variables for comparative analysis between Croise´ and A la seconde were as such: spent time, c.o.g distance, angular velocity of both arms, lean angle, hip joint angle and height of c.o.g. As a result of analyzing the data, the following conclusions were drawn. 1. The overall duration of Croise´ is less than that of A la seconde, but there was no significant difference two motions. 2. C.O.G. distance in Croise´ in view of horizontal plane tend to be shorter than that in A la seconde, but there was no significant difference between two motions. 3. The angular velocity of right arm in Croise´ is larger than that in A la seconde only at LS. There was no significant difference in the angular velocity of left arm in two motions, but the angular velocity f left arm in A la seconde tend to be larger than that in Croise´both at LSI and at LS2. and the angular velocity of left arm un Croise´ tend to be larger than that in A la seconde both at LB1 at LB2. 4. There was no significant difference in the lean angle and right hip joint angle between two motions. But the lean angle of Croise´ tend to be larger than that of A la seconde and the right hip joint angle of Croise´ tend to be larger than that of A la seconde. The right knee joint angle of Croise´ was larger than that of A la seconde at LS1 which proved to be significant difference between two motions. At other factors, there was no significant difference, but the right knee joint angle of A la seconde tend to be larger than that of Croise´. 5. There was significant difference between two motion at all factors on the height of c.o.g.. The height of c.o.g. of Croise´ tend to be higher than that of A la seconde at LS1 and at LS2. Besides, the height of c.o.g. of A la seconde tend to be higher than that of Croise´ at LB1 and at LB2.

슬래브-유한요소혼합기법에 의한 냉간압연해석

유인창,박종진 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.1

Compared to a full three dimensional FEM, the Slab-FEM hybrid method reduces the required computation time distinctly and it can be applied to the analysis of a shape rolling process. However, the method is somewhat approximate and predictions by the method contain certain inaccuracies. In the present investigation, a parameter called T-factor was introduced to compensate the inaccuracies of the method and proper values of the parameter were estimated for different widths of bars and reduction ratios. Then, the method was applied to analyze cold rollings of rectangular bars and predicted results were compared to those of experiments. It was found out that accuracies of spread and roll separating force predictions could be enhanced by using proper values of the T-factor.

유전성 대사질환에서의 동종조혈모세포이식 : 단일 기관에서의 경험 A single center experience

유건희,김흥렬,이지은,이호영,천정미,성기웅,구홍회,이문향,진동규,김종원,김대원,김형록 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

