임상가를 위한 외상후 스트레스 장애 척도의 신뢰도, 타당도 연구

이병용,김임,이선미,은헌정,김동인,김지연 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적 : 본 연구의 목적은 임상가를 위한 외상후 스트레스 장애 척도의 신뢰도와 타당도를 알아보고자 하는 것이다. 방 법 : 28명의 PTSD 군, 30명의 Non-PTSD군, 36명의 정상군에 대하여 임상가를 위한 외상후 스트레스 장애 척도를 실시하였다. 면담자간 신뢰도를 평가하기 위하여 10명의 외상후 스트레스 장애 환자를 2명의 검사자가 동시에 평가하였다. 타당도를 평가하기 위하여 모든 피검자들을 대상으로 사건 충격 척도, Beck의 우울 검사, Spielberger의 상태 특성 불안 검사 Ⅰ, Ⅱ를 시행하였다. 결 과 : Cronbach's α와 면담자간 일치도는 각각 .95와 .89였다. 임상가를 위한 외상후 스트레스 장애 척도는 각각 사건 충격 척도(r=.80), Beck의 우울 검사(r=.70), Spielberger의 상태 특성 불안 검사 Ⅱ(r=.56)와 높은 상관을 가지고 있었다. 그러나 Spielberger의 상태 특성 불안 검사 Ⅰ(r=.20)과는 상관을 보이지 않았다. 임상가를 위한 외상후 스트레스 장애 척도는 임상 진단과 82.1%의 일치도를 보였다. 결 론 : 임상가를 위한 외상후 스트레스 장애 척도는 충분한 신뢰도와 타당도를 가지고 있었다. 임상가를 위한 외상후 스트레스 장애 척도는 외상후 스트레스 장애를 진단하기에 유용한 도구라 할 수 있다. Objectives : The purpose of this study was to examine the reliability and validity of A Clinician-Administered PTSD Scale (CAPS). Methods : CAPS was administered to 28 PTSD subjects, 30 non-PTSD subjects, and 36 normal subjects, Interrater reliability for the CAPS was established by interviewing 10 PTSD subjects. The interviews were conducted by 2 interviewers simultaneously. The authors administered to all the subjects Impact of Event Scale(IES), Beck Depression Inventory(BDI), State Trait Anxiety InventoryⅠ, Ⅱ(STAI-I, Ⅱ) for measuring concurrent validity. Results : The value of Cronbach's α and interrater agreement were .95 and .89, respectively. The CAPS was highly correlated with IES(r=.80), BDI(r=.70), STAI-Ⅱ(r=.56). But the CAPS was not correlated with STAI-I(r=.20). The CAPS showed an overall agreement with clinical diagnosis of 82.1%. Conclusions : The CAPS shows a reasonable degree of reliability and validity. The CAPS could be a valuable tool to diagnose PTSD.

2,2' -디히드록시설포 아조메친 유도체에 의한 알미늄 및 갈륨의 형광 정량

이종원,이지연,허문회,안문규 慶星大學校 1998 論文集 Vol.19 No.2

Four azomethine dyes were synthesized in order to get excellent fluorescent reagent having hydroxyl and sulfo substituents. They are 2-hydroxy-3-sulfo-5chloroaniline-N-salicylidene(Ⅰ), 2-hydroxy-3-sulfo-5chloroaniline-N-2, 4-dihydroxybenzylidene (Ⅱ), 2-hydroxy-5-sulfoaniline-N-salicylidene(Ⅲ) and 2-hydroxy-5-sulfoaniline-N-2, 4-dihydroxybenzylidene(Ⅳ). These compounds react with aluminum and gallium in an aqueous dimethyl-formamide solution to form fluorescent 1:1 (metal-azomethine) complexes. Several conditions, such as the pH of the solution, the reagent concentration, the time of standing and fluoresence characteristics cincellar media were investigated. the maxium fluorescence intensity of the aluminum complex was found at pH 6 (heated for 10 min, at 50℃), and the gallium complex was at pH 4. The fluorescence was stable at least for 2 hours by using 2-hydroxy-5sulfoanilin-2-, 4-dihydroxybenzylidene in Triton X-100 media, 0.1∼4 ㎍ of aluminum and 0.5∼30 ㎍ of gallium in 25 mL solution could be determined. Ni(Ⅱ), Cu(Ⅱ), Fe(Ⅱ), Mg(Ⅱ), and Zn(Ⅱ) ions interfered with the determination. On the other hand, the effect of surfactants on the fluorescence characteristics in Triton X series media show a remarkable enhancement of fluorescence intensity as compared with that of azomethine complexes in aqueous media.

