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( Ji Hyun Lee ),( Jeong In Lee ),( So Yeon Park ),( Yoo Kyeong Jang ),( You Bin Lim ),( Hye Yoon Lee ),( Young Min Jung ),( Hae Chang Lee ),( Jong Hwa Lee ),( Shaheen Amna ),( Jae Kweon Park ) 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.1
The present study was aimed to isolate the bacteria producing chitinolytic enzymes including chitin deacetylase (CDA) from soil origin. About 24 bacteria were screened for their chitinolytic enzymes producing ability on the basis of colloidal chitin. Amongst one of the most potent isolates designated to JI-02 was further selected as the most prominent chitinolytic and CDAlike enzyme (CDA-X) producer based on the ability of deacetylation of an artificial substrate pNP-acetamilide. The maximum production of CDA-X in crude enzyme from JI-02 was observed in the presence of 1% colloidal chitin at 37°C and pH 6.4 after 120 h of incubation. Potent enzyme activity of CDA-X was determined toward pNP-acetamilide, demonstrating that optimal pH, temperature and ionic strength of the CDA-X were assessed to be 7.0, 52°C and 125 mM, respectively. Unexpectedly, Nacetylglucosamine (GlcNAc) was not fully converted by the action of CDA-X to glucosamine (GlcN) under the established conditions. Further study on enzyme activity toward chitin-oligosaccharides consisting of multi-N-acetylglucosamine (GlcNAc)n, n=2-5 may be necessary to elucidate the mode of action which requires the minimum size of (GlcNAc)n. However, our data suggest that CDA-X can convert chitin to chitosan with the maximum yield of approximately 0.08g/L during the fermentation of the strain in the presence of chitin. Furthermore, we found that crude enzyme showed the significant chitosanolytic activity. Taken together, our data suggest that the strain JI-02 may be a potential candidate as a particular strain for better understating of chitin catabolic pathway.
이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1
In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.
중학교 가정교과의 열린교육 활성화를 위한 수업 모듈 및 웹 기반 교육자료 개발
신상옥,유태명,한규정,윤지현,홍정숙,김유정,양정혜 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3
This study is about open and secondary level Home Economics Education which is applicable to field and which includes the characteristics, purpose and problems of each open education. secondary education and home economics education. Based on the ideology of open education, this study will identify the meaning of openness in terms of Home Economics Education reconstructing meaning. purpose, characteristics, curriculum paradigm and curriculum. The instructional model and module which use web, will be Presented as the results of the reconstruction works. The open instructional module in Home Economics Education, which will be operated on the web, is consisted of 1)setting the orientation of curriculum development, 2)instructional model development. 3)rebuilding the Home Economics Education curriculum 4)development of instructional modules and web-based materials and 5)construction of the web-site . Six instructional module begin with critical/emancipatory curriculum Paradigm in open Home Economics Education. use module as a unit of class management instead of 1 class. facilitates nest-type integration which is applied from open education keeping the nature of Home Economics Education. and focus on practical problem and problem solving through reconceptualization with dialectical perspective on individual, family and society. The practical problem solving model has four steps : Identifying practical problems. Understanding the contexts of Problem, Searching for solutions and examining its consequences . Action and evaluation . The web-site has to be developed based on the six instructional module includes those issues : self-identification for reinforcing autonomy and self-esteem. living with famity. living with friends, autonomous living. healthy living, and understanding sexuality.
P108 : Histopathological features in psoriasis and seborrheic dermatitis of the scalp
( Ji Hye Park ),( Sue Kyung Kim ),( Ji Eun Kwon ),( You Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: The differential diagnosis between seborrheic dermatitis and psoriasis of the scalp can be difficult due to their similarity of clinicopathological features. Objectives: We tried to find favorable criteria for histopathological differential diagnosis of psoriasis and seborrheic dermatitis of the scalp. Methods: Eight cases of psoriasis and Twenty cases of seborrheic dermatitis of the scalp were evaluated clinically and histopathologically. Results: In the psoriasis group, 2 women and 6 men were included with an age range from 8 to 63 years. In the seborrheic dermatitis group, 8 women and 12 men were included with an age range from 16 to 79 years. The histological features showed an increased number of mitotic figures in psoriasis compared with seborrheic dermatitis (p < 0.05); follicular plugging was more common in seborrheic dermatitis than in psoriasis (p < 0.05); clubbed and even lengths of rete ridges were more common in psoriasis than in seborrheic dermatitis (p < 0.05). There were no significant differences in the amount of plasma within parakeratosis, dilatation of infundibulum, epidermal spongiosis, lymphocytic exocytosis, edema of papillary dermis, and solar elastosis. Conclusion: We suggest difference in mitotic figures would be helpful in the differential diagnosis between psoriasis and seborrheic dermatitis of the scalp: more than 5 mitotic figures in 3 high power fields favors the diagnosis of psoriasis, whereas less than 3 suggests seborrheic dermatitis.
Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp
( Ji Hye Park ),( Young Joon Park ),( Sue Kyoung Kim ),( Ji Eun Kwon ),( Hee Young Kang ),( Eun So Lee ),( Jee Ho Choi ),( You Chan Kim ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4
Background: The differential diagnosis of psoriasis and seborrheic dermatitis can be difficult when both conditions are localized to the scalp without the involvement of other skin sites. Objective: We aimed to evaluate the histopathological differences between psoriasis and seborrheic dermatitis on the scalp and identify favorable criteria for their differential diagnosis. Methods: We evaluated 15 cases of psoriasis and 20 cases of seborrheic dermatitis of the scalp that had been clinicopathologically diagnosed. Skin biopsy sections stained with H&E were examined. Additional immunohistochemistry was performed, including Ki-67, keratin 10, caspase- 5, and GLUT-1. Results: On histopathological examination, mounds of parakeratosis with neutrophils, spongiform micropustules of Kogoj, and clubbed and evenly elongated rete ridges were significantly more frequently observed in psoriasis. Follicular plugging, shoulder parakeratosis and prominent lymphocytic exocytosis were significantly more common in seborrheic dermatitis. Moreover, significantly higher mitotic figures were observed in psoriatic lesions than in seborrheic dermatitis. Immunohistochemistry did not show any difference between psoriasis and seborrheic dermatitis. Conclusion: Histopathological features favoring psoriasis include mounds of parakeratosis with neutrophils, spongiform micropustules of Kogoj, clubbed and evenly elongated rete ridges, and increased mitotic figures (≥ 6/high-powered field). Features indicating seborrheic dermatitis are follicular plugging, shoulder parakeratosis and prominent lymphocytic exocytosis. Immunohistochemistry was not helpful in differentiating psoriasis from seborrheic dermatitis. (Ann Dermatol 28(4) 427∼432, 2016)
P224 : Clinical and histopathologic characteristics of postinflammatory hyper- and hypopigmentation
( Ji Hye Park ),( Ji Eun Kwon ),( Hee Young Kang ),( Eun So Lee ),( You Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Inflammatory skin disease can cause clinical hypopigmentation, hyperpigmentation, or both. There have been only few studies of clinical and histopathologic characteristics of postinflammatory pigmentary alteration. Objectives: To investigate the clinical and histopathologic characteristics of postinflammatory hyper- (PIHyper) and hypopigmentation (PIHypo). Methods: A clinical survey was carried out with 16 patients diagnosed with PIHyper and 9 patients with PIHypo. Punch biopsies from lesional and perilesional normal skin were performed. The sections were stained with hematoxylin-eosin, Fontana-Masson. Immunohistochemistry for melanocytes was performed. Results: No predisposition of age and sex was found in the incidence of PIHyper and PIHypo. Among PIHyper patients, contact dermatitis (25.0%) was the most common previous inflammatory skin disease, while laser treatment (33.3%) was that of PIHypo patients. Histologically, hyperkratosis, acanthosis, vacuolar alteration, dermal inflammation, as well as pigmentary incontinence were observed variably in the PIHyper lesion. Hyperpigmentation was seen in suprabasal, basal, or dermal layer. However, significant change in the number of melanocytes was not observed in the majority of PIHyper lesions. In the most cases of the PIHypo, the melanocytes did not showed change in the number of melanocytes as well. Conclusion: Both clinical and histologic features should be considered together to make a diagnosis of PIHyper or PIHypo.