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      • SCOPUSKCI등재

        Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

        ( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

        Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

      • 안정화제를 사용한 회수수의 고형분량 및 방치시간에 따른 시멘트 모르터의 특성

        金光華,김기정,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

        This study is intended to investigate the fundamental properties of cement mortar with solid content and leaving time of recycled water that stabilizing agent is added. According to the results, fluidity and air content does not make a big difference with variation of solid content. As the leaving time of recycled water is long, fluidity and air content increases. Setting time is shortened due to fine particle with an increase of solid content and leaving time. Compressive strength and flexural strength increase with an increase of solid content, and they increase at the leaving time of 1 day, but decrease after 2days. Length change by drying shrinkage is smaller than that of plain concrete, and is almost same with variation of solid content. And it is reduced at the leaving time of 1 day, but increases after that. Therefore, it analyzed that the effect of stabilizing agent is best under condition of adding ratio of 0.15%, solid content of 3% and leaving time of 1day, and it also works upto solid content of 5% and leaving time of 2days.

      • KCI등재

        백서 뇌의 정상 노화와 병적 노화 과정의 조직학적 차이 및 약물효과

        전진숙,한호성,장희경,길영기,김순옥 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

        Objectives : Besides of malnutrition and neurotoxic effect of alcohol on the prefrontal cortex or subcortical structures, premature aging may be involved in alcohol-induced cognitive disorders. The aims of this study were to evaluate the effect of alcohol on short-term memory function and histology, and to identify the drug responses and an association with aging process to understand a biological mechanism underlying alcoholic dementia. Methods: In experiment 1, T-maze tests were done in 5 aged controls and 5 atropine-treated rats. In experiment 2, T-maze tests were repeated on every week for a month in 5 normal adult and 5 ethanol-treated rats. In experiment 3, T-maze tests were repeated on every week for a month in seven groups of 5 ethanol-treated rats injected with normal saline, fluoxetine, bromocriptine, bethacholine, nimodipine, clonidine and ketamine. After completion of behavioral tests rats were sacrificed by the intracardiac perfusion with phosphate buffered 10% formaldehyde solution, and the brain specimen was stained with hematoxylin-eosin to count cells in prefrontal cortex and hippocampus. Results: 1) Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were reduced in ethanol-treated rats(P<0.05) without significant changes on T-maze tests. 2)Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were recovered by bethacholine(P<0.05), while those of hippocampus raised by bromocriptine and clonidine(P<0.05 respectively). There were no significant changes on T-maze tests. 3) Cell numbers of prefrontal cortex in ethanol-treated rats were correlated with those of atropine-treated(r=0.977,P<0.001), and of normal aged(r=0.448, P<0.05) rats. Conclusions : Alcohol-induced memory disorder might be mainly related with cholinergic system as well as adrenergic or dopaminergic ones. Pathological aging process could be involved in a mechanism underlying alcoholic dementia.

      • KCI등재

        한국판 소아 양극성장애 설문지 2.0(Child Bipolar Questionnaire 2.0)의 신뢰도 및 타당도 연구

        천근아,신동원,김보라,소윤섭,전진용,송동호 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

        Objectives : The Child Bipolar Questionnaire 2.0 (CBQ 2.0) is a rapid screener with a Core Index subscale of symptom dimensions frequently reported in childhood-onset bipolar disorder (BD) and scoring algorithms for DSM-Ⅳ BD, with and without ADHD, and the proposed Narrow, Broad, and Core phenotypes. This report provides preliminary data on the reliability and validity of the CBQ 2.0-Korean version. Methods : Core Index subscale to effectively predict diagnostic classification by structured interview was assessed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version (K-SADS-PL-K). Test-retest and inter-rater reliabilities of the CBQ 2.0 were assessed. Correlation of Korean Child Behavior Checklist (K-CBCL) with CBQ 2.0-Korean version was performed. Results : The CBQ 2.0 screening algorithms performed with a specificity of 66.7% and a sensitivity of 94.7% in classifying subjects with K-SADS-PL-K diagnosis of BD vs. no BD. The Core Index subscale had “good” agreement with K-SADS-PL-K diagnosis (Kappa=0.676) in identifying BD, ADHD-only, and no diagnosis. Conclusion : This preliminary data is from a sample derived from the child and adolescent psychiatric clinics, further validation is needed with community based samples in which childhood-onset BD is rarer and diagnoses more diverse. The CBQ 2.0-Korean version shows potential for rapid and economically feasible identification of possible childhood-onset BD cases as defined by DSM-Ⅳ criteria as well as by alternate disease phenotypes.

