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Plasma Myokine Profiles in Patients With AChRand MuSK-Ab-Positive Myasthenia Gravis
Jo Woon Seok,Jinny Lee,MinGi Kim,Min Ju Kim,Ha Young Shin,Seung Woo Kim 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.5
Background and Purpose Myokines include cytokines secreted by muscle fibers, which are the final targets of myasthenia gravis (MG). This pilot study investigated whether myokine plasma concentrations are altered in patients with MG and assessed the association between the concentration of each myokine and disease severity. Methods We compared the plasma concentrations of 15 myokines in 63 patients with acetylcholine receptor antibody (Ab)-positive MG and 14 with muscle-specific tyrosine kinase Ab-positive MG (MuSK MG) with those in 15 healthy controls. Plasma myokine concentrations were measured using a Luminex multiplex assay kit with magnetic beads that contained Abs for 15 myokines. Correlations between myokine concentration and clinical scale results were analyzed. Results The concentration of fractalkine in plasma was higher in MG (median [interquartile range]=419.6 [38.7–732.5] pg/mL) than in controls (158.5 [0.0–313.2] pg/mL, p=0.034). The leukemia inhibitory factor concentration was also found to be higher in MuSK MG (29.9 [8.7–40.1] pg/mL) than in healthy controls (7.6 [0.0–15.6] pg/mL, p=0.013). Fatty-acid-binding protein 3 (FABP3) concentrations in plasma were positively associated with clinical parameters for MG severity, including scores on the Quantitative Myasthenia Gravis score (p= 0.008), Myasthenia Gravis Activities of Daily Living (p=0.003), and Myasthenia Gravis Composite (p=0.024) scales. FABP3 concentration in plasma tended to decrease after treatment in patients without additional relapse but increased in those with further relapse. Conclusions The plasma myokine profile was significantly altered in patients with MG. FABP3 concentration may be useful in assessing disease severity and predicting the treatment response.
타이타늄-구리 폭발압접 이종 클래드 판재의 TIG 용접 건전성 평가
조평석 ( Pyeong-seok Jo ),윤창석 ( Chang-seok Youn ),황효운 ( Hyo-woon Hwang ),이동근 ( Dong-geun Lee ) 한국열처리공학회 2021 熱處理工學會誌 Vol.34 No.2
Cladding material, which can selectively obtain excellent properties of different metals, is a composite material that combines two or more types of dissimilar metals into one plate. The titanium-copper cladding material between titanium which has excellent corrosion resistance and copper which has high thermal and electrical conductivity, are highly valuable composite materials. It can be used as heat exchangers with high conductivity under severe corrosion conditions. In order to apply the clad plate to the heat exchanger, it must be manufactured in the form of a tube and additional welding is required. It is important to select the cladding material manufacturing process and the welding process. The process of manufacturing the cladding material includes extrusion, rolling, and explosive bonding. Among them, the explosive bonding process is suitable for additional welding because no heat-affected zone is formed. In this study TIG welding of the explosive-bonded dissimilar clad plates was successfully performed by butt welding. The microstructures and bonding interface of the welded part were observed, and the effect of the bonding layer at the welding interface and the intermetallic compounds on the mechanical properties and tensile plastic deformation behaviors were analyzed. And also the integrity of TIG-welded dissimilar part was evaluated. (Received February 25, 2021; Revised March 4, 2021; Accepted March 9, 2021)
Seok, Hyun,Lee, Sang-Woon,Kim, Seong-Gon,Seo, Dong-Hyun,Kim, Han Sung,Kweon, Hae Yong,Jo, You-Young,Kang, Tae Yeon,Lee, Myung-Jin,Chae, Weon-Sik Korean Society of Sericultural Science 2013 International Journal of Industrial Entomology Vol.27 No.1
The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (${\mu}$-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by ${\mu}$-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.
( Hyun Seok ),( Sang Woon Lee ),( Seong Gon Kim ),( Dong Hyun Seo ),( Han Sung Kim ),( Hae Yong Kweon ),( You Young Jo ),( Tae Yeon Kang ),( Myung Jin Lee ),( Weon Sik Chae ) 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.1
The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (μ-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by μ-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.
In Silico Study of the Ion Channel Formed by Tolaasin I Produced by Pseudomonas tolaasii
( Geun Hyeong Jo ),( Do Seok Hwang ),( Sun Hee Lee ),( Yoon Kyung Woo ),( Ji Ye Hyun ),( Yeon Joong Yong ),( Kyung Rai Kang ),( Dong Woon Kim ),( Yoong Ho Lim ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.10
A toxin produced by Pseudomonas tolaasii, tolaasin, causes brown blotch disease in mushrooms. Tolaasin forms pores on the cellular membrane and destroys cell structure. Inhibiting the ability of tolaasin to form ion channels may be an effective method to protect against attack by tolaasin. However, it is first necessary to elucidate the three-dimensional structure of the ion channels formed by tolaasin. In this study, the structure of the tolaasin ion channel was determined in silico based on data obtained from nuclear magnetic resonance experiments.
