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온실에서 동양란인 심비디움 재배에 공생균의 효과에 관한 연구
이상선,이준기,이정우,박소영,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-
The orchid symbiotic fungus (Tulsanella repens P-01; OSF) was cultured on the soil materials by solid culture and inoculated in the two varieties of GwanUm and SaGae of Cymbidium hybrids with the barks. The two varieties of the oriental orchid were measured after 12 months' cultivation under the conditions of greenhouse; fresh weight, numbers of bulb, and rate of dead bulb for an individual plant. The fresh weight of plants were measured to be different for the individual plant. The fresh weight of plants were measured to be different for the individual plants treated with the OSF or not, depending on the varieties, but the rates of dead bulb were significant, disregarding with the varieties. The roots of the plants treated were observed to be more health and heavier weight than those not treated. The bulbs of the plants not treated were measured to be dead at the rate of 20% for a year's cultivation. The roots of two varieties were also observed by naked eyes and by microscope; Several peletons were observed to be in the root cells in the individual plants treated with OSF, but not in the individual plants treated without the OSF. Further, the pathogenic fungal hyphae were observed to be in the roots under the dead bulbs of both varieties not treated; appessorium or hasutorium on the epidermal cells of root. The inoculation of OSF was speculated to stimulate the growth of plants by absorption of mineral nutrition and defense the invasions of soil pathogenic fungi for the cultivations of Cymbidium hybrids.
Park, Jeong Youp,Kim, Hee Man,Choi, Yun Ah,Jeon, Tae Joo,Oh, Tae-Hoon,Kim, Chang Hoon,Youn, Young Hoon,Bang, Seungmin,Kim, Hyung Gil,Lee, Don Haeng,Shin, Yong Woon,Song, Si Young G. Thieme 2010 Hepato-gastroenterology Vol.57 No.101
<P>BACKGROUND/AIMS: Wireless capsule endoscopes (CEs) have become a useful diagnostic tool for small bowel diseases, but they may fail to examine the entire small bowel. We analyzed the clinical experience of the MiRo CE in patients with suspected small bowel disease to assess whether longer operation time could increase the complete examination rate of the small bowel and diagnostic yield. METHODOLOGY: A total of 96 patients with suspected small bowel disease received CE examination at 4 tertiary hospitals in Korea. The recorded information was uploaded to a computer and analyzed by the physicians responsible for each patient. RESULTS: The average total capsule operation time was 11 hours and 39 minutes (range: 5 hours 18 minutes approximately 12 hours). In 87 (90.6%) out of 96 cases, the CE was able to explore the entire small bowel. In 32 cases (33.3%), it took more than 8 hours to reach the cecum. Capsule retention occurred in 2 cases (2.1%). The CE found meaningful small bowel lesions in 62 (64.6%) out of 96 total cases. CONCLUSIONS: A CE with a long operation time had more chance to explore the entire small bowel even in patients with suspected small bowel disease.</P>
Up-regulated claudin 7 expression in intestinal-type gastric carcinoma.
Park, Jeong Youp,Park, Kyung Hwa,Oh, Tae Yun,Hong, Sung Pil,Jeon, Tae Joo,Kim, Chang Hoon,Park, Seung Woo,Chung, Jae Bock,Song, Si Young,Bang, Seungmin National Hellenic Research Foundation 2007 Oncology reports Vol.18 No.2
<P>The disruption of tight junction protein expression in cancer might account for invasiveness, loss of cohesion, and lack of differentiation. Our cDNA array data indicated that claudin 7 was up-regulated in gastric carcinoma. We investigated the expression patterns and clinical implications of claudin 7 in gastric cancer. By immunohistochemical staining and Western blot, claudin 7 was significantly more often expressed in intestinal metaplasia, adenoma and cancer than in normal gastric epithelium. Twenty-seven (47.4%) of 57 normal gastric epithelium samples did not express claudin 7, but 50 (86.2%) of 58 intestinal metaplasia, 11 (91.7%) of 12 adenoma tissues, and 129 (82.7%) of 156 cancer samples did. Claudin 7 was more often unexpressed in diffuse type gastric cancer than in intestinal type. Only 13 (11.2%) of 116 intestinal type samples did not express claudin 7, but 14 (41.2%) of 34 diffuse type samples showed no expression. Compared to normal gastric epithelium, intestinal type gastric cancer significantly more often expressed claudin 7, but diffuse type did not. The expression pattern of claudin 7 did not change as cancer progressed. In this study we show that claudin 7 expression changed with the gastric carcinogenic process and that this is implicated in cancer characteristics.</P>
Long-term follow up of gallbladder polyps
