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Jingcui Yu,Songbin Fu,Peng Liu,Xiaobo Cui,Yu Sui,Guohua Ji,Rongwei Guan,Donglin Sun,Wei Ji,Fangli Liu,An Liu,Yuzhen Zhao,Yang Yu,Yan Jin,Jing Bai,Jingshu Geng,Yingwei Xue,Jiping Qi,Ki-Young Lee 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1
Previously, we identified 3 overlapping regions showing loss of heterozygosity (LOH, R_1-R_3 from 11 to 30 cM) on chromosome 17 in 45 primary gastric cancers (GCs). The data indicated the presence of tumor suppressor genes (TSGs) on chromosome 17 involved in GC. Among the putative TSGs in these regions, HIC1 (in SR_1) and TOB1 (in SR_3) remain to be examined in GC. By immunohistochemistry (IHC), methylation-specific PCR (MSP) and western blot, we evaluated the expression and regulation status for HIC1 and TOB1 protein in GC. We narrowed down the deletion intervals on chromosome 17 and defined five smaller LOH subregions, SR_1-SR_5 (0.54 to 3.42 cM), in GC. We found that HIC1 had downregulated expression in 86% (91/106) and was methylated in 87% (26/30) of primary GCs. Of the primary GCs showing downregulation of HIC1 protein, 75% (18/24) had methylated HIC1 gene. TOB1 was either absent or expressed at reduced levels in 75% (73/97) of the GC samples. In addition, a general reduction was found in total and the ratio of unphosphorylated to phosphorylated TOB1 protein levels in the differentiated GC cell lines. Further analysis revealed significant simultaneous downregulation of both HIC1 and TOB1 protein in GC tissue microarray samples (67%, 52/78) and in primary GCs (65%, 11/17). These results indicate that silencing of HIC1 and TOB1 expression is a common occurrence in GC and may contribute to the development and progression of the disease.
최경옥(주저자) ( Jing yu Cui ),이연숙(공동저자,교신저자) ( Yeun sook Lee ),황지혜(공동저자) ( Ji hye Hwang ) 디자인융복합학회 2016 디자인융복합연구 Vol.15 No.2
본 연구의 목적은 고령화 사회에서 융합될 수 있는 미래 스마트주택의 고령친화기술 특성을 분석하는 것이다. 이를 위해 먼저 스마트융합기술을 전문적으로 다루고 있는 대표적인 국제 저널 ICOST의 게재 논문을 중심으로 고령친화기술 특성의 주요 분석유목을 선별하였다. 2007년~2014년까지 발표된 215개의 논문 중 사용자 지향적 기준에 해당되는 논문 65개를 재 선별하였다. 그리고 선별 된 논문에 나타난 기술 항목은 76개의 요소로 세분화 하였다. 분류된 기술 항목의 특성은 크게 기술의 개발목적과 기술의 적용방식 두 가지 측면으로 구분되었다. 기술의 개발목적에서는 지속가능한 노인의 독립적 생활을 지원하기 위한 사용자의 생리적, 심리적, 편의성, 건강성, 오락성이 우선적으로 고려되고 있었다. 기술의 적용방식에서는 하드웨어와 소프트웨어 두 가지로 측면으로 접근하고 있었으며, 소프트웨어는 활용 프로그램을 위주로, 하드웨어 부분은 주택의 고정적인 구조체에서 부터 이동성이 용이한 주택 내 가구, 제품, 착용아이템(wearable device), 로봇 등으로 나타났다. 그리고 구조체나 가구보다 가변적이고 융통적으로 활용 가능한 생활 제품이 압도적으로 많은 것으로 볼 때 기술의 적용방식 연구 추세에 있어서 로봇기술 분야는 더욱 많이 증가될 것으로 나타났다. 이러한 점은 미래 스마트주택의 고령친화기술에 있어 노인 개개인의 신체적·심리적·사회적 특성을 고려한 사용자의 라이프 스타일에 보다 맞춤으로서 노인은 물론 다양한 연령과 생활패턴을 수용할 수 있는 범용적인 단계로 발전될 것으로 여겨진다. The purpose of this study is to identify the characteristics of aging-friendly technology that can be integrated into future smart homes in an aging society. The literature survey and content analysis method were used to collect and analyze data. Papers of the international journal ICOST (International Conference on Smart Homes and Health Telematics) that professionally deal with converged technologies were analysis units. Sixty-five papers among 215 papers published from 2007 through 2014 were selected on the basis of end-users orientation. Totally, out of 65 papers 76 technology items were extracted. Characteristics of those technologies were analyzed focusing on purpose and application methods. As results, in terms of purpose, the technologies were oriented to provide both of psychological and physiological support to the users, focusing on the safety, convenience, health and entertainment to extend independent life of the elderly. Among the application method such as building structure, furniture, product, wearable device and free movable robot, product were dominant. Through those results, the aging-friendly technology is expected to alleviate a wide range of issues in aging society.
Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma
Yu, Zu-Hu,Zhang, Qiang,Wang, Ya-Dong,Chen, Jing,Jiang, Zhi-Mao,Shi, Min,Guo, Xin,Qin, Jie,Cui, Guang-Hui,Cai, Zhi-Ming,Gui, Yao-Ting,Lai, Yong-Qing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognostic value. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative realtime polymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and 91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1 expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 in RCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemical assays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated high expression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p = 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients with high expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. This is the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affected patients.
Cui Qin,Jing Zhao,Huilong Yu,Jian Zhang 한국광학회 2017 Current Optics and Photonics Vol.1 No.6
In this paper, we theoretically demonstrate that semiconductor optical amplifiers (SOAs) with strongwavelength dependence of gain and phase are capable of all-optical inverted and non-inverted wavelengthconversion (WC) over a wide range, with the assistance of an optical filter. First, the gain dynamics andphase dynamics in a common quantum well (QW) SOA with the In0.53Ga0.47As/In0.7322Ga0.2678As0.5810P0.4190material system are found to be strongly dependent on wavelength, which is mainly related to thewavelength dependence of the differential gain and the differential refractive-index change. Second, thewavelength dependence in an all-optical wavelength converter based on the QW SOA cascaded with adetuning band pass filter is studied. Simulations show that the quality of the converted signal has littledependence on the operation wavelength. Both inverted and non-inverted WC can be achieved, over alarge wavelength range. Therefore, although the gain and phase change are strongly wavelength-dependent,the effects of this dependence can be erased by appropriate optical filtering.
Branched polymeric prodrug/programmed cell death 4 complexes for combinational cancer therapy
Yu‑Jing He,Lei Xing,Peng‑Fei Cui,Jia‑Liang Zhang,Jian‑Bin Qiao,Cheng‑Qiong Luo,Ge Jiang,Hu‑Lin Jiang 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.2
Here, we demonstrate a co-delivery system constructed by integrating chemotherapeutic molecules into branched polymeric prodrug which can condense nucleic acids. Demethylcantharidate (DCA) was chosen as a model drug and premodified through nucleophilic substitution reaction by its two carboxylic groups with allyl chloride. The synthesized intermediate (DCA-dially) was then used to polymerize with tris (2-aminoethyl) amine (TAEA) through progressively ammonolysis reaction. The obtained poly (DCA-alt-TAEA) (DCAT) was used to pack PDCD4 into spherical-like nanoparticles through electrostatic interaction. Gel retardation assays implied that DCAT could integrate DNA at the weight ratio of 1 and protect it from digestion by nuclease. Acid-base titration experiments showed that DCAT obtained preferable buffering capability which was beneficial for the endosomal escape of DCAT/PDCD4 complexes. Cellular tests involving gene transfection efficiency and cytotoxicity indicated that DCA and PDCD4 co-delivered by the complexes significantly and synergistically suppressed the viability of SMMC-7721 cells. These results suggest that integrating chemotherapeutic molecules into nucleic acid-packing polymeric prodrug as cationic polymer/PDCD4 complexes is a highly efficient way to co-deliver chemotherapeutic drugs and nucleic acids for cancer therapy.
Cui, Jing,Shen, Liang,Wang, Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Background: The Cyclin D1(CCND1) G870A polymorphism may be associated with breast cancer, but the evidence from individual studies is inconclusive. The aim of this study was to investigate the correlation between the CCND1 G870A polymorphism and breast cancer risk in a meta-analysis. Materials and Methods: We searched Pubmed and analysed 11 articles on 5,528 cases and 5,353 controls before February 1, 2012. Results: we found there are significant association for AA versus GG and AA versus GA/GG. No significant associations were found for GA versus GG, GA/AA versus GG. There are significant association for AA versus GG, and AA versus GA/GG in Caucasians. We didn't find any significant main effects for G870A polymorphism on breast cancer risk either in recessive or dominant models in Asians. Conclusion: This meta-analysis suggests that AA of the CCND1 G870A polymorphism is associated with breast cancer susceptibility.
