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김훈,조우진,안준석,조두희,김지혜,차용준 창원대학교 생활과학연구소 2003 생활과학연구 Vol.- No.7
The volatile compounds in natural sweet smelt were analyzed by liquid liquid continuous extraction/gas chromatography/mass spectrometry (LLCE/GC/MS) methods. A total of 64 compounds were detected in sample, and these were mainly composed of lipid oxidative compounds such as aldehydes, ketones, alcohols, acids and hydrocarbons besides terpens and aromatic compounds. Among these, 9-carbon compounds including (E)-2-nonenal, (E,Z)-2,6-nonadienal and (E,Z)-3,6-nonadien-1-ol were suspected to have a key role on odor of natural sweet smelt because these compounds have low odor threshold and water melon-like and melon-like odor, characteristic odor in sweet smelt.
감각통합기능장애에 대한 집중치료프로그램의 효과 : 사례보고
박지훈,노종수,이향숙,차정진 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.2
목적: 본 연구는 감각통합기능장애를 가진 아동을 대상으로 주간에 걸친 집중치료프로그램을 제공하였을 때 미치는 효과를 알아보기 위한 것이며, 사후 평가를 통하여 감각통합기능의 유지 여부를 알아보았다. 연구방법: 단일사례연구로써 2주간 9회기 1회기에 40분씩 치료접근을 실시하고, 가정에서 Sensory diet와 더불어 Wilbarger Protocol을 실시하였다. 초기평가와 1차 재평가 사이의 시간은 15일이며, 5개월 후 2차 재평가를 실시하였다. 결과: 집중치료프로그램 적용 후, 아동은 전반적인 감각영역에서 감각방어가 감소되었고 자기조절 (수면, 각성)이 향상되었다. 또한 실행과 시-지각에서도 향상을 보였으며, 정서적 안정과 일상생활에서도 향상을 보였다. 프로그램 적용 5개월 후 감각조절능력, 안정적인 수면은 유지되고 시-지각에서도 지속적인 발달을 보였지만 정서적인 안정은 지속되지 않았다. 결론: 집중치료프로그램이 긍정적인 효과가 있음을 알 수 있었고, 집중치료프로그램 적용 후 치료적 접근이 없어도 대부분의 감각영역에서 감각조절능력을 유지할 수 있음을 알 수 있었다. Objective : The purpose of this study was to identify effects of intensive sensory integration (SI) treatment and home-program for a child who has a sensory integration disorder. This study also examined whether the positive effect is long-lasting by a follow-up test. Method : A boy with sensory integration dysfunction underwent an intensive SI treatment for 2 weeks. The intervention was consisted of 9 sessions and duration of the each session was 40 minutes. Sensory diet and Wilbarger protocol was provided as home program. The child's sensory function was evaluated before and after the SI intervention. Five month later, re-evaluation was executed for follow-up purpose. Results : In the evaluation after the Si intervention, the child's sensory defensiveness was decreased. Praxis, visual perception, sensory regulation dysfunction (sleep function), affective stabilization and performance of activities of daily living are also improved. In the re-evaluation after the 5 month later, the self-regulation ability, especially sleep function, has been maintained and the visual perception was developing continually. However, the child showed some affective regulation such as bothering his mother and losing his temper. Conclusions : The intensive SI intervention showed positive effects in terms of SI function improvement and the effect lasted long without any additional therapeutic intervention.
