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경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염
홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.
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In Vitro에서 골 형성과 흡수에 대한 Endothelin-1의 영향
사석진,안도환 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Background: Balanced regulation of the receptor activator of nuclear factor-kB (RANK) ligand (RANKL) and osteoprotegerin (OPG) by osteoblasts is important for osteoclastogenesis. Sex hormones, glucocorticoids, and prostaglandin E2 (PGE2) are known to modulate osteoblast proliferation and osteoclast formation. Endothelin (ET)-1 is a mitogen as well as a strong vasoconstrictor.It stimulates proliferation of osteoblasts, but its effects on differentiation are controversial. In addition, little is known about ET-1 regulation of osteoclast formation. Thus, the present study was undertaken to investigate whether ET-1 canregulate the expression of RANKL and OPG genes in osteoblasts and affect RANKL-induced osteoclastogenesis. Methods: Osteoblasts were derived from neonatal calvariae and monocytic preosteoclasts from the bone marrow of adult mice, respectively. Cells were cultured in a-minimum essential medium containing 10 nM ET-1. The gene expressions of RANKL and OPG in osteoblasts and RANK in preosteoclasts were measured by real-time RT-PCR. Mineralization by osteoblasts was determined by Alizarin-red staining. Osteoclastogenesis was examined using tartrate-resistant acid phosphatase (TRAP) staining and resorption pit assay. Results: Osteoblasts expressed both ETA and ETB receptors (ETAR and ETBR). ET-1 (10 nM) increased osteoblast proliferation 1.6-fold compared with the control after 3 days in culture and stimulated differentiation, which was indicated by increased formation of mineralized matrix. Proliferation and differentiation of osteoblasts was blocked by 1 uM BQ123, an ETAR antagonist. ET-1 suppressed RANKL gene expression by 50% but did not affect OPG gene expression, and thus reduced the ratio of RANKL to OPG mRNA. PGE2 production by osteoblasts was increased by ET-1. In preosteoclast cultures, ET-1 had little effect on RANK mRNA expression and suppressed RANKL-induced osteoclastogenesis by decreasing the number of TRAP-positive osteoclasts and the resorbed areas. Conclusions: These findings demonstrate that ET-1 can increase bone formation by stimulating proliferation and differentiation of osteoblasts and decrease bone resorption by suppressing RANKL-induced osteoclastogenesis as well as suppressing RANKL mRNA expression In vitro에서 골 형성과 흡수에 대한 endothelin-1의 영향 배경: 조골세포에서 생성되는 receptor activator of nuclear factor-kB ligand (RANKL)과 osteoprotegerin (OPG) 사이의 균형은 파골세포 형성에 매우 중요하다. Enodothelin-1(ET-1)은 강력한 혈관수축제일뿐만 아니라 다양한 세포에서 세포 증식을 촉진시키는 물질이다. 그러나 ET-1의 조골세포의 분화에 대한 영향은 상반될 뿐만 아니라 ET-1이 조골세포의 RANKL과 OPG의 생성을 변화시켜 간접적으로 파골세포 형성에 영향을 주는지 혹은 파골세포의 분화에 직접적으로 영향을 주는지에 대해서는 연구된 바 없다. 따라서 본 연구에서는 ET-1에 의한 조골세포의 분화와 RANKL 및 OPG 유전자 발현이 파골세포 형성에 미치는 영향을 조사하였다. 재료와 방법: 조골세포는 생쥐의 두개골로부터 그리고 파골전구세포는 골수로부터 각각 분리하였다. 이들 세포들을 10 nM ET-1이 포함된 α-MEM 배지에서 배양하였다. 유전자의 발현은 real-time RT-PCR을 통해 정량적으로 측정하였다. 조골세포의 분화는 alizarin-red 염색으로, 파골세포의 형성과 활성은 tartrate-resistant acid phosphatase 염색과 골 흡수와(resorption pit)의 크기로 평가하였다. 결과: ET-1은 조골세포의 증식과 분화를 촉진시켰으며, 이는 ETA 수용체를 통해 이루어졌다. 조골세포에서 ET-1은 PGE2 생성을 크게 증가시켰을 뿐만 아니라 RANKL 유전자 발현을 대조군에 비해 50% 감소시켰다. 그러나 OPG 유전자의 발현에 영향을 주지 않았다. 파골 전구세포에서 ET-1은 RANK 유전자의 발현에 영향을 주지 않았지만 RANKL에 의해 유도된 파골세포 형성과 활성은 억제시켰다. 결론: ET-1은 조골세포의 증식과 분화를 촉진시키고 RANKL mRNA 발현을 감소시켜 파골세포 형성을 간접적으로 억제한다. 또한 RANKL에 의해 유도되는 파골세포 형성과 활성을 직접적으로 억제한다. 이러한 결과로 미루어 ET-1은 골형성은 촉진하고 골흡수는 억제할 것으로 사료된다.
