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Ruegeria conchae sp. nov., isolated from the ark clam Scapharca broughtonii
Lee, Jina,Whon, Tae Woong,Shin, Na-Ri,Roh, Seong Woon,Kim, Jandi,Park, Seong-Kyu,Kim, Min-Soo,Shin, Kee-Sun,Lee, Jung-Sook,Lee, Keun Chul,Kim, Young-Ok,Bae, Jin-Woo Microbiology Society 2012 International journal of systematic and evolutiona Vol.62 No.12
<P>A slightly halophilic, Gram-negative, strictly aerobic, non-motile rod, designated TW15<SUP>T</SUP>, was isolated from an ark clam in South Korea. Growth occurred at 10-37 °C, with 1-5 % (w/v) NaCl and at pH 7.0-10.0. Optimal growth occurred at 25-30 °C, with 2 % (w/v) NaCl and at pH 8.0. Strain TW15<SUP>T</SUP> exhibited both oxidase and catalase activities. The major fatty acids of strain TW15<SUP>T</SUP> were summed feature 8 (consisting of C18 : 1ω7<I>c</I> and/or C18 : 1ω6<I>c</I>) and 11-methyl C18 : 1ω7<I>c</I>. The predominant isoprenoid quinone was ubiquinone-10 (Q-10). The polar lipids of strain TW15<SUP>T</SUP> comprised phosphatidylcholine, phosphatidylglycerol, diphosphatidylglycerol, an unidentified phospholipid, an unidentified aminolipid and five unidentified lipids. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain TW15<SUP>T</SUP> was most closely related to <I>Ruegeria lacuscaerulensis</I> DSM 11314<SUP>T</SUP> (98.0 % 16S rRNA gene sequence similarity). DNA-DNA relatedness with closely related strains was <52±3 %. The DNA G+C content was 55.7 mol%. On the basis of phenotypic, genotypic and phylogenetic data, strain TW15<SUP>T</SUP> represents a novel species of the genus <I>Ruegeria</I>, for which the name <I>Ruegeria conchae</I> sp. nov. is proposed. The type strain is TW15<SUP>T</SUP> ( = KACC 15115<SUP>T</SUP> = JCM 17315<SUP>T</SUP>).</P>
Paenibacillus oceanisediminis sp. nov. isolated from marine sediment.
Lee, Jina,Shin, Na-Ri,Jung, Mi-Ja,Roh, Seong Woon,Kim, Min-Soo,Lee, Jung-Sook,Lee, Keun Chul,Kim, Young-Ok,Bae, Jin-Woo Society for General Microbiology 2013 International journal of systematic and evolutiona Vol.63 No.2
<P>A Gram-stain-negative, non-motile, aerobic, endospore forming and rod-shaped bacterium, designated strain L10(T), was isolated from marine sediment collected from the South Korean coast. The organism grew optimally under conditions of 30 C, 1?% (w/v) NaCl and pH 6.0. It was oxidase-negative and catalase-positive. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain L10(T) was associated with the genus Paenibacillus and most closely related to Paenibacillus barcinonensis BP-23(T) (98.2?% similarity). The major fatty acids of strain L10(T) were iso-C(14?:?0), anteiso-C(15?:?0) and iso-C(16?:?0). The cell-wall peptidoglycan was the A1γ type, and the predominant isoprenoid quinone was menaquinone-7. Strain L10(T) contained two unidentified lipids, an unidentified amino-phospholipid, phosphatidylethanolamine, phosphatidylglycerol, and diphosphatidylglycerol. The G+C content of the genomic DNA was 44 mol% and the DNA-DNA hybridization values with closely related strains were below 142?%. Based on phenotypic, genotypic, and phylogenetic data, strain L10(T) should be classified as a novel species within the genus Paenibacillus. The name Paenibacillus oceanisediminis sp. nov. is proposed. The type strain is L10(T) (?=?KACC 16203(T)?=?JCM 17814(T)).</P>
Lee, Hyungjoo,Lee, Jina,Lee, Yang-Hwa,Lee, Jooran,Yoon, Minjoong Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.34
<P>Ag<SUP>+</SUP>-coupled N-doped TiO<SUB>2</SUB> (Ag<SUP>+</SUP>–N–TiO<SUB>2</SUB>) nanochains were newly synthesized by combination of sol–gel and hydrothermal methods, and their structures were characterized by TEM, SEM, and XPS. The UV-visible diffuse reflectance absorption spectrum of Ag<SUP>+</SUP>–N–TiO<SUB>2</SUB> nanochains was observed to absorb visible light in the broad range of 400–800 nm as compared to neat N–TiO<SUB>2</SUB>, exhibiting efficient visible light-photocatalytic activity. Their visible light absorption band became much broader and stronger upon formation of composites with heteropoly phosphotungstic acid (HPA), and their photocatalytic