SBNR process에서 암모니아 부하가 N₂O 발생에 미치는 영향

장광언,장현섭,황선진 경희대학교 2004 環境硏究 論文集 Vol.13 No.-

A laboratory scale BNR reactor was built to study the fate of N₂O production during BBNR(Bhortcut Biological' Nitrogen Removal. process and A/O process. Nitrous oxide(N₂O) is emitted from wastewater treatment processes. It is known as a greenhouse gas that contributes to global warming. Therefore it is importance to develop technology, that can suppress N₂O emission. Especially, N₂O emission' from the SBNR process was higher than that of A/O process. When a ono loading was increased(0.15 ∼ 0.6g/㎥day), dissolved N₂O concentration of nitrification was increased. And when nitrite concentration of aerobic basin was increased(0 ∼200 mg/L). N₂O emission rate was increased. As a results of this study, BURN process had an more effect on N₂O emission than A/O process.

단축질소제거공정에서의 C/N비에 따른 N₂O발생 특성에 대한 연구

장광언,황선진,장현섭 경희대학교 2003 環境硏究 論文集 Vol.12 No.-

Nitrous oxide(N₂O) is produced as by-production of nitrogen removal system from wastewater and associated with many parameter(such as DO, pH, Temperature, C/N ratio, accumulation of nitrite etc...). Especially SBNR (Shortcut Biological Nitrogen Removal) process have high potential of N₂0 production, but research about this relationship is insufficient. Ammonia concentration of Influent was 600 ppm and 2 sets of reactor (for A/O process and SBNR process) were used. Based on the results of this study A/O process (conventional nitrification and denitrification) was effected by C/N ratio but SBNR process did not. And N₂O production of BSNR oxic tank was observed constantly.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

오렌지로부터 아플라톡신B₁의 정량분석에 관한 연구

장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2

Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.

쉰소리로 발현한 흉부 대동맥류 1예 : Ortner씨 증후군 orther`s syndrome

장이선,진승원,박희철,박진아,윤희정,이종민,김재형 대한내과학회 2003 대한내과학회지 Vol.64 No.1

Ortner씨 증후군은 다양한 심장 질환에 이차적으로 생긴 반회 후두 신경 마비에 의한 쉰소리를 특징으로 하는 임상 질환이다. 저자들은 흉통없이 발생한 쇤소리를 주소로 내원한 환자에서 좌측 반회 후두 신경의 손상에 따른 성대 마비의 1차원적인 원인으로 대동맥궁 부위에서의 대동맥류를 진단하였기에 문헌 고찰과 더불어 보고하는 바이다. Ortner's syndrome is a clinical entity with hoarseness due to a left recurrent laryngeal nerve palsy caused by cardiac disease. It is a recognized complication of a number of conditions including, atrial septal defect, patent ductus arteriosus, primary pulmonary hypertension, Eisenmenger's syndrome and aortic aneurysm. A 71-year-old woman with a history of hypertension and diabetes complained hoarseness and hemoptysis for 3 days. Chest X-ray showed a soft tissue mass shadow in the left upper lung field and chest CT scan revealed a thoracic aortic aneurysm. We report a case of left recurrent laryngeal nerve palsy due to a huge thoracic aortic aneurysm in an old woman. (Korean J Med 64:105-108, 2003)

[논문]메타카올린 치환에 따른 알칼리-실리카 반응 억제효과

전쌍순,강신화,엄장섭,진치섭 釜山大學校生産技術硏究所 2005 生産技術硏究所論文集 Vol.64 No.-

본 연구에서는 메타카올린의 알킬-리-실리차 반응에 의한 팽창 저김-효과를 알아보고자 시멘트에 대한 메타카올린의 치환율을 달리하여 반응성 골재에 대한 ASTM C 1260 시험법으로 팽창 저감효과를 평가하여 보았다. 사용 된 반응성 콜재는 ASTM C 1260 시험법에 의해 유해한 것으로 판정된 변성암 골재이다. 메타카올린은 시멘트 중량에 대하여 0, 5, 10 15, 25 및 35% 로 치환하였다. 모르타르 강도측면만 고려한 메타카올련의 치환율은 15% 가최적인 것으로 판단되며,모르타르 유동성 측면에서 메타카올린의 적절한 치환율은 5% 인 것으로 판단된다. 메타카올린으로 시멘트를 15% 이상 치환을 하면 ASTM C 1260에 의해 14 일에 0.2% 이상의 팽창을 나타낸 반응성 골재의 경우, 알칼리-실리차 반응에 대한 팽창 저감효과가 있는 것으로 나타났으며, 메타카올린의 최소 유효 치환율은 25% 인 것으로 판단된다.

혐기성 소화시 온도와 기질 부하에 따른 메타생성균 거동에 관한 연구

장현섭,황선진 경희대학교 2003 環境硏究 論文集 Vol.12 No.-

Anaerobic digestion is a biological treatment process that has many advantages over the more conventional aerobic processes including low levels of excess sludge production, low space requirements and the production of valuable bigots. this study was carried out to evaluate the effect of organic loading rate on thermophilic(55℃) and mesophilic(35℃) anaerobic digestion. Moreover, fluorescent in situ hybridization(FISH) method was used for studying the microbial community it the reactors. The results of this study was as follows ; The stabilizing time of mesophiwic anaerobic reactors were shorter as approximately 20 days than 40 days of the thennrophiwic anaerobic reactors. The methane production of anaerobic reactors were independent of the feed substrate concentration and methanogens. The microbial diversity of two types of methanogenic reactor, mesophiwic (35℃) and thermophiwic (55℃), which had beet treating acetate-based artificial wastewater were compared. Methanogensis is carried out by microbial consortia consisting of bacteria and archer such as methanogens. the bacterial and archaic populations of all anaerobic reactors were investigated during a period of the process reflected by at accumulation of acetate. Archaea wore predominant it all reactors, and methanothrix-wike methanogens appeared it the mesophiwic anaerobic reactors with high feed substrate concentrations but it was tot preset it thermophiwic anaerobic reactors.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

휘발성유기화합물 제거를 위한 생물공정기에서 분리한 톨루엔 분해 세균

장현섭,황선진,조영철 경희대학교 2005 環境硏究 論文集 Vol.14 No.-

We isolated a toluene degrading bacterium from the bioactive foam reactor(BFR) which designed to remove volatile organic compounds(VOCs) from the contaminated air. In order tofind the taxonomic and phylogenetic relationship with known bacteria, the partial sequence of 16S ribosomal DNA gene was analyzed. The isolated bacterium was classified as Pseudomonas sp. based on the close relationship to bacteria belonging to this genus. From the sequence, we designed the appropriate DNA probe which will be useful to detect this bacterium with the molecular methods such as FISH. The isolated bacterium and designed probe will be helpful to optimize the operating conditions and to improve the efficiency of BFR in detoxification of VOCs.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)