Dibucaine-금속 요오드 착물을 이온교환체로서 이용한 Dibucaine의 정량

최현영,이지연,허문회,안문규 慶星大學校 1998 論文集 Vol.19 No.1

Dibucaine-selective poly(vinyl chloride) menbrance electrodes were designed based on ion-association complex between dibucaine and metal iodide complex such as H??, Bil?? and CdI??. Stable potentiometric response was obtained with Meyer reagent at pH 3.0-5.5, with Dragendorff reagent at pH 3.0-5.0 and with Marume reagent at pH 3.0-5.5. The best plasticizer was 49 w/w% acetyl-tri-n-butly critrate for Meyer reagent, 65.3 w.w% for Marume reagent. The electrodes exhibited a linear response based on Meyer, Dragendorff and Marume complex were the concentration range of 2×10?4×10?M ,2×10×4×10?M, 2×10?1×10?M,respectively. The potentiometric response slope of optimized membrane electrodes based on Meyer, Dragendorff and Marume complex for dibucaine were 56.12,57.81 and 56.45?? with relative standard deviation of 2.75, 2.29 and 1.96%, respectively. This ISE methods are found to be sensitive, rapid, fairly accurate and are able to be empolyed successfully for the determination of dibucaine preparations.

플라비아닌산을 이용한 클로르프마진의 용매추출 분광광도법

정문모,남수자,이미나,이지연,허문회,안문규 慶星大學校 1998 論文集 Vol.19 No.2

Neurosphere formation potential resides not in the caudal cell mass, but in the secondary neural tube

Lee, Ji Yeoun,Lee, Eun Sun,Kim, Saet Pyoul,Lee, Myung-Sook,Phi, Ji Hoon,Kim, Seung-Ki,Hwang, Young-Il,Wang, Kyu-Chang University of the Basque Country Press 2017 The International journal of developmental biology Vol.61 No.8

<P>The caudal cell mass (CCM) is known as the main player in secondary neurulation, forming the secondary neural tube (2NT). This suggests that the CCM may have the character of neural progenitor cells. The neural potential of the CCM and the 2NT (CCM + 2NT) was assessed by in vitro culture of neurospheres during Hamburger and Hamilton stages (HH) of secondary neurulation (HH16 to HH32). We also analyzed the neural potential of the developing central nervous system (CNS) by comparing the neurosphere culture from the brain, upper / lower spinal cord, and CCM + 2NT from various HH stages. The CCM + 2NT was capable of forming neurospheres. Of the various HH stages, the greatest number of neurospheres from CCM + 2NT were cultured at HH28. Because the 2NT is most prominent at HH28, we hypothesized that the 2NT, rather than the CCM, had the main potential to produce neurospheres. When the neurospheres were cultured separately from the CCM and the 2NT, 2NT made significantly more neurospheres. When comparing different parts of the CNS, at HH16, the greatest number of neurospheres was formed from the brain. At HH32, it was the CCM + 2NT. The region with the greatest number of neurospheres progressed in a cephalo-caudal direction during development. This study showed that neurospheres can be cultured from CCM + 2NT, and the main player in neurosphere formation was the 2NT. The present study has also revealed cephalo-caudal trend in the neural potential of developing CNS.</P>

Screenshot identification by analysis of directional inequality of interlaced video

Lee, Ji-Won,Lee, Min-Jeong,Lee, Hae-Yeoun,Lee, Heung-Kyu Springer (Biomed Central Ltd.) 2012 EURASIP journal on image and video processing Vol.2012 No.-

Treatment of hidradenitis suppurativa patient with klinefelter syndrome using adalimumab