efficiency was observed to be further enhanced. The Ag<SUP>+</SUP>–N–TiO<SUB>2</SUB> nanochains also exhibited improved photovoltaic performance with significantly high photoenergy conversion efficiency (PCE) (5.6%) under AM 1.5 (100 mW cm<SUP>−2</SUP>) as compared to N–TiO<SUB>2</SUB> nanochains. The PCE was observed to be further enhanced to 7.6% by formation of HPA-composites. These results suggest that Ag and HPA play important roles in enhancement of PCE through the cooperative Z-scheme process of the electron transport triggered by two-color visible lights as in the plant photosynthetic system. The HPA-composites were also found to be useful for the dye-sensitized solar cells (DSSCs) as proved by synergistic enhancement of PCE to 10.2% as they are additionally incorporated with Ru-dye.</P> <P>Graphic Abstract</P><P>HPA-composites of Ag<SUP>+</SUP>–N–TiO<SUB>2</SUB> nanochains were fabricated and shown to be highly visible light-sensitive photocatalysts for efficient two-color solar cells operated by cooperative Z-scheme electron transfer as in the plant photosynthetic system. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm11439e'> </P>
Kim, Jina,Song, Jaeyoung,Ji, Hyun Dong,Yoo, Eun Kyung,Lee, Jae-Eon,Lee, Sang Bong,Oh, Ji Min,Lee, Seungmi,Hwang, Ji Sun,Yoon, Heeseok,Kim, Dong-Su,Lee, Su-Jeong,Jeong, Minseon,Lee, Sungwoo,Kim, Kyung- American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.4
<P>An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E<I>srrg</I>, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro. We synthesized potent, selective, and orally bioavailable ERRγ-inverse agonists and evaluated their activity by analyzing in vitro pharmacology and absorption, distribution, metabolism, excretion, and toxicity profiles. X-ray crystallographic analysis of the ligand and ERRγ complex showed that <B>35</B> completely binds to the target protein (PDB 6A6K). Our results showed improved radioiodine avidity in ATC cells through compound <B>35</B>-mediated upregulation of iodide-handling genes, leading to enhanced responsiveness to radioiodine therapy in vitro. Importantly, in vivo <SUP>124</SUP>I-positron emission tomography/computed tomography imaging revealed that <B>35</B> increases radioiodine avidity in CAL62 tumors. Collectively, these results demonstrated that <B>35</B> can be developed as a promising treatment for ERRγ-related cancer in the future.</P> [FIG OMISSION]</BR>
Sei Won Lee, M.D., Ph.D,So Youn Shin,Tai Sun Park,Yoon Young Choi,Jong Chun Park,Jina Park,오상영,Namkug Kim,Se Hee Lee,Jae Seung Lee, M.D,Joon Beom Seo,오연목,Sang-Do Lee, M.D., Ph.D.,이상민 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.7
Objective: The absence of collateral ventilation (CV) is crucial for effective bronchoscopic lung volume reduction (BLVR) with an endobronchial valve. Here, we assessed whether CT can predict the ChartisTM results. Materials and Methods: This study included 69 patients (mean age: 70.9 ± 6.6 years; 66 [95.7%] males) who had undergone CT to assess BLVR eligibility. The ChartisTM system (Pulmonox Inc.) was used to check CV. Experienced thoracic radiologists independently determined the completeness of fissures on volumetric CT images. Results: The comparison between the visual and quantitative analyses revealed that 5% defect criterion showed good agreement. The ChartisTM assessment was performed for 129 lobes; 11 (19.6%) of 56 lobes with complete fissures on CT showed positive CV, while this rate was significantly higher (40 of 49 lobes, i.e., 81.6%) for lobes with incomplete fissures. The size of the fissure defect did not affect the rate of CV. Of the patients who underwent BLVR, 22 of 24 patients (91.7%) with complete fissures and three of four patients with incomplete fissures (75%) achieved target lobe volume reduction (TLVR). Conclusion: The quantitative analysis of fissure shows that incomplete fissures increased the probability of CV on ChartisTM, while the defect size did not affect the overall rates. TLVR could be achieved even in some patients with relatively large fissure defect, if they showed negative CV on ChartisTM.
