한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

白蘚皮와 穿山甲이 人體 癌細胞柱에 미치는 細胞毒性의 效果

鄭鉉雨,田炳薰 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1

국내 사망률중 가장 높은 비율을 차지하고 있는 惡性腫瘍에 대하여 국내외적으로 다양하게 연구되고 있다. 그러나 아직까지도 腫瘍을 치료하기 위하여 手術療法ㆍ放射線療法ㆍ化學療法등의 많은 치료법들을 개발하고 있지만 腫瘍에 대한 치료원칙이나 치료약물에 대하여서는 아직까지 미흡한 것이 국내의 현실이다. 현재 일반적으로 抗癌劑를 이용한 化學療法등이 사용되고 있지만 이에 따른 副作用이 많아 抗癌劑와 韓藥材를 倂用投與함으로써 副作用을 최소화하고, 이에 따라 韓藥材가 正常細胞에 영향을 미치며, 癌腫細胞에는 영향을 미칠 것으로 사료되어 관찰한 결과 有意性이 있어 보고하게 되었다. 淸熱作用과 活血化瘀작용이 있는 白鮮皮와 穿山甲을 인체의 皮膚癌細胞인 A431 細胞, 子宮癌細胞인 HeLa 細胞, 急性白血病細胞인 MOLT-4 細胞, 慢性骨髓性白血病細胞인 K562 細胞에 대한 細胞毒性과 抗癌劑인 mitomycin C와 倂用처리결과를 MTT assay를 통하여 관찰하였다. 또한 正常細胞에 대한 細胞毒性을 검색하기 위하여 마우스 섬유아세포(Balb/c3T3), 마우스 胸線 및 脾臟細胞, human lymphocyte에 미치는 細胞毒性을 검토하였다. 白蘚皮와 穿山甲은 A431 細胞와 K562 細胞, 마우스 섬유아 細胞인 Balb/c 3T3 細胞 및 mitomycin C와 幷用處理하였을 때 mitomycin C를 단독처리 하였을 때보다 A431 細胞의 증식을 억제하였고, 白蘚皮는 mitomycin C와 幷用處理時 K562 細胞의 증식을 mitomycin C 단독처리시보다 억제하였으며, 穿山甲은 마우스 胸腺細胞의 증식을 억제하였다. 또한 白蘚皮는 마우스 脾臟細胞의 증식을, 白蘚皮와 穿山甲은 human lymphocyte의 증식을 촉진하였다. The purpose of this research was to investigate effect of water extract of Dictamni Cortex Radicis and Manitis Squama on the proliferation of human cancer cell-lines. The effects of Dictamni Cortex Radicis and Manitis Squama on the proliferation of A431, HeLa, MOLT-4, K562 cells, Balb/c 3T3 cells, mouse thymocytes, splenocytes and human lymphocytes were estimated by MTT colorimetric assay. 1. Dictamni Cortex Radicis and Manitis Squama inhibited the proliferation of A431 cells and K562 cells. 2. The cytotoxicity of mitomycin C on A431 cells was increased by the combination of Dictamni Cortex Radicis or Manitis Squama, and the cytotoxicity of mitomycin C on K562 cells was increased by the combination of Dictamni Cortex Radicis. 3. Cortex Radicis and Manitis Squama inhibited the proliferation of Balb/c 3T3 cells. 4. Manitis Squama inhibited the proliferation of mouse thymocytes. 5. Dictamni Cortex Radicis stimulated the proliferation of human lymphocytes. 6. Dictamni Cortex Radicis and Manitis Squama stimulated the proliferation of human lymphocytes.

그룹 기여법에 의한 삼성분계의 액-액 평형 예측에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

The experimemtal binodal curve and tie line data were determined for ternary systems of 2-propanol-water with benzene, toluene and n-butyl acetate as solvents at 25℃. These experimental data were compared with values predicted from UNIFAC model, using group contribution method. From these results the deviation between experimental and calculated equilibrium composition were very small, so it was proved that UNIFAC is good model to predect multicomponent equilibria.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

비선형 음향효과에 의한 고온 재료의 파괴인성 열화도 평가

정현조,남승훈,장경영,남영현 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.5

고온 장시간 사용재의 열화로 인한 파괴인성의 저하를 초음파 방법으로 평가하기 위하여 Cr-Mo-V 강을 실험실에서 인공 열화처리하여 열화로 인한 손상 기구를 규명하고, 열화도에 따른 초음파 파라미터의 변화를 체계적으로 관찰하였다. 초음파 파라미터로서 속도, 감쇠와 보다 최근에 개발된 비선형 음향 파라미터를 사용하였는데, 비선형 음향 파라미터가 가장 민감한 변화를 보였다. 또한 전기비저항 측정 결과와 비교할 때 두 방법 모두 전체적으로 유사한 거동을 보였다. Charpy V-notch 충격시험으로부터 구한 파면양상 천이온도(FATT)와 비선형 파라미터 사이에는 비교적 좋은 상관관계가 성립하였으며, FATT와 파괴인성(KIC) 사이의 관계식에 근거하여 열화된 발전설비 재료의 파괴인성을 초음파 비선형 파라미터의 측정을 통하여 간접적으로 구할 수 있음을 보였다. In order to develop an ultrasonic evaluation method for properties degradation of high temperature materials, a number of Cr-Mo-V steel samples were heat-treated, and their damage mechanism was examined. Ultrasonic parameters such as velocity, attenuation, and more recently developed nonlinear acoustic parameter were measured. The nonlinear acoustic parameter was found to be most sensitive to material degradation mainly attributed to the precipitation of impurities in grain boundaries. When compared to the electrical resistivity results, the nonlinear parameters showed similar behavior. There existed a relatively good correlation between the nonlinear parameter and the fracture appearance transition temperature (FATT) obtained by Charpy V-notch impact test. Based on the relationship between the FATT and the fracture toughness (KIC), correlation between the nonlinear parameter and KIC was established.

