강직성 슬관절에서의 슬관절 전치환술

조우신,박종희,김정민,오세관 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적: 강직이 동반된 슬관절염 환자에서 슬관절 전치활술의 문제점, 결과 및 합병증을 분석하고자 하였다. 대상 및 방법: 1994년 1월부터 2000년 12월까지 슬관절 강직(운동 범위 50도이하)이 있는 환자에게 슬관절 전치환술을 시행하여 2년 이상 추시가 가능하였던 16례를 대상으로 하였다. 수술은 관절 강직이 발생한지 평균 12.2년(1~40년)에 시행하였으며, 추시기간은 평균 3.3년(2~6년)이었다. 16례 중 남자 3례, 여자 13례였고, 평균 나이는 55.8세(34세~75세)였다. 감염에 의한 후유증 6례로 가장 많았고 그 외 퇴행성 관절염 4례, 외상 후 관절염 3례, 류마티스성 관절염 3례의 순이었다. 술 후 평가는 추시기간 중의 운동 범위와 HSS score 및 합병증을 분석하였다. 결과: 관절 운동 범위는 술 전 평균 31.6도(0~50도)에서 추시시 평균 95.4도(80~120도)로 증가하였으며, 1례에서만 5도의 굴곡 구축이 있었다. HSS score는 술 전 평균 59.6점(43~76점)에서 추시시 평균 84.6점(76~92점)으로 향상되었다. 1례에서 수술 중 슬개건 부분파열이 있었으나 보조기 착용과 적극적 재활로 술 후 1년째 90°의 관절 운동이 가능했다. 표재성 감염 1례는 창상의 변연절제술 후 피부이식으로 치유되었고, 심부 감염된 3례는 추후 관절 유합술을 시행하였다. 결론: 슬관절 전지환슬은 강직된 슬관절의 기능을 회복시킬 수 있는 좋은 술기이지만 감염등의 합병증을 고려해서 시행되어야 한다. Purpose: To evlauate the results of TKRA (Total knee replacement arthroplasty) for the treatment of stiff knee. Methods & Materials : TRKA has been performed for 18 cases of stiff knee ( ROM < 50° ) between January 1994 and December 2000. 16 cases which have been followed up for more than 2 years were analysed. Average follow-up was 3.3 years(2~6 years). 3 were male and 13 female. The average age was 55.8 years(34~75 years). Sequales of infection were most with 6 cases and followed by osteoarthritis (4 cases, 2 cases had been performed arthroscopic debridement) and rheumatoid arthritis (3 cases) and traumatic arthritis (3 cases) in order. TKRA was performed on average 12.2 years (1~40 years) after knee stiffness has been developed. We evaluate the results with ROM, HSS score and complications. Results : Average ROM was increased from 31.6°(0°~50°) preoperatively to 95.4°(80°~120°) postoperatively. 5° of flexion contracture was present in only 1 cases. Average HSS score was improved from 59.6 points preoperatively to 84.6 points postoperatively. The patella tendon was partially ruptured in 1 case surgery, but by brace application and rehabilitative exercise, ROM was improved to 90°, 1 year post operatively. There were 1 superficial skin infection which was resolved by revision of wound and skin graft, and deep infection in 3 cases, which needed knee fusion finally. Conclusion : TKRA is a good method for improving function in knee stiffness although infection risk is high.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

나노크리스탈 약물 전달 기술

황우신,황성주,박정숙,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

Nanotechnology affects on various aspects including medicine and pharmaceutics. This nanocrystal technology which transforms to nano-sized material is able to develop the innovational formulation strategy for poorly water-soluble drugs due to the change of physicochemical properties of drug. Scale-up methods using pearl milling or high pressure homogenizer was described and commercialized products based on nanotechnology were introduced in this manuscript.

PWC170의 算出方法 評價에 關한 硏究

趙庚旭,金泰完,張鳳愚,張鍾仁 忠北大學校 平生體育硏究所 1985 平生體育硏究所 論文集 Vol.1 No.-

The purpose of this study is to estimate the maximal oxygen up-take and the physical work capacity by four experimental methods in PWC170. The subjects of this study start to pedal the bicycle ergometer at the three work loads; the first work rate with 450∼600kpm/min, the second work rate with 600∼750kpm/min, and the third work rate with 750∼900kpm/min. Each exercise bout is 6 minutes long. We used a pedal frequency of 50 revolutions per minute. The first method is the first and second work rates the second method the second and the third work rates the third method the first second and hird work rates and the fourth method an integration by the third work rate. We measured and recorded the heart rate during the last 30 seconds of every minute of exercise. Since the subjects worked in a steady state, it is not necessary that they should exercise exactly 6 minutes each time. If problems happened during the taking of heart rate or other data, we continued to exercise another 30 to 60 second. The estimation of maximal oxygen uptake and physical work capacity was conducted by work loads and heart rates during exercise. The results are as follows: 1. The estimation by four different, methods showed 2∼3 persentile difference in maximal oxygen uptake(1min, ml/kg/min) and PWC170(kpm/min, kpm/kg/min). 2. The estimation by four different methods did not show significant differene, therefore for the estimation we had better use simplified method for the first work rate and the second work rate.