IL-17A Secreted by Th17 Cells Is Essential for the Host against Streptococcus agalactiae Infections
( Jing Chen ),( Siyu Yang ),( Wanyu Li ),( Wei Yu ),( Zhaowei Fan ),( Mengyao Wang ),( Zhenyue Feng ),( Chunyu Tong ),( Baifen Song ),( Jinzhu Ma ),( Yudong Cui ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.5
Streptococcus agalactiae is an important bacterial pathogen and causative agent of diseases including neonatal sepsis and meningitis, as well as infections in healthy adults and pregnant women. Although antibiotic treatments effectively relieve symptoms, the emergence and transmission of multidrug-resistant strains indicate the need for an effective immunotherapy. Effector T helper (Th) 17 cells are a relatively newly discovered subpopulation of helper CD4<sup>+</sup> T lymphocytes, and which, by expressing interleukin (IL)-17A, play crucial roles in host defenses against a variety of pathogens, including bacteria and viruses. However, whether S. agalactiae infection can induce the differentiation of CD4<sup>+</sup> T cells into Th17 cells, and whether IL-17A can play an effective role against S. agalactiae infections, are still unclear. In this study, we analyzed the responses of CD4<sup>+</sup> T cells and their defensive effects after S. agalactiae infection. The results showed that S. agalactiae infection induces not only the formation of Th1 cells expressing interferon (IFN)-γ, but also the differentiation of mouse splenic CD4<sup>+</sup> T cells into Th17 cells, which highly express IL-17A. In addition, the bacterial load of S. agalactiae was significantly increased and decreased in organs as determined by antibody neutralization and IL-17A addition experiments, respectively. The results confirmed that IL-17A is required by the host to defend against S. agalactiae and that it plays an important role in effectively eliminating S. agalactiae. Our findings therefore prompt us to adopt effective methods to regulate the expression of IL-17A as a potent strategy for the prevention and treatment of S. agalactiae infection.
( Hui Jing ),( You Jin Dai ),( Yuan Yuan Bian ),( Hui Li ),( Xiao Jin Cui ),( Xiao Jie Yu ),( Song You ),( Feng Qing Hu ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.7
Based on their respective antitumor and thrombolytic activities, the superantigen staphylococcal enterotoxin C2 (SEC2) and staphylokinase (Sak) were chosen for the construction of the novel chimeric proteins Sak-linker- SEC2 and SEC2-linker-Sak using a linker composed of nine Ala residues. Both chimeric proteins possessed nearly the same PBMC proliferation stimulating activity and antitumor activity as SEC2 and thrombolytic activity as Sak. Neither the SEC2 or Sak component of each chimeric protein affected the activity of the other component. The results presented in this study provide a possible strategy to prevent and cure tumor thrombus.
Xiao Cui,Jing Guo,Qi‑dong Zhang,Xiao‑jun Meng,Bing‑chuan Bian,Ren‑gao Zhao,Yu‑bai Ma,Fang‑qiu Zu 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.10
The slow β relaxation which occurring at temperatures far below glass transition temperature, typically playing importantroles in the plastic deformation behavior of metallic glasses. Compared with polymer glasses, most of the metallic glasses donot exhibit obvious β relaxation based on dynamic mechanical analysis. In the current work, prominent β relaxation behaviorsof a series (LaxCe100−x) Al10Co25(x = 50, 60, 70, 80) bulk metallic glasses (BMGs) at low temperature are observed usingdynamic mechanical analysis. Compared with other BMGs, the LaCe based BMGs show a pronounced β relaxation peak andrelative low peak temperature, the activation energy of the β relaxation based on Arrhenius equation are calculated around79.3 kJ/mol to 86.4 kJ/mol, which obey an empirical rule that Eβ ≈ (26 ± 4) RTg, with the coefficient of 23. Experimentalresults from room temperature compression tests for the LaCe based BMGs indicate that low temperature activated β relaxationbehaviors facilitate the good plasticity of the LaCe based BMGs.
Development and Application of Polymorphic SSR Markers in Luffa cylindrica
Junjie Cui,Zhen Lv,Tianwen Yang,Jing Wang,Yu Hong 한국원예학회 2022 원예과학기술지 Vol.40 No.5
Two published genomes of Luffa cylindrica, ‘SG2019’ and ‘SO3’, were used to develop polymorphic SSR markers for L. cylindrica by searching and comparing the SSR motifs at the same site in the two genomes. Based on the SSR search conditions and primer design criteria, 2130 polymorphic SSR markers for L. cylindrica were developed. The main motif type was dinucleotide, accounting for 80.28% of the total; the main motif units were AT/AT and AAT/ATT, accounting for 87.80% of the total. Furthermore, 40 polymorphic SSR markers developed in this study were randomly selected and amplified in 24 Luffa samples. According to the results, the 40 polymorphic SSR markers showed an amplification rate of 100% and a polymorphism rate of 80%. Cluster analysis classified the 24 Luffa samples into two main groups, L. cylindrica and L. acutangula. Overall, the polymorphic SSR markers developed in this study display a high polymorphic rate and reliable utilization value.