Combination Effects of Essential Oils from Thymus species with Norfloxacin against Streptococcus pneumoniae

Kim, Ji-Hyun,Sim, Youn,Shin, Seung-Won 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

The combination effects of essential oils from Thymus quinquecostatus and T. magnus with norfloxacin were evaluated against three strains of Streptococcus pneumoniae. The checkerboard titer test results demonstrated significant combined effects of norfloxacin and the two Thymus oils or thymol, the main component of this oil, against the susceptible and resistant strains of S. pneumoniae, with FICIs ranging from 0.14 to 1.00. Additionally, the anti-Streptococcus effects of the oils were dose-dependent on Tryptic soy agar plates containing 5% defibrinated sheep blood.

Chlorpromazine으로 유발된 음경지속발기증 1례

신유호,윤도준,이충현,송지영,이상철 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.3

저자들은 항정신병약물 chlorpromazine 치료 중에 음경지속발기증이 발생하여 수술까지 시행하여 회복된 환자 1례를 체험하였기에 문헌고찰과 함께 보고하였다. 항우울제 trazodone과 함께 chlorpromazine, thioridazine과 같은 항정신병약물이 음경지속발기증의 원인과 관련이 있는 것으로 알려지고 있다. 이러한 약물에 의해 유발되는 음경지속발기증의 기전에 대해서는 알파-아드레날린 차단으로 인한다는 설이 많은 지지를 받고 있다. 치료는 보존적인 치료와 외과적인 치료가 있으며, 외과적인 치료로는 음경해면체 천자와 흡입 세척술 그리고 분로를 만들어 주는 방법들이 있다. 음경지속발기증은 신속한 진단과 치료를 하지 않을 경우 영구적인 발기불능을 초래할 수도 있는 부작용이므로 향정신약물 투여시 이에 대한 관심과 주의를 가져야 할 것이다. Antipsychotic drugs can induce several sexual side effects. Priapism, one of the side effects, is defined as "the persistent abnormal erection of the penis, which usually occurs without sexual desire". There has been an increasing number of reports recently linking the etiology of priapism with psychotropic medication. The drugs known to be associated with priapism are psychotropic drugs such as trazodone, chlorpromazine, thioridazine as well as antihypertensives, anticoagulants and so on. The mechanism of a drug which induces priapism is proposed to be mediated by its alpha-adrenergic blocking effect. Prompt diagnosis and treatment are essential. Priapism is a severe side effect, which can lead to impotence if prompt diagnosis and treatment are not carried out. There are medical and surgical treatments for priapism. The surgical treatments usually involve aspiration, irrigation and the creation of shunt. We report a case of priapism which developed after two years of chlorpromazine treatment. He is a 20-year-old man with schizophrenia. He experienced two times of brief episode of prolonged penile erection before developing intractable priapism. He was treated by shunt operation which showed satisfactory relief of priapism. It seemed by this case that duration and dosage of chlorpromazine were not closely related with priapism. Psychiatrist is needed to give attention to the priapism as one of sexual side effects due to antipsychotics though it is not common.

석면함유 슬레이트 지붕 물받이 퇴적물 중 석면 섬유 함유율

임지현,한솔민,김현석,신유민,박시은,허정윤,김민영,장봉기 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

This study attempted to determine the degree of asbestos release from the aging slate roof by comparing the asbestos content in the slate roof rain gutter with a colored steel plate (tin plate) over the slate roof. Four slate roof houses located in Haengmok-ri, Asan-si, Chungcheongnam-do, and one house constructed with a colored steel plate on the slate roof were selected to collect the sediment of the roof rain gutter. The asbestos fiber content was calculated by a point counting method using a polarization microscope after pretreatment with conversion treatment and hydrochloric acid treatment. The average asbestos content of the four slate roof rain gutter were 1.89%. However, asbestos was not detected in the Slate covering roof rain gutter, which were constructed on the slate roof. Asbestos fiber content was the highest at 2.89% in the slate roof rain gutter installed in 1976, followed by 2.44% in 1953. From the above results, it is necessary to minimize secondary damage as asbestos fibers released from slate roof houses to the surrounding atmosphere or leaked from slate roofs as rainwater may cause soil pollution and seriously affect residents' health. Although covering with colored steel plates (tin plates) has been shown to prevent the leakage of asbestos fibers to some extent, it is believed that a policy alternative to remove the slate roof as soon as possible is needed to solve the fundamental problem.

