복귀돌연변이시험을 이용한 이온화에너지 처리 우유 및 아이스크림의 유전독성학적 평가

유지숙, 한선경, 신명수, 구본철, 최지현, 이주운, 조철훈, 함준상, 이완규 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.1

본문참고

Depressor Septi Nasi Muscle의 비후에 의한 비축주 변형의 치험례

하지운 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

The columella is penetrated by the paired depressor septi nasi muscles which arise from the incisive fossa of the maxilla and insert into the caudal portion of the septum and have a few fibers into the cephalic portion of the ala of nose. Its principal function is to tense the membranous septum. The author present a case of congenital columella deformity due to hypertrophy of depressor septi nasi muscle, which is initially misdiagnosed as a soft tissue tumor such as lymphangioma. Exploration though a columella base incision revealed a distinct columella muscle(5㎜ wide by 5㎜ thick)with is origin at the nasal spine and insertion on the upper septum. The hypertrophic muscle and the excess columella tissue were excised. A pathologic examination demonstrated a normal skeletal muscle. There was noticeable improvement in the columella contour after the operation.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.

갑상선결절의 임상 및 초음차소견의 진단적 가치

박거운,박철진,박일구,신지혜,정중화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Backgrounds: Thyroid nodule have been relatively common disease and it's prevalence estimated about 4-7%. Recently, high resolution ultrasonography has made the detection of small thyroid nodule possible, Increases in the detection of thyroid nodule have created a clinical dilemma on how to properly manage such thyroid nodules. We investigated the prevalence, clinical and ultrasonographic characterristics, and optimal diagnostic approach toward detected benign and malignant thyroid nodules. Methods: A retrosepctive review was undertaken on the 372 patients who was done Ultrasonograpy guided fine needle aspiration biopsy in Chosun University Hospital, Gwang-Ju, Korea between July 2003 and Spring 2005. Devided into four group such as benign and malignant thyroid nodule on the basis of size 1.5Cm. The review consisted of thyroid function test, antithyroid antibodies, thyroid autoantibodies, thyroid ultrasonography, fine needle aspiration biopsy in each group. Results: The prevalence of thyroid nodule malignancy rate was 18.0%. The prevalence of thyroid incidentaloma malignanct rate was 17.5%. There were no significant differences in age, sex, thyroid function test and size between the benign, malignant incidentalomas and nodule. Ultrasonographic characteristics, include ultrasonography index point showed meaningful diagnostic value for the detection of malignancy in thyroid nodule, Conclusion: Thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodule; however, ultrasonographic findings can be used to decision of optimal management strategies 배경: 최근갑상선 초음파의 빈번한 시행으로 갑상선 결절의 발견이 증가하고 있다. 이러한 갑상선 결절중 특히 갑상션우연종을 임상적으로 어떻게 접근하고 치료를해야하는지는 적지 않는 문제가 되고 있다. 본 연구에서는 갑상선 우연종 및 직경 1.5 cm 이상의 갑상션결절의 유병률, 임상적 특징, 초음파특정 및 초음파의 진단적 유용성에 대해 알아 보았다. 방법: 2003년 7윌부터 2005년 3월까지 조선 대학교병원 내과 및 일반외과및 건강검진 센터를 통해 갑상선 초음파, 경동맥 초음파 및 경부 CT등을 통해 우연히 발견된 갑상션결절을 가진 372명을 대상으로 후향적 연구를 시행하였다. 크기 1.5 cm 미만의 양성및 악성 갑상선 결절군과 크기 1.5 cm 이상의 양성 및 악성결절로 그룹을 나누고 각 군에서 나이, 성별, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침흡인세포검사등을 검토하였고, 모든 갑상선 결절에 Koike (6)가 제한한 초음파지표 점수(Ultrasonographie index point)를 부여하여 각 군을 비교하였다. 결과: 분석한 갑상선 결절 372예 중 악성결절의 유병율은 18.0% (67예)였다. 갑상선 우연 종의 유병율은 81.5% (303예)였다. 갑상선 우연 종에서의 악성률은 17.5% (53예)로 나왔다. 크기 1.5 cm 이상의 양성 및 악성 갑상선 결절과 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 항갑상선항체에는 의미있는 차이가 없었다. 또한 양성 및 악성우연종에서 의 갑상선 결절크기에도 의미있는 차이는 보이지 않았다. 갑상선 결절의 초음파 지표점수만이 양성 및 악성우연종과 양성 및 악성갑상선 결절의 감별에 의미있는 차이를 보였다. 갑상 선우연종과 크기 1.5 cm 이상의 갑상선 결절에 서 양성을 나타내는 초음파지표점수는 각각 3 점과 4점으로 다르게 나타났다. 양성 및 악성 갑상선우연종의 감별에서 초음파 지표점수의 민감도는 93.6%, 특이도는 52.8%, 양성예측율은 92.4%로 나왔고, 진단적 효율은 86.4% 였으며 크기 1.5 cm 이상의 양성 및 악성 갑상선 결정의 감별에서 초음파지수 민감도는 92.7%, 특이도가 42.9%, 양성 예측도 86%, 효율 82.6%를 보였다. 결론: 갑상선결절에서의 양성 및 악성의 유무는 임상적으로 판단하기 힘들지만 갑상선 결절에서의 초음파 소견 및 초음파 지표 점수를 도입하면 이에 대한 감별에 도움을 줄 수 있다. 따라서 갑상선 초음파검사시 초음파지표점수의 사용은 향후 갑상선 결절의 진단 방향을 제시하는 중요한 길잡이가 될 수 있으리라 사료된다.

