진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

자연의 아름다움과 고급스러움이 공존하는 마임 비에타 쇼룸 제안 -오감 (시각, 청각, 후각, 촉각, 미각)을 중심으로-

김보현,이서연,은다솜,엄연정,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 국내 브랜드 ‘마임'의 뷰티와 연계한 뷰티 쇼룸을 제안함에 있어서 공간속에 오감을 담아내는 일련의 프로세스를 밝히는데 목적이 있다. 이는 브랜드가 소유하고 있는 다양한 감각과 가치가 결여된 채 시각적 요소만이 담긴 브랜드 뷰티 쇼룸이 대다수를 차지하는 오늘날, 이에 대한 문제를 해결하기 위해 ’융합 연출 디자인'적 시점에서 폭넓게 바라보고 브랜드의 정신과 오감의 결합을 통해 이를 해결하고자 하였다. 이에 본 연구는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출 디자인>수업에서 진행된 수업의 결과물로서 산학 연계된 화장품 브랜드의 쇼룸디자인 개발 프로세스를 제안한다. 또한 본 연구의 범위는 오감을 담고 있는 뷰티 쇼룸(4D)이 되기까지의 과정 전체로 한다. 그 결과, 마임 뷰티쇼룸은 공간 디자인과 오감을 융합하여 영상에서 공간에 이르기까지 오감의 조화와 브랜드의 정신을 녹여내고 확장시켰다. 끝으로 본 연구는 뷰티 쇼룸 공간 디자인을 제안함에 있어서 오감을 활용하여 통합된 시점에서 그래픽·제품·공간을 개발 및 제시한 것에 의의가 있다. 또한 향후 이와 관련된 쇼룸 공간 개발에 있어서 기초 자료로 활용될 것으로 기대된다.

청소년 지도학의 활동영역 활성화 연구

육현철,장갑석,최강진 한국체육대학교 2001 韓國體育大學校 敎養敎育論文集 Vol.- No.6

The Curriculum of National Cooking(Guidance) for the Youth Had Been established at the Myungji University in 1994 for the first time in the history of Korean college, and 8 universities Has, Recently and operate the course, These days the curriculum mostly concentrates on the subject of pedagogy and educational psychology. (ⅰ) To vitalize the juvenile's physical activity, the government concerned needs to make a political support in order each university to found the curriculum for the youth.And each university must open the course which the teenager can make physical activities free of charge. (ⅱ) The educational policy researching and developing the activity area of the youth is required.By educating them based upon the activity area, the youth can have a healthy body which results from sound spirit. (ⅲ) The youth Activity Centre is to be established and operated at each community or local district to vitalize the section for sport activity which the juvenile prefer.Physical promotion is needed to be desirable adult. (ⅳ) Today the computer system like internet and dlectronic entertainment/game give the large influence on all the juvenile.Herein we need to remind that almost young generation study by day and indulge in computer without Physical activity that lead to weak body and feeble spirit.Under those circumstances, we can find out the juvenile delinquent from to time. (ⅴ) Finally, it is greatly important and imperative to foster lots of professional experts/coaches who can understand the youth and guide them in a sound way.

KS H ISO 1242 표준의 평가 : 라반딘 정유의 산값 측정

전혜림,이은지,장혜진,손현화,김건,김남선,전명숙,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-

The acid value (AV) as well as the ester value of essential oil is an important index to evaluate quality of essential oil. The official standard analytical method of KS H ISO 1242 dealing with “Essential oils - Determination of acid value” was assessed experimentally using two lavandin essential oils obtained in France as an example. One French lavandin oil sample showed the results of AV= 0.9 by both indicator method and potentiometry. Another sample showed AV = 1.9 by indicator method and AV = 1.6 by potentiometry. Latter lavandin oil sample exhibited significantly higher acid value than maximum value of 1 described in the standard. This result suggests that latter lavandin oil was contaminated, because this oil was contained in an orange juice bottle. Results of this study proved that KS H ISO 1242 could be used as a suitable scientific standard for the determination of acid value of essential oils.

타액분비량이 증가하는 입체조의 효과와 만족도

방혜인(외 3명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-

Objectives: This study was performed to grasp the relation between the effect and the satisfaction of mouth gymnastics program on the promotion of oral function of students. We investigate the degree of digestion due to stress and the changes in salivary flow. We should investigate about the relationship of xerostomia according to the changes in salivary secretion. Methods: Total 79 students for two weeks, Silla University Dental Hygiene Department participated in this survey. Results: In the point of view of oral xerostama, people without drinking have lower symptom and action of xerpstama than those who drink three or four times a week. As the change rate of salivation amount is large, the degree of digestion, stress and xerpstama symptom and action is low. However the satisfication of oral exercise program is high. Conclusions: Adult should pay attention to oral health through oral exercise which increases the amount of salivation. Also Oral and total health should be increased through oral health education for the methodical oral health program

