위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.

혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상

이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.

UV/TiO₂ 광촉매산화 복합공정을 이용한 악취 및 VOCs 제거를 위한 장치 개발 연구

박정섭,박진우,김종범,이현정,박정우,최금찬 동아대학교 환경문제연구소 2006 硏究報告 Vol.28 No.1

We have developed UV/TiO₂ photocatalytic oxidation combined process to control odor and VOCs in industrial applications. Three types of individual processes are introduced to test of their ability to increase treatment efficiency. Odor and VOC gases such as ammonia, hydrogen sulfide, formaldehyde and toluene are used for target gas. UV/TiO₂ photocatalytic oxidation combined process with activated carbon was excellent among the three types processes without relation to gas species. It will promise that this new type UV/TiO₂ photocatalytic oxidation combined process can apply industrial applications to remove odorous gases from the emission source. 본 연구에서는 대표적인 악취물질과 VOCs 의 처리 를 목적으로 UV 광촉매산화 복합공정을 이용하여 암모니아와 황화수소 그리고 포름알데히드와 툴루엔의 제거율을 높임으로써 산업공정 등에서 UV 광촉매산화 복합공정의 적용가능성을 검토하였다. 현단계까지는 악취물질의 각 물질별로 전환효율은 낮으나, 본 연구에서 제작된 UV 광촉매산화 복합공정은 악취 물질과 VOCs가 많이 발생되는 산업현장내 근무자로부터 악취물질과 VOCs등 각종 대기오염물질 저감을 위한 장치로서 실용화 가능성을 기대할 수 있다.

초음파와 적외선 센서를 이용한 AGV 위치 보정

박진모,박경섭 울산대학교 1996 공학연구논문집 Vol.27 No.1

본 논문은 고정된 경로를 가지지 않는 자율 주행 방식 위치 보정에 관한 내용이다. 자율 주행 방식에서 가 좌표상의 주어진 경로를 주행하려면 작업 공간상에서 현재 자신의 위치를 파악할 수 있어야 하며, 바퀴의 회전량을 휠 엔코더로 측정하여 위치를 계산하는 방법이 널리 사용된다. 그러나 이 경우 주행 경로가 길어질수록 오차가 계속 누적되며 이러한 오차는 자체의 내부 센서만으로는 확인할 수 없다는 단점을 가지고 있다. 이러한 내부 센서의 단점을 보완하기 위해 외부 센서가 필요하며, 의 위치를 측정하고 보정하기 위한 방법으로 비전 센서와 센서, 초음파 센서등을 이용한 방법들이 제시되고 있다. 또한 이러한 외부 센서와 내부 센서를 보완하기 위한 방법으로 데이터 융합이 시도되고 있다. 본 논문에서는 외부 센서로 적외선과 초음파 센서를 사용하여, 두 매체간의 전달시간차를 측정하고 이를 이용하여 의 위치를 구하였다. 그리고 외부센서로 부터 구한 데이터와 내부 센서 데이터를 칼만 필터를 이용하여 데이터 융합을 시도하였다. 데이터 융합을 한 경우가 내부 센서만을 이용하는 것보다 유용하다는 것을 실험 결과를 통해 보였다. In this paper, we proposed a new method of position comentsation for AGV navigation. When the AGV run along a desired trajectory, the AGV must recognize current position. The simple method, taking current position, is to count the rotation frequency of driving motors or wheels. But this method has weak point that as path longer, errors are accumulated. Therefore external sensor is required for compensation of the position measured by internal sensor. In example of external sensor that are vision sensor, psd sensor and ultrasonic sensor. We use infrared and ultrasonic sensor as external sensor and encoder as internal sensor. We measured AGV's position by using external and internal sensors and used data fusion technique to compensate errors of the datum. Experimental results show that the presented method is useful for position compensation of AGV.

