Alendronate가 백서에서 두개골 결손의 재생에 미치는 영향

정찬두,김정근,정현주 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.4

Previous studies have demonstrated an increase in bone mass and density with the use of bisphosphonate in osteoporosis. This agent acts as an inhibitor of osteoclastic activity, and results in increase of net osteoblastic activity. Currently, it has been reported that bisphosphonate has direct effect on osteoblast. This study was designed to evaluate the effect of alendronate on bone regeneration in defect of rat calvaria. The animals used for these experiments were 48 male rats, over 6-8 weeks old. They were divided into three groups according to the dose of alendronate(MK-217®, Merck, USA) administered. After the calvarial defects were surgically created, the rats received a peritoneal alendronate (0.25mg/kg) in group I, a peritoneal alendronate (1.25mg/kg) in group Ⅱ, and a peritoneal normal saline injection in the control group. Three and six weeks later, blood was sampled and evaluated for alkaline phosphatase activity. the animals were sacrificed for histological observation and histometric analysis of the level of bone formation. The alkaline phosphatase activity was similar in three groups at 3 weeks of experiment. The activity at 6 weeks increased more than twice, compared to 3 weeks, and was slightly higher in group Ⅰ than the other two groups. In histological observation, all the groups at 3 weeks, osteoblast rimming and new bone formation were observed along the defect margin. At 6 weeks, the defect was almost closed with new and more mature bone, but new bone is thinner than original bone in the central portion of defect. In histometric analysis, group Ⅰ and Ⅱ at 3 weeks showed significantly greater new bone formation than the control, and all the groups at 6 weeks showed similar amount of bone formation. These result suggest that alendronate administration in the dose of 0.25mg/kg and 1.25mg/kg promote osseous regeneration.

위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구

박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.

도시근린공원의 이미지와 이용만족도에 관한 연구

하영철,정수일,곽윤근,신현익,하헌정,김익환,김석만 金烏工科大學校 1999 論文集 Vol.20 No.-

This paper presents the future direction of the development and maintenance of the urban park of the Kumi city. The direction was obtained by analyzing the evaluation results on the satisfaction level of park use and the park image of the park users. The analysis results are as follows. 1) It turns out that the rest and accommodation facilities are the major facilities that uplifts the total image of the park. 2) Among the park images, the image on the pleasantness was the major image, related with the satisfaction on the park equipments. 3) The social class, who gave a bad score on the above equipments and images, is a low-aged class, who is a white class with high income as well. Therefore, it is suggested that the park maintenance plan, with emphasis on the class, is an important task.

대학생의 개인재무관리역량

이슬기, 박현정, 김민정 충북대학교 생활과학연구소 2012 생활과학연구논총 Vol.16 No.1

The purpose of this study is to measure financial competency of students in Chung-buk national university. The financial competency included financial attitude, financial knowledge, and financial skills. The major findings are as follows: First, as the financial management competency of university students, their attitude towards financial management was 75 points, knowledge in financial management was 68.5 points, and financial management skill was 59.9 points. Second, male students showed higher scores than female students in all areas. Third, students in the fields of medicine, education, and laws showed higher levels of financial management knowledge yet their financial management skill was low. Forth, students who receive allowances from parents showed high points of attitude towards financial management yet their financial management skill was low. Those who receive allowances from people that are not parents showed lower points in the attitude towards financial management or the knowledge than those who do not receive allowances. Fifth, students who spend money they earned showed higher points in every area than other students’ points. Finally students who received financial education showed similar or lowered points in financial management attitude and financial management knowledge with students who did not receive the financial education. However, the level of their financial management function was higher. Students who have saving accounts, periodicaldeposits, fixed deposits, a check card, or debit card showed higher levels of financial management knowledge and function that those who do not have the above items.

잔류응력 완화 중 나노접촉 형상의 천이거동 모델링을 통한 DLC 박막의 잔류응력 평가

李潤熙,池源宰,鄭增鉉,權東一 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.7

Assessment of residual stress is an important point to prevent the failures of thin film devices. Nanoindentation technique was proposed as a stress-measuring method of thin film in a previous research. However, the stress-analyzing model used at the previous research had the problems of a partial deformation-irrelative stress interaction concept and no consideration of the change in the contact area during continuous stress relaxation. Therefore, we modified the model by analyzing a new residual stress-induced normal load based on deformation-dependent shear stress component and by calculating the continuous relaxation procedure as an integration method. The modified model was applied to evaluate the residual stresses in two diamond-like carbon films. The evaluated residual stresses from the newly modified model were more consistent with the results from the conventional curvature method than those from the earlier model.

정전기력 구동 마이크로 액츄에이터를 이용한 Si 소재 탄성특성의 온도의존성 평가

鄭聖勳,李世昊,鄭增鉉,權東一 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.8

Electrostatically actuated testing devices were used to estimate the elastic modulus of single-crystalline Si for microeletromechanical systems. The devices were moved laterally by alternating electrostatic force at a series of frequencies, and then a resonance frequency was determined, with temperature cycling, by detecting the maximum displacement. The elastic modulus was calculated from the detected resonance frequency by Rayleigh's energy method. The elastic modulus decreased with heating and then increased with cooling, but after thermal cycle the specimen showed a permanent change to a value lower than the initial one. This phenomenon can be explained, to some extent, by the temperature-dependent variation in interatomic force of Si atoms, but the permanent change in elastic modulus implies that it may also be caused by the formation of a thermal oxide layer on the Si with increasing temperature. Composite bending theory was invoked to analyze the oxide effect and the thickness of the oxide layer formed during thermal cycling was estimated from the permanent change in the resonance frequency. The existence of the oxide layer was confirmed by field emission scanning electron microscopy. Finally, the method for compensating the decreasing elastic modulus with increasing temperature were proposed by using the temperature coefficient of elastic modulus.

Quality Characteristics of Jeung-pyun Using Dry-Milled Rice Flour

Ji Won Park,Yoon Jeung Lee,Min Young Kim,Myeong Seob Song,Hyun Ah Oh,Park Gi Hoon,Sun Young Choi,Heon Sang Jeong 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

마이크로 인장시험법을 이용한 단결정 실리콘의 파괴강도에 미치는 공정 및 크기효과 평가

이성훈,김종진,정증현,김동원,권동일 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

The process and size effects on the fracture strength of single-crystal Si were evaluated using a microtensile testing method. The microtensile specimens of single-crystal Si films were fabricated by CMP(chemical-mechanical polishing) and micromachining processes, The microtensile test setup was built to accommodate requirements such as specimen handling, jig, alignment and very small loads and displacements. The variations in the fracture strength with thickness and effective volume of the Si film were evaluated. In addition, the results were discussed statistically. The effects of dry-etched surface and CMP surface on the mean fracture strength were compared. Through AFM (atomic force microscopy) observation, it could be found that the larger flaws of the dry-etched surface affected significantly on the decreasing of the mean fracture strength.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.