경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

외국인 근로자들의 주택선호 결정요인분석-경제자유구역 입주대상 외국인기업 종사자를 대상으로

김진유,김홍주,김용순 경기대학교 부설 산업기술종합연구소 2011 산업기술종합연구소 논문집 Vol.39 No.-

IMF에 관련된 경제적 스트레스가 정신 건강에 미치는 영향

유희정,황성훈,홍진표,김헌수,이철,한오수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

본 연구는 IMF에 관련된 경제적 스트레스가 정신 건강에 미치는 영향과 그 과정을 밝히기 위해 설계되었다. 스트레스 과정에 관여하는 요인으로 사회적 지지와 문제 해결 양식, 그리고 무망감을 도입했으며, 이들에 의해 스트레스의 영향이 매개되는지를 검증하였다. 경제적 스트레스의 수준에 따라 표집된 221명의 일반인들을 대상으로 우울, 불안, 신체화, 적대감, 사회적 지지, 그리고 문제 해결 양식 등을 측정하였다. 가정한 대로 실직으로 대표되는 경제적 스트레스는 정신 건강에 부정적 영향을 미치는 것으로 나타났다. 그 구체적인 양상을 살펴보면 다음과 같다. 먼저, 사회적 지지는, 높은 스트레스 조건에서 증상의 발현을 억제하는 완충 효과가 있음이 입증되었다. 두번째로, 남성이 여성에 비해 경제적 스트레스의 부정적 영향에 더 취약한 것으로 나타났다. 세번째, 경제적 스트레스는 문제 해결 양식의 다양한 구성요소중 문제 해결에 대한 무기력감에만 영향을 미치는 것으로 나타났다. 네번째, 무망감은 경제적 스트레스와 정신 건강간의 관계를 매개하는 변인임이 인과모형 검증을 통해 확인되었다. 끝으로, 이러한 결과가 스트레스 개입 프로그램 개발을 위한 이론적 기초를 제공한다는 의의가 있음을 논의 했고, 본 연구의 몇 가지 한계점을 지적하였다. This study was designed to investigate the influence of the so-called IMF-related economic stress upon the mental health and to analyze the process of the influence. As the possible variables moderating the stress process, social resource, problem solving style, and hopelessness were included. 221 male and female subjects were recruited according to the intensity of economic stress and classified into four groups(employees of solid companies, employees of the companies at risk, short-term unemployed and long-term unemployed). Relevant measures including economic stress scale, selected SCL-90R subscales(somatization, depression, hostility, anxiety), social support scale, problem-solving scale, and job hopelessness scale were administered. As assumed, it was proved that economic stress had adverse effects on the mental health. In addition to this basic causal relationship, moderating effects of several variables were found as follows: First, social support had the buffering effect upon the economic stress. That is, strong social support played the role suppressing the development of psychiatric symptoms under high stress. Second, men were more vulnerable to the adverse effects of economic stresses than women. Third, economic stresses had influence on the helplessness concerning the problem solving. However other problem solving strategies such as creative style, approach style, avoidance style, etc were proven to have no relationship with the economic stress. Fourth, in the analysis of unemployed group, it was found that hopelessness mediates the relationship between economic stress and mental health. In conclusion, the clinical implications of such findings in economic stress process were discussed and several limitations and the suggestions for future researches were also addressed.

β-Lactamase 의 최신 지견 : Extended-Spectrum β-Lactamase를 중심으로 Extended-Spectrum β-Lactamase

유진홍 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.4

Characterization of a Constitutive β-Lactamase from a Pseudomonas aeruginosa

유진홍,허동호,최정현,김양리,신원식,강문원 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

Objective : We analyzed some physicochermical chracteristics of a constitutive β-lactamase from a clinical isolate of a Pseudomonas aeruginosa which resistant to various β-lactams except imipenem and susceptible to aminoglycosides the proportion of its contribution to such resistance profile. Method : 1. Antimicrobial susceptibility test was done by the broth dilution method. 2. In hibition profile was done using EDTA, HgCl₂ and p-chloromercuribenzoate (pCMB). We also measured 50% inhibitory concentration(IC??) using β-lactamase inhibitors, such as clavulanic acid, sulbactam. 3. Kinetics study for substrate profile was performed by spectrophotometric assay using crude extracts and various antimicrobial agents. Relative hydropysis rates were determined. 4. The isoelectric point(pI) was determined by isoelectric focusing. The molecular weight was estimated by SDS-polycrylamide gel electrophoresis. Results : 1. The strain was resistant to ceftriaxone, sulperazon, piperacillin, ceftazidime, and aztreonam, while it was susceptible to gontamicin, tobramycin, amikacin and imipenem. 2. The β-lactamase was not inhibited by EDTA, and pCMB, whereas it was inhibited by HgCI₂. The IC?? of clavulanic acid was over 100μM and that of sulbactam was 22μM. 3. The relative maximal hydrolysis rate was calculated by setting V_(max) for cephaloridine at 100. The enzyme hydrolyzed cephalosporins more rapidly than penicillins. 4. The pI was 9.3 by isoelectric focusing. The molecular weight was estimated to be 40kDa. Conclusion : According to its substrate profile, pI and molecular weight, the β-lactamase from a clinical isolate of P. aeruginosa was a cephalosporinase belonging to group 1 in the Bush-Jacoby-Medeiros classification scheme.