( Ji Yeoun Shin ),( Ho Jung Lee ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Hidradenitis suppurativa (HS) is a chronic recurrent suppurative skin disease of unknown etiology, frequently involves axillae, inguinal area, buttock, and perineum, and is more frequent in women. Klinefelter syndrome, known as 47,XXY or XXY, is the set of symptoms that result from two or more X chromosomes in males. There have been reported many cases of autoimmune disease in patients with Kleinfelter syndrome, but no case has been reported with HS. We reported at a 30-year-old man with Klinefelter syndrome presenting suppurative nodules around the anus. We found that multiple purulent nodules with tenderness and odor was present around the anus and perineum, accompanied by scar and sinus on the periphery through physical examination. We diagnosed him as HS, based on clinical findings. When serum testosterone level was low (e.g, Klinefelter syndrome), level of tumor necrosis factor-α (TNF-α) was significantly increased. TNF-α is overexpressed in intact skin as well as lesions in patients with HS, which correlates with the severity of the disease. Although the exact mechanism is unknown, low male hormone level in Klinefelter syndrome associated with increased TNF-α, may have contributed to worsening the patient's disease. We reported that biologics were more effective than primary treatment such as antibiotics in patients with autoimmune or genetic diseases, which may be accompanied by increased TNF-α in patients with HS.

Identification of <i>P2Y12</i> single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation

Lee, Su-Jun,Jung, Il-Sun,Jung, Eun-Ji,Choi, Ji-Yeop,Yeo, Chang-Woo,Cho, Doo-Yeoun,Kim, Yang-Weon,Lee, Sang-Seop,Shin, Jae-Gook Elsevier 2011 Thrombosis research Vol.127 No.3

<P><B>Abstract</B></P><P><B>Introduction</B></P><P>Although P2Y12 has a significant role in normal hemostasis and thrombosis, no genetic study has been described about the association between P2Y12 variants and the extent of ADP-induced platelet activation in the Korean population.</P><P><B>Materials and Methods</B></P><P>The expression levels of two reference sequences of <I>P2Y12</I> mRNA transcripts (variants 1 and 2) were examined in the whole blood before direct DNA sequencing. The subjects were screened for single-nucleotide polymorphisms (SNPs) in <I>P2Y12</I> by direct DNA sequencing (n=50). Frequencies of <I>P2Y12</I> single nucleotide polymorphisms (SNPs), linkage disequilibrium blocks, haplotype structures, and haplotype-tagging SNPs were determined. The effects of genetic variation in the <I>P2Y12</I> gene on the extent of ADP-induced platelet aggregation were studied in healthy Korean men (n=40).</P><P><B>Results</B></P><P>Variant 2 (NM 176876.1) was the predominantly expressed form in all subjects, but variant 1 was also weakly expressed in all cases (n=10). A total of 20 SNPs were identified: 2 in exons, 5 in introns, and 8 and 5 in the 5’-untranslated regions of the known <I>P2Y12</I> RNA variants 1 and 2, respectively. Genetic analysis of the <I>P2Y12</I> SNPs and haplotypes revealed a statistically significant association between <I>P2Y12</I> haplotype, denoted H3, and an increase in the ADP-induced platelet aggregation response relative to that for the reference haplotype H1 (<I>P</I>=0.01).</P><P><B>Conclusions</B></P><P>Application of these findings to the development of a multivariate model might be useful in explaining the variable outcome of antiplatelet drug therapy in Asian populations.</P>

Primary atypical melanocytoma arising from the cavernous sinus in a child.

Lee, Na-Kyoung,Lee, Ji Yeoun,Wang, Kyu-Chang,Kim, Dong Gyu,Park, Sung-Hye,Cheon, Jung-Eun,Phi, Ji Hoon,Kim, Seung-Ki Springer Verlag 2015 Child's nervous system Vol.31 No.9

<P>Primary melanocytic lesions of the central nervous system originate from leptomeningeal melanocytes, with a spectrum ranging from well-differentiated benign meningeal melanocytomas to malignant melanomas. Atypical melanocytomas are borderline tumors, which have clinical and pathological characteristics between benign melanocytomas and malignant melanomas. Melanocytomas are rare in children and infrequently arise from the cavernous sinus. Approximately five patients with such an origin site have been reported.</P>

Functional recovery after injury of motor cortex in rats: effects of rehabilitation and stem cell transplantation in a traumatic brain injury model of cortical resection.

Lee, Do-Hun,Lee, Ji Yeoun,Oh, Byung-Mo,Phi, Ji Hoon,Kim, Seung-Ki,Bang, Moon Suk,Kim, Seung U,Wang, Kyu-Chang Springer Verlag 2013 Child's nervous system Vol.29 No.3

<P>Experimental studies and clinical trials designed to help patients recover from various brain injuries, such as stroke or trauma, have been attempted. Rehabilitation has shown reliable, positive clinical outcome in patients with various brain injuries. Transplantation of exogenous neural stem cells (NSCs) to repair the injured brain is a potential tool to help patient recovery.</P>