Fatty Acid Synthesis Pathway Genetic Variants and Clinical Outcome of Non-Small Cell Lung Cancer Patients after Surgery

Jin, Xin,Zhang, Ke-Jin,Guo, Xu,Myers, Ronald,Ye, Zhong,Zhang, Zhi-Pei,Li, Xiao-Fei,Yang, Hu-Shan,Xing, Jin-Liang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total of 500 NSCLC patients who underwent surgery treatment were included. Eight SNPs in 3 genes (ACACA, FASN and ACLY) of the DNL pathway were examined using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards regression and Kaplan-Meier curves were used to analyze the association of SNPs with patient survival and tumour recurrence. We found that two SNPs in the FASN gene were significantly associated with the recurrence of NSCLC. SNP rs4246444 had a significant association with lung cancer recurrence under additive model (hazard ratio [HR], 0.82; 95% confidence interval [95%CI], 0.67-1.00; p=0.05). Under the dominant model, rs4485435 exhibited a significant association with recurrence (HR, 0.75; 95%CI, 0.56-1.01; p=0.05). Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model. Further cumulative effect analysis showed moderate dose-dependent effects of unfavorable SNPs on both survival and recurrence. Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.

Soil Organic Matter Controls of Soil Hydrological Functions in an Alpine Ecosystem in the Qinghai-Tibet Plateau

Fei Yang,Gan-Lin Zhang,Jin-Ling Yang,Min Yang 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample

Fei Han,Fei-Fei Zhai,Quan Wang,Li-Xin Zhou,Jun Ni,Ming Yao,Ming-Li Li,Shu-Yang Zhang,Li-Ying Cui,Zheng-Yu Jin,Yi-Cheng Zhu 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.2

Background and Purpose Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH), and cerebral microbleeds (CMBs) in a community-based sample in China and compare the results with those of other studies. Methods This was a cross-sectional analysis of the population-based Shunyi Study in China. A total of 1,211 stroke-free participants (mean age, 55.6±9.3 years; 37.4% men) with available 3 Tesla (3T) magnetic resonance images were included in this analysis. Demographic information and risk factor data were assessed. The overall and age-specific prevalence of lacunes, WMH, and CMBs was evaluated. Associations between cardiovascular risk factors and the presence of these lesions were analyzed by multiple logistic regression. Results Our study showed a prevalence of 14.5% for lacunes, 72.1% for periventricular hyperintensity (PVH), 65.4% for deep white matter hyperintensity (DWMH), and 10.6% for CMBs. When compared with other community-based samples, individuals in the same age group showed a higher burden of lacunes and a relatively lower prevalence of CMBs. Advanced age was independently associated with the prevalence of these CSVD markers, while the presence of hypertension increased the risk of lacunes, PVH/DWMH, and CMBs in deep or infratentorial locations. Conclusions A higher burden of lacunes but a relatively lower prevalence of CMBs was observed in this Chinese population. This notable result highlights the challenge of CSVD prevention in China. Chinese have a risk factor profile for CSVD similar to those in other populations.

First Record of a Brown Frog Rana huanrenensis (Family Ranidae) from Korea

Yang, Suh-Yung,Kim, Jong-Bum,Min, Mi-Sook,Suh, Jae-Hwa,Kang, Young-Jin,Matsui, Masafumi,Fei, Liang The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.1

We found a brown frog species, which is unrecorded from South Korea. Rana huanrenensis Fei, Ye, and Huang (1990), This species was originally described from northeastern China. In having 2n=24 chromosomes, this species is closely related to Rana dybowskii, R. chensinensis, R. ornativentris, R. pirica, and Chinese R. huanrenensis, but it is different from the first four species in the ecological, morphological, and genetic characteristics. By contrast, this species Is identical to Chinese R. huanrenensis In the habitat of montane stream-breeding, absence of the vocal sac, and genetic properties. This record is a significant range extention of R. huanrenensis.