주요 그람음성균의 내성양상 : Extended Spectrum β-Lactamase, Quinolone 및 Carbapenem 내성 Extended Spectrum β-Lactamase, Quinolone-& Carbapenem-Resistance

유진홍 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2

중공사 모듈에 의한 페놀의 분리

유홍진,한성록 순천향대학교 부설 산업기술연구소 2002 순천향 산업기술연구소논문집 Vol.8 No.1

Phenol was separated from wastewater by membrane solvent extraction, using a microporous bydrophobic hollow fiber module. The system was operated counter-currently and cocurrently with the aqueous phase flowing through the fiber lumens and the solvent flowing through the shell side. MIBK was used as an extracting solvent. Separation efficiency of countercurrent flow method was better than that of cocurrent flow method.

PSA에 의한 이산화탄소의 분리

유홍진 순천향대학교 부설 산업기술연구소 1995 순천향 산업기술연구소논문집 Vol.1 No.2

Adsorption equilibrium isotherms for pure CO² were studied at 293-323 K and 0.1-15 atm because these can play a key role in developing a PSA process. Volumetric method was used for the collection of adsorption isotherm data and domestic and foreign activated carbons were used as adsorbents. Adsorbed amount decreases as temperature increases and increases as pressure increases.

혈액질환 환자에서 조혈모세포 이식과 화학요법 후의 침습성 진균감염의 분석

유진홍,최정현,이동건,최수미,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : 조혈모세포 이식이나 화학요법을 받은 혈액질환 환자에서 침습성 진균감염의 양상을 분석하고 예후 인자를 정하기 위하여 이 연구를 실시하였다. 방법 : 2000년 3월부터 2001년 2월까지 가톨릭 조혈모세포이식센터에 입원한 318명의 환자들 중 진균 감염으로 의심되어 항진균제를 투여받은 122명의 환자를 대상으로 후향적 분석을 실시하였다. 결과 : 74명의 환자가 EORTC/MSG 기준에 의해 침습성 진균증으로 판정되었다. 이들 중 6명이 확진이었고, 46명이 추정, 22명이 가능 증례이었다. 가장 많이 침습된 장기는 하부 호흡기이었다(72/74). 사망률은 32.4%이었다. 단변량 분석으로 예후 인자를 도출한 결과 입원 기간, 진단까지 걸린 시일, 그리고 amphotericin B의 총 투여량이 유의한 인자로 나왔다. 그러나 다변량 분석을 시행한 결과 입원 기간만이 독립적으로 유의하게 영향을 미치는 예후 인자로 산출되었다. 결론 : 침습성 진균 감염은 현재도 조혈모세포 이식이나 화학요법 후의 중요한 합병증으로 작용하고 있음을 알 수 있었다. 진균 감염 합병증의 예후에 영향을 미치는 요소로 입원 기간이외에 진단의 신속성과 항진균제의 투여도 유의한지에 대해서는 후속 연구를 통해 재치 규명해야 할 것으로 생각된다. Background : Invasive fungal infections (IFI) are one type of representing total infections in compromised patients. To analyze the characteristics and to determine the prognostic factors of IFI in patients with hematologic diseases undergoing hematopoietic stem cell transplantation (HSCT) and/or chemotherapy. Methods : We retrospectively reviewed consecutive patients (n=122) who received antifungal treatment with the impression of fungal infection complicating post-HSCT or chemotherapy from March-2000 to February-2001. Results : Seventy-four out of 122 registered patients belonged to the IFI on the basis of EORTC/MSG criteria. Six patients were proven IFI, 46 were probable, and 22 were in the category of possible one. The most commonly involved organ was lower respiratory tract (72/74). The mortality was 32.4%. Univariate analysis revealed duration of hospitalization, days to diagnosis of IFI, and total amount of amphotericin B as significant prognostic factors. But multivariate analysis determined only duration of hospitalization from these variables as an independently influencing factor on the prognosis. Conclusion : Invasive fungal infection is still the major threatening complication of HSCT and chemotherapy. Further follow-up and extension of this study is necessary to elucidate more prognostic factors.