배경: 유전성 대사질환의 치료로서 효소 요법 및 유전자 치료가 제한적인 현실에서 동종 조혈모세포이식이 현재로선 가장 중요한 치료가 될 수 있다. 본 연구에서는 단일 기관에서 유전성 대사질환에 대해 동종 조혈모세포이식을 시행한 경험을 보고하고자 하였다. 방법: 삼성서울병원 유전성 대사질환 조혈모세포이식팀에서는 1999년 12월부터 2001년 3월까지 총 6례의 유전성 대사질환을 대상으로 동종 조혈모세포이식을 시행하였다. 대상 질환은 Hunter 증후군 3례, galactosialidosis 1례, 이염성 백질이영양증 1례, 부신백질이영양증 1례였으며 성별 분포는 남아가 5명, 여아가 1명이었으며 연령 분포는 2년 9개월에서 15년 9개월이었다. 5례는 HLA 일치 혈연간 골수이식이었으며 1례는 HLA 불일치 T 림프구 제거 말초혈액 조혈모세포이식이었다. 전처치는 모두 BuCy를 사용하였으며 이식편대숙주반응의 예방에는 cyclosporine을 사용하였다. 이식된 세포는 유핵세포가 4.81×10^(8)(2.40~7.01×10^(8))/kg이었으며 CD34+ 세포는 3.65×10^(6)(0.88~10.72×10^(6))/kg이었다. 결과: 이식 후 조혈기능의 회복은 모두 조기에 달성되었으며(ANC>500: 정중 9.5일, 범위 9~14일; PLT>50K: 정중 32일, 범위 23~34일) 이식과 관련된 합병증은 Gr I의 aGVHD 3례, 국한성의 cGVHD 1례, 경증의 간정맥 폐쇄성 질환이 1례이었다. 모든 환자에서 직간접적으로 이식 후 효소의 생산이 증가함이 확인되었으며 임상적인 호전을 보인 경우가 4례, 질병 진행이 중단된 경우가 1례, 질병이 진행된 경우가 1례이었다. 질병 진행이 중단되었던 1례는 면역억제제 투여 중 수두 감염에 의한 폐출혈로 사망하였다. 결론: 유전성 대사질환에서 동종 조혈모세포이식이 가장 중요한 치료법으로 사용될 수 있고 중추신경계 증상이 나타나기 전, 가능한 조기에 조혈모세포이식을 시행하는 것이 바람직할 것이며 적극적인 지지 요법이 필요하다. 향후 더 많은 임상 경험이 필요하리라 사료된다. Background: Allogeneic hematopoietic stem cell transplantation (HSCT) may be the most important treatment modality to cure a number of genetic metabolic disorders because of the limitation of enzyme replacement or gene therapy. In this study, we report our single center experience about HSCT in several genetic metabolic disorders. Methods: We performed 6 cases of HSCT for genetic metabolic disorders from December 1999 to March 2001. Patients' diagnoses were Hunter syndrome (3), galactosialidosis (1), metachromatic leukodystrophy (1), and adrenoleukodystrophy (1). Stem cell sources were bone marrow from HLA matched sibling donors in 5 patients and mother's peripheral blood stem cells in one patient who did not have HLA matched donors. Busulfan and cyclophosphamide for conditioning, and cyclosporine for the prevention of graft versus host disease were used in all patients. Transplanted total nucleated cell counts were median 4.81×10^(8)(2.40~7.01×10^(8))/kg , and CD34+ cells 3.65×10^(6)(0.88~10.72×10^(6))/kg. Results: All patients achieved early hematologic recovery (median 9.5 days, range 9~14 days for ANC>500/μL; median 32 days, range 23~34 days for PLT>50,000/μL). Transplant-related complications were 3 cases of grade 1 acute GVHD, a case of limited chronic GVHD, and a case of mild hepatic veno-occlusive disease. Enzyme levels were normalized in 4 patients evaluated and there were indirect evidences of enzyme production in the other 2 patients after HSCT. Four of the 6 patients showed symptomatic improvement, 1 patient (galactosialidosis) experienced disease stabilization without progression before he eventually died due to pulmonary hemorrhage, and the other 1 patient deteriorated progressively even after HSCT. Conclusions: Allogeneic HSCT can be done as the only curative treatment in a number of genetic metabolic disorders. It seems desirable to perform HSCT as early as possible before the onset of central nervous system symptoms. More experience and long term follow up is needed to evaluate the efficacy and to monitor the long term transplant-related complications.

스포츠 상해와 투기종목 선수의 경기력 : 상해유형별 분석

유종만,김혜진,박재현,신범철 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The purpose of this study is to investigate on sports injures and performance in combat sports events. For the purpose, in the study 239 subject(boxing 50, taekwundo 54, wrestling 41, fencing 54, judo 40) completed the questionnaire for sports injures and performance in combat sports events. It was divided sports player's performance into high performance elite level and low performance elite level. To assess of the distribution in high performance elite level and low performance elite level player's injures pattern, it was used cross table and percentile scores by SPSS version 11.0 for Windows. The result was follow that: There was different pattern in sports injures by combat sports event. And there was different pattern in sports performance in high performance elite leve and low performance elite level players.

