공황장애에서 Paroxetine 단기약물치교가 심리적 상태에 미치는 영향

이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

공황장애에서 Paroxetine 단기약물치료가 심리적 상태에 미치는 영향

이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

Objectives : This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological Pre-dictors of treatment response. Methods : Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by Pa-roxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sen&itivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. Results : Panic patients showed significant improvement in seventy of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective seventy was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). Conclusion : This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without ago-raphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on Catastro-phic thoughts may play an important role in symptom improvement in panic disorder.

열처리가 Teflon^(??) FEP film의 전하보존특성에미치는 영향

김성준,이현석,김지균,권정열,이헌용 명지대학교 산업기술연구소 2007 産業技術硏究所論文集 Vol.26 No.-

In this paper, we studied the method of electrets electrode which formed to accumulate negative electric charges by corona discharges. The breakdown voltage samples and damaged samples by various corona discharges have made material stabilization and improved characteristics of electric charge storage throughout the annealing processes. After the experiment made material stabilization nearly melting point by many kinds of annealing conditions, we did the corona discharge again by the charged high voltages, a discharge electrode gap, and a discharged time. As we compared it with the best condition, we confirmed that characteristics of electric charge storages were improved.

전이성 신세포암 환자에서의 IFN-α와 5-FU를 이용한 복합 면역 화학 요법

김세웅,이지열,장광식,박왕진,정호석,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 전이성 신세포암의 경우 일반적으로 항암 화학요법, 방사선 치료 그리고 호르몬 치료 등의 다양한 치료 방법에도 불구하고 그 치료 성적이 불량하며 최근 진행된 전이성 신세포암이 치료에 사용되고 있는 면역요법과 면역화학요법의 치료 효과에 대한 많은 논란이 있다. 이에 저자들은 전이성 신세포암 환자들을 대상으로 시행한 interferon-α와 5-fluorouracil의 병용투여에 대한 면역화학요법의 치료 성적, 추적관찰 결과 및 부작용의 발현정도를 확인하여 그 임상적 유용성을 알아보고자 하였다. 방법 : 1995년 3월부터 2000년 2월까지 가톨릭 대학 부속 성모 병원에서 치료를 받았던 진행성, 전이성 신세포암 환자들 중 interferon-α와 5-fluorourcail의 복합면역화학요법을 시행 받고 추적관찰이 가능했던 총 17명의 환자를 대상으로 하였다. 대상 환자들에 대해 28일을 주기로 5-fluorouracil 750㎎/㎡(Body surface area)을 5일간 지속성 정맥 주사로 투여한 후 주 3회 interferon-α 300만 unit를 4주간 피하 주사하였다. 이들에 대해 8주마다 전산화 단층촬영, 동위원소 골주사, 흉부단순 촬영 등의 영상 진단을 통한 정기적인 추적 관찰을 시행하고 이들의 치료 성적, 추적관찰 결과 및 부작용 등에 대해 알아보았다. 결과 : Interferon-α와 5-Fluorouracil의 복합면역화학요법을 이용한 전체 17명의 전이성 신세포 암 환자의 경우 반응율은 완전관해는 없었으나 부분관해를 보인 경우가 2명(11.8%), 안정상태 유지는 6명(35.3%)이었다. 폐전이의 경우 복합면역화학요법에 대해 비교적 좋은 반응을 기대할 수 있었으며 이들의 생존 기간의 중앙값은 13.8개월이었다. 거의 모든 환자에서 미열을 동반한 전신 증상과 전신 쇠약감을 관찰 할 수 있었고 그 밖에 오심, 구토 및 설사 등의 소화기 증상과 두통 등의 경미한 부작용을 일부 환자에서 관찰할 수 있었으나 백혈구 감소증, 혈소판 감소증과 간기능 이상 등의 심각한 부작용을 보인 경우는 극히 적었다. 결론 : 전이성 신세포암은 비교적 그 예후가 불량하며 동시에 효과적인 치료 방법이 명확히 알려지지 않은 상태이다. 이러한 전이성 신세포암의 치료에 대한 interferon-α와 5-fluorouracil의 복합면역화학요법은 다른 종양의 치료에 비해 비교적 낮은 반응률과 고비용이 문제점으로 생각되나 비교적 부작용이 적은 안전한 치료 방법이므로 전이상 신세포암 환자에 있어 시행해 볼 가치가 있는 치료 방법의 하나로 사료된다. Background : Renal cell carcinoma is relatively resistant to both chemotherapy and immunotherapy. In this study, we evaluated and verified the efficacy and toxicity of therapies using interferon-α plus 5-fluorouracil in patients with metastatic renal cell carcinoma. Methods : A total of 17 patients with metastatic renal cell carcinoma were treated with interferon-α (3 million units/day. 3 times/week) subcutaneously plus 5-fluorouracil (750㎎/㎡ /day for 5 days) intravenously every 28 days from March 1995 to February 2000. We studied the response rate and the side effects of this regimen. Results : Among 17 patients treated with interferon-a plus 5-fluorouracil, 2 patient with lung metastasis was achieved partial remission (11.8%) and 3 patient with lymph node metastasis, 2 patients with lung metastasis and I patient with lung and bone metastases were achieved stable disease (35.3%). I and 5 year survival rates and median survival duration were 55%, 7% and 13.8 months, respectively. There were only mild to moderate side effects. The most common side effects were flu-like symptom such as fever, chill and malaise followed by gastrointestinal symptom such as nausea, vomiting and diarrhea, headache. High grade toxicities such as severe neutropenia and thrombocytopenia were rare. Conclusion : Immunochemotherapy using interferon-α plus 5-fluorouracil were moderately effective with modest toxicity in metastatic renal cell carcinoma. The most favorable response can be expected in lung metastasis. Most of side effects were tolerable. The effective therapy in patients with metastatic renal cell carcinoma should be studied and evaluated by further large randomized trials.

