양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

모 축전지 회사 근로자들의 연폭로 지표에 대한 경시적 관찰

강명식,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

Lead poisoning is still prevalent and one of important occupational disease in Korea. To prevent undue high lead burden and maintain good health condition of lead workers in lead using industries, periodic health examination and regular biological monitoring of lead workers are often required in addition to the fundamental improvement of their working condition. To evaluate the effect of comprehensive occupational health program with regular biological monitoring on the level of lead exposure of lead workers in lead using industries, 11 year database from 1983 to 1994 of one storage battery factory was reviewed. From 1983 to end of 1986 only periodic health examination was provided to the lead workers, but from 1987 comprehensive occupational health program with regular biological monitoring was provided to maintain better health condition of lead workers. Selected study variables for lead exposure were blood lead(PbB), zinc protoporphyrin in blood(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb), hematocrit(HCT). Information on sex, age and work duration was also reviewed. 5 years data from 1983 to 1987 and 3 years data from 1990, 1993 and 1994 were available for all lead exposure indices except ALAU which has only 5 years data from 1983 to 1997. The results of 11 years longitudinal observation of lead indices are all follows: 1. The mean value of ZPP of lead workers in 1983 was 148.7±73.1 ㎍/㎗(Male: 145.5±72.3, Female: 168.1±79.1), whereas that of ZPP of lead workers in 1994 was decreased to 64.3±32.7 ㎍/㎗(Male: 60.2±28.8, Female: 95.2±43.4). 2. The mean value of PbB of lead workers in 1983 was 56.4±18.8 ㎍/㎗(Male: 55.59±19.1, Female: 59.6±19.1), whereas that of PbB of lead workers in 1994 was dcreased to 35.4±11.9 ㎍/㎗(Male: 35.7±12.0, Female: 32.8±10.8). 3. The mean value of Hb of lead workers in 1983 was 14.1±1.4 g/㎗(Male: 14.4±1.1, Female: 11.7±0.8), whereas that of Hb of lead workers in 1994 was increased to 15.6±1.5 g/㎗(Male: 15.9±1.2, Female: 12.9±1.1). 4. Blood lead is most highly correlated with ZPP(r=0.522, male:0.54 and female:0.50) and also correlated with ALAU and work duration also. 5. The simple regression analysis of PbB and ZPP showed different coefficient of regression by the measurement year, but there was no difference of coefficient of regression between sex. The slope of equation of pooled data for 1983-1986 without comprehensive occupational health program was 2.16 and differed from that of pooled data for 1987-1994(1.25). This difference suggests that the unit effect of blood lead on ZPP was relatively smaller in later period of comprehensive occupational health program than carly period without comprehensive program. The slope change in the analysis of linear regression of PbB on ZPP in lead workers can be used to evaluate the possible effect of health intervention to prevent undue high lead absorption in lead using industries. 6. 11 years occupational health service in this storage battery factory brought out considerable improvement of health status of lead workers in terms of decrease of PbB and ZPP and increase of Hb and the improvement was more remarkable after the introduction of comprehensive occupational health program.