우미선(Miseon Woo),차지현(Ji Hyeon Cha),김용환(Yonghwan Kim),강희택(Hee-Taik Kang),김현덕(Hyeondok Kim),조경원(Kyong Won Cho),박성선(Sung Sun Park),이종훈(Jong Hun Lee) 한국식품과학회 2021 한국식품과학회지 Vol.53 No.1
숙취를 해결하기 위해서는 숙취를 직접적으로 유발하는 물질인 아세트알데하이드의 조절이 가장 중요한 인자로 작용한다. 숙잠을 함유하는 복합물인 시험식품(CKDHC)의 섭취로 혈중 아세트알데하이드 농도가 대조식품 대비 통계적으로 유의하게 감소하여 숙취개선 효능을 확인하였다. 특히, 30분부터 각 시간별(mg/L), 혈중 아세트알데하이드 농도-시간곡선하 면적(AUC), 최고 혈중 아세트알데하이드 농도(C<SUB>max</SUB>)의 감소를 통해 30분부터 빠른 숙취개선 효능을 확인하였다. 본 연구의 주원료로 사용된 숙잠은 Ji등(2016a)에 따르면 18종의 아미노산 및 무기질을 모두 함유하며, 고단백 식용곤충으로 간에 좋은 주요 아미노산인 Alanine, Arginine 등을 많이 함유하여 간의 효소활성에 긍정적인 영향을 줄 수 있음을 알수있다. 본 연구결과를 통해 숙잠을 함유하는 시험식품이 숙취해소제로 작용할 수 있으며, 특히 음주 전 섭취시 아세트알데하이드를 빠르게 분해하여 30분부터 숙취 개선에 효과가 있음을 입증하였다. Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
Cha, Ji Hun 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4
Dlx3 is a homeodomain protein and is known to play a rolein development and differentiation of many tissues. Deletionof four base pairs in DLX3 (NT3198) is causally related totricho-dento-osseous (TDO) syndrome (OMIM #190320), agenetic disorder manifested by taurodontism, hair abnor-malities, and increased bone density in the cranium. Themolecular mechanisms that explain the phenotypic charac-teristics of TDO syndrome have not been clearly determined.In this study, we examined phenotypic characteristics ofwild type DLX3 (wtDlx3) and 4-BP DEL DLX3 (TDO mtDlx3)in C2C12 cells. To investigate how wtDlx3 and TDO mtDlx3differentially regulate osteoblastic differentiation, reporterassays were performed by using luciferase reporters containingthe promoters of alkaline phosphatase, bone sialoprotein orosteocalcin. Both wtDlx3 and TDO mtDlx3 enhancedsignificantly all the reporter activities but the effect ofmtDlx3 was much weaker than that of wtDlx3. In spite ofthese differences in reporter activity, electrophoretic mobilityshift assay showed that both wtDlx3 and TDO mtDlx3formed similar amounts of DNA binding complexes withDlx3 binding consensus sequence or with ALP promoteroligonucleotide bearing the Dlx3 binding core sequence.TDO mtDlx3 exhibits a longer half-life than wtDlx3 and itcorresponds to PESTfind analysis result showing thatpotential PEST sequence was missed in carboxy terminal ofTDO mtDlx3. In addition, co-immunoprecipitation demonst-rated that TDO mtDlx3 binds to Msx2 more strongly thanwtDlx3. Taken together, though TDO mtDlx3 acted as aweaker transcriptional activator than wtDlx3 in osteoblastic cells, there is possibility that during in vivo osteoblastdifferentiation TDO mtDlx3 may antagonize transcriptionalrepressor activity of Msx2 more effectively and for longerperiod than wtDlx3, resulting in enhancement of osteoblastdifferentiation.
Cha, Ji-Hun,Kim, YunHo,Sathish Kumar, Sarath Kumar,Choi, Chunghyeon,Kim, Chun-Gon Elsevier 2020 Acta astronautica Vol.168 No.-
<P><B>Abstract</B></P> <P>Space debris impacts at hypervelocity of several tens of km/s threaten the survival of space structures. In the case of International Space Station, the concept of Whipple shield is applied to protect the astronauts and the electronic devices from impact of space debris. In this study, a Whipple shield design comprising of ultra-high-molecular-weight polyethylene were proposed to improve the space debris impact shielding efficiency over conventional Whipple shields. Ballistic performance was evaluated by a two-stage lightweight gas gun capable of accelerating 5.56 mm diameter aluminum projectiles to 4 km/s. High-temperature impact tests and outgassing tests were performed for space environment application. Through the test, ultra-high-molecular-weight polyethylene was better ballistic performance and outgassing properties than Kevlar used in conventional Whipple shield. Ultra-high-molecular-weight polyethylene can be an effective way to provide cosmic radiation shielding and ballistic capability for future spacecraft designs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ballistic performance of UHMWPE was better than Kevlar. </LI> <LI> Space-temperature has degraded UHMWPE's ballistic performance. </LI> <LI> The outgassing properties of UHMWPE were superior to Kevlar. </LI> </UL> </P>