      • 수축저감제와 혼화재를 병용한 콘크리트의 공학적 특성

        金光華,김종,한민철,정평유,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

        The objective of this paper is to investigate the physical and mechanical properties of concrete incorporating shrinkage reducing admixture(SRA) and mineral admixture(MA) such as fly ash and blast furnace slag powder. According to results, for fresh concrete properties, increase of SRA content leaded to reduce the fluidity and air content sharply. For setting time, use of SRA caused concrete to accelerate setting time, and compared with plain concrete it retarded by incorporating MA. Compressive strength decreased with an increase in SRA content, and when incorporating MA, compared with plain concrete, it shows lower compressive strength in early age but similar or increase by the elapse of age due to the pozzolanic and latent hydration reaction. For drying shrinkage, concrete shows decline tendency with an increase in SRA content due to the relaxation effect at the capillary tension in concrete by SRA. In the scope of this paper, it is found that the use of SRA with 1.0% has optimum effects on the various properties of concrete, and the combinations of SRA and fly ash will ensure the stability for drying shrinkage.

      • 반복치료로 호전된 호산구성 폐렴 유사 폐흡충증 1예

        박세진,김희규,김봉준,이천우,옥철호,정만홍 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

        우리나라에서 인기 있는 게장등의 섭취로2) 성인뿐만 아니라 소아에서도 지속적으로 보고되고 있는 폐흡충증은 다양한 임상양상을 보일 수 있다. 저자들은 방사선 소견상 만성 호산구성 폐렴과 유사하였고, 반복적인 치료로 호전된 폐흡충증 1예를 경험하였기에 보고하는 바이다. Paragonimiasis mostly occurs by ingestion of raw or undercooked freshwater crabs or crayfish. Recently, re-emergence of paragonimiasis is reported because of ingestion of raw food such as freshwater fish and Gejang (marinated raw crabs). As the radiological features as well as the laboratory findings are similar to those of chronic eosinophilic pneumonia, the diagnosis of pulmonary paragonimiasis is often difficult and delayed. A 43 year-old female was visited our hospital for migrating and new developing consolidative lung lesions and peripheral blood eosinophilia. The eosinophil profile of leukocyte was 32% (absolute count 2,690 /mm3). Histologic finding was organizing pneumonia pattern with severe infiltration of eosinophils. Parasite specific antibody IgG forParagonimus westermani was positive (titer:0.61, normal range<0.20). After treatment with praziquantel (75mg/Kg once a day for 2days), the chest x-ray was clearly resolved. Follow-up study showed right pleural effusion, newly developed focal infiltration, and several nodules. After retreatment, we couldn't find any recurrent evidence.

      • Borrmann 4형으로 진단된 진행성 위암환자의 임상적 검토

        천영국,김영태,홍수진,김진오,조주영,이문성,심찬섭 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

        Background/Aim: It is difficult to dignosis of Borrmann type 4 gastric cancer at the early stage, because of its special morphology. Most of the cases have been detected at the advanced stage with poor survival rate. We reviewed patients with advanced gastric cancer, to define clinicopathologic characteristics of Borrmann type 4 gastric cancer comparing other types of gastric cancer. Methods: 1033 patients with advanced gastric cancer were divided into two groups, consisting of 50 patients with Borrmann type 4 gastric cancer, and the remaining 983 patients with all other types of gastric cancer, which were then compared clinicopatologically. Results: The proportion of Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer were composed 20 males and 30 males and revealed the highest frequency 3rd decade (24.0%) in age (range 26-78). In giant folds group (n=27), the number of poorly differentiated cell type, lymph node metastasis, peritoneal seeding were 20 (74.1%), 17 (63,0%), 12 (44.4%). In non-giant folds group (n=23), the number of poorly differentiated type, lymph node metastasis, peritoneal seeding were 17 (73.9%), 15 (65.2%), 6 (26.1%). Rate of tumor invasion in serosa and beyound serosa was 88.9% in giant fold group, 63.0% in non-giant fold group. Surgery was performed in only 32% as a modality of treatment (vs. 82.5%). Characteristics findings of Borrmann type 4 gastric cancer in EUS showed a thickening of the third (submucosa) and fourth (muscularis propria) layers in 72% of 50 patients, and a well preserved five-layered gastric wall structure in 33 patients. Conclusions: We concluded that Borrmann type 4 gastric cancer was diagnosed more in females, as a more advanced disease, early detection was needed. And endoscopic ultrasonography is useful for diagnosis of Borrmann type 4 gastric cancer in the cases of suspicious results of gastroscopy.