만성 남자 정신분열병 환자의 병식 정도와 기질 및 성격 유형과의 관계

강여화,김봉조,손진욱 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 남자 만성 정신분열병 입원 환자에서의 병식 정도와 기질 및 성격유형간의 관련성을 규명하고자 한다. 부가적으로 병식 정도에 따른 사회 인구학적 변인 및 질병 연관 변인의 차이를 알아보고자 한다. 연구방법 병식 평가를 위해 McEvoy등이 고안한 '병식과 치료태도에 대한 설문(ITAQ : Insight and Treat-ment Attitudes Questionnaire)'과 Amador 등이 고안한 병식 평가 검사(SUMD : Scale to As-sess Unawareness of Mental Disorder)를 이용한 구조화된 면담을 시행하였다. 다음, Cloninger의 기질-성격 철도(TCI : Temperament and Character inventory) 한국판을 이용하여 기질 및 성격특성을 측정하였다. 또한 병록지 검토와 면담을 통해 인구학적 변인 및 질병 연관 변인에 관한 자료를 얻었다. DSM-Ⅳ 진단기준에 의한 최종 분석의 대상이 된 환자는 113명이었다. 병식의 정도에 따라 병식이 높은 군(중간값 11점 이상)과 낮은 군(11점 이하)으로 양분하였다. 연구결과 1) ITAQ 병식 점수에 따른 양군의 비교에서 통계적으로 유의한 차이를 보인 척도는 '새로운 것을 추구하는 성향'이었다. 2) ITAQ 병식 점수와 위험 회피적 성향 사이에서 유의한 상관관계가 있었고, '새로운 것을 추구하는 성향'과는 유의한 음성적 상관관계를 보였다. 하지만, 후천적으로 결정되는 성격 척도 사이에서는 통계적 유의성이 없었다. 3) 질병 연관 변인들 중 첫 발병 나이, 입원 형태, 유병기간, 현재 입원기간, 약물투여량은 양군간에 통계적으로 유의한 차이가 있었다. 결 론 본 연구 결과는 새로움 추구 성향이 높고 위험 회피 성향이 낮을수록 낮은 병식을 가질 수 있다는 병식 정도에 대한 기질특성의 영향을 시사한다. 그러므로 병식의 평가 단계에서 기질 유형을 파악하는 것이 임상적으로 의미가 있을 것이다. 앞으로 정신분열병 환자의 기질 및 성격 유형에 관한 지속적인 연구가 필요할 것이다. Objectives : This study was conducted to investigate the relationship of insight level with temperament and character pattern in chronic male schizophrenics. In addition, we tried to examine demographic variables and illness-related variables which may affect the level of insight. Methods : To assess insight level by psychiatrists, Insight and Treatment Attitudes Question-naire(ITAQ), Scale to Assess Unawareness of Mental Disorder(SUMD) were applied. Tem-perament and character patterns were evaluated by the Korean version of Cloninger's self-rated Temperament and Character Inventory(TCI). The authors investigated the correlations between insight level, and scores of temperament and character dimensions. Data on the demographic and illness-related variabres for the subjects were gathered from hospital records and clinical interviews. A total of 113 patients with schizophrenia according to DSM-Ⅳ criteria was analyzed. The insight level was dichotomized into good(≥median value of 11) and poor insight group(<11). Results : 1) There was a significant difference between good insightgroup and poor insight group in novelty seeking dimension in TCI. 2) There was a significant negative correlation between novelty seeking scores by TCI and insight scores by ITAQ(rs : Spearman correlation coefficient=-0.20, p<0.05). 3) Significant differences between good and poor insight groups were identified in diverse clinical variables such as age at onset of illness, mode of hospitalization, duration of illness, current length of stay, and dosage of drug. Conclusion : The results suggest that high scores in the temperament dimension of novelty seeking and low scores in the temperament dimension of harm avoidance may influence poor insight in patients with chronic male schizophrenia. Therefore it is clinically valuable for us to assess the pattern of temperament at the stage of insight evaluation. The authors suggest that further studies on temperament and character in schizophrenia is needed.