개에서 발생한 이혈종의 임상적 관리

이우철,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A 14-year-old male pomeranian was present with swollen left ear. The swelling occurred from base to apex of pinna. Otitis externa persisted for two years. Hematological and serum biochemistry values were not remarkable. The surgery treatment was the most appropriate method among indwelling drain, surgical, and steroid treatment in the aural hematoma because the dog was very sensitive to touching pinna and the size of aural hematoma. Longitudinal incision was applied after general anesthesia. Cefovecin was injected to prevent secondary infection. The outcome of surgery was good. There was no evidence of recurrence for one year.

에어컨 냉각 팬용 브러쉬레스 DC 전동기의 역기전력 분석에 대한 연구

조정현,김지현,정정원,황흥식,이치우 경성대학교 공학기술연구소 2012 공학기술연구지 Vol.18 No.-

Compared to conventional dc motors having the combination of commutators and brushes, a brushless DC (BLDC) motor is one of the highly efficient motors due to its electrical commutation without a brush, and this feature allows the BLDC otor to be more suitable for an application requiring no maintenance due to mechanical wear between a commutator and a brush. Also, the BLDC motor has a few benefits over both a dc motor and an induction motor such as high dynamic response, high efficiency, logn life span, and low noise in wide speed-torque region. This paper investigates the variation of voltage induced in phase windings in a BLDC motor in several cases with respect to stack length, steel grade, and coil material. This study is numerically conducted and it is verified from the theoritical point of view by comparing the result of simulation with that of experimental measurement.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

좌심방에 발생한 원발성 미분류 방추세포 육종 1례

조정환,홍그루,송인욱,손창우,정선영,남종호,김미진 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.2

열전대(thermocouple)를 이용한 Buchanan Plugger 표면의 온도상승 분석

조진숙,황윤찬,김선호,황인남,최보영,정영진,정우남,오원만 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

This study was performed to evaluate the actual temperature rise on the surface of Buchanan plugger using thermocouple. The heat carrier system 'System B Heatsource'(Model 1005, Analytic Technologies, Redmond, WA, USA) and the Buchanan pluggers of F, FM, M and ML sizes are used for this study. The temperature was set to 200℃ on digital display and the power level on it was set to 10. Five thermocouples were placed in direct contact with the surface of each size of Buchanan's pluggers at 1 mm increments from the tip to the 4 mm length of shank. The heat control spring was touched for 5 seconds, and temperature rise on the surface of the pluggers were measured at 1 sec intervals for more than 5 seconds with an accuracy of 0.01 using Data Logger. The data were statistically analyzed by one-way ANOVA. The results were as follows. 1. The position at which the temperature peaked was approximately at 1~2 mm far from the tip of Buchanan plugger (p<0.01). 2. The peak temperature was 215.25±2.28℃ in F plugger, 185.94±2.19℃ in FM plugger, 169.51±9.12℃ in M plugger, and 160.79±1.27℃ in ML plugger and the peak temperature was highest in F plugger and followed by, in descending order, FM plugger, M plugger. ML plugger showed the lowest peak temperature (p<0.01). 3. The temperature on the pluggers was decreased with the increase of touching time. This results suggest that the actual temperature on the surface of the pluggers dose not correlate well with the temperature set on digital display. Heat concentrates around the up. The larger plugger reveals lower temperature rise relatively.

상이한 악궁처치방법에 따라 채득한 인상체의 보철학적 평가

정우인,조인호 단국대학교 치의학연구소 1996 논문집 Vol.8 No.1

The antagonisitic cast must accurately reproduce the occlusal morphologic features to simulate the actual clinical occlusoarticular situation in the articulator. Various preimpression preparation procedures have been used for obtaining the accurate quality of occlusal reproduction in taking irreversible hydrocolloid impressions. This study evaluated and determined how different procedures for preimpression preparation of the oral cavity influence the quality of the occlusal reproduction of teeth on the casts. In this study, bubble counts on the casts according to preimpression preparation or alginate types (normal set and fast set) were compared and analyzed. The results were as follows; 1. The bubble count on casts was increased in GroupⅠ, GroupⅢ, GroupⅣ and GroupⅡ, GroupⅤ in that order, and the quality of occlusal reproduction according to preimpression procedures showed GroupⅠ to be excellent. There was no significant difference between bubble counts according to alginate types. 2. There was significantly difference between bubble counts according to preimpression procedures in each of three bubble sizes(p<0.05). GroupⅠ in case of Type Ⅰ and Type Ⅱ bubbles, GroupⅠ and Group Ⅲ in the case of Type Ⅲ bubbles showed the lowest bubble count with stastically significant difference(p<0.05). 3. There was no significant difference between bubble counts according to alginate types in each of three bubble sizes(p>0.05). According to the results of this study, it was considered that the quality of occlusal reproduction was the most excellent when fluid hydrocolloid was finger -painted onto the occlusal surfaces in taking hydrocolloid impressions after the oral cavity and occlusal surfaces were dried by a vacuum suction and jet of air.