한국형 운동-정서 척도의 개발과 타당화 검증

유진,김종오 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.2

이 연구의 목적은 신체활동 참여자들이 일반적으로 느끼는 기분 및 정서상태를 평가할 수 있는 측정도구를 한국의 문화/언어적 측면을 고려하여 개발하는데 있다. 한국형 운동-정서척도(Korean Exorcise-Emotion Scale: KEES)의 개발과 타당화 과정은 크게 3 단계의 절차에 의하여 이루어졌다. 첫째, 선행문헌에서 밝혀진 '한국인의 일반적 정서용어' 834개(한덕웅, 강혜자, 2000)에 대한 내용타당도검증을 시행하여 72개의 운동-정서 문항이 산출되었다. 둘째, 사회체육에 지속적으로 참여하고 있는 성인 남녀 266명을 대상으로 72개의 문항에 대한 문항분석과 탐색적 요인분석을 시행하여 5요인 28문항의 KEES가 구조화되었다: 재미, 긍지, 활력감, 정화, 성취감. 셋째, 일련의 확인적 요인분석을 통하여 KEES의 가설적 요인 모델들을 비교 검증한 결과 수정지수를 사용한 5요인 24문항의 모델에서 가장 높은 적합도 지수를 나타내었다. 이 연구는 한국의 문화적 측면에서 KEES가 다양한 신체활동 상황에서 발생하는 참여자들의 정서상태를 평가할 수 있다는 일차적 가능성을 시사하였다. The purpose of this study was to develope a scale assessing emotion of physical activity participants with regard to Korean cultural and linguistic aspect. The Korean Exercise-Emotion Scale(KEES) was developed and validated through the three stages of psychometric procedures. First, the 72 items related exercise-induced emotion were selected after conducting the content analysis of 'Korean general emotion terms(Han & Kang, 2000)'. Next, the item analysis and the exploratory factor analysis for 72 items were carried out by 370 people participating in various physical activities, and the KEES was categorized into 5 factors(fun, pride, vigor, catharsis, and achievement) with 28 items. Lastly, the hypothetical models of the KEES were verified by a series of confirmatory factor analyses. The results of confirmatory factor analyses revealed that the data fit the hypothesized five factor-24 item KEES model reasonably well. These results suggest that the KEES possesses adequate factorial validity useful to measure exercise-induced emotion for Korean participating in various physical activities.

해안서식 어패류 중 유해중금속 함량에 관한 연구 (Ⅰ)

유영찬,정진일,박유신,이종숙,인상환,최동기,김동우 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

LES를 이용한 비정상 난류유동장 연구

유근종,한진우,김수태 창원대학교 산업기술연구소 2001 産技硏論文集 Vol.15 No.-

LES is applied to analyze transient turbulent flows which may cause thermal stripping. The LES is formulated based on Sub-Grid k model. For evaluating performance of the LES, two test cases of vertical water jet flow and parallel sodium jet flow are selected. Through the analysis, the LES confirms that it has proper ability to predict time dependent flow variables such as magnitude of temperature fluctuation and its frequency. For the better prediction, however, the LES is required to be improved through further evaluation of various SGS models and implementation of temperature SGS model into its energy equation.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

유전자 재조합 사람 IFN-beta인 제네베타와 베네세린의 생물학적 활성의 비교

하종천,이협준,박봉환,김진숙,유대근,남상윤 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1

Background: Recombinant IFN-beta products have been approved for the treatment of several diseases. Recently, Inbionet, Co. has successfully developed rhIFN-beta product, Genebeta. This study was performed in a purpose of confirming the biological activity of Genebeta by comparison with another recombinant IFN-beta, Beneserin which was already approved. Methods: In vitro antiporliferative activity, regulation of MHC class I expression, antiviral activity, regulation of natural killer cell cytotoxicity were studied for functional comparison of these two rhIFN-beta products. Results: Proliferation assay data showed that two recombinant IFN-beta inhibited T cell and Daudi cell proliferation to a similar extent. When antiviral activity was compared, there was no significant difference between them. The treatment of these two rhIFN-beta also resulted in a similar level of upregulation of class I expression on the surface of A549 cells. Cytotoxicity experiment against tumor cells revealed that both of rhIFN-beta could enhance NK cell cytotoxicity to comparable level. Conclusion: All comparison data indicated that rhIFN-beta products, Genebeta and Beneserin have comparable potentials as a biological response modifier.