Poster Session : Caffeic acid protects WI 38 human Lung fibroblast cells against hydrogen peroxide induced cell damage

( Kyoung Ah Kang ),( Kyoung Hwa Lee ),( Rui Zhang ),( Mei Jing Piao ),( Sung Wook Chae ),( Kil Nam Kim ),( You Jin Jeon ),( Doek Bae Park ),( Ho Jin You ),( Jin Sook Kim ),( Jin Won Hyuna ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

Fine-Tuning of the Carbon Dioxide Capture Capability of Diamine-Grafted Metal-Organic Framework Adsorbents Through Amine Functionalization

Jo, Hyuna,Lee, Woo Ram,Kim, Nam Woo,Jung, Hyun,Lim, Kwang Soo,Kim, Jeong Eun,Kang, Dong Won,Lee, Hanyeong,Hiremath, Vishwanath,Seo, Jeong Gil,Jin, Hailian,Moon, Dohyun,Han, Sang Soo,Hong, Chang Seop WILEY-VCH 2017 CHEM SUS CHEM Vol.10 No.3

<P>A combined sonication and microwave irradiation procedure provides the most effective functionalization of ethylenediamine (en) and branched primary diamines of 1-methylethylenediamine (men) and 1,1-dimethylethylenediamine (den) onto the open metal sites of Mg-2(dobpdc) (1). The CO2 capacities of the advanced adsorbents 1-en and 1-men under simulated flue gas conditions are 19 wt% and 17.4 wt%, respectively, which are the highest values reported among amine-functionalized metal-organic frameworks (MOFs) to date. Moreover, 1-den exhibits both a significant working capacity (12.2 wt%) and superb CO2 uptake (11 wt%) at 3% CO2. Additionally, this framework showcases the superior recyclability; ultrahigh stability after exposure to O-2, moisture, and SO2; and exceptional CO2 adsorption capacity under humid conditions, which are unprecedented among MOFs. We also elucidate that the performance of CO2 adsorption can be controlled by the structure of the diamine ligands grafted such as the number of amine end groups or the presence of side groups, which provides the first systematic and comprehensive demonstration of finetuning of CO2 uptake capability using different amines.</P>

A cytokine study of pediatric Tourette's disorder without obsessive compulsive disorder

Yeon, Seung-min,Lee, Ju Hyung,Kang, Daewon,Bae, Hyuna,Lee, Ki Yong,Jin, Seohoon,Kim, Jung Ryul,Jung, Yong Woo,Park, Tae Won Elsevier 2017 Psychiatry Research Vol.247 No.-

<P><B>Abstract</B></P> <P>It has been suggested that post-infectious inflammation in central nervous system is a cause of tic disorder including Tourette’s disorder (TD). Since pro-inflammatory cytokines are important mediators inducing inflammation, the cytokine levels are regarded as one of the important indicators of inflammation. Several studies have investigated the relationship of autoimmunity and the pathogenesis of TD by measuring the inflammatory cytokine levels of blood. However, when using human samples, the experimental results can be affected by the factors like size of sample, comorbidity, medication that patients take and the severity of the diseases. Thus, it is important to exclude the possibility that comorbidity and medication affects the level of inflammatory cytokines in the serum of TD patients. In our experiment, we recruited 29 patients without obsessive compulsive disorder (OCD) comorbidity and the majority of these patients did not take medication. The six pro-inflammatory cytokine levels of blood between patient and healthy groups were compared, considering the factors above, to determine more accurate results. Of the cytokines we investigated, the interleukin 12 p70 (IL-12p70) and tumor necrosis factor α (TNFα) levels increased in patient group compared to healthy controls and the patient group which have anti-streptolysin O (ASO) score under the 200 or YTGSS score from 10 to 19 also showed higher IL-12p70 or TNFα levels. In addition, the patients who did not take medication showed higher TNFα levels compared to healthy controls. In conclusion, we suggest that inflammatory pathways that involve IL-12p70 or TNFα are important to the pathogenesis of TD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IL-12 and TNFα levels were increased in the patient with TD compared to the controls. </LI> <LI> The levels of these cytokines were increased depending on an ASO and an YTGSS score. </LI> <LI> TNFα levels in the unmedicated were higher than those in healthy controls were. </LI> </UL> </P>

