濯纓 金馹孫의 同人文化와 그 의미

金鍾求 ( Kim Jong-gu ) 동방한문학회 2022 東方漢文學 Vol.- No.90

본 연구는 濯纓 金馹孫과 同人의 문화를 분석했다. 이를 위해 同人文化가 형성되어 작품으로 남겨진 모든 부분을 고찰했다. 그들의 同人文化는 다음과 같이 나타나고 있었다. 첫째, 김일손과 同人은 신분을 뛰어넘어 文으로써 交遊하는 문화가 드러나고 있었다. 김종직 학단과 그 문하·관료·친인척·생육신 등 다양한 신분과 자유롭게 문으로써 교유를 하고 있었다. 둘째, 김일손과 同人은 山水에 노니는 놀이문화가 나타나고 있었다. 특히 정여창, 김굉필과 함께한 산수유람은 의미가 있다. 그 외 누정과 강 등에서 뱃놀이를 하거나, 詩會를 열기도 했다. 셋째, 김일손과 同人은 지역 및 士林을 회합하는 문화를 형성하고 있었다. 이는 훗날 다른 학파에서 그 명맥이 이어지기도 했다. 김일손의 여러 기문과 서문에서 이러한 의식이 잘 나타나고 있었다. 김일손과 同人이 형성한 문화는 초기 사림파의 同人文化를 잘 확인할 수 있다. 이들은 文·山水·同人이 서로 결합해 그 즐거움을 만끽하며, 士林을 결집하는 역할을 하고, 지역사회에 그들의 이상을 실천하고자 했다. This study analyzed the culture of 金馹孫 and the same person. To this end, a sympathetic culture was formed and all the parts left as works were examined. Their cognate culture was manifested as follows. First, there was a culture in which Kim Il-son and the same person communicated with each other through writing, transcending their status. He was acquainted with the Kim Jong-jik Academy and his followers, bureaucrats, relatives, physical bodies, etc. and freely as a teacher. Second, a culture of play in which Kim Il-son and the same person played in the mountains and water was emerging. In particular, the landscape tour with Yeo-chang Jeong and Gong-pil Kim is meaningful. Other than that, they played boats in Nojeong and rivers, and held public demonstrations. Third, Kim Il-son and his contemporaries were forming a culture that brought together regions and communities. It was later carried on by other schools of thought. Kim Il-son's various keynotes and prefaces showed this consciousness well. The culture formed by Kim Il-son and the same person can clearly confirm the culture of the same person of the early Sarim school. They wanted to enjoy the joy of literacy, mountain water, and the same person united with each other, to play a role of uniting friendships, and to put their ideals into practice in the local community.

협동학습 모형에 근거한 숲 체험 활동에서의 유아리더십 효과 분석

유구종 ( Gu Jong Yoo ),김소리 ( So Ri Kim ),김은아 ( Eun Ah Kim ) 한국어린이문학교육학회 2016 어린이문학교육연구 Vol.17 No.1

본 연구는 유아의 리더십 증진 방안의 일환으로 협동학습 모형에 근거한 숲 체험활동이 3-5세유아의 리더십을 증진시킬 수 있을 것이라는 가정을 검증하는데 목적이 있다. 이를 위하여 본 만 3,4세 유아 15명에게 협동학습 모형에 근거한 숲 체험 활동을 적용하였고, 비교집단 만 3, 4세 유아 15명에게는 3-5세 누리과정에 기초한 자유선택활동을 적용하였다. 또한 유아의 리더십을 측정하기 위하여 김경현(2007)의 AF분석법과 리더십 구성요소를 사용하였으며, 총 16주간 실험처치와 더불어 3회기에 걸쳐 반복측정을 실시하였다. 그 결과 첫째, 협동학습 모형에 근거한 숲 체험활동 집단과3-5세 누리과정에 기초한 자유선택활동 집단 간 처치회기에 따른 유아 리더십은 통계적으로 유의미한 차이가 있었다. 둘째, 협동학습 모형에 근거한 숲 체험활동 집단과 3-5세 누리과정에 기초한 자유선택활동 집단 간 처치회기에 따른 유아 리더십의 하위요인 간에도 통계적으로 유의미한 차이가 있었다. 결론적으로 본 연구에서는 협동학습 모형에 근거한 숲 체험활동이 유아의 리더십과 하위요소에 미치는 영향이 크다는 것이 입증되었다. As an effort to promote young children’s leadership, the aim of this study was to test the hypothesis ‘forest experience activities based on a cooperative learning model will enhance young children’s leadership’ by comparing them with play-centered integrated education activities. The subjects of this study were 15 three or four-year-old children for whom cooperative learning model based on a forest experience activities were applied, and 15 three or four-year-old children attending to whom free choice activities were applied. The children’s leadership was measured with Gyeong-Hyeon Kim’s AF analysis and leadership components. In order to analyze young children’s leadership behaviors based on the forest experience activities and play centered integrated education activities, the experimental treatment was done for 16 weeks’ experimental treatment was used. The results of this study for each research question are as follows. First, young children’s leadership during the treatment sessions was statistically significantly different between the cooperative learning model forest experience activity group and the free choice activity group. That is, young children’s leadership level was higher in the cooperative learning model forest experience activity group than in the free choice activity group. Second, a statistically significant difference was observed also in the sub-factors of leadership during the treatment sessions between the cooperative learning model forest experience activity group and the free choice activity group. In conclusion, it was proved shown in this study that ‘forest experience activities based on a cooperative learning model have a significant effect on young children’s leadership. The educational implication of this finding is that young children’s leadership may be enhanced through forest experience based on a cooperative learning model.

