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Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
Kim, Myung-Gyou,Choi, Jae-Hwan,Lim, Jong-Pil,Kim, Dae-Keun,Shin, Tae-Yong,Boo, Yungmin,Kim, Sun-Yeou,Kim, Hocheol,Ha, Eunyoung,Park, Hun-Kuk,Kim, Jeongseon,Lim, Ha-Sup,Kim, Ee-Hwa,Kim, Jeung-Beum,Leem Informa UK (TaylorFrancis) 2007 Neurological research Vol.29 No.suppl1
Kim, Jeongseon,Kim, Mi Kyung,Lee, Jae Kwan,Kim, Jae-Hoon,Son, Sung Kyong,Song, Eun-Seop,Lee, Kwang Beom,Lee, Jung Pil,Lee, Jong Min,Yun, Young Mi Routledge 2010 Nutrition and cancer Vol.62 No.2
<P> Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, &bgr; -carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, &bgr; -carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, &bgr; -carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.</P>
Jeongseon Kim,Mi-Hyeon Jang,김창주,Ee-Hwa Kim,Myung-Gyou Kim,Kang-Hyun Leem 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
The roots of Platycodon grandiflorum, which belongs to the Campanulaceae family, have been used as a foodmaterial and as a traditional Oriental medicine. The effect of P. grandiflorumagainst lipopolysaccharide (LPS)-stimulated in-flammation was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E2 (PGE2) immunoassay, nitric oxide (NO) detection assay, and interleurkin-8 (IL-8) immunoassay on BV2 microglial cells. The aqueous extract of P. grandiflorumwas shown to suppress PGE2 synthesis andNO production by inhibiting LPS-stimulated cyclooxygenase (COX)-2 activity and expression of inducible NO synthase(iNOS) mRNAs. In addition, the treatment with P. grandiflorumreduced the LPS-induced IL-8 release. These results suggestthat P. grandifloruminhibits PGE2 and NO production through its suppression of LPS-induced COX-2 and iNOS expression,and also reduces IL-8 secretion by microglial cells.
Dietary Habits and Lifestyle Factors in Relation to Sa-Sang Constitution
Kim Jeongseon,Kang Hye-Jung,Kim Ee-Hwa The Korean Nutrition Society 2005 Nutritional Sciences Vol.8 No.2
According to Sa-Sang constitution, people can be classified into 4 types, Tae-Yang-In, Tae-Eum-In, So-Yang-In, and So-Eum-In. 1he purpose of this study was to examine any significance between types of Sa-Sang constitution and dietary factors. Physical and constitutional examinations as well as a questionnaire survey were conducted on a group of 483 college students. Among the group of 483 college students, only 428 subjects were determined to have identical constitution through both the questionnaire survey and Korean traditional medical doctors' inquiries. Of 428 subjects, $29.7\%$ were determined to be Tae-Eum-Ins; $35.5\%$ were identified as So-Yang-Ins; $34.8\%$ were classified as So-Eum-Ins. Tae-Eum-Ins showed a statistically significant difference in BMI and higher smoking rate in comparison with groups of So-Yang-Ins and So-Eum-Ins. So-Eum-Ins had a tendency to take vegetables and fruits more often but they had lower preferences for balanced diets. Tae-Eum-Ins showed higher propensity to eat a visible fat protein. In terms of degrees of doneness of meat, So-Yang-Ins showed a higher tendency to prefer well-broiled meat Tae-Eum-Ins also tended to have significantly higher iron, potassium, sodium, vitamin $B_1$, niacin, $\beta$-carotene and vitamin E in their diet So-Eum-Ins had significantly lower intakes of protein, phosphorous, and folate. Considering the fact that most chronic degenerative diseases could be developed by any lifestyle factors, it is necessary to conduct educational programs about lifestyles including dietary habits for maintaining good health; On the basis of the results of this study, it is expected that the scientific, objective and accurate diet information depending upon individual's type of constitution will be provided.
Effects of a Raw Diet on Plasma Glucose and Lipid Levels in Streptozotocin-induced Diabetic Rats
Kim, Jeongseon,Park, Jun-Young,Kim, Sunggoo The Korean Nutrition Society 2003 Nutritional Sciences Vol.6 No.3
This study investigates the effects of a raw diet (RD) on blood glucose and lipid metabolism in non-diabetic (normal) and streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley vats were assigned to four groups (normal control, normal RD, diabetic control, and diabetic RD), for the four-week experimental period. The control groups were fed the AIN diet and the RD groups were fed a diet consisting only of raw materials. Weight gain was statistically lower in the RD group than the control. fasting plasma glucose was significantly lower in the diabetic RD group compared to the diabetic control group. The levels of triglycerides (TG), and of total cholesterol (TC) and LDL-cholesterol in the plasma, were lower in the RD groups than the control groups, but not significantly. There was a statistically significant decrease in the levels of TG and TC in the livers of the diabetic RD group, compared to the diabetic control group. The fecal levels of total lipids, TG, and TC were significantly higher in the RD groups, compared to the non-RD groups. It can be postulated that this raw diet may possess substantial hypoglycemic/hypolipidemic properties in diabetic rats.
Kim, Jeongseon,Park, Jun-Young,Kim, Sunggoo The Korean Nutrition Society 2004 Nutritional Sciences Vol.7 No.1
This study was performed to investigate the effect of a raw diet (RD) on blood glucose and immune function in non-diabetic (normal) and streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were assigned to four groups (normal control, normal RD, diabetic control and diabetic RD). The control groups and the RD groups were fed an AIN-diet and RD for four weeks, respectively. Weight gain was statistically lower in the RD groups than in the controls. Fasting plasma glucose was significantly lower in the diabetic RD group than in the diabetic control group. The $CD4^+$ T-cell population was higher along with the $CD4^+/CD8^+$ ratio of the mesenteric lymph nodes in the normal RD group compared to the other groups. It can be concluded that RD may reduce the plasma fasting glucose concentration in diabetic rats and improve mesenteric lymph node immune function in normal rats.