Study of the structure-properties relations of carbon spheres affecting electrochemical performances of EDLCs

Kim, Hee Soo,Abbas, Muhammad Awais,Kang, Min Seok,Kyung, Hyuna,Bang, Jin Ho,Yoo, Won Cheol Elsevier 2019 ELECTROCHIMICA ACTA Vol.304 No.-

<P><B>Abstract</B></P> <P>For high performance of electrical double layer capacitors (EDLCs), a high specific surface area (SSA) and N-doping level, and small particle size of carbonaceous materials, have been believed to be crucial factors. However, there have been few reports on simultaneous study of the structure-properties relations of carbons and the electrochemical performances of EDLCs. Herein, we report the relationship between the structural properties of carbons, such as the SSA, N-doping, and particle size, and the electrochemical properties of EDLCs by using a series of well-defined carbons. Monodisperse and size-tunable resorcinol-formaldehyde carbon (RFC) spheres were synthesized and activated by hot CO<SUB>2</SUB> treatment to increase the SSA up to 3958 m<SUP>2</SUP>/g (RFC_C390 sample). When the specific capacitances of the RFC spheres were plotted in terms of their SSAs, an almost perfect correlation (R<SUP>2</SUP> = 0.99) was observed, which confirmed the linear relationship between the specific capacitance and the SSA. In addition, N-doped melanin C (MC) spheres were synthesized and subsequently activated for N-doping effect. Activated MC (MC_C130), which exhibited similar SSA (2618 m<SUP>2</SUP>/g) and size (301 nm) but a different N-doping level (3.1%) compared with those (2793 m<SUP>2</SUP>/g, 312 nm, and 1.3%, respectively) of the activated RFC spheres (RFC_C120), displayed higher specific capacitance (288 F/g), capacitance retention (64%), and long term stability over 5000 cycles (93%) compared with those (260 F/g, 58%, and 90%, respectively) of the RFC counterparts. To observe the particle size effect, different sizes (98, 280, and 579 nm) of RFC spheres with similar SSAs (3981, 3958, and 3898 m<SUP>2</SUP>/g, respectively) and pore size distributions were prepared, such that the smallest RFC revealed the best EDLC performance in terms of specific capacitance (360 F/g), capacitance retention (70%), and long term stability over 5000 cycles (98%), all of which could be compared with the values reported in the literature. Furthermore, all of the Carbon samples were analyzed by using electrochemical impedance spectroscopy for confirming the structure-properties relations of carbon spheres with the electrochemical performances of EDLCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Monodisperse and size-tunable carbon spheres were synthesized and activated by hot CO<SUB>2</SUB> treatment. </LI> <LI> Structure-properties relations of carbon spheres with electrochemical performance of EDLCs were elucidated. </LI> <LI> EIS study also supported the relationship of structure-properties of carbon and EDLC performances. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Photoprotective Effect of Carpomitra costata Extract against Ultraviolet B-Induced Oxidative Damage in Human Keratinocytes

Zheng, J.,Hewage, S.R.K. Madduma,Piao, Mei Jing,Kang, Kyoung Ah,Han, X,Kang, H.K.,Yoo, E.S.,Koh, Y.S.,Lee, N.H.,Ko, C. S.,Lee, J. C.,Ko, Mi Hee,Hyuna, Jin Won Begell House Inc. 2016 Journal of environmental pathology, toxicology, an Vol.35 No.1

<P>Natural marine products show various biological properties such as antiphotoaging, antioxidant, anticancer, and anti-inflammation. This study evaluated the protective effects of the brown alga Carpomitra costata (Stackhouse) Batters (Sporochnaceae) against ultraviolet B (UVB)-provoked damage in human HaCaT keratinocytes. C. costata extract (CCE) effectively reduced superoxide anion, hydroxyl radical, and UVB-stimulated intracellular reactive oxygen species (ROS) levels. CCE also restored the expression and activity of UVB-suppressed antioxidant enzymes. Furthermore, CCE decreased UVB-triggered oxidative damage to cellular components including DNA, protein, and lipid and defended the cells against mitochondrial membrane depolarization-medicated apoptosis. The results of this study indicate that CCE can safeguard human keratinocytes against UVB-induced cellular damage via a potent antioxidant mechanism. CCE may find utility as part of a therapeutic arsenal against the damaging effects of UVB radiation on the skin.</P>