위전절제술 후 Kim 's Tie 부근 공장에 국소 재발한 위암환자 1예

배병구,서병조,유항종,강윤경,김진복,Bae Byung-Gu,Suh Byoung-Jo,Yu Hang-Jong,Kang Yun-Kyung,Kim Jin-Pok 대한위암학회 2005 대한위암학회지 Vol.5 No.1

위암은 국내에서 발생 빈도가 가장 높은 암으로서 근치적 절제술 및 확대 영역 림프절 절제술의 도입과 더불어 술후 보조 항암화학요법 및 면역요법 등의 이용으로 최근 치료성적의 향상을 보이고 있다. 그러나 수술적 치료를 포함한 치료법의 발전에도 불구하고 다양한 형태의 재발을 경험하게 되고, 대부분의 재발은 3년 이내에 일어난다. 재발양상으로는 크게 국소재발, 원격재발, 복막재발 등이 있으며, 여러 가지 재발양상이 한꺼번에 보이는 경우도 있다. 이 중 국소재발의 호발 부위로는 림프절($48\%$), 문합부($32\%$, 잔존 위($20\%$)의 순으로 보고되고 있다. 증례: 51세의 여자 환자로 1999년 10월 진행성 위암으로 근치적 위전절제술을 시행 받았고, 당시 병기는 T3N1M0(IIIa,AJCC 1997)이었다. 수술 후 10회의 보조적 정맥 주사용 항암화학요법 및 경구용 항암화학요법을 2년간 실시하였고, 외래를 통한 추적검사상 약 5년간 재발을 보이지 않았으나 2004년 9월 시행한 내시경상 Kim's tie 부근공장에서 궤양성 병변을 발견하고 조직검사를 시행, 병리학적으로 낮은 분화도를 보이는 인환 세포암종 형태의 위선암 재발로 진단하고 수술을 시행하였다. 수술 방법은 Kim's tie 위치를 포함해 근위부 6.5 cm, 원위부 4 cm의 절제연을 두고 공장부분 절제술을 시행하였다. 수술 당시 다른 복부장기로 전이는 없었으며 전이성 복수도 없었다. 수술 후 별다른 합병증 없이 회복하였으며 보조 항암화학요법 제제로써 TS-1을 사용하며 외래 통한 추적검사 중이다. Despite improvements in the surgical treatment of gastric adenocarcinomas, the recurrence rates remain high in patients with advanced-stage disease. Most of the recurrence occurs within 3 years of the surgical resection, and nearly $90\%$ of the patients with recurrence die within 2 years of the diagnosis of recurrence. A recent study analyzed recurrence patterns for patients who had undergone a potentially curative gastrectomy. For those patients, $33\%$ of the recurrences involved locoregional sites, $44\%$ the peritoneum, and $38\%$ distant sites. A 51-year-old female patient was diagnosed with stomach cancer and underwent a total gastrectomy with D2 lymph node dissection during Oct. 1999. The pathologic report indicated a T3N1M0 tumor. We performed immunochemotherapy for 2 years with regular follow up. A gastrofiberscopic examination done during sep. 2004, cancer recurrence was found at the Kim's tie site of the jejunual loop. We did an abdominal exploration and a segmental resection of cancer site with pathologically negative resection margins. After the operation, we started secondary chemotherapy with TS-1.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

The cytotoxic T lymphocyte (CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the Class I MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface protein that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs.Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectant T2 cells showed that 3 out of 4 synthetic peptides enhanced the expression of HLA-A2 molecule on T2 cell surface.Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding.Structural. characteristics of the peptides addressed by molecular dynamics simulation was analysed and compared.These peptides also partially triggered CTL isolated from human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-spcific.These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by their immunogenicity among natural T cell repertoire.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

The cytotoxic T lymphocyte(CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the ClassⅠ MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface proteion that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs. Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectantn T2 cells showed what 3 out of 4 synthetic peptides enhaced the expression of HLA-A2 molemule on T2 cell surface. Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding. Structural chacteristics of the peptides addressed by molecular dynamics simulation was analysed and compared. These peptides also parially triggerd CTL isolatied frmo human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-specific. These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by thier immunogenicity among natural T cell repertoire.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

웨브 개구부를 갖는 합성보의 한계상태 설계법에 관한 연구

金昌湖,朴鍾圓,金熙球 홍익대학교 산업기술연구소 1999 産業技術 Vol.9 No.-

A practical approach of calculating the ultimate strength of composite beams with unreinforced web opening is proposed. In this method, the slab shear contribution at the opening is calculated as the smaller of the shear strength of the slab and the pullout capacity of the shear connectors at the high moment end. A simple interaction equation is used to predict the ultimate strength under simultaneous bending moment and shear force. Strength prediction by the proposed method is compared with previous test results and the predictions by other analytical methods. The comparison shows that the proposed method predicts the ultimate capacity with resonable accuracy.