임베디드 리눅스 기반의 영상처리기법에 관한 연구

원지운,정원교,홍원기,이용두 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.1

현재 embedded system에서 많은 기업체들이 리눅스를 채용하고 있고, 우리 생활에서 쓰이는 각종 전자기기, 정보가전, 제어장치 등에 적용되고 있다. 최근 멀티미디어 처리와 같은 점차 복잡한 기능이 요구되면서 임베디드 운영체제를 사용하기 시작하였고, 이러한 운영체제로 리눅스가 주목받게 되었다. 이는 가격 경쟁력뿐만 아니라 각 H/W에 따라 운영체제와 응용프로그램을 다양하게 변화시킬 수 있다. 본 논문에서는 CCD 카메라로부터 영상을 입력받아 압축하여 LCD 모니터에 출력하기 위한 임베디드 시스템 기반의 영상처리에 관해 기술한다. Recently, many industries adopts linux as an operating system for embedded system, which is commonly used in our life as the type of electronic machinery, electric home appliances and so on. The embedded operating system is getting more complex as lots of features such as multimedia are required. The operating system should be adjusted to the hard ware and software in order to satisfy a competitive price. In this paper, a operating system is discussed in order to compress the images form the CCD camera and then spread the LCD.

국내·외 관련 제도 및 실태분석을 통한 한국형 장애인 자립생활센터의 계획방향에 관한 연구

강지혜,윤영삼,김상운,성기창,박광재,강병근 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.2

The wealth of Korean disability people’s paradigm has developed by the meaning of whole rehabilitation of the small society for acception and protection. Today, that meaning has been changed to make and choose disability people’s future plans by themselves. The CENTER FOR INDEPENDENT LIVING in Korea has been accepted through the American and Japanese’s activity systems with no objection. Following result of the real reserching, because the CENTER FOR INDEPENDENT LIVING in Korea have no legal basement, so there are little support for these centers and no proper rules and check systems. Therefore, we have to make the legal basement of CENTER FOR INDEPENDENT LIVING and separate by each parts of system and to specialize about them. That means, each parts of system have to mark role mode for doing well, and each systems have to develop new programs and services, and to specialize for in Korea. To add, we should have more small CENTER FOR INDEPENDENT LIVING in each area, and the CENTER FOR INDEPENDENT LIVING which are already started should make network system to contact with other centers in society for giving support of proper information.

