18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

Jun-Jang Jin,Il-Gyu Ko,Sung-Eun Kim,Lakkyong Hwang,Man-Gyoon Lee,Dae-Young Kim,Sun-Young Jung 한국운동재활학회 2017 JER Vol.13 No.4

Aerobic Exercise Affects Myostatin Expression in Aged Rat Skeletal Muscles: A Possibility of Antiaging Effects of Aerobic Exercise Related With Pelvic Floor Muscle and Urethral Rhabdosphincter

Ko, Il Gyu,Jeong, Jin Woo,Kim, Young Hoon,Jee, Yong Seok,Kim, Sung Eun,Kim, Sang Hoon,Jin, Jun Jang,Kim, Chang Ju,Chung, Kyung Jin Korean Continence Society 2014 International Neurourology Journal Vol.18 No.2

<P><B>Purpose</B></P><P>Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recommended for the prevention and the treatment of these age-related frail states. We investigated the effects of treadmill exercise on muscle strength, myostatin mRNA and protein expression, and gastrocnemius myocytes proliferation in aged rats to investigate the possible antiaging effects of aerobic exercise on skeletal muscles such as pelvic floor muscles and urethral rhabdosphincter muscle.</P><P><B>Methods</B></P><P>In this study, 5-month-old male Sprague-Dawley rats were used as the young-age group (n=20) and 24-month-old rats were used as the old-age group (n=20). Each group was randomly divided into two groups (n=10 in each group): the sedentary and the treadmill exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 minutes, once a day, for 6 weeks. For this study, a weight load test, hematoxylin and eosin staining, real-time and reverse transcription polymerase chain reaction for myostatin mRNA, myostatin western blot, and 5-bromo-2'-deoxyuridine immunohistochemistry were performed in the gastrocnemius muscle.</P><P><B>Results</B></P><P>The age-induced reduction of muscle mass and strength was associated with a decrease in myocyte proliferation and an increase in myostatin mRNA and protein expression in the gastrocnemius. However, treadmill exercise improved muscle mass and strength through suppression of myostatin mRNA and protein expression, and myocyte proliferation increase in the gastrocnemius against the aging process.</P><P><B>Conclusions</B></P><P>Aerobic exercise is a useful strategy for enhancing muscle function against aging-induced loss of skeletal muscle mass and functions.</P>

Ethylenediaminetetraacetic acid(EDTA)항응고제에 의한 Mean Corpuscular Volume(MCV)변화

홍승민,박영진,최하영,임진,정옥연,이호준,이호영,장숙진,문대수 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

It is essential that we put the anticoagulant into the blood specimen of the CBC test. However, the value of some parameters in the CBC test can be changed whenever using some anticoagulants. EDTA anticoagulant is mostly used these days. There are 3 kinds of EDTA, that is K_(2-), K_(3-), and Na_(2-) EDTA. The author studies how many effects each the EDTA gets into the true value of blood specimen for MCV of RBCs. Especially we compared the MCV effect of different concentrations of 3 EDTA anticoagulants on the bias with time and instrument. Some results are gotten. In our results, K_(3-)EDTA anticoagulant shows more satisfactory MCV value than K_(2) or Na_(2-)EDTA. On using concentration of EDTA, 1.5㎎ EDTA/㎖ of blood show more satisfactory MCV value than 7.5㎎ EDTA/㎖ of blood. However, the choice of anticoagulant may be dependant on the different instruments.

Ethylenediaminetetraacetic acid (EDTA)항응고제에 의한 Mean Corpusculaar Volume(MCV)변화

홍승민,박영진,최하여,임진,정옥연,이호준,이호영,장숙진,문대수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업의 효과와 학생들의 인식