백서 해마에서 카이닌산 유도 경련에 의한 JNK 경유 신호전달경로 활성화의 발달 단계에 따른 변화

김종흔,정희연,노명선,안용민,강웅구,김용식,조수철 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 어린 백서의 해마에서 전기경련충격(electroconvulsive shock, ECS) 후 활성화되는 것으로 알려져 있는 MAPK계 신호전달경로가 카이닌산(Kainic acid, KA)에 의한 경련 후 어떤 양상으로 활성화되는 지를 초기 발달 단계에 따라서 관찰하고자 하였다. 방 법 : 생후 7일, 14일, 21일 된 어린 백서와 성년 백서의 해마에서 면역블롯 방법으로 MAPK계 효소의 인산화 효소 중 하나인 SAPK/ERK kinase-1(SEK-1), MAPK계 효소인 c-Jun N terminal protein kinase(JNK), 전사인자 c-Jun 및 조기유전자 단백질 Fos의 단백질 양과 기저 인산화를 측정하였고, 백서에게 KA를 주사하여 경련을 유발한 후 위 단백질들의 인산화 변화의 양상을 같은 방법으로 관찰하였다. 결 과 : SEK-1, JNK, c-Jun 모두 연령 증가에 따른 단백질 양 자체에는 변화가 없었다. JNK와 c-Jun은 기저 인산화의 양적 변화도 없었으나 SEK-1의 경우 기저 인산화 양이 생후 7일에 가장 높고 이후 연령이 높아짐에 따라 감소하였다. JNK의 경우 KA 주사 후 인산화 변화 양상이 관찰되지 않았으나 SEK-1과 c-Jun은 생후 14일부터 연령의 증가와 함께 인산화 양도 증가하였다. Fos 역시 생후 7일부터 발현되어 연령의 증가와 함께 발현양이 증가하였다. 결 론 : 백서 해마에서의 MAPK계 신호전달계의 성숙은 연령의 증가에 따라, 또 신호전달 물질에 따라 차이를 보였다. KA 유도 경련 후 JNK는 생후 21일까지도 활성화가 되지 않는 것으로 보아, 세포주에서 알려진 SEK-1 - JNK-c-Jun - Fos로 연결되는 신호전달 경로가 어린 백서의 해마에서는 적용될 수 없음을 시사한다. Objective : We observed the developmental pattern of activation of MAPK signal transduction pathways known to be activated by eletroconvulsive shock(ECS) in young rat hippocampus after kainic acid(KA)-induced seizure. Methods : We used the method of immunoblotting for examining the basal protein amount and basal level of phosphorylation of MAPK kinase(SAPK/ERK kinase -1, SEK-1), MAPK(c-Jun N terminal protein kinase, JNK), transcription factor(c-Jun) and immediate early gene proteins(Fos) in rat hippocampus at postnatal day 7, 14 and 21, respectively. We also examined the changes of phosphorylation of those proteins after kainic acid-induced seizure in the same way. Results : The basal protein amounts of SEK-1, JNK, and c-Jun did not show age-dependent changes and basal level of phosphorylation of JNK and c-Jun remains unchanged throughout the early developmental period. The basal level of phosphorylation of SEK-1 was peaked at postnatal 7 days and then decreased with aging. After kainic acid-induced seizure, the change of phosphorylation of JNK was not observed but those of SEK-1 and c-Jun increased after postnatal day 14. The expression of Fos was observed at postnatal day 7 and also increased with aging. Conclusion : These results show that the MAPK signal transduction system in rat hippocampus matures in accordance with aging, but the process of maturation differs depending specific proteins. This study suggests the signal transduction cascade(SEK-1 - JNK - c-Jun - Fos) which is well established in cell line studies may not be applied to rat hipposcampus because we could not observe the activation of JNK after KA-induced seizure in young rat hippocampus.

米堤貯水池의 水質特性에 관한 硏究

김환기,오태선,유선재,김종구 全北大學校 附設 都市및環境硏究所 1996 都市 및 環境硏究 Vol.11 No.1

To investigate the characteristic and the cause of the eutrophication in Mijae Reservoir, chemical analyses were made on surface, bottom waters collected from 7 stations in July, September in 1995 respectively. 1. The Water quality of Mijae reservoir were Ⅳ grade over lake water quality criteria. 2. The trophic state of Mijae reservoir is placed eutrophic or Hypereutrophic state. 3. In order to protect of eutrohication, It is necessary that get ride of sediments, Nutrients and algaes.