Kim Harin,Park Kee Jeong,Shin Yong-Wook,Lee Jung Sun,Chung Seockhoon,Lee Taeyeop,Kim Min-Jae,Jung Jiwon,Lee Jina,Yum Mi-Sun,Lee Beom Hee,Koh Kyung-Nam,Ko Tae-Sung,Lim Eunyoung,Lee Jung Soo,Lee Jee Yeo 대한의학회 2020 Journal of Korean medical science Vol.35 No.28
Quarantine often provokes negative psychological consequences. Thus, we aimed to identify the psychological and behavioral responses and stressors of caregivers quarantined with young patients after a close contact to a coronavirus disease 2019 case at a children's hospital. More than 90% of the caregivers reported feelings of worry and nervousness, while some of them reported suicidal ideations (4.2%), and/or homicidal ideations (1.4%). Fear of infection of the patient (91.7%) and/or oneself (86.1%) were most frequently reported stressors. A multidisciplinary team including infection control team, pediatrician, psychiatrist, nursing staff and legal department provided supplies and services to reduce caregiver's psychological distress. Psychotropic medication was needed in five (6.9%), one of whom was admitted to the psychiatry department due to suicidality. Quarantine at a children's hospital makes notable psychological impacts on the caregivers and a multidisciplinary approach is required.
Lee, Sujin,Lee, Yong Jae,Choi, Saehae,Park, Su-Bin,Tran, Quynh-Giao,Heo, Jina,Kim, Hee-Sik Springer Netherlands 2018 Journal of applied phycology Vol.30 No.4
<P>Microalgae have been widely considered for the production of valuable products, such as lipid-based biofuel, value-added pigments, and anti-photo aging reagents. More recently, microalgae have been considered an alternative host for recombinant protein production because of their economic benefits and ecofriendly characteristics. Additionally, many microalgal strains identified to date are generally recognized as safe (GRAS); therefore, the use of microalgae-based technology is promising. However, basic studies on the genetic engineering of microalgae are rare, despite their importance. Particularly, inducible promoter systems that can be applied for strain engineering or recombinant protein production are rarely studied; hence, a number of challenging issues remain unsolved. Therefore, in this study, we focused on the development of a convenient and compact-inducible promoter system that can be used in microalgae. Based on previous success with plant systems, we employed the alcohol-inducible AlcR-P<SUB><I>alc</I>A</SUB> system, which originates from the filamentous fungus, <I>Aspergillus nidulans</I>. This system comprises only two components, a regulatory protein, AlcR, and an inducible promoter, P<SUB><I>alc</I>A</SUB>. Therefore, construction and transformation of the gene cassettes can be easily performed. Ethanol-dependent gene expression was observed in the transformants with no significant growth retardation or inducer consumption observed in the cells cultivated under optimized conditions.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1007/s10811-018-1480-8) contains supplementary material, which is available to authorized users.</P>