정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

범가자미, Verasper variegatus의 난황단백질 분리 및 면역학적 특성

백혜자,한창희,김우진,박중연,김진한,김윤 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

The yolk protein of spotted flounder, Verasper variegatus was purified by precipitation with cold distilled water, followed by Sepharose CL-6B column chromatography. The purified protein was identified as vitellin by Ouchterlony's immunodiffusion test and immunoelectrophoresis. The purified vitellin from ovarian crude extracts has same antigenic determinants with the female specific serum protein, vitellogenin. The molecular weight of purified vitellin was estimated about 550kD by gel filtration. The vitellin was composed of three major subunits with molecular weight of about 108, 85 and 31 kD, and two minor subunits. The vitellin was identified by western blot analysis using anti-vitellin antibody.

성장시기별 무순의 화학적 조성 변화

한진희,문혜경,김종국,김귀영,강우원 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.5

The chemical components of radish buds were investigated during the growth stage. The vitamin C and total phenol contents were lowered after 4 days of early sprout growth, and were 22.19 and 4.99 mg%, respectively.These increased according to the growth time, showing the highest value on day 8, 25.85 and 17.87 mg%, respectively. However, these values decreased around day 12, which seemed to be the bud end point. The major free sugar component of the radish buds was glucose, showinged the highest content on day 8. The total organic acid content gradually increased as the growth proceeded. The detected oxalic acid content was only small on day 8. During the early growth stage, the total and essential amino acids contents were 3,020~3,575 and 1,206~1,499 mg, respectively. These contents tended to decrease with growth time. Glutamic acid, aspartic acid and alanine were the major amino acid components (39%).

유치원과 초등학교의 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지

한윤경,김희진 이화여자대학교 교육과학연구소 2000 교육과학연구 Vol.31 No.3

본 연구의 목적은 유치원과 초등학교의 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지도와 그 두 요소간의 관계를 알아보는 것이다. 연구대상은 서울 시내에 소재 한 유치원에 재직 중인 교사 179명과 초등학교에 재직 중인 교사 201명이었으며, 연구를 위하여 유치원 교사용 설문지와 초등학교 교사용 설문지를 사용하였다. 연구결과 연계교육에 대한 교사의 인식은 유치원 교사가 초등학교 교사보다 연계교육의 정의, 필요성, 개선 및 증진방안에 대한 인식에서 높게 나타났으며, 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지도는 관계가 있는 것으로 나타났다. The purpose of this research was to investigate teachers´ perceptions of the educational continuity between kindergarten and elementary school and their understanding of the curriculum of the counterpart.The subjects were 179 kindergarten teachers and 201 elementary school teachers. The results of this study are summarized as follows: First, there were differences between the perceptions of kindergarten teachers and that of elementary school teachers.Second, there weren´t any significant differences between the kindergarten teachers´ understanding of the elementary school curriculum and the elementary school teachers´ understanding kindergarten curriculum, Third, there were relationship between teachers´ perception of the educational continuity and their understandings of the counterpart´s curriculum.This means that the higher the degrees of teachers´ perception of the educational continuity, the better their understandings of the curriculum of the counterpart.

白鼠의 末梢 및 中樞 인슐린/도파민 調節樣相에 關한 硏究

韓辰熙,李定均,金容植 서울醫大 1991 精神醫學 Vol.16 No.2

간호사의 정신과 자문에 대한 기대도

韓辰熙,房勝規,金光壽,柳太烈 최신의학사 1991 最新醫學 Vol.34 No.1

정신분열증의 역학

韓辰熙 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.1

Current knowledges on epidemiology of schizophrenia were briefly reviewed with respect to basic rates(prevalence and incidence) and risk factors(demographic correlates, antece-ding and precipitating factors, genetic factors, and other factors). To date, it seems that epidemiological researches on schizophrenia were hampered by definitional ambiguity and some methodological problems, which, in turn, made the compa-rison across the studies more difficult. Despite these limitations, there have been emerging new trends in both descriptive studies and exploration of risk factors of schizophrenia. Ge-netic epidemiology could be one of such powerful strategies in the epidemiologic research of schizophrenia. It is necessary that future epidemiological research of schizophrenia should incorporate current laboratory measures of vulnerability into field survey studies.

精神醫學的 疫學 : 歷史的 考察 A Historical Overview

韓辰熙 漢陽大學校 精神健康硏究 1987 精神健康硏究 Vol.5 No.-

Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells

Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4

The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.

여성병원 공용공간의 구성상의 특성과 유형에 관한 연구 : 외래진료부를 중심으로 Focused on the Outpatient Department

한진희,박재승 대한건축학회 2003 대한건축학회논문집 Vol.19 No.5

Recently, due to deepening of competition by user's varied demand, changed healthcare environments, etc, the marketing concept has been introduced at healthcare facility. There is a trend that a establishment of women's hospital is increasing as specialized type. In different from general hospital, they are providing specialized and integrated services in response to the women's disease and demand. Particularly, public space in women's hospital has been changed in terms of area, shape and program. However, there used to be not enough research efforts of responding these changes. Therefore, the purpose of this study investigates and analyzes the spatial characteristics of the public space in women's hospital through a analysis of case study. The conclusion of this study is acquired by investigation and analysis the pubic space of the women's hospital which is situated in capital region and investigation the variation of space composition and development process of public space and user's behaviour in representative public space that is classified with three types(hall-type, corridor-type, courtyard-type).