Chemotherapy and Late Course Three Dimensional Conformal Radiotherapy for Treatment of Patients with Stage III Non-small Cell Lung Cancer

Liu, Yang-Chen,Zhou, Shao-Bing,Gao, Fei,Ye, Hong-Xun,Zhao, Ying,Yi, Xiao-Xiang,Huang, Xin-En,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Objective: To compare the efficacy and complications of chemotherapy and late course three-dimensional conformal radiotherapy (3DCRT) in treating patients with stage III non-small cell lung cancer (NSCLC). Patients and Methods: All patients were divided into two groups: to receive chemotherapy and late course 3DCRT (3DCRT group), or chemotherapy and conventional fraction radiation (control group). In the 3DCRT-group, patients were given 6~15 MV X-rays with a total dose of 40 Gy, followed by 3DCRT, 2.5 Gy~3.0 Gy per fraction, 1 fraction/every day, total 68 Gy~70 Gy; in the control group, with conventional fraction radiation the total dose was 64~66 Gy. The chemotherapy regimen in both cases was EP (VP-16 and DDP). Results: Sixty four patients with stage III NSCLC were divided into two groups: 32 patients into 3DCRT, 32 into the control group. One and 2-year survival rates in 3DCRT and control group were 87.5%, 56.3%mad 65.6%, 34.4%, respectively (P<0.05); local control rates were 90.6%, 81.3% and 65.6%, 53.1%, respectively (P<0.05). Conclusion: Chemotherapy and late course 3DCRT is associated with improved survival rate in patients with stage III NSCLC with good tolerability.

프로 농구선수들의 몰입 경험에 대한 탐색

양한승 ( Yang Han Seung ),이비 ( Li Fei ),풍해도 ( Feng Haitao ),황진 ( Hwang Jin ) 한국스포츠심리학회 2021 한국스포츠심리학회지 Vol.32 No.2

목적: 이 연구는 프로농구선수들이 시합상황에서 경험하는 ‘농구 몰입’에 대한 심층적인 정보를 제공하는 것이다. 방법: 프로농구선수 11명을 대상으로 몰입 상황, 몰입 전 또는 순간에 대한 느낌, 몰입 이후 필수요소 등의 질문을 통해 심층 면담을 실시하고 귀납적 내용분석을 통해 결과를 도출하였다. 결과: 몰입발생 이전과 몰입 진입 단계에서 경기 전에 나타나는 몰입 단서를 통해 몰입의 전조 증상을 진술했으며 이를 통해 플레이에 보다 집중하는 것으로 나타났다. 몰입경험 중에는 몰입상황을 통제할 수 없었으며 시합상황 파악, 상대 움직임 예측, 완벽한 컨디션 그리고 시간의 변형 같은 몰입을 경험하는 것으로 나타났다. 몰입결과 단계에서는 시합 영상분석을 통해 몰입 유지 및 재정비를 하는 것으로 나타났으며, 부상 통증을 잊고 경기에 뛰거나, 몰입경험의 놀라움 반응 등의 몰입의 특별함이 진술되었다. 결론: 이상의 결과를 바탕으로 몰입상황을 유지하고 적응하기 위해서 자기 수행에 긍정적인 요소들이 활성화 되어야하며, 더 많은 경험을 추구할 수 있는 충분한 기회의 제공 여건이 마련되어야 할 것이다. Purpose: The purpose of this study was to provide in-depth information on ‘basketball flow’ that professional basketball players experience in real game situations. Methods: 11 professional basketball players were given in-depth interviews based on questions about flow situations, their feelings before and at the moment of flow, and the essential factors after flow. The results were derived from inductive contents analysis. Results: The results of the study said that before flow and at the beginning of flow, players stated signs of flow through the clues to flow occurring before games and those signs helped players to pay more attention to games. The results also said that players couldn’t control flow situation but experienced flow such as the grasp of the game situation, the prediction about the opponents, perfect condition, and the transformation of time. At the stage of flow result, players were provided with self-regulatory feedback through analysis of video images of the game and they stated reactions of surprise about their flow experiences like finishing games without recognizing their pain from injury. Besides, players’ mood states, routine, feelings of achievement, and their relations with coaches were mentioned. Conclusion: Discussions were made based on results and more follow-up research on professional sport players’ flow was suggested.

AN INTELLIGENT TOOL KIT FOR EMBEDDED SAFETY-CRITICAL SOFTWARE AUTOMATIC TESTING

Yi-fei MAO,Jin-hui YANG 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-

The safety-critical software (SCS) is often directly related to the safety of the people's lives and wealth; it has to undergo safety testing strictly. The fault injection approach can generate testing cases to find dangerous prone defects quickly by running the SCS under a faulty environment. A fault injection tool kit for SCS is developed to implement fault injection to enhance the safety testing ability of the existing method. The tool kit generates test cases for safety testing according to an operational profile automatically and provides a script language as interface. When this tool kit applied in the testing of interlocking software, a typical class of SCS, the level of testing automation as well as testing efficiency is improved.