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

국내에서 파상풍의 연령별 면역혈청학적 역학연구

강진한,허재균,김종현,이경일,박수은,마상혁,이명숙,반상자,홍성화,조대현,이성호 대한감염학회 2001 감염 Vol.33 No.2

Background : The incidence of tetanus in adults and neonatal tetanus have been markedly reduced by world-wide use of DTP vaccines. But, tetanus is still one kind of major health problems in many developing countries, and several serosurvey stduies in developed ountries revealed that substantial proportions of adult opulation may lack immunity against tetanus and imunity level against tetanus is continuously decreasing by age. In Korea, tetanus outbreaks have been disappeared since the 1980s by high acceptant DTaP vaccination rates. Annually, few tetanus patient has been reported since 1990s. But, there knave been no seroepide-miological studies to tetanus, no trials to assess tetanuts immunizations. And we do not use Td vaccine in adults for maintaning tetanus immunity. In this aspect, we conducted age related survey of immunity to tetanus and indirectly assessed the immunogenecity of tetanus vaccines, used in Korea. Methods : For the evaluation of age related sero-survey of tetanus immunity in Korean population, study subjects were classified into 16 groups (A∼J group; below 10 years with one year interval, K∼O group; 11~60 yrs with 10 years interval, p group; over 60 yrs). The numbers of each group were 100, and sex distributions of each group were almostly equal. And far the indirect assessment of tetanus immunization in Korean children, children under 15 years old age were classified into 6 groups (I∼VI) according to the status of DTaP vaccination. The numbers of this each group were 50, and sex ratio was almostly equal. Specific IgG antibody to tetanus toxin were detected by ELISA. And the ANOVA repeated t-test was used to compare antibody levels in study groups. Results : In age related groups, the antibody levels to tetanus toxin were well maintained until 20 years old age group (L group), but thereafter the titers abruptly decreased below 0.1 IU/mL and over 75% populations among the groups over 30 years old age needed maintenance of protective immunity to tetanus. The antibody level of male was statistically higher than that of female in P group. In the groups related DTaP vaccination status, the antibody titer was very low in pre-vaccination group (I), but the titers after primary vaccinations were sharply increased and highly maintained until 15 years. Conclusion : The results of our study revealed that the immunity to tetanus was dramatically decreased in age groups over 30 years old. This result indicates that Td vaccination program in adults should be considered for maintenance of immunity to tetanus. And our study indicate that DtaP vaccination programs and vaccines, used in Korea, are effective for acquisition and maintenance of tetanus immunity in Korean children. (Korean J Infect 33:104~111, 2001)

초고속 통신망에서 비디오의 주관적 품질 평가에 관한 연구

강명화,강진석,최연성,김장형 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1

According to information communication business faces with competitions in a various spheres with the development of multimedia and information communication, the time when we have to make an effort to improve a quality comes from an era when we devote ourselves to quantitative expansion. we will try to perform quality assessments of real-time interactive multimedia service, and so on - in this research and present criteria of new subjective quality assessments which is fit on Korea by analyzing examples of ITU-T and foreign countries and Korea.

초고속 통신망에서 비디오의 주관적 품질 평가에 관한 연구

강명화,강진석,최연성,김장형 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1

According to information communication business faces with competitions in a various spheres with the development of multimedia and information communication. the time when we have to make an effort to improve a quality comes from an era when we devote ourselves to quantitative expansion. we will try to perform quality assessments of real-time interactive multimedia service. and so on - in this research and present criteria of new subjective quality assessments which is fit on Korea by analyzing examples of ITU-T and foreign countries and Korea.

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

세 도시의 생활 쓰레기 발생량의 장래 추이 예측

오정화,강호,이진홍 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-

This study centers on a long-term prediction for the generation of municipal solid wastes for 3 cities such as Pusan, Taejon and Cheongju. For the long-term prediction several statistical models based on time or population were proposed and utilized. The MSW discharge per day from 3 cities predicted is in the range of 12,100~14,600 ton for Pusan, and 3,100~3,800 ton for Taejon, and 2,200~2,600 ton for Cheongju in the year of 2008, respectively. However, the volume-based charge system since January 1995 has made a great effect on the generation of MSWs. Unfortunately, there has been few data to consider this effect for the prediction. Therefore, there has been an urgent need to collect new baseline data for the more realistic long-term prediction.

NaCl이 보리(Hordeum vulgare L.) 잎의 엽록소 형광에 미치는 영향

정화숙,임영진,박강은,박신영 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12

This study was conducted to investigate the changes of chlorophyll contents and chlorophyll fluorescence in barley(Hordeum vulgare L.) 7 day old seedling treated with 0.2M, 0.4M, 0.6M, 0.8M, and 1.0M NaCl concentration containing Hepes buffer(pH 7.5). Barley was affected by NaCl treatment. The chlorophyll a, b and carotenoid of barley decreased with an increase in NaCl concentration. However, chlorophyll a, b and carotenoid of barley were not greatly influenced by o.8M and 1.0M NaCl. Fv, Fv/Fm and qP were gradually decreased by higher concentration of NaCl. qP, qNP, qR and qE were gradually decreased by 6hr. During barley chloroplast was development NaCl affected chlorophyll synthesis than photosynthetic activity. Whereas barley seedling leaves were more influenced photosynthetic activity than chlorophyll contents by NaCl.