사이버 가정학습체제 구축 모형 개발

권성호,최인호,심현애,이승진,김경현,장상현 한국교육정보미디어학회 2003 교육정보미디어연구 Vol.9 No.4

본 연구는 초·중등 사이버 가정학습체제의 구축 모형 개발을 목적으로 한다. 이를 위해 첫째, 사교육비 관련 현황 및 우리나라의 사회·현실적 요구를 분석하고, 둘째, 사이버 공간에서의 학습을 지원하는 학습이론을 탐색하여 얻은 시사점을 바탕으로 사이버 가정학습체제 개발 원리를 도출하였으며, 셋째, 학습이론적 적용의 틀을 기반으로 사이버 가정학습체제 구축 모형을 개발하고, 각 모형에 대한 세부적인 설명과 시행 시 고려해야 할 사항을 제시하였다. 사이버 가정학습체제 구축 모형은 체제 구성요소와 각 요소들 간의 관계를 도식화한 체제 구성도를 바탕으로 사이버 가정학습체제를 운영하는 활동 주체들의 역할을 정의한 운영 모형, 사이버 가정학습체제 내에서의 학습 유형과 흐름을 보여주는 학습 모형, 사이버 가정학습체제 내 학습 콘텐츠의 구성 기준을 제시하는 콘텐츠 모형 그리고 사이버 가정학습체제 내에서의 학습에 대한 학업성취도 평가와 체제 평가를 위한 평가 모형으로 구성되었다. 각 유형별 모형은 필요에 따라 하위 모형으로 분류되어 총 17개의 사이버 가정학습체제 모형을 제시하였다. 또한 사이버 가정학습체제가 사교육비 절감과 공교육 지원이라는 궁극적인 목적을 달성하기 위해 고려되어야 할 시사점으로 환경자원, 학습자원, 인적자원, 홍보 마케팅 등의 네 가지 측면으로 나누어 제시하였다. The study is purposed to develop a set of construction models for Cyber Home Study System(CHSS) to support the students' self study through internet at the level of elementary, middle and high school students. This is intended to reduce the over spending of the private educational payment, causing the social conflict and antagonism in Korea, and finally to support the public education. The study problems are as follows: 1. Analysis on the social and authentic needs for reducing the private educational payment which causes the social conflict and antagonism in Korea. 2. Setting up the principles to develop the construction model for CHSS to apply the learning theories in support of the learning in the cyber space. 3. Development of a set of construction models for development and construction for CHSS, based on the theoretical developmental principles. The construction model for CHSS developed in this study contains a systemic diagram of the whole CHSS, and 4 major models: a model for management, the model for learning process, the model for content design, and the model for evaluation. The systemic diagram for CHSS demonstrates various components, which consist of the whole system, and the relationship among the components. The model of management identifies the role of each organization by which the CHSS is operated. The Learning process model is classified with 9 sub-models converging on the three factors. These factors are the learner subject, the existence of tutor support, and the relationship to the local school. The models for content design proposes the guideline for design and production of learning content. The evaluation model is composed of three sub models: evaluation for individual learning achievement, evaluation for learning achievement of the tutor supported calss members, and the system evaluation. Finally, 4 kinds of suggestions is suggested to accomplish the purpose of CHSS in terms of environmental resources, learning resources, man power, and advertising and marketing strategies.

Identification of Dinitrotoluene Selective Peptides by Phage Display Cloning

Hyeon-Jun Jang,나정현,Bong-Suk Jin,이원규,Woong-Hee Lee,Hyun Jin Jung,Seok-Chan Kim,임시형,유연규 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12

Biomolecules specific to explosives can be exploited as chemical sensors. Peptides specific to immobilized dinitrotoluene (DNT) were identified using a phage display library. A derivative of DNT that contained an extended amine group,4-(2,4-dinitrophenyl)butan-1-amine, was synthesized and immobilized using a self-assembled monolayer surface on gold. Filamentous M13 phages displaying random sequences of 12-mer peptides specific to the immobilized DNTderivate were isolated from the M13 phage library by biopanning. A common peptide sequence was identified from the isolated phages and the synthesized peptides showed selective binding to DNT. When the peptide was immobilized on a quartz crystal microbalance (QCM) chip, it showed a binding signal to DNT, while toluene barely showed significant binding to the QCM chip. These results demonstrate that peptides screened by biopanning against immobilized DNT can be useful for quick and accurate detection of DNT.

Establishment of specific antibodies against viral hemorrhagic septicemia virus in infected olive flounder (Paralichthys olivaceus) diagnostic method using enzyme-linked immunosorbent assay

Jin Hyeon Jang,Jee Youn Hwang,Dong jun Kim,Tae hyeong Kim,Mun Gyeong Kwon,Jung Soo Seo,Seong Don Hwang,Bo-Young Jee 한국수산해양기술학회(구 한국어업기술학회) 2018 한국수산해양기술학회 학술발표대회 Vol.2018 No.11

Carbon Dioxide-Generating PLG Nanoparticles for Controlled Anti-Cancer Drug Delivery

Jang, Hyeon Jin,Jeong, Eun Ju,Lee, Kuen Yong Springer-Verlag 2018 Pharmaceutical research Vol.35 No.3

Cloning, Expression Analysis and Enzymatic Characterization of Cathepsin L from the Inshore Hagfish (Eptatretus burgeri)

Jin-Hyeon JANG(장진현),So-Hee SON(손소희),Hyeon-Kyeong JO(조현경),Joon-Ki CHUNG(정준기),Hyung-Ho LEE(이형호) 한국수산해양교육학회 2016 水産海洋敎育硏究 Vol.28 No.4