지적 통신 방식을 이용한 3차원 수화 통신 시스템

김상운,오지영,靑木 由直 明知大學校 産業技術硏究所 1999 産業技術硏究所論文集 Vol.18 No.-

In this paper we implement a sign-language communication system using the intelligent image communication in order to provide the deaf-mute with participating in the multimedia information society. At first, we transform the input Korean text into their sign language images. Then, the images are encoded and transferred by intelligent method in real-time. At last, the received parameters are decoded intelligently by computer graphics techniques to reconstruct the sign language images. The proposed system is implemented with Windows NT Visual C++ 5.0 with Open Inventor library. Experimented results show that the system could be used efficiently.

프로스타글란딘 E₁에칠에스테르의 외용 리오겔 제제 설계

양성운,이진교,이지은,김희규,박혜숙,김종석,최한곤,용철순,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

External lyogels containing prostaglandin E₁ethyl ester(PGE₁-EE), a produrg of prostaglandin E₁(PGE₁) as a therapeutic agent for erectile dysfunction, were formulated to overcome the aqueous instability and enhance the percutaneous absorption. Lyogels of PGE₁-EE were prepared with ethanol (EtOH)/proplyene glycol (PG) cosolvent system as a vehicle, cineol as an enhancer, and hydroxypropylcellusose as a gelling agent. In vitro percutaneous absorption studies were performed to determine the rate of PGE₁ absorption through rat or hairless mouse skin. The permeability of PGE₁-EE lyogel with enhancer was 16-fold greater than that of lyogel without enhancer. Cosolvent produced 9-fold increase in percutaneous absorption. Pharmacodynamic effects of lyogels were evaluated in mature male cats in terms of intracavernosal pressure (ICP). Lyogles containing 0.01% of PGE₁-EE showed higher ICP compared to intraurethral preparation of PGE₁(1%) and enhancer-free control lyogel. The shelf-life (t_(10%) of lyogel at refrigerated condition (4℃) was calculated as 928 days, which is 4.2 times longer than that of control hydrogel. As a result, PGE₁-EE was formulated successfully to a lyogel system with a selective enhancer and cosolvent system for the topical delivery of PGE₁.

INVERTED MATTRESS SUTURE를 이용한 선천성 이개연골 변형의 교정

하지운,최병욱,서인석 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

There are many kinds of congenital auricular deformities but some congenital deformities have no lack or excess of cartilage, which are mild to a moderately constricted ear, cryptotia and Stahl's ear etc. Even if some kinds of surgical treatments, such as cartilage graft, cartilage turn over and cartilage flap were reported for the correction of them but they were comlex and sometimes unsatisfactory. The method of inverted mattress suture to correct the cartilage deformities is not a new method and some authors reported it previously to correct ear cartilage deformities. Authors have tried to correct several kinds of congenital ear deformities, 2 constricted ears, 5 cryptotias, 2 stahl's ears. 1 satyr ear by using of simple inverted cartilage mattress suture and added Z-plasty or V-Y advancement to corrcet the auricular skin in each cases, respectively. The result was promising without recurrences during average 3 months folloe up periods. This method is immediative, simple, easy to perform and a very useful procedure for the correcton of congenital ear auricular cartilage deformities.

肺炎 誘發菌의 生育을 抑制하는 韓藥材 探索에 關한 硏究

정병운,서운교,정지천,한영환 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

韓藥材 중 肺炎의 치료효과가 기대되는 淸熱化痰, 止咳平喘藥을 중심으로 23種의 藥材를 사용하여 肺炎을 유발하는 K. pneumoniae, S. pyogenes 및 S. pneumoniae 세균의 생육을 억제하는 藥材를 탐색하고, 탐색된 藥材의 추출물에 대한 세균의 最小生育抑制濃度를 측정하였다. 韓藥材의 水溶性 추출물 중 黃連, 胡黃蓮, 敗醬, 黃芩이 K. pneumoniae에서, 黃連이 S. pyogenes에 대해서 생육억제 효과가 있었으며, S. pneumoniae에 대한 比較沮止環의 直徑은 黃連, 鳥梅, 五味子, 黃芩이 우수하였으나 黃連 추출물 사용시 병원균 모두에서 生育沮止環의 크기가 가장 크게 나타났으며 對照群로 사용된 大腸菌과 枯草菌에서도 어느 정도의 抗細菌 효과를 볼 수 있었다. 에탄올 추출물에서는 敗醬, 黃芩, 五味子, 鳥梅가 K. pneumoniae 세균의 생육을 억제하였으며, S. pyogenes 세균은 黃連, 五味子, 鳥梅, 馬兜鈴찾, 黃芩에 의하여 생육이 억제되어 黃連은 水溶性 및 에탄올 溶解性 주출물에서 모두 우수한 抗細菌 효과를 보여주고 있다. 각 세균에 대한 最小生育沮止濃度(MIC)는 K. pneumoniae 세균일 경우 黃連 및 黃芩의 水溶性 추출물과 鳥梅 및 敗醬의 에탄올 溶解性 추출물이 유의성을 보였으며, S. pyogenes 세균은 黃連의 水溶性 및 에탄올 溶解性 추출물과 鳥梅의 에탄올 溶解性 추출물, S. pneumoniae 세균은 黃連과 鳥梅의 水溶性 및 에탄올 溶解性 주출물에서 유의성이 나타났다. 이상의 결과를 통하여 黃連, 五味子, 鳥梅, 黃芩, 胡黃蓮, 敗醬의 水溶性 및 에탄올 溶解性 추출물이 肺炎 誘發菌f K. pneumoniae, S. pyogenes, S. pneumoniae에 對하여 우수한 生育抑制 作用을 나타냄을 알 수 있었다. The various oriental herbal medicines, which have usually been used for treatment of reducing fever, purging intense heat and detoxication, were screened to determine the antibacterial activity and the minimal inhibitory concentration against pulmonary disease-causing Klebsiella pneumoniae, Streptococcus pyogenes, and Streptococcus pneumoniae. The results obtained were as follows: 1. Among the 23 oriental medicines tested, the water-soluble extracts of Coptis japonica, Scutellaria baicalensis and Picrorrhiza kurroca showed the antibacterial activity against K. pneumoniae and that of C. japonica against S. pyogenes. The antibacterial activities of C. japonica, Prunus mume, Schizandra chinesis, Scutellaria baicalensis were also found against S. pyogenes. When C. japonica was used, the high antibacterial activity was shown against Bacillus subtilis and other extracts showed a little activity against B. subtilis and E. coli as a control. 2. The ethanol-soluble extracts of Patrinia scabriosaefolia, P. mume, S. baicalensis, S. chinensis showed the antibacterial activity against K. pneumoniae and those of S. baicalensis, C. japonica, S. chinensis P. mume against S. pyogenes and S. pneumoniae. However, those extract showed a little antibacterial activity against B. subttilis and E. coli except for that the extract of C. japonica showed comparatively high growth inhibition of B. subtilis. 3. Among the medicinal herbs tested, the water- and ethanol extracts of C. japonica showed very extcellent antibacterial activity against the pathogenic bacteria and controls. 4. When the water-soluble extracts of C. japonica and S. baicalensis, minimal inhibitory concentrations (MICs) against K. pneumoniae were 10 ㎎/㎖ and 22 ㎎/㎖, respectively. The MICs of the ethanol-soluble extracts of P. mume and P. scabriosaefolia were 5 ㎎/㎖ and 20 ㎎/㎖, respectively. 5. For the MICs against S. pyogenes, C. japonica showed 15 ㎎/㎖ with the water-soluble extract and P. mume and C. japonica with the ethanol-souble extract did 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. 6. For the MICs against S. pneumoniae, C. japonica and P. mume with the water- and ethanol-souble extract showed 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. As a result, the highest antibacterial activity was found in the water- and ethanol-soluble extracts of C. Japonica against pulmonary disease-causing bacteria, K. pneumoniae, S. pyogenes, and S. pneumoniae. Also, the water- and ethanol-soluble extracts of S, chinensis, P. mume, S. baicalensis and P. kurrooa showed high antibacterial activities.