에스테르류에 의한 2-프로판올의 액-액 추출에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2

The experimental binodal curves and tie-line data were determined for ternary systems of 2 propanol-water with ethylacetate, butylacetate and isoa-mylacetate as solvents at 25℃, and those tie-line data were used to examine thermodynamic consistency. The experimental tie line data were correlated with UNIQUAC and modified UNIQUAC model and the parameters in each model and the calculated values of tie line were predicted. The distribution and selectivity curves in the equilibrium of ternary systems were determined to find the extraction effect.

BTX에 의한 2-프로판을 액-액 추출계의 상평형에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.1

The experimental binodal curves and tie line data were determined for ternary systems of 2-propanol-water with benzene, toluene and o-xylene as solvents at 25℃, and those tie line data were used to examine thermodynamic consistency. The experimental tie line data were correlated with UNIQUAC and modified UNIQUAC model and the parameters in each model and the calculated values of tie lines were predicted. The distribution curves in the equilibrium of ternary systems were determined to find the extraction effect.

골반 교정운동이 요부형태의 천골각 및 통증에 미치는 효과

정훈교,김현준 忠北大學校 平生體育硏究所 1997 平生體育硏究所 論文集 Vol.9 No.-

The purpose of this study was to examine the effects of pelvis corrective exercise for low back pain sampled from high school baseball players who complained their low back pain. Lumbar shape, and pain responses were examined before and after treatment to identify the effects of pelvis corrective exercises. The number of subjects were 39 consisted of four groups: control group, active goroup, assistive group, and active/assistive combined group. The time periods of treatments were 30 minutes per day, 5 times a week, total 18 weeks. Lumbar X-ray, DITI(Digital Infrared Thermographic Imaging) were utilized before and after treatment for data collection. Kruskal-Wallis Analysis was used to compare the differences of lumbar shapes as well as the differences of pain responses in between groups. The results of this study were as follow: 1. The effects on lumbar sacral angle among tests of lumbar shape were found most forcefully in assistive group and active/assistive combined group next. 2. The effects on pain responses were shown in rank such as active/assistive combined group first, assistive group second, and active group third. Therefore, pelvis corrective exercises could be regarded as an effective method to correct body type and relieve low back pain.

抵當湯이 血栓症에 미치는 실험적 연구

田炳薰,任光模,鄭鉉雨,禹元洪,鄭遇悅 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 뇌혈관계 질환이 우리나라의 높은 사망률을 차지하고 있고, 또한 혈전증에 활혈화어법을 대단히 많이 응용되고 있어 실증의 어혈증후군에 사용되는 저당탕으로 뇌혈관계 질환중의 하나인 혈전증이 "어혈" 의 범주에 속하는 지를 고찰할 필요가 있었다. 그리하여 본 연구는 저당탕을 임상에서 혈전증 치료에 응용할 수 있는지를 알아보기 위하여 실시하였다. 방법 : 저당탕 5첩분량(138.75g)을 100ml로 감압농축하여 0.2mg/kg의 endotoxin을 시로투여 1시간 후에 백서의 미정맥에 주입하고 4시간이 경과되면 urethane마취하에서 심장채혈 하였다. 결과 : 혈소판수는 대조군에 비하여 유의성 있게 증가하였고 protheombin time도 대조군에 대조군에 비하여 유의성 있는 단축을 보였으나 fibrinogen 량은 대조군에 비하여 증가를 하였지만 유의성은 보이지 않았다. 또한 전혈점도와 혈장점도는 대조군에 비하여 유의성 있는 감소를 보였다. 결론 : 저당탕이 혈전증에 미치는 영향은 유의한 것으로 나타났다. 그렇기 때문에 혈전증과 어혈과는 깊은 관련을 가지고 있어 저당탕이 뇌혈관 질환뿐만 아니라 어혈성 질환에 임상적으로 응용하면 보다 높은 치료효과를 거두리라 사려된다.

인공 치아우식 발생 모델에서 디지털 방사선 공제술을 이용한 인접면 치아우식증의 진단

박정훈,최용석,황의환,이기자,최삼진,박영호,김경숙,진현석,홍경원,오범석,박헌국 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Materials and Methods : Digital radiographies of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size #2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. Results : In artificial caries activity model, the range of lesional depth was 572-1,374 μm and the range of lesional area was 36.95-138.52mm². The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. Conclusion : The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.