소아 혈액 종양 환자 및 가족의 심리적 특징

박종익,문형남,박인호 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

This study is to investigate the psychological characteristics of children suffering from hematologic cancer patients and to compare them with those of their siblings as control according to age groups. We also examined the psychopathology of their patents and family environment, Forthis reason, 1) We examined the difference in age groups(children vs adolescents) using the self-report psychological questionnaire for anxiety and depression. 2) We examined the difference of the study group by age variable using the child behavior checklist for parents. 3) We examined the difference of the result reported by adolescents and by the parents. 4) We also examined the psychopathology of the parents using self-reports for parents. So 22 leukemic outpatients(10 children and 12 adolescents) in their maintenance chemotherapy phase for acute lymphocytic leukemia or lymphoma have completed the psychiatric interviews and the self-reports. For the self-reports, we have used Children's Depression Inventory(CDI), revised Children's Manifest Anxiety Scale(RCMAS), State-trait Anxiety Inventory for Children(STAIC) for all age groups and in additon the Youth Self Report(YSR) for adolescents. To evaluate the children's problem behavior, Child behavior checklists(CBCL) were filled up by their parents. And 36 parents performed Symptomcheck List-90-Revison(SCL-90-R), Beck Depression Inventory(BDI). We concluded that the child hematologic cancer patients have the tendency to express no prominent depression or anxiety and no age effect when self-reports such as CDI, RCMAS, STAIC were administered. And the siblings showed no significant difference compared to cancer patients. However, when CBCL was administered to by the parents, there were high scores in the childhood leukemic patients and the adolescent sibling controls group comparing to the other groups and such trend was more prominent in the leukemic patients group(p<0.05). also when the YSR and CBCL were compared, the YSR showed high scores in the both adolescent leukemic patients(p<0.01) and sibling controls group(p<0.05). Therefore we can suggest that the leukemic patients have the tendency to repress their own symptoms as they grow older. the patents are relatively well adapted when there are leukemic patients in their family.

고강도 할로겐광으로 중합한 복합레진 수복재의 경도

박종석,이광희,김대업,김성형,안호영 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.3

복합레진의 광중합시간 단축과 관련하여 최근에 개발된 고강도 할로겐광 중합기를 기존의 중강도 할로겐광 중합기와 비교 평가하기 위하여. 세 종류의 광중합용 복합레진을 두께가 2, 3, 4, 5mm인 스테인레스 스틸 몰드에 충전하고, 레진 상면을 중강도 할로겐 광은 (1) 400mW/cm²으로 40초간, 고강도 할로겐광은 (2) 10초동안 100mW/cm²부터 1000mW/cm²까지 출력량이 증가하면서 중합하고 다음 10초동안 1000mW/cm²로 중합하는 ramp 모드로 20초간, (3) 1000mW/cm²의 boost 모드로 10초간. (4) 850mW/cm²의 표준 모드로 20초간 조사하고. 상면과 하면의 표면경도를 미세경도측정기로 측정한 후 실험군간의 차이를 분석하였다. 레진 상면의 경도는 중합광의 강도와 중합시간 및 레진 두께에 따른 차이가 없었다(유의수준 0.05, 이하 동일). 레진 하면의 경도는,두께 2mm의 중강도군(1)을 제외하고,상면의 경도보다 낮았다. 레진 하면의 경도는 두께 2mm에서 중강도군(1)이 ramp군(2) 및 boost군(3)보다 높았고 중강도군(1)과 표준군(4) 간 및 ramp군(2)과 boost 군(3)간에 차이가 없었으며 두께 3mm에서 중강도군(1)이 가장 높았고 표준군(4)이 boost군(3)보다높았다. 따라서, 복합 레진의 중합 깊이 측면에서 볼 때. 1000mW/cm²의 고강도 할로겐 광을 10초간 조사한 것은 400mW/cm²의 중강도 할로겐광을 40초간 조사한 것에 미치지 못하였으며, 레진 두께 2mm이내인 경우에는 850mw/cm²의 고강도 할로겐 광을 20초간 조사함으로써 400mw/cm²중강도 할로겐 광을 40초간 조사한 것과 대등한 중합을 일으킬 수 있었다. The purpose of this study was to compare the effect of the high intensity halogen light (850∼ 1000 mW/cm²) with that of the conventional halogen light (400 mW/cm²) on the hardness of composite resin. Three resin com-posites (Z-100, 3M, U.S.A ; Tetric Ceram, Vivadent, Liechtenstein : Surefil, Dentsply, U.S.A.) were filled in the stainless steel moulds which were 4mm in diameter and 2, 3, 4, and 5 mm in depth, respectively. They were cured under the four different modes : (1) conventional mode,40 seconds at 400 mW/cm²; (2)'ramp'mode, 10 seconds at 100 to 1000 mW/cm² plus 10 seconds at 1000 mW/cm²: (3)'boost'mode, 10 seconds at 1000 mW/cm²: and (4) 'standard'mode, 20 seconds at 850 mW/cm² The surface hardnesses of the top and the bot-tom of the resin samples Were measured with a microhardness tester (MXT70, Matsuzawa, Japan) . The top surface hardness was not significantly different among the curing modes . The bottom surface hardness was gen-erally the highest in the conventional mode and the lowest in the high intensity boost mode There was no sig-nificant difference in the bottom surface hardness between the conventional mode and the high intensity standard mode in 2mm depth. The results suggest that the curing time of the high intensity halogen light (850 mW/cm²) should be at least 20 seconds to produce the equal level of the bottom surface hardness of 2mm resin composite as compared to the hardness produced by the conventional halogen light (400 mW/cm²).