Park, Jeong Youp,Hong, Sung Pil,Kim, Yoon Jae,Kim, Hong Jeoung,Kim, Hee Man,Cho, Jae Hee,Park, Seung Woo,Song, Si Young,Chung, Jae Bock,Bang, Seungmin Blackwell Publishing Asia 2009 Journal of gastroenterology and hepatology Vol.24 No.2
<P>Abstract</P><P>Background and Aim: </P><P>The management of gallbladder polyps (GBP) is directly linked to the early diagnosis of gallbladder cancer (GBC). This study aimed to evaluate the malignant risk of GBP.</P><P>Methods: </P><P>In total, 1558 patients diagnosed with GBP were followed. Neoplastic polyps were defined as GBC and its premalignant lesions. The risk for malignancy was estimated with the cumulative detection rate of neoplastic polyps.</P><P>Results: </P><P>Thirty-three cases (2.1%) were diagnosed with neoplastic polyps. The cumulative detection rates of neoplastic polyps were 1.7% at 1 year, 2.8% at 5 years, and 4% at 8 years after diagnosis. The size of GBP and the presence of gallstones were risk factors for neoplastic polyps. Polyps ≥ 10 mm had a 24.2 times greater risk of malignancy than polyps < 10 mm. However, 15 of 33 neoplastic polyps (45.5%) were < 10 mm at the time of diagnosis of GBP. During follow up in 36 (3.5%) of 1027 cases, an increase in size was detected; of these, nine (25%) had neoplastic polyps.</P><P>Conclusion: </P><P>Even small polyps have a risk of malignancy, and careful long-term follow up of GBP will help detect and treat early GBC.</P>
( Semi Park ),( Moon Jae Chung ),( Jeong Youp Park ),( Jae Bock Chung ),( Seungmin Bang ),( Seung Woo Park ),( Si Young Song ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: Erlotinib and gemcitabine combined chemotherapy is becoming the treatment of choice in ad-vanced pancreatic cancer. We evaluated the effectiveness of treatment with erlotinib plus gemcitabine and the prognostic factors for chemotherapeutic response in Korean pancreatic cancer patients. Methods: Sixty-nine patients with advanced pancreatic cancer who were treated with daily erlotinib 100 mg orally and gemcitabine 1,000 mg/m2/30 min intrave-nous infusion on days 1, 8, and 15 of each 4-week cycle from 2006 to 2009 were included in this study. This study was a phase II single-center trial. Results: All 69 patients with advanced pancreatic cancer were chemotherapy-naive. The objective response rate was 18.8%, and the overall tumor-stabilization rate was 49.2%. The median overall sur-vival was 7.7 months (95% confidence interval [CI], 6.0 to 9.4 months). The median progression-free survival was 1.9 months (95% CI, 1.4 to 2.5 months). Prognostic factors for good chemotherapeutic response were good performance status and the presence of skin rash during chemotherapy. Patients with lower performance scores showed worse che-motherapeutic responses (odds ratio [OR], 7.6; 95% CI, 2.4 to 24.8). Poor responses were predicted by the absence of skin rash during chemotherapy (OR, 3.0; 95% CI, 1.4 to 6.3). Conclusions: Erlotinib and gemcitabine chemotherapy is a tolerable treatment regimen and has a favorable therapeutic effect in Korean patients with advanced pancreatic cancer. (Gut Liver 2013;7:611-615)
Radiotherapy Prolongs Biliary Metal Stent Patency in Malignant Pancreatobiliary Obstructions
( Semi Park ),( Jeong Youp Park ),( Seungmin Bang ),( Seung Woo Park ),( Jae Bock Chung ),( Si Young Song ) 대한소화기학회 2013 Gut and Liver Vol.7 No.4
Background/Aims: Biliary stenting is the most effective decompressive method for treating malignant biliary obstructive jaundice. Although the main cause of stent occlusion is tumor growth, few studies have investigated whether stent patency is affected by the combination of cancer-treatment modalities. The aim of this study was to evaluate the effects of local radiotherapy on metal-stent patency in patients with malignant biliary obstruction. Methods: Patients who underwent self-expandable biliary metallic stenting for malignant biliary obstruction from 1999 to 2007 were included. Forty patients received chemotherapy and radiation therapy (radiation group, RG), and 31 patients received only chemotherapy (nonradiation group, NRG). Results: The cumulative median stent patency was significantly longer in the RG than in the NRG (17.7 months, 95% confidence interval [CI], 1.8 to 33.6 months vs 8.7 months; 95% CI, 4.9 to 12.5 months; p=0.025). Stent occlusion caused by tumor growth or stent migration occurred in two (5%) and three (7.5%) cases in the RG and in six (19.3%) and two (6.5%) cases in the NRG, respectively. Conclusions: The patency of biliary metal stents in pancreatobiliary cancer patients who receive chemoradiation therapy is significantly longer than that in patients who do not receive radiotherapy, which suggests that local cancer control significantly affects stent patency. (Gut Liver 2013; 7:480-485)