William Faulkner의 흑인관

박진섭 檀國大學校英美文化硏究所 1996 英美文化 Vol.5 No.-

The purpose of this study is to investigate the racial question in William Faulkner's Light in August, The Sound and the Fury, Go Down, Moses, and Intruder in the Dust. As a Southern writer, Faulkner dealt with uniquely Southern materials with much emphasis on Black and White relationship. I have carried out this study on the assumption that the racial theme is one of the main themes in his novels. In this study I have investigated the cause and effect of the racial question and Faulkner's attitudes toward the solution to this question.. The racial problem resulting from the peculiar history of the South, slavery, is one of the most complicated and subtlest social problems in America, and quite naturally many of intellectuals are seriously concerned for its ideal solution. By 1950, when the opposition to the civil rights program was threatening to become violent, Faulkner was compelled to express his views on desegregation, equality, and civil rights in serious nonfiction statements. But his nonfiction statements were made under the influence of the surrounding circumstances, some of which were ambivalent or contradictory. However, in his fictions where he could present his ideal without conflicting with reality, we can find a progression from his early Southern stereotype to personal vision of Negroes. These shifting attitudes were presented in his major Negro characters : Dilsey, Joe Christmas, and Lucas Beauchamp. Dilsey in The Sound and the Fury emerges from th traditional black image of a loyal old black servant and stands out as an embodiment of love and endurance. Yet, she accepts her subservient position as "nigger" and expresses no criticisms of social inequality or racial discrimination. Joe Christmas in Light in August is an image of a Negro in wander and resistance. Because of his dubious blood, he fails to identify himself and repudiates the society dichotomized to skin colors, and finally accepts death as the only way to peace. Evidently Faulkner deals with less sympathy mulattoes than pure Negroes, but he also suggests that miscegenation can be ultimate solution the problem of racial antagonism. Lucas Beauchamp in Intruder in the Dust is a self-proud black man who asserts his individuality and human dignity against white people, and finally makes white people recognize and accept him as an equal man. Faulkner suggests here that the only and the best way to the ideal black-white relationship is to transcend the racial barrier through pursuing and asserting humanity and dignity as individual human beings. Finally we should remember that Faulkner, as novelist, intends to portray various universal problems which a man can face through Negroes' concrete alienation and plight in the South America.

대관령의 일조시간을 이용한 월별 일사량의 추정

박진기, 오시영, 백신철, 김봉섭, 신형섭, 박종화 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1

The monthly mean daily global solar radiation and sunshine duration, have been employed in this study to develop correlation model for Daegwallyeong during 2011. The corresponding monthly value of extraterrestrial solar radiation and possible duration of sunshine are calculated for Daegwallyeong meteorological data. Forecasting performance parameters such as coefficient of determination (R2), mean bias error (MBE) and root mean square error (RMSE) are presented as analyzed for the model. The model with multi-linear regression has the highest R2 value of 0.95 and average MBE and RMSE values of −0.11 MJ/m2day and 1.63 MJ/m2day, respectively. The model exhibited negative MBE which shows that the model resulted in underestimation of the global solar radiation relative to the meteorological measured value. The equation could be employed in the estimation of solar radiation at Daegwallyeong, other locations with similar meteorological characteristics.

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

흰쥐 경동맥 풍선손상 모델에서 리포좀 전달체를 이용한 에스트로겐의 국소전달 효과

윤영섭,장양수,정광회,박요석,김형관,강웅철,권진욱,정보영,조상호,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

의대생의 스트레스에 영향을 미치는 요인 분석

전진용,김상아,문동석,강동원,박웅섭 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Background : Generally, it is well known that medical students have lots of stress because they have many classes of which the courses are much different from those of non-medical students. So, this study was designed for the purpose of evaluating the influencing factors on medical students' stress. Method : This study was carried out with the data of 69 students in premedical course and 66 students in medical course, who answered the survey by Kwandong Medical College, Department of Preventive Medicine and Public Health in June, 1999, The independent variables are the general characteristics, the characteristics related with study, the state of health, the activity for free time. The amount of stress is measured by Korean-translated BEPSI (Brief Encounter Psychosocial Instrument). Result : The multiple recession and logistic analysis show that the grade influence the significant difference of the stress level of the students in premedical course. The entrance age, average selfstudy time, hobby and religion influence the significant difference of the stress level of the students in medical course. The grade, avercage self-studying time and smoking habits influence the signifiant difference of the stress level of the medical students. Conclusion : This result will be used for the management of the stress level of the medical students' that influences their study.