김완조,김종희,김석련,윤기운 대한스포츠의학회 1994 대한스포츠의학회지 Vol.12 No.1
The purpose of the present investigation was to assess the relationship between sports massage and positive mood enhancement. Subjects were the student in physical education. Experimental conditions were rest, massage and recovery 30min after performing maximal exercise with short duration, In massage treatment condition a cetified massage therapist gave a 15-min warm-up massage. All subjects completed the profile of mood states Results indicated that massage condition produced positive mood enhancement with significant decreases in tension and total mood distribution while maintaining high levels of vigor, which is representative mental health. Practical applications o the use of massage both before and after competition and exercise are discussed.
염산, 무기질 및 DHA를 보충한 식이가 흰쥐의 출산능력과 어린 쥐의 학습능력에 미치는 영향
김승조 ( Seong Jo Kim ),하태열 ( Tae Yel Ha ),한찬규 ( Chan Kyu Han ),김나영 ( Na Young Kim ),안홍석 ( Hong Seok Ahn ),신현경 ( Hyeon Kyeong Shin ),신승주 ( Seong Ju Shin ),장성운 ( Sung Woon Chang ),이정노 ( Jung Noh Lee ),임준규 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
목적 : 영양부족이나 영양장애는 임신에 문제를 일으킬 수 있으며, 임신기간 동안 적절한 영양 섭취가 모체의 건강과 태아의 성장발달에 지대한 영향을 미친다. 그러나 여성에서 미량영양소와 임신율 등 생식능력과의 관련성에 관한 보고는 매우 드문 실정이다. 본 연구는 엽산, 아연, 철분, 칼슘, DHA 등을 첨가한 영양보충식이 암컷 흰쥐의 생식 능력과 임신결과 및 나아가 새끼 쥐의 성장발육과 학습능력에 미치는 영향을 알아보고자 하였다. 연구 방법 : 4주령의 암컷 쥐 60마리를 각각 대조군과 영양보충식군으로 나누어, 각각의 실험식이를 공급하였고, 수컷 쥐 20마리는 일반고형사료를 주었다. 사유 2주 후 암컷 쥐와 수컷 쥐를 교미시킨 후 약 3주 후부터 분만이 시작되었으며, 출생 후 새끼 쥐의 성별 구분 및 출생체중을 측정한 뒤 사육 3주 후부터 수미로 테스트를 실시하였다. 분만한 어미 쥐는 실험식이로 4주간 더 사육한 뒤 황체호르몬, 에스트라디올, 난포수, 황체수 등을 측정하여 실험군과 대조군을 비교하였다. 결과 : 영양보충식군에서 암컷 쥐는 대조군의 2배로 30마리 중 22마리가 분만에 성공하였으며 두 군 모두 분만상태는 양호하였다. 두 군의 암컷 쥐들로부터 태어난 새끼 쥐에서는 체중증가의 차이는 없었으나 수미로에서의 유영시간, 오반응수를 측정한 결과, 영양보충식군이 대조군보다 유영시간이 짧았고, 오반응수도 적은 것으로 나타났다. 결론 : 엽산, 아연, DHA 및 타우린 등의 영양보충은 모체의 임신율을 높이고, 태아의 학습능력 향상에 기여하는 것으로 사료된다. 또한 본 연구의 결과는 여성에 있어서 영양과 임신과의 관련성을 연구하는데 기초자료가 될 것으로 기대한다. Objective : Malnutrition and nutritional disorder may cause problem of fertility and therefore adequate nutrition is very important during pregnancy. In this study, we investigated effects of supplemental diet contained folic acid, zinc, calcium, Iron, DHA and taurine on fertility outcome in the female rats and learning ability of their offsprings. Methods : The female rats at 4 week were fed by two group divided control (AIN-76 diet) and supplement diet. The male rats were taken pellet type diet. After 3weeks, female rats and male rats were mated. Then, at 3 weeks after mating, parturition was begun. After paturition, sex and birth weight of offsprings were examined for their offsprings. When the offsprings were 3 weeks of age, position reversional test in a water maze was done for 4 weeks. After female rats were fed experimental diet for 4 weeks, their follicle, corpus luteum, corpus albicans, progesterone, estradiol and ovary weight were measured. Results : 22 rats of 30 in supplemental diet group succeeded on parturition, and 11 rats of 30 in control group succeeded. Pregnancy outcome was fine in both group. There was no significant difference in weight of major bowels and femur length of their offspring. The position reversional test of offspreings in a water maze showed a significant difference between control group and supplement group. Elapsed time and erromeous response to reach the escape platform were significantly lowered in supplemental group than control group. Conclusion : This result suggest that supplementation contained folic acid, multivitamins, DHA and taurine may increase fertility rate in the maternal rats and also learning ability in offsprings.