Klebsiella pneumoniae infection secondary to bovine viral diarrhea in neonatal calves of premature birth

Ji-Youl Jung(Ji-Youl Jung),Kyunghyun Lee(Kyunghyun Lee),Eun-Jin Choi(Eun-Jin Choi),Ha-Young Kim(Ha-Young Kim),ByungJae So(ByungJae So) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-

Dormancy-breaking and Germination of Chelidonium majus L. subsp. asiaticum H. Hara Seeds by Stratification and Gibberellins

Boran Ji(Boran Ji),Hayan Lee(Hayan Lee),Kyungtae Park(Kyungtae Park),Sang Yeob Lee(Sang Yeob Lee),Bo-Kook Jang(Bo-Kook Jang),In Hwan Chae(In Hwan Chae),Chung Youl Park(Chung Youl Park),Sung Pil Kwon(S 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.6

The demand for Chelidonium majus L. subsp. asiaticum H. Hara is expected to increase due to its pharmacological properties such as antibacterial, antioxidant, and anti-inflammatory effects. However, an effective propagation system for this species has not yet been established. This study was conducted to analyze the seed dormancy and germination characteristics of C. majus L. subsp. asiaticum H. Hara native to Korea and establish a mass propagation system. The dormancy type was primarily classified by analyzing the general information of the collected seeds. The seed dormancy breaking was investigated by comparing the effects of cold stratification (0, 2, 4, 8, 10, or 12 weeks) with warm stratification (S, summer temperature, 25/15°C) and intermediate temperature stratification (A, autumn temperature, 15/10°C) of alternating temperature stratification (S12-A4 or S12-A8 weeks). After dormancy break, 500 ㎎/L GA3 and GA4+7 treatment replaced cold stratification and improved seed germination. The results of this study are expected to provide basic data for future seed propagation and mass propagation by analyzing the dormancy and germination characteristics of C. majus L. subsp. asiaticum H. Hara seeds.

Inhibition of NADPH oxidase 4 (NOX4) signaling attenuates tuberculous pleural fibrosis

( Ji Young Hong ),( Youngmi Kim ),( So Yeong Park ),( Jae Jun Lee ),( Myung Goo Lee ),( Chang Youl Lee ),( Youlim Kim ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