장진아,이경희,박소영,김동진,최병순,박국태 韓國敎員大學校 敎育硏究院 2009 敎員敎育 Vol.25 No.3

이 연구는 7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업이 중학교 1학년 학생들의 개념 이해와 학업 성취도에 미치는 효과와 학생들의 인식을 알아보기 위한 것이다. 연구를 위하여 S시 소재 Y중학교 1학년 3개 학급 107명을 실험집단l파 실험집단2 및 통제집단으로 나누어, 실험집단l에는 학생간의 사회적 상호작용을 강조한 탐구실험 수엽을 실시하고, 실험집단2에는 교사와 학생간의 사회적 상호작용을 강조한 탐구실험 수업을 실시하였으며, 통제집단에는 전통적인 실험 수엽을 실시하였다. 수업 전과 후에 개념 이해도 검사를 하였으며, 성취도 검사와 인식 조사는 수업 후에 실시하였다. 연구 결과에 의하면, 실험집단1과 섣험집단2의 사회적 상호작용을 강조한 탐구싣험 수업이 통제집단의 전통적인 설험 수엽에 비하여 분자의 운동에 대한 개념 이해에 효과적이었다. 학업 성취도에 있어서는 사회적 상호작용을 강조한 실험집단1과 실험집단2의 학업 성취도 평균이 통제집단의 학업 성취도 평균에 비해 통계적으로 유의마하게 높았다. 실험집단1과 실험집단2의 학생들은 전반적으로 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업을 긍정적으로 인식하였다. 실험집단1에서 인지수준이 높은 학생들은 명확하게 답을 제시해 주는 것보다 동료와의 상호작용을 통해 시행착오를 거치면서 스스로의 힘으로 문제를 해결함으로써 자신감과 만족감을 느꼈다. 실험집단2에서 인지수준이 중하위인 학생들은 애매하고 시행착오적인 동료와의 상호작용보다는 교사와의 상호작용을 통해 직접적으로 답에 이르고 명확하게 개념 정리를 해주는 것을 선호하였다. The purpose of this study was to investigate effects of the inquiry experiment instruction emphasizing social interaction in the 7th grade motion of molecules unit on middle school students' scientific concept, achievement, and the perception of the instructions. For this study, 107 7th grade students were divided into three groups: the experimental group I, the experimental group 2, and the control group. The experimental group 1 were given inquiry experiment instruction emphasizing student-student interaction and the experimental group 2 were given inquiry experiment instruction emphasizing teacher-student interaction, while the control group were given traditional experiment instruction. They were all tested on their level of scientific concept understanding before and after the instruction and after the instruction they were given achievement test and surveyed on their perception. According to the result of this study, the inquiry experiment instruction emphasizing social interaction of experimental group 1 and 2 was more effective than the traditional experiment instruction of the control group in understanding the scientific concept of molecular motion, and the achievement level of experimental group 1 and 2 was significantly higher than the control group. Generally both students of group 1 and 2 were found to affirmatively perceive the inquiry experiment instruction emphasizing social interaction in the motion of molecules unit. Students of group 1 with high cognitive level were satisfied when they were able to independently solve problems by trial and error through student-student interaction than being given the exact answers. Meanwhile students of group 2 with middle to low cognitive level preferred the inquiry experiment instruction emphasizing teacher-student interaction that easily and cleary gives them the correct answer than student-student interaction which can be obscure and requires trial and error.

하지에 발생한 피부 결손의 치료에서 전 외측 대퇴부 유리 피판술의 유용성

권영호,장수진 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : The objective of this study was to evaluate the clinical results of operative treatment on skin defect of lower extremities by free anterolateral thigh flap. Methods : Between 2005 to 2009 we followed up 10 cases who undergoing anterolateral thigh free flap because of lower extremity skin and soft tissue defect. 3 cases are heel, ankle and foot dorsum are each 2 cases, sole and knee, thigh are each 1 case. We observed that of implanted area's color, peripheral circulation at 3, 5, 7 days after operation and evaluation with operating time, amount of hemorrhage, implanted skin necrosis, additional operation, complications. Results : 9 cases of 10 showed successful localization and 1 case showed fail. Size of soft tissue defect due to trauma was 9.5 × 7.3cm (5 × 6cm∼13 × 8cm), due to trauma or infection was 18.3 × 11.8cm (13 × 6cm∼30 × 20cm). Skin color change was mainly due to congestion with hematoma, flap was not observed global congestion or necrosis except 2 cases which showed partial necrosis on margin that treated with conservative therapy. Conclusion : Anterolateral thigh free flap is useful in radical skin defect treatment and had a good results after operation functional reconstruction.

화상창상의 치유 및 반흔형성 과정에서 신경펩티드의 변화

장영철,범진식,이종욱,오석준 대한화상학회 2003 대한화상학회지 Vol.6 No.2

GMDP 신경망 알고리즘과 PID 제어기를 이용한 효율적인 PLANT 제어에 관한 연구

장진청,설재훈,장종승,추연규,임영도 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2

Adapative control theory or parameter tuning of PID controller is mainly limited in linear systems. But in this paper, using a nonlinear mapping capability of NNS, we derive a realtime tuning method of PID controller based on a Back-Propagation method of single GMDP NN. A variety of neural models, especially higher-order networks, are known to computationlly powerful for complex application. While they have advantages over traditional multilayered perceptrons, the uniformity in their network structures, learning algorithms and loop time creates practical problems. Thus this paper evaluates the capability between MLP and GMDP for performing velocity control. Backpropagation is applied to the GMDP as learning rule.

生體血의 保存環境과 腐敗産物에 依한 血中알콜濃度變化에 關한 硏究

張成吉,金英雲,柳在薰,吳世珍,權五星,朴世延 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-