Computer Graphics에 의한 3성분계 Wilson, NRTL 및 UNIQUAC 방식을 이용한 VLE 추정방식의 비교

신형섭,박종철 慶熙大學校 1988 論文集 Vol.17 No.-

The purpose of this study is to estimate VLE by means of the Wilson, NRTL, UNIQUAC equations and to compare with these three methods for two ternary systems: ethanol-benzene-cyclohexane, cyclohexanone-cyclohexanol-phenol, by the computer graphic technology. The temperatures and compositions of two systems were estimated by means of three TPTT equations. Isothermal lines of these two ternary systems were graphically illustrated from these estimated values and the reported experimental values. As a result of the analysis of the parameters and computer graphics, these parameter pairs changing with respect to the temperature and composition of the solutions. From the result of plotting the parameter pairs, A_12, vs, A_21, a locus contour between two parameters is observed, therefore numerous number of roots to satisfy these TPTT equations are found. These phenomena is nearly identical with the previously reported results that there are some correlation between these parameter pairs.

연 폭로가 남성호르몬에 미치는 영향

김형수,장성훈,이원진,최재욱,박종태,백남원,김록호 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1

목 적 : 본 연구는 직업성 연 폭로근로자에서 연폭로가 남성 생식기계 독성중 성호르몬에 미치는 영향과 그 정도를 평가하고자 시도되었다.방 법 1998년 하반기에 실시한 일반, 특수건강진단자중 경기도 지역 직업성 연 폭로 근로자 33명과 과거 직업력에서 연 폭로가 없었던 사무직 근로자 33명을 연구대상으로 선정하였다. 연의 생물학적지표로는 혈색소, ZPP, 혈중 연, 및 요중 연을 이용하였으며, 성호르몬으로는 LH, FSH, testos-terone, SHBG 및 FTI를 이용하였다. 연 폭로 지표와 성호르몬과의 상관관계를 조사하였다. 결 과 : 연의 생물학적 지표중 혈색소는 폭로군에서 대조군보다 유의하게 낮았으며, ZPP, 혈중 연및 요중 연등은 폭로군에서 대조군보다 유의하게 높았다. 성호르몬에서 FSH, testosterone, SHBG및 FTI는 모두 폭로군에서 대조군보다 낮았으나 통계적 유의성은 없었다. 폭로군의 성호르몬중에서 연령은 FSH 및 FTI, ZPP는 FSH, 혈중 연은testosterone과 유의한 상관관계가 있었다. 대조군에서 연령은 FSH, testosterone, SHBG 및 FTI와 흡연량은 FSH와 유의한 상관관계가 있었다. 연령군별 폭로군과 대조군의 성호르몬 비교에서 30-39세군의 FTI에서 폭로군이 대조군보다 유의하게 낮았으며 그 밖의 호르몬에서는 모두 유의한 차이가 없었다. 결 론 : 연 폭로군의 FSH, Testosterone, SHBG 및 FTI가 대조군에 비교하여 낮았으나 통계적 유의성은 없었다. 그러나 폭로군에서 연의 생물학적 지표와 일부 성호르몬간에 유의한 상관관계를보였으며 이는 본 연구 대상 근로자의 연 폭로 수준이 일부 성호르몬에 영향이 있음을 보여주는 것으로 판단된다. 향후 이에 대한 지속적인 연구가 진행되어 야 할 것이다. Objectives : This study was performed to evaluate the relationship between biological markers of lead exposure and level of sex. hormones in men occupationally exposed to lead. Methods : In this study, 33 male workers who employed at smelting and battery factories were compared with 33 male workers who were not exposed to lead. As biological markers of lead exposure, hemoglobin, ZPP, blood lead and urine lead were measured. As sex hormones, FSH, LH, testosterone, SHBG and FTI were determined. Results : Hemoglobin level was significantly lower in exposed than in nonexposed group. Level of ZPP, blood lead, and urine lead were significantly higher in exposed than in nonexposed group. There was a trend that level of FSH, testosterone, SHBG, and FTI was lower in exposed than in nonexposed group respectively, but there were no statistical significance. In exposed group, FSH level was correlated with age, ZPP, and blood lead; testosterone level was correlated with hemoglobin, blood lead, urine lead, and SHBG ; and FTI level was correlated with age. Conclusions : Level of some sex hormones were lower in exposed than in nonexposed group but there were no statistical significance between the exposed and the nonexposed group. But level of sex hormones were correlated with several biological markers of lead in exposed group. It suggests that occupational lead exposure might affect sex hormones.

전격성 제1형 당뇨병 1예

노동현,김도형,김나래,박종선,이창헌,김미경,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

전격성 제1형 당뇨병은 특발성 당뇨병환자에서 임상 경과가 짧고 진단 당시 심각한 대사 합병증을 동반하면서 췌장 효소 수치가 높고 췌도 특이 자가항체가 음성인 새로운 아형으로 알려져 있으며, 일본과 일본 외에서의 유병률에는 차이가 있는 것으로 보인다. 아직 전격성 제1형 당뇨병의 발생 기전은 명확하지 않으며 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 요구된다. 저자들은 케톤산증으로 내원하여 전격성 제1형 당뇨병을 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Some patients with idiopathic type 1 diabetes have a fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset and high serum pancreatic enzyme concentrations. This is referred to as fulminant type 1 diabetes. A 29-year-old man suffering from abdominal pain, nausea and vomiting consulted to our hospital. Laboratory findings revealed high blood glucose level and the evidence of diabetic ketoacidosis, but the serum HbA1c was normal nevertheless. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. The patient satisfied the criteria for the diagnosis of fulminant type 1 diabetes. After the patient has been treated with insulin, his symptoms were improved and abnormal laboratory data were normalized. We report this case with a review of the literature

롤포밍을 위한 박판 미세구조물 기초 연구

정동원,김형종,최두선,제태진,박재현 濟州大學校 海洋硏究所 2004 해양과환경연구소 연구논문집 Vol.28 No.2

Sandwich sheets consisting of two or more different material layers are widely used in various industries due to the diversity of properties they Possess, such as high electrical conductivity. high corrosion resistivity. high strength. etc. The production of sandwich sheets by a rolling process. which is a more efficient and economical approach compared to other types of Processes. has become an increasingly important subject of study. In this study, the focus of the analysis is to evaluate stress and strain of the micro structure by the roll forming.

젊은 성인 남자의 흡연과 혈청 지질과의 관련성

조선,류소연,박종,강명근,김은숙,김형철,박광희,윤혜은,노희송 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Objectives: This study was performed to find the association of cigarette smoking and blood lipid profiles in healthy young adults. Methods: The data was collected by a self-administered questionnaire and health examination in 489 professional soldiers from 6 to 12 May, 2004. The status of cigarette smoking was classified by non-smoking, ex-smoked, ≤4.9, 5-9.9, and ≥10 pack-years. The statistical analysis were used by chi-square test, analysis of variance and analysis of covariates. Results: In status of subjects cigarette smoking, current smoking, ex-smoked, and non-smoking were 71.8%, 11.2%, and 17.0%, respectively, In distribution by amount of smoking, non-smoking, ex-smoked, ≤4.9 pack-years, 5-9.9 pack-years, and ≥10 pack-years were 17.0%, 11.2%, 37.4%, 21.3%, and 13.1%, respectively. At other confounding variables were controlled, total cholesterol and LDL-cholesterol were increased significantly when amount of smoking was increased. However, triglyceride and HDL-cholesterol did not showed statistically significant differences, Conclusion: Smoking has relevant to total cholesterol and LDL-cholesterol and it is need to perform the further study for finding how blood lipid profiles are affected its level by cigarette smoking and to find an influence of cigarette smoking on cardiovascular disease.

단치소요산이 구속 스트레스를 가한 흰쥐의 뇌내 catecholamine 함량변화에 미치는 영향

황귀서,이기선,박종형 한국환경독성학회 1998 환경독성보건학회지 Vol.13 No.2

To elucidate the preventive effect of Danchisoyosan (DS) on stress, we investigated the physiological change of rats which were applied immobilization stress. For immobilization stress, rats were placed in restrainer for 12 hours a day for 3 days. During application of stress, body weight of rats was measured. After sacrifice, 8 organs were taken for measurement of organ weight. Brain was sectioned into 4 parts that are Frontal Cortex, Corpus Striatum, Hypothalamus and Hippocampus. Each part was homogenated and its catecholamine and serotonin contents were measured with HPLC. In our study, stress mainly induced increase of concentration of neurotransmitters in brain without other significant physical change of rats. DS inhibited stress induced changes of neurotransmitter content in brain.

제대 및 신생아 혈중 cytokine(IL₁β, IL6, TNF) 수치의 변화

강진무,김홍식,박인식,이형종 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

분만방법에 따른 제대혈과 양수 그리고 감염 및 stress가 있는 신생아혈중과 세포성분을 배양한 상청액의 cytokine치를 ELISA법으로 측정하여 다음과 같은 성적을 얻었다. 제대혈중 IL₁β치는 질식 유도분만때가 질식 자연 분만, 응급 제왕절개 및 계획 제왕절개때보다 유의하게 높았다(p<0.001). 신생아 혈중 IL₁β치는 감염이 동반된 경우와 stress가 동반된 경우에 높았으며, 감염이 동반되었을 때가 stress보다 더 높게 나타났고, 저체중 출생아에서 높았다. 계획 제왕절개시의 제대혈 IL₁β치는 양수보다 낮았다. 질식자연 분만시 제대혈 세포상청액의 IL₁β 혈장치보다 높았고, 양자간에 유의한 상관관계를 보였다(r=0.92, p<0.05). 감염이 동반된 신생아에서 IL₁β치는 혈장치가 높은 경우 세포 상청액치는 낮고, 혈장치가 낮은 경우 세포 상청액치는 높았다. IL6는 감염이 있는 신생아 혈장과 세포 상청액, 양수 등에서 검출되었다. TNF는 감염이 있는 신생아 세포 상청액 8례중 3례에서 측정되었다 The cytokines, interleukin-1β(IL₁β), interleukin-6(IL6) and tumor necrosis factor(TNF) are important mediators of host response to stress and infection. Impaired immune reaction and febrile responses to the infection in newborn period may result from abnormal cytokine regulation and there were difference in the responses between newborn and adult due to the different cytokine regulation system. To investigate the cytokine regulation in different circumstances of the delivery and newborn conditions, the measurement of the levels of IL₁β,IL6 and TNF in cord blood, amniotic fluid and the blood of the newborn were performed, using enzyme linked immunosorbent assay(ELISA,R&D Co.). Cytokines of the supernatant of incubated cellular pellet were also measured. Cord blood IL₁β level was significantly higher in induced vaginal delivery than that of the normal vaginal, emergency, and elective cesarian section delivery(p<0.001). Plasma IL₁β level of the newborn with infection or stress was elevated and the level was higher in infection than that of the newborn with stress during delivery. Premature baby had higher level than normal newborn. Cord blood IL₁βlevel was lower than that of amniotic fluid in elective cesarian section delivery. In normal vaginal delivery, IL₁βlevel of the cellular supernatant was higher than that of the plasma and showed good correlation(r=0.92, p<0.05). In newborn with infection, plasma IL₁βlevel was high in the cases with low supernatant level and the plasma level was low in the cases with high supernatant IL₁β. IL6 was detcted from the plasma and cellular supernatant of the newborn with infection and the amniotic fluid. TNF was detected in cellular supernatant of 3 among 8 newborn with infection.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.