Introduction: Respiratory failure from pleural fibrosis may occasionally be induced by tuberculous pleurisy (TP). While NADPH oxidase (NOX) enzymes serve several hemostatic and host defense functions in the lung, and NOX4 is involved in several key processes in fibrotic lung disease, the role of NOX4 signaling in TP is not well understood. Methods: The role of NOX4 signaling in tuberculous pleural fibrosis was studied using in-vitro pleural mesothelial cell (PMC) experiments and a murine model of Mycobacterium bovis bacillus Calmette-Guerin (BCG) pleural infection. Results: The production of NOX4 reactive oxygen species (NOX4-ROS) and the epithelial mesenchymal transition (EMT) in PMCs were both induced by heat-killed mycobacterium tuberculosis (HKMT). In cultured PMCs, HKMT-induced collagen-1 synthesis and EMT were blocked by pretreatment with siRNA NOX4. Moreover, NOX4-ROS production and subsequent fibrosis were reduced by treatment with losartan and the toll-like receptor 4 (TLR4) inhibitor TAK-242. HKMT-induced EMT and intracellular ROS production were mediated by NOX4 via the activation of extracellular signal-regulated kinase (ERK) signaling. Finally, in a BCG-induced pleurisy model, recruitment of inflammatory pleural cells, release of inflammatory cytokines, and thickened mesothelial fibrosis were attenuated by SiNOX4 compared to SiCon. Conclusions: HKMT-induced pleural fibrosis is mediated by NOX4-ERK-ROS via TLR4 and AT1R. Accordingly, NOX4 may be a novel therapeutic target for intervention in tuberculous pleural fibrosis.

Applying Fishing-gear Simulation Software to Better Estimate Fished Space as Fishing Effort

( Ji Hoon Lee ),( Chun Woo Lee ),( Moo Youl Choe ),( Gun Ho Lee ) 한국수산과학회(구 한국수산학회) 2011 Fisheries and Aquatic Sciences Vol.14 No.2

Modeling fishing-gear systems is essential to better understand the factors affecting their movement and for devising strategies to control movement. In this study, we present a generalized mathematical modeling methodology to analyze fishing gear and its various components. Fishing gear can be divided into a finite number of elements that are connected with flexible lines. We use an algorithm to develop a numerical method that calculates precisely the shape and movement of the gear. Fishing-gear mathematical models have been used to develop software tools that can design and simulate dynamic movement of novel fishing-gear systems. The tool allowed us to predict the shape and motion of the gear based on changes in operation and gear design parameters. Furthermore, the tool accurately calculated the swept volume of towed gear and the surrounding volume of purse-seine gear. We analyzed the fished volume for trawl and purse-seine gear and proposed a new definition of fishing effort, incorporating the concept of fished space. This method may be useful for quantitative fishery research, which requires a good understanding of the selectivity and efficiency of fishing gear used in surveys.

스마트병원과 외과의사

Ji Youl Lee 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

Efficacy of an Alpha-Blocker for the Treatment of Nonneurogenic Voiding Dysfunction in Women: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial

Lee, Young-Suk,Lee, Kyu-Sung,Choo, Myung-Soo,Kim, Joon Chul,Lee, Jeong Gu,Seo, Ju Tae,Lee, Jeong Zoo,Lee, Ji Youl,Oh, Seung-June,Na, Yong Gil Korean Continence Society 2018 International Neurourology Journal Vol.22 No.1

<P><B>Purpose</B></P><P>To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study.</P><P><B>Methods</B></P><P>This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological Association symptom score (AUA-SS) ≥15 and a maximum flow rate (Qmax) <15 mL/sec with a voided volume of >100 mL and/or a postvoid residual (PVR) volume >150 mL, were randomly allocated to either the alfuzosin or placebo group. After 8 weeks of treatment, changes in the AUA-SS, Bristol female lower urinary tract symptoms (BFLUTS) questionnaire, Qmax/PVR, and voiding diary were compared between groups. Patients’ satisfaction with the treatment was compared. Patients were categorized into 3 groups according to the Blaivas-Groutz bladder outlet obstruction (BOO) nomogram: none, mild, and moderate to severe. Subgroup comparisons were also made.</P><P><B>Results</B></P><P>Of a total of 187 women, 154 (79 alfuzosin, 75 placebo) were included in the analysis. After 8 weeks of treatment, the AUA-SS decreased by 7.0 in the alfuzosin group and by 8.0 in the placebo group. Changes in AUA-SS subscores, BFLUTS (except the I-sum), the voiding diary, and Qmax/PVR were not significantly different between groups. Approximately 54% of the alfuzosin group and 62% of the placebo group were satisfied with the treatment. No significant difference was observed between groups according to the presence or grade of BOO.</P><P><B>Conclusions</B></P><P>Alfuzosin might not be more effective than placebo for treating FVD. The presence or the grade of BOO did not affect the results. A further study with sufficient power is needed to determine the efficacy of α1-AR blockers for the treatment of FVD.</P>