한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

In vitro Mammalian Chromosomal Aberration Test of Fullerene-C60

Soo Jin Kim(김수진),Kyung Taek Rim(임경택),Hae Won Cho(조해원),Jeong Hee Han(한정희),Hyeon Yeong Kim(김현영),Jeong Sun Yang(양정선) 환경독성보건학회 2009 환경독성보건학회지 Vol.24 No.1

Fullerene의 유전독성을 평가하기 위하여 Chinese hamster유래의 난소유아세포(CHO-K1 cell)를 이용하여 직접법(-S9)과 대사활성화법(+S9 mix)의 염색체이상시험을 실시하였다. 시험물질은 1% CMC 나트륨염의 현탁액(l% CMC 용액)에 희석하여 조제하였다. 대사활성화를 시키지 않은 직접법의 염색체이상시험에서 24시간 투여군은 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)로 투여하여 실시하였다. 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 48시간의 투여군에서는 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)로 투여하여 실시하였는데 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 배수체의 염색체이상은 직접법에서 관찰되지 않았다. 대사활성화법을 이용하여 6시간 시험물질을 투여한 시험에 있어서는 8단계의 용량단계 (0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)를 설정하였는데 투여 농도가 증가함에 따른 염색체이상빈도의 증가양상이 관찰되지 않았다. 이상의 결과를 종합할 때 본 시험물질은 본 시험 조건하에서 CHO-K1세포에서 대사활성화를 시켰을 때 염색체 이상을 유발하지 않는 것으로 판단된다.

벌매 Pernis ptilorhynchus의 번식보고

조해진(Hae-Jin Cho1),이영석(Young-Suk Lee),강태한(Tae-Han Kang),김인규(In-Kyu Kim),우희철(Hee-Chul Woo),이한수(Han-Soo Lee) 한국조류학회II 2010 한국조류학회지 Vol.17 No.1

2009년 8월 16일 강원도 홍천군 북방면 일대에서 벌매의 번식을 확인하였다. 이 종은 국내에는 번식하는 것으로 추정은 하고 있었지만, 실제 번식 둥지가 확인된 것은 첫 사례라고 할 수 있을 것이다. 이에 번식에 대한 보고하고자 한다. On 16 August 2009, Nest of Oriental Honey Buzzard (Pernis ptilorhynchus) was observed at Bukbang-myeon, Hongcheon-Gun, Gangwon-Do Province. This species was known to breed in korea, but actual breeding nest was not observed. This is the first record of observed breeding nest of the Oriental Honey Buzzard in korea.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

압력비에 따른 2차원 초음속 터빈의 유동특성에 대한 실험적 연구

조종재,김귀순,김진한,이은석 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1

본 연구에서는 초음속 충동형 터빈의 유동특성을 알아보기 위해 소형 초음속 풍동을 설계 하였으며 Single pass Schlieren system을 이용하여 유통을 가시화하였다. 실험은 2차원 초음속 노즐과 익렬을 조합하여 압력비에 따라 실시하였다. 실험을 통해 충격파를 포함한 복잡한 유동 형태와 노즐-익렬, 충격파-경계층 상호작용 등을 관찰할 수 있었다. In this paper, a small supersonic wind tunnel is designed and built to study the flow characteristics of a supersonic impulse turbine. The flow is visualized by means of a single pass Schlieren system. The supersonic cascade with 2-dimensional supersonic nozzle was tested over a wide range of pressure ratio. Highly complicated flow patterns including shocks, nozzle-cascade interaction and shock boundary layer interactions are observed.

관찰학습 과정에서 모델시범 능력변인 수용에 대한 이론적 접근

한태준,조진규 경성대학교 1998 論文集 Vol.19 No.1

The purpose of present study was to investigate the effects of model's demonstration abilities through analysis of the related theories and earlier studies on observational learning. Therefore, the kernel interest of present study was to present the approach methods about acceptance of model's demonstration abilities on the observational learning variables. The present study achieved the following conclusion by analysis of the related theories and the earlier studies on observational learning 1. In the cognitive acceptance situation of the observers about model's demonstration abilities, unskilled modeling is effective as well as excellent modeling. 2. Such observational learning conditions as observation methods are critical variable which can overcome the demonstration abilities of unskilled models. In other words, there are the interaction effects between model's demonstration abilities and observational learning methods conditions. In conclusion, observational learning conditions have to approach as interactive relationship between the cognitive development level of children and the methods of observational learning and model's demonstration abilities.

한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.

광중합방식이 콤포머의 변연폐쇄에 미치는 영향

조옥환,한진순,임미경,이수종 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.1

The aim of this study was to evaluate the effect of various polymerization techniques on the microleakage of compomer restorations. Fifty extracted human premolar and molar were used and randomly divided into 5 groups. After cavity preparation, compomer (F2000) was filled according to the manufacturer's directions. All groups, except group 5, were filled using an incremental technique. Group 1was polymerized for 40 seconds at a continuous 485mW/㎠ with a VIP (Bisco, USA) light cure unit. Group 2 was polymerized for 20 seconds at a continuous 345mW/㎠ and then for 20 seconds at 645mW/㎠ with the VIP light cure unit. Group 3 was polymerized at 400mW/㎠, gradually increased to 50mW/㎠ per 10 seconds until 550mW/㎠ was reached; total 40 seconds with a Spectrum 800 (Dentsply Caulk, USA) light cure unit. Group 4 was polymerized for for 3 seconds using an incremental technique with a Flipo (LOKKi, France) light cure unit. Group 5 was polymerized for 3 seconds using a bulk fill technique with the Flipo light cure unit. The specimens were embedded with acrylic resin, and were sectioned with diamond saws in a mesiodistal direction along the longitudinal axis of the tooth so as to pass through the center of the restoration, and three surfaces (occlusal, pulpal, and gingival) were examined with SEM. The results were as follows; 1. Group 5 showed a significantly larger gaps compared to other groups on the gingival, occlusal, and pulpal walls. 2. All groups except group 5 had no statistically significant gap on the gingival, occlusal, and pulpal walls. 3. There was no significant correlation between the amount of enamel on the gingival and occlusal walls and polymerization shrinkage.

지역사회 공공보육시설 설치를 위한 학부모 인식 연구

조복희,이옥,이진숙,한유미 한국영유아보육학회 2003 한국영유아보육학 Vol.0 No.35

This study examined the parents' perception to the establishment of educare center in local area. The subject were 1,313 mothers with zero to five-year-old children. The major findings were as follows : First, most mothers preferred chid care support center(40%), child care center for infant(38%), especially dual-career wives preferred child care center for infant, but house wives preferred chid care support center. Second, in the opinion of program center operated by part-time, the preferrance to the program operated by once a week or anytime tended to be high, and also dual-career wives preferred weekend program. Third, in the services of chid care support center, most mothers preferred the providence of free-playroom for kid, parent-child playroom. And child care/education information and chid care counseling were preferred by mothers. Finally, we proposed the new model of public educare center in local area in the basis of results.

세가지 형상의 부유식 방파제 특성에 대한 비교연구

조원철,한덕만,양우석,이진원 중앙대학교 기술과학연구소 2000 기술과학연구소 논문집 Vol.30 No.-

본 연구는 2차원 유한요소모델을 이용한 부유식 방파제의 파랑감쇠특성에 대한 이론적 연구이다. 유체의 운동은 선형적이고, 2차원적인 포텐셜 흐름으로 가정하고 수치해석을 수행하였으며, 2차원 유한요소해석과 무한요소해석을 채택하여 부유식 방파제 영역에 적용하였다. 따라서 2개의 영역에 있어 방파제 근처 영역에서는 유한요소해석을 적용하였으며, 그 외의 영역에서는 무한요소해석을 사용하였다. 방파제의 형식은 직사각형, 원형, 사다리꼴의 세가지 형상으로 하였으며, 그 결과를 기존의 실험결과와 비교하였다. A theoretical investigation on the wave-attenuation characteristics of floating breakwaters are presented. The fluid motion is idealized as linearized, two dimensional potential flow. A two-dimensional finite element model is adopted to study the performance of floating breakwaters. The near field region surrounding the solid body is modeld using conventional finite elements, however, the far field region is represented appling the infinite elements. Numerical analysis is carried out for floating breakwaters with three different cross-sectional shapes, rectangular, circular and trapezoidal shapes, respectively. Comparison with hydraulic experimental results measured in the past is carried out to prove the validity of the numerical results.