Diphlorethohydroxycarmalol, a phlorotannin isolated from Ishige okamurae, induces Ca<SUP>2+</SUP>-dependent glucose uptake in C2C12 cells and zebrafish model

Hye-Won Yang,Yun-Fei Jiang,You-Jin Jeon,BoMi Ryu 한국수산과학회 양식분과 2020 한국수산과학회 양식분과 학술대회 Vol.2020 No.7

MDCT로 측정한 체지방 체적과 DEXA로 측정한 체지방 질량을 이용한 남, 여 체지방의 비중 측정

김현진(Hyun-Jin Kim),양비(Yang Fei),노승무(Seung-Moo Noh),박종원(Jong Won Park) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11

본 논문에서는 남, 여 신체의 체지방을 분석하여 성별에 따른 체지방 비중의 차이에 대하여 연구하였다. MDCT(Multidetector Computed Tomography)로 스캔하여 획득한 영상을 CT Obesity를 이용하여 남, 여 다리의 체지방의 부피를 측정하였고, DEXA(Dual Energy X-ray Absorptiometry)를 이용하여 체지방의 질량을 측정하였다. 여기서 사용된 CT Obesity는 충남대학교 정보통신공학과 영상처리실에서 이미 개발한 체지방 분석 프로그램으로 실측자료와 비교하여 에러율이 0.2%이다. 남, 여 다리체지방의 부피와 질량을 측정하여 비중을 계산한 결과 남자의 체지방 비중은 0.83g/㎖이고 여자의 체지방 비중은 0.79g/㎖로 4.8%의 차이를 보였다. 비교와 검증을 위하여 수퇘지와 암퇘지의 다리의 체지방을 각각 10개의 표본으로 만들어 실측하여 계산한 결과, 수퇘지의 비중은 평균이 0.87g/㎖이고 표준편차는 0.021이었으며, 암퇘지의 비중은 평균이 0.84g/㎖이고 표준편차는 0.046이었다. 남자와 수퇘지 비중은 4.5%의 차이를 보였고, 여자와 앙퇘지 비중은 5.9%의 차이를 보였으며 수퇘지와 앙퇘지의 체지방 비중의 평균은 3.1%의 차이를 보였다. 이와 같은 체지방 비중의 계산은 MDCT를 이용한 체지방의 분석을 정확하게 하는데 도움이 될 것으로 보인다.

A GFP-labeled Human Colon Cancer Metastasis Model Featuring Surgical Orthotopic Implantation

Chen, Hong-Jin,Yang, Bo-Lin,Chen, Yu-Gen,Lin, Qiu,Zhang, Shu-Peng,Gu, Yun-Fei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Colorectal cancer has become a major disease threatening human health. To establish animal models that exhibit the characteristics of human colorectal cancer will not only help to study the mechanisms underlying the genesis and development effectively, but also provide ideal carriers for the screening of medicines and examining their therapeutic effects. In this study, we established a stable, colon cancer nude mouse model highly expressing green fluorescent protein (GFP) for spontaneous metastasis after surgical orthotopic implantation (SOI). GFP-labeled colon cancer models for metastasis after SOI were successfully established in all of 15 nude mice and there were no surgery-related complications or deaths. In week 3, primary tumors expressing GFP were observed in all model animals under fluoroscopy and two metastatic tumors were monitored by fluorescent imaging at the same time. The tumor volumes progressively increased with time. Seven out of 15 tumor transplanted mice died and the major causes of death were intestinal obstruction and cachexia resulting from malignant tumor growth. Eight model animals survived at the end of the experiment, 6 of which had metastases (6 cases to mesenteric lymph nodes, 4 hepatic, 2 pancreatic and 1 mediastinal lymph node). Our results indicate that our GFP-labeled colon cancer orthotopic transplantation model is useful with a high success rate; the transplanted tumors exhibit similar biological properties to human colorectal cancer, and can be used for real-time, in vivo, non-invasive and dynamic observation and analysis of the growth and metastasis of tumor cells.