심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

백운산(제천시) 일대의 식물상

양종철, 엄정애, 장창석, 장창기, 이철호, 김규식, 오병운 忠北大學校部設基礎科學硏究所 2006 自然科學硏究 Vol.20 No.-

-본문참고-

The Study on Medicinal Flora of Several Uninhabited Islands in Jindo-gun, Chonnam province

Yang,Hyo-Sik,Kim,Jong-Wook,Oh,Man-Ho 한국자원식물학회 2003 Plant Resources Vol.6 No.1

The medicinal plants in 22 unhabited islands of Jindo-gun, Chonnam provincde were investigated from March 2000 to October 2002. The medicinal plants in 22 uninhabited islands of Jindo-gun were consisted 366 taxa; 95 families, 269 genus, 309 species, 52 varieties, 3 forma, and 2 subspecies. Important medicinal plants on survey area were Lemmaphyllum microphyllum, Dendropanax morbifera, Ficus erecta, Farfugium japonicum, Machilus thunbergii, Juniperus chinensis var. procumbens, Dendrobium moniliforme, Pyrrhosia tricuspis, Cinnamomum japonicum, Pittosporum tobira, Kadsura japonica, and Daphniphyllum macropodum, This result can be used as basic information data for medicinal research and the conservation of uninhabited islands.

제주지역 고등학생들의 수학에 대한 신념과 태도 분석

양성호,박종관 濟州大學校 師範大學 科學敎育硏究所 1998 科學敎育 Vol.15 No.-

This thesis shows how high school students in Cheju feel about each unit of a math textbook and what attitude they have toward each one. It also shows why they have such a faith and an attitude and then, the relationship between them. This study will serve as basic data for understanding what have an effect on the students' faith in and attitude toward learning math, and it will be useful for teaching and learning math, too.

CuO/ZnO/Al₂O₃촉매에서 저온 역수성가스 전환반응 속도 연구

양정일,박종호,김종남 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.5

역수성가스 전환반응(RWGS)의 CuO/ZnO/Al₂O₃에 대한 반응 메커니즘과 반응 속도식을 미분 반응기를 이용하여 조사하였다. 실험은 523 K, 2.9-5.7 atm 하에서 수행하였고, 반응 속도에 대한 반응물 농도 영향을 조사하기 위해 P^(0)_(CO₂)와 P^(0)_(H₂)를 변화시켰다. 그 결과 P^(0)_(CO₂)와 P^(0)_(H₂)가 작을 때에는 반응 속도가 두 반응물의 분압에 모두 영향을 받으며, H₂ 분압에 대한 의존성이 크게 나타났다. 반면, P^(0)_(CO₂)와 P^(0)_(H₂)가 클 경우에는, H₂ 분압에 대한 반응 차수는 0이며, CO₂ 분압에 대한 반응 차수는 0.23으로 나타났다. 실험에서 얻은 결과를 power law와 Langmuir-Hinshelwood 메커니즘, 그리고 Cu가 활성점으로 작용하는 surface redox 메커니즘을 통해 모델링하였다. 그 결과 surface redox 메커니즘에서 유추된 반응 속도식은 power law에 의한 반응 속도식과 잘 일치하며, 여기서 계산된 r_(0)는 실험에서 얻은 결과를 잘 나타냄을 알 수 있었다. 또한 생성물 P^(0)_(CO)에 대한 반응 속도 의존성 실험에서 surface redox 메커니즘에서 나타난 CO 농도와 반응 속도식 사이의 관계가 잘 일치함을 확인하였다. 이로서 523 K, 저온에서의 역수성가스 전환반응은 촉매의 활성점인 Cu의 산화-환원에 의한 surface redox 메커니즘에 의해 이루어짐을 알 수 있었다. The kinetics and reaction mechanism of the reverse water-gas shift reaction (RWGS) over CuO/ZnO/A12O3 catalysts were studied using a differential reactor. The experiments were carried out at 523 K and 2.9-5.1 atm. Effect of reactants composition on the reaction rate was checked by changing P^(0)_(CO₂), and P^(0)_(H2). When the P^(0)_(CO₂) and P^(0)_(H₂) were low, the reaction rate was dependent on partial pressures of both reactants and there was a strong dependency on P^(0)_(H₂). At high P^(0)_(CO₂) and P^(0)_(H₂), reaction order with P^(0)_(H₂) was zero, and order with P^(0)_(CO₂) was 0.23. The data was analysed using rate equations based on power law, Langmuir-Hinshelwood mechanism, and surface redox mechanism in which Cu was considered as an active site. The reaction rate derived from surface redax mechanism matched well with the reactim rate derived from power law, and the calculated ro values, based on surface redox mechanism, was in good agreement with the experimental values. Also, a linear relationship between P^(0)_(CO), and reaction rate indicated that the surface redon mechanism was operative under these conditions. Therefore, it was conclued that the RWGS at 523 K proceeds by surface redox mechanism via oxidation and reduction of the Cu active site.

하계 실내 및 실외환경의 공기 중 휘발성 유기화합물 농도 및 개인노출

양원호,손부순,박종안,장봉기,박완모,김윤신,어수미,윤중섭,류인철 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9

Volatile organic compounds (VOCs) are present in essentially all natural and synthetic materials from petrol to flowers. In this study, indoor and outdoor VOCs concentrations of houses, offices and internet-cafes were measured and compared simultaneously with personal exposures of each 50 participants in Asan and Seoul, respectively. Also, factors that influence personal VOCs exposure were statistically analyzed using questionnaires in relation to house characteristics, time activities, and health effects. All VOCs concentrations were measured by OVM passive samplers (3M) and analyzed with GC/MS. Target pollutants among VOCs were Toluene, o-Xylene, m/p-Xylene, Ethylbenzene, MIBK, n-Octane, Styrene, Trichloroethylene, and 1,2-Dichlorobenzene. Indoor and outdoor VOCs concentrations measured in Seoul were significantly higher than those in Asan except Ethylbenzene. Residential indoor/outdoor (I/O) ratios for all target compounds ranged from 0.94 to 1.51 and I/O ratios of Asan were a little higher than those of Seoul. Relationship between personal VOCs exposure, and indoor and outdoor VOCs concentrations suggested that time-activity pattern could affect the high exposure to air pollutant. Factors that influence indoor VOCs level and personal exposure with regard to house characteristics in houses were building age, inside smoking and house type. In addition insecticide and cosmetics interestingly affected the VOCs personal exposure. Higher exposure to VOCs might be caused to be exciting increase and memory reduction, considering the relationship between measured VOCs concentrations and questionnaire (p<0.05).

수동식 시료채취기를 이용한 사무실 직장인의 이산화질소 노출평가 및 예측 : 한국의 서울과 호주의 브리스베인 비교 연구 Comparative Study of Seoul in Korea and Brisbane in Australia

양원호,손부순,김종오 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

Indoor and outdoor nitrogen dioxide (NO_2) concentrations were measured and compared with measurements of personal exposures of 95 persons in Seoul, Korea and 57 persons in Brisbane, Australia, respectively. This activity diary was used to determine the impact on NO_2 exposure assessment and microenvironmental model to estimate the personal NO_2 exposure. Most people both Seoul and Brisbane spent their times more than 90% of indoor and more than 50% in home, respectively. Personal NO_2 exposures were significantly associated with indoor NO_2 levels with Person coefficient of 0.70 (p<0.01) and outdoor NO_2 levels with Person coefficient of 0.66 (p<0.01) in Seoul and of 0.51 (p<0.01) and of 0.33 (p<0.05) in Brisbane, respectively. Using microenvironmental model by time weighted average model, personal NO_2 exposures were estimated with NO_2 measurements in indoor home indoor office and outdoor home. Estimated NO_2 measurements were significantly correlated with measured personal Exposures (r = 0.69, p<0.001) in Seoul and in Brisbane (r = 0.66, p<0.001), respectively. Difference between measured and estimated NO_2 exposures by multiple regression analysis was explained that NO_2 levels in near workplace and other outdoors in Seoul (p = 0.023), and in transportation in Brisbane (p = 0.019) affected the personal NO_2 exposures.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

부가채널공격을 고려한 타원곡선 연산 H/W 구현 방안

양종원,이창원,서창호 公州大學校 工學硏究院 生産技術硏究所 2004 論文集 Vol.12 No.-

암호 알고리즘이 장착된 하드웨어를 통한 신뢰할 수 있는 보안 서비스를 제공하기 위해서는 부가채널공격에 대한 이해와 이에 대비한 암호 알고리즘이 개발이 필수적이다. 본 논문에서는 타원곡선 연산 H/W 설계하기 위해 부가 채널에 안전한 공격 방법에 대해서 살펴 본다. 또한 효율적인 RSA 암호 알고리즘을 구현하기 위해서 몽고메리 알고리즘의 정확한 분석을 포함하여 성능 개선을 위한 구현 방법을 정립했다. ECC(Elliptic Curve Cryptography)는 소인수분해 난제를 이용하는 RSA 암호 기법과는 다르게 타원 곡선에서의 이산 대수 해결 난제를 이용한 암호 기법으로, RSA에 비해 적은 키 길이로서 동등한 안전도를 제공한다. 그리고 타원곡선의 효율적인 측면에서 구현 몯ㄹ에 관한 연구하였으며, 타원곡선 스칼라 곱셈 알고리즘이 부가 채널 공격인 시차 공격과 전력 분석 공격에 안전하기 위한 일반적인 조건과 H/W 구현 방안에 대해 제시한다.