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안진우,오석규 慶星大學校 1998 論文集 Vol.19 No.1
This paper proposes a control scheme reducing the torque ripple of SRM using ANN(Artificial Neural Network). The torque of SRM depends on phase current and the rate of inductance variation. But the latter is nonlinearly changed according to phase current, which makes a difficulty to control the instantaneous torque. Therefore learned inductance of SRM using ANN that is known to treat nonlinear system recently, is used to predict instantaneous torque and to reduce torque ripple in SR drives.
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안승찬,류석용,이상래,조석진,오성찬,김홍용 인제대학교 2008 仁濟醫學 Vol.29 No.-
Necrotizing fasciitis (NF) is a rare, life-threatening infection resulting in necrosis of the skin, subcutaneous tissue, and fascia. A very severe and usually fatal fasciitis is caused by a virulent species of streptococcus that is often referred to as the "flesh-eating bacteria". Mortality rates have been noted high. Certain conditions can predispose patients to NF, such as diabetes mellitus, immunosuppressive medications, and AIDS. Patients usually complain of excessive pain as well as constitutional symptoms. Because of this rapid progression, it is important to diagnose and treat NF quickly to decrease mortality. Treatment includes broad-spectrum antibiotic coverage, nutritional supplements, hemodynamic support, wound care, and prompt surgical debridement. We report a case of a 51-year-old man who had presented with right hip pain. Previously, he had been diagnosed with diabetes mellitus and alcoholic liver cirrhosis.
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安奉遠,李錫孫,姜喆基,林秀眞,金恩一 경희대학교 1988 造景論叢 Vol.1 No.1
The goal of this study is to propose a plan for the construction of Chonan Samgori park. Present this park is designated a neighborhood park of Chonan city. This park is located on the point of traditionally important traffic point linked to Samnam province. And, this place is where the perspective experience of history and culture, which is a unique folk related activities. The site which covers about 96,000㎡is located about 4 km from the cityhall of Chonan city. This basic idea of this plan is to reconstruct the ancient culture and traditional way of life which is rapidly disappearing, to offer the place of education of vernacular culture, to give the recreation place to be a center where city dwellers release and enjoy. Facilities of this park are divided into five groups according to function such as support facilities, folk facilities, play facilities, educational and cultural facilities, and landscape facilities. Design principles are established as follows; to provide the folk park with identity, effectively to admit the folk-related activities, to maintain a functional linkage between facilities. The frame works for final master plan are Landuse plan, Circulation plan, Planting Plan, Facility plan.
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안상진,김웅용,윤석환 충북대학교 건설기술연구소 2004 建設技術論文集 Vol.23 No.1
Urbanized areas, it is essential to predict how the runoff characteristics, such as runoff peak and volume, and travel time, change with time for planning and designing various kinds of hydraulic facilities with given recurrence interval Mushim stream basin is simulated using HEC-HMS model to get runoff characteristics of an urbanization basin. The effects of urbanization was analysed to uniform change CN value and impervious area, the results of runoff analyses were investigated. Overtopping risk of levee is also presented by comparing levee height with simulated flood level.
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안상진,윤석환,곽현구 충북대학교 건설기술연구소 2004 建設技術論文集 Vol.23 No.1
This study is to analyze the flood damages such as an inundation by overflow levee during rainfall duration. HEC-HMS and HEC-RAS are used to analyze rainfall-runoff and inundated area, respectively. Yeongwoon area is a study catchment for runoff effect analysis. As the result, it was understood that inundated area was magnified gradually according to the increase of rainfall recurrence interval in years. Inaddition GIS technique is an effective tool for calculating the exact flood damage area.
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