층상구조 산화물 Na_(x)Ni_(x/2)Ti_(1-x/2)O₂의 합성과 구조적 특성

신유주,곽지현 가톨릭대학교 자연과학연구소 1998 자연과학논문집 Vol.19 No.-

층상구조 산화물 Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤X≤1.0)이 고상합성법에 의해 Ar 분위기하에서 950℃-1100℃로 가열하여 합성되었다. 단일상 영역은 0.75≤x≤1.0에서 rhombohedral(O3), 0.60≤x≤0.75에서는 primitive hexagonal 상(P2)으로 결정되었고, x<0.60은 층상구조와 함께 pruderite 구조상이 공존하는 혼합상 영역이었다. 격자상수 a는 x가 감소함에 따라 단순감소 하였고 c는 반대로 증가하는 것이 관측되었는데 이는 Ni^(2+)와 Ti^(4+) 이온 반경의 차, (Ni/Ti)O₂ 층간의 정전기적 반발력, (Ni/Ti)O_(6) 정팔면체의 trigonal distortion 정도와 관련지어 논의되었다. O3에서 P2로의 구조전이 과정은 (Ni/Ti)-O와 Na-O간 경쟁적인 공유-이온 결합성의 변화에 기인하는 것으로 이해되었다. Na_(0.67)Ni_(0.33)Ti_(0.67)O₂의 경우 Rietvelt 분석법을 이용하여 그 결정구조를 결정하였다. Layer-type oxides Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤x≤1) have been prepared for the first time by solid-state reaction by heating the appropriate mixtures of starting materials at 950℃-1100℃ under Ar ambience. Two consecutive single phases were observed, rhombohedral(03) phase for 0.75≤x≤1.0 and hexagonal one(p2) for 0.60≤x<0.75, and a mixed-phase appeared including pruderite phase with x<0.60. Lattice parameter a decrease with x, while c increases as x diminishes. Such behaviors have been discussed on the basis of the difference of ionie radii between Ni^(2+) and Ti^(4+), the electrostatic repulsion of (Ni/Ti)0₂ slabs and the evolution of trigonal distortion of (Ni/Ti)0_(6) octahedra. Structural transition from 03 to P2 has been understood due to the competitive iono-covalency between (Ni/Ti)-0 and Na-0 bonds. As for Na_(0.67)Ni_(0.33)Ti_(0.67)O, the crystal structure has been determined by the Rietveld profile-analysis method.

복귀돌연변이시험을 이용한 이온화에너지 처리 우유 및 아이스크림의 유전독성학적 평가

유지숙, 한선경, 신명수, 구본철, 최지현, 이주운, 조철훈, 함준상, 이완규 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.1

본문참고

난원공 개존을 통한 우심방에서 좌심방으로의 단락 진단에 있어 경흉부 심초음파 하모닉 영상의 유용성

신미승,강석민,장길진,변기현,하종원,정남식,허지회,이병인 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

중학교 가정교과의 열린교육 활성화를 위한 수업 모듈 및 웹 기반 교육자료 개발

신상옥,유태명,한규정,윤지현,홍정숙,김유정,양정혜 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3

This study is about open and secondary level Home Economics Education which is applicable to field and which includes the characteristics, purpose and problems of each open education. secondary education and home economics education. Based on the ideology of open education, this study will identify the meaning of openness in terms of Home Economics Education reconstructing meaning. purpose, characteristics, curriculum paradigm and curriculum. The instructional model and module which use web, will be Presented as the results of the reconstruction works. The open instructional module in Home Economics Education, which will be operated on the web, is consisted of 1)setting the orientation of curriculum development, 2)instructional model development. 3)rebuilding the Home Economics Education curriculum 4)development of instructional modules and web-based materials and 5)construction of the web-site . Six instructional module begin with critical/emancipatory curriculum Paradigm in open Home Economics Education. use module as a unit of class management instead of 1 class. facilitates nest-type integration which is applied from open education keeping the nature of Home Economics Education. and focus on practical problem and problem solving through reconceptualization with dialectical perspective on individual, family and society. The practical problem solving model has four steps : Identifying practical problems. Understanding the contexts of Problem, Searching for solutions and examining its consequences . Action and evaluation . The web-site has to be developed based on the six instructional module includes those issues : self-identification for reinforcing autonomy and self-esteem. living with famity. living with friends, autonomous living. healthy living, and understanding sexuality.

국내 의학용 스마트폰 앱의 분류 및 분석

신지윤, 김우현, 이태수 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

-본문참고-

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.