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이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1
In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.
Usefulness of Bronchoscopy in Patients with Microbiologically Negative Pulmonary Tuberculosis
( Jee Youn Oh ),( Sung-soon Lee ),( Hyung Woo Kim ),( Jinsoo Min ),( Yousang Ko ),( Hyeon-kyoung Koo ),( Ji Young Kang ),( Ju Sang Kim ),( Jae Seuk Park ),( Yunhyung Kwon ),( Jiyeon Yang ),( Jiyeon Ha 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Recently, bronchoscopy has been widely used to aid microbiological diagnosis in patients with little sputum. However, the usefulness of bronchoscopy and the patient groups that benefit from subsequent microbiological confirmation have not been established. Methods We retrospectively analyzed the data of the Korean tuberculosis (TB) cohort, a nationwide prospective observation cohort including patients with TB, from September 2018 to October 2019 to evaluate the usefulness of bronchoscopy in patients with microbiologically negative (based on initial sputum polymerase chain reaction and culture Results) pulmonary TB. The primary outcome was the proportion of microbiological diagnoses after bronchoscopy. The secondary outcomes were the predictors of microbiological confirmation and the percentage of additional resistance detection after bronchoscopy. Results A total of 5194 patients were diagnosed with pulmonary TB, and 937 patients were microbiologically negative based on initial sputum findings. Of them, 319 patients underwent bronchoscopy; further microbiological confirmation was checked in 157 (49.1%) patients. The predictors of microbiological confirmation after bronchoscopy were age >65 years, female sex, and low body mass index (BMI). The rate of additional resistance detection was 10.5% [Multidrug resistant (MDR)/Rifampin resistant (RR) 3.8%; Isoniazid resistant (Hr) 5.7%]. Conclusion Bronchoscopy was useful for detecting resistant pathogens. Bronchoscopy should be consider for microbiologically negative pulmonary TB with female, aged >65 years, and low BMI for subsequent microbiological confirmation.
Osteoporosis in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Oh, Jee Youn,Lee, Young Seok,Min, Kyung Hoon,Lee, Sung Yong,Shim, Jae Jeong,Kang, Kyung Ho