      • 국산 및 수입 Luncheon Meat의 품질비교에 관한 연구

        김천제,최수일,한의수,이효진,고원식 건국대학교 동물자원연구센터 1991 動物資源硏究誌 Vol.16 No.-

        본 연구는 국내에서 생산되고 있는 돈육 luncheon meat과 수입 luncheon meat의 성분조성 및 품질을 비교 평가하기 위하여 실시하였다. 그 결과를 요약하면 다음과 같다. 1) 국산돈육 luncheon meat의 수분함량은 57.2%로 수입품(53.1%)보다 높았으며 조지방 함량은 수입품(53.1%)보다 높았으며 조지방 함량은 수입품이 26.6%로 국산품(20.6%)보다 높았다. 그러나 조단백질 함량은 거의 같았다. 2) 국산돈육 luncheon meat와 수입품 모두 대장균이 검출되지 않으며, 타르색소(tar colors)도 사용하지 않은 것으로 나타났다. 3) 국산돈육 luncheon meat의 NO₂의 함량은 4 ∼ 35ppm으로 돈육수입 luncheon meat(1.7∼6ppm)보다 높았다. 4) 국산돈육 luncheon meat의 TBA가는 0.09∼0.13로 비교적 낮았으나, 유통기간이 긴 수입돈육 luncheon meat는 0.09∼0.39로 국내제품에 비하여 상대적으로 높은 값을 나타내었다. 5) 국산돈육 luncheon meat의 VBN(12.3∼18.4mg%)은 수입품(15.7∼18.2mg%)보다 낮았다. 6) 수입 luncheon meat는 국산 luncheon meat보다 jelly loss가 약2배 높았다. 7) 경도는 국산돈육 luncheon meat통조림이 수입품보다 높은 것으로 나타났으나, 탄력성과 응집성은 큰 차이가 나지 않았다. The aim of this study was to assay and compare the ingredient or composition and quality of imported pork luncheon meat with those of domestic's. The results obtained were as follows. 1. The amount of water in domestic pork luncheon meat products(57.2%0 was higher than that of imported products(52.2%0, and the content of crude fat in imported products(26.6%) was higher than that of domestic products(20.6%). The amount of crude protein, however, both domestic and imported products was approximately the same. 2. E.coli was not found in both domestic and imported products. No tar-colors were detected in both samples. 3. The amount of NO₂in domestic pork luncheon meat products(4 to 35ppm) was higher than that of imported products(1.7 to 6ppm). 4. The TBA-value of domestic pork luncheon meat products(0.09 to 0.13) was relatively low, whereas the value of imported products was higher than that of domestic products(0.09 to 0.39). 5. The VBN-value of domestic luncheon meat products(12.3∼18.4mg%) was lower than that of imported products(15.7∼18.2mg%). 6. The jelly loss of imported pork luncheon meat products was approximately 2 times higher than that domestic's . 7. The hardness of imported pork luncheon meat products was lower than that of domestic products. Elasticity and coheshiveness in both products were not significantly different.

      • 한국어 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/의 음향 음성학적 연구

        김병천,梁鎭宇 안성산업대학교 1994 論文集 Vol.26 No.-

        본 논문은 한국어의 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/에 대한 음향 음성학적인 분석에 관한 연이다. 본 논문에서는 세 개의 종성 폐쇄음 /k^ㄱ/,/t^ㄱ/,/p^ㄱ/이 8개의 단모음(ㅏ,ㅓ,ㅗ,ㅜ,ㅡ,ㅣ,ㅐ,ㅔ)과 조합되어 형성된 24개의 음절을 선택하여 3인의 성인 남성이 각각 3회씩 발음하여 구성한 216개의 음성 데이터를 사용하여 포만트 주파수를 추출한 연후에 각각의 모음에 대해 종성 폐쇄음의 포만트 주파수가 이동하는 방향을 분석하였다. 실험 걸과 모음에서 종성 폐쇄음으로 이동하는 과도 구간의 최종 포르만트 주파수는 각 모음마다 상당한 차이를 내었으며, 과도 구간에서 각 모음에 따라 각기 다르다는 것을 알 수 있었다. This paper is a study on the acoustic-phonetical analysis of Korean final stops /k^ㄱ/,/t^ㄱ/,/p^ㄱ/. In this paper, I selected twenty four syllables in order to constitute corpora. These syllables are formed by combination of three final stops /k^ㄱ/,/t^ㄱ/,/p^ㄱ/ and eight single vowels /a/,/∂/,/o/,/u/,/?/,/i/,/æ/,/ε/. Three adult men pronounced these corpora three times a man and stored them files. After extraction of the final stop's frequencies from the stored files, I analysed the moving directions of the final stop's final formant frequencies for each vowel. As a result of the analysis, I was able to confirm that the final formant frequencies of transition section moving from the vowels to the final stops were very different for each vowel, and the features of each formant frequencies.

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