젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

원광의대 부속 제 2병원 신경정신과 환자에 대한 통계적 고찰

박민철,김종주,박남진,오상우,권혁일,권영숙,박종호 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We examined 1,856 patients who visited Won Kwang Neuropsychiatric hospital since July 11 of 1984(since the hospital opened) until June 11 of 1986. We researched diagnostic and other distributions of inpatients and outpatients. The study revealed as follows : 1. Of total patients males visited this hospital more than females as 52.7%. Most of them(67.1 %) resided in Iri, Iksan and Kimje. In the point of insurance, insured patients and uninsured patients except medicaids were 73 %. Males(60%) were more insured medically than females (55.4%). While insured patients relatively resided in urban area, but uninsured patients except medicaids did in rural area. 2. Of outpatients neurotic disorder was the most as 35.1%, secondly schizophrenic disorder and thirdly affective disorder, but of inpatients schizophrenic disorder was the most as 41.4%, secondly neurotic disorder thirdly affective disorder. 3. Alcohol abuse (98.2 %), paranoid disorder, convulsive disorder and child mental disorder were mostly found in males, but neurotic disorder (59 .6 %), affective disorder and other psychotic disorder were mostly found in females. 4. In unmarried ones schizophrenic disorder ( 43 .6 %), neurotic disorder, other psychotic disorder were common, but in married ones neurotic disorder (55.1 %), schizophrenic disorder, affective disorder were common. 5. On the distribution of age schizophrenic disorder was found the most in the twenties (28.4 %), next in the thirties and in the forties, but neurotic disorder was found the most in the thirties, next in the twenties and in the forties. 6. On the distribution of age at onset schizophrenic disorder develops mostly during the twenties (45.5 %), secondly during the teens and thirdly during the thirties, but neurotic disorder develops mostly during the thirties and the twenties (53.1 %). 7. On the duration of hospitalization 34.4% of the patients was hospitalized during less than 15 days, 22.0% during 60-90 days and 80.4% during less than 3 months. 8. In the result of treatment 41.2% of the patients was improved and 31.7% a little improved. In total 72.9% of the patients got helped therapeutically.

대류경계층에서 난류흐름에 관한 수치해석적 연구

박종혁,이우범,이정전 國立 麗水大學校 環境問題硏究所 1998 環境硏究論文集 Vol.1 No.-

As turbulent flow include a complex physical process in the convective boundary layer(CBL), it is difficult to explain the physical phenomena exactly. Therefore, it is possible to explain the model in a simple and limited way. For the explanation of the CBL turbulence, enormous amounts of data are required concerning in CBL turbulence. A method to study the structure and characteristics of CBL is numerical simulation of important parts of the flow field i.e. through large eddy simulation(LES). In this study, turbulence in the CBL uniformly heated from below and topped by a layer of uniformly stratified fluid is investigated for flows by numerical simulation(LES). LES uses a finite-difference method to integrate the three-dimensional grid-volume-averaged Navier-Stokes equation for a Boussinesq fluid. In LES, the contribution of the large-carrying structures to momentum, heat and energy transfer are computed exactly, and only the effect of the smallest scales of turbulence is modeled. The purpose of this study is to analyze the velocity and temperature distributions in CBL turbulence in order to study the dispersion of atmospheric pollutant by LES.

Transthyretin의 Glutathione 자동산화 촉진작용

박종근,정신,김재휴,김수한,강삼석,이제혁,안봉환 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.8

When reduced glutathione(GSH) was incubated at neutral pH and at 37°, its concentration decreased slowly with formation of oxidized glutathione(GSSG). Autooxidation of GSH was accelerated by Cu^(2+) and Hg^(2+), but not by other common mono-, di-, and tri-valent cations. Transthyretin was found to stimulate autooxidation of GSH in the presence or absence of Cu^(2+) and Hg^(2+). EDTA inhibited perfectly the autooxidation of GSH regardless of the presence of transthyretin. The stimulating activity of transthyretin was maximal at pH 7.0, declining progressively with increase or decrease of pH from 7.0. Sulfhydryl-blocking agents such as p-hydroxymercuribenzoic acid and Nethylmaleimide markedly inhibited the stimulating activity of transthyretin. Transthyretin stimulated autooxidation of other sulfhydryl compounds such as clithiothreitol and cysteine. However, it did not show a significant effect on autooxidation of sulfhydryl group of egg albumin and eye lens proteins. And transthyretin did not cause any oxidative change to thyroxine(T₄), 3, 5, 3Ltri iodo thyronine(T₃) and 3, 3: 5~triiodothpnine(rT₃) bound to it in the presence of GSH and Cu^(2+). The above results suggest that transthyretin may play a role in regulation of oxidized status of sulfhydryl groups in blood plasma and cerebrospinal fluid

정규화 반경벡터 함수에 기반한 2D-형태 정보검색

박혜진,이상학,이광재,장민혁,박종안 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

형태 정보는 컨텐츠 기반 하의 시각적 특징 중의 하나이며 영상 정보검색에서 광범위하게 사용된다. 본 연구에서는 물체 윤곽선의 반경 벡터함수를 이용한 스타형 및 비스타형 2D 형태인식을 위한 효과적인 알고리즘을 제안한다. 알고리즘에서 무게중심은 형태의 기준점이 되며 축의 중심으로부터 반경벡터는 주요 특징벡터가 된다. 이를 위한 코너 포인트는 노드로 표시되고, 정규화 거리는 중심점에서 노드까지의 상대적 거리비로 규정한다. 데이터베이스에서 유사 물체와 조회 물체 사이의 중심에서 코너 거리까지의 기하학적 거리가 형상 정합을 위한 유크리드 거리 값으로 정합평가에 이용된다.

건설장비 활용방안에 관한 연구

朴鍾奕 瑞逸專門大學 1992 論文集 Vol.10 No.-

Construction equipment are of an variety in its type, size, and capability. Because of its prices being high, an appreciable effect on cost reduction is expected depending on the way of acquisition. It is therefore necessary to investigate all the modes of equipment acquisition before making a commitment. The different modes of acquisition and how they compare with each other economically constitute the object of this study.

Material Balance and Metabolic Flux Analysis for Styrene Epoxidation Reaction by a styC Knockout Mutant of Pseudomonas Putida SN1

Jong_Wan Bae,Seung-Hyuk Kim,Sun-Gu Lee,Sunghoon Park 한국생물공학회 2005 한국생물공학회 학술대회 Vol.2005 No.4

Work Sampling 기법에 의한 철근콘크리트 작업의 작업분석

朴鐘奕,姜仁錫,李培浩 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

The present study was intended to find the method of improving productivity at construction work sites by employing and adapting the work measurment techniques. The study includes analysis of individuals worker's activities and work time distribution, and evaluation of work time-rates. The study adapted the work sampling method which is known to be simple and easy to use for the intended purposes and applied the method to the most typical construction operation of reinfored concrete structure works at an on-going building construction site. The operation comprises the work processes of form erection, steel bar installation and concrete placing. The study reveal that the actual working time rates, contributed to the effective work contents range from 22 to 42 percent of the total work time which are quite below the generally accepted standard of 55 percent. Assuming that the results of the study are typical in the construction industry of KOREA today, it is suggested that the improvement of productivity in construction work site requires better preplanning of work processes in such a way as to eliminate or reduce ineffective time contents to reasonable levels.

청미래덩굴의 뿌리에서 추출한 조분획의 항균활성

박인호,권혁동,이원구,송종호 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1

청미래덩굴(Smilax china L.)의 뿌리에서 추출한 methanol, n-hexane, chloroform 및 수용성 추출물의 항균활성을 Agrobacterium rhizogenes, Agrobacterium tumefaciens, Candida utilis, Saccharomyces cerevisiae, Bacillus megaterium, Bacillus natto, Bacillus subtilis 및 Escherichia coli에 대하여 disc diffusion과 broth dilution method로 조사하였다. Methanol추출물은 A. rhizogenes, A. tumefaciens, B. megaterium 및 B. subtilis 대하여 항균활성이 나타났고, 수용성 추출물은 B. megaterium와 B. subtilis에 대하여 항균활성을 보였으나 hexane과 chloroform 분획물은 항균활성이 없었다. 또한 수용성 추출물은 800ppm 농도에서 현탁배양중인 A. rhizogenes, A. tumefacience, B. megaterium 및 B.subtilis에 대하여 각각 80, 40, 20, 81%의 성장 억제를 보였고, 특히, 동일 농도의 수용성 추출물을 재첨가한 경우 B. subtilis의 성장이 완전히 억제되었다. Gas chromatography/mass spectrometry에 의한 추출물의 분석 결과, 그 주요 구성 성분은 5-(hydroxymethyl)-2-furancarboxaldehyde(46.95%), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one(21.08%) 및 2-furancarboxaldehyde(5.85%)였다. Antimicrobial activity of four extract fractions from the root of Smilax china L.(Liliaceae) was investigated by diffusion and broth dilution methods against several microorganisms, Agrobacterium rhizogenes, Agrobacterium tumefaciens, Candida utilis, Saccharomyces cerevisiae, Bacillus megaterium, Bacillus natto, Bacillus subtilis and Escherichia coli. Methanol extract exhibited potent antimicrobial activity against A. rhizogenes, A. tumefaciens, B. megaterium and B. subtilis. However, hexane and chloroform extracts did not show antimicrobial activity against the test microorganisms. Aqueous extract inhibited growth of the tested microbial strains. The relative growth inhibition of A. rhizogenes, A. tumefaciens, B. megaterium and B. subtilis were 80, 40, 20, 81% at 800㎍/mL, respectively. Methanol extract was analyzed by gas chromatography/mass spectrometry(GC/MS). Major components were determined to be 5-(hydroxymethyl)-2-furancarboxaldehyde(46.95%), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one(21.08%) and 2-furancarboxaldehyde(5.85%).

염색체이상에 관한 연구(611례 분석)

박종우,구선회,민혁기 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

From March, 1988 to October, 1993, we studied chromosomal analysis from peripheral blood to investigate chromosomal abnormalities in 611 patients showing multiple congenital anomaly, growth or mental retardation, repeated pregnancy losses, infertility, amenorrhea, pubertal failure, ambiguous genitalia, fetal anormaly, malignant disease and others. 82 chromosomal abnormalities were recognized as follows. 1. The rate of chromosomal abnormality is 13.2%. Among them, autosomal abnormality is 67% and sex chromosomal abnormality is 33%. 2. 22 cases of 47, XY,+21, 21 cases of 47, XX,+21, 3 cases of 46, XX, t(14;21)(qll;qll), and 1 case of 46, XX, t(15;21)(q11;q11) were found in Down syndrome. 3. 13 cases of 45, X, 4 cases of 46X, i(Xq), 2 cases of 46X, i(Xq)/45, X, 1 case of 45, X/46, Xr(X), and 1 case of 45, X/47, XXX were found in Turner syndrome. 4. 6 cases of Kleinfelter syndrome were found. 5. 4 cases of reciprocal translocation, 3 cases of Robertsonian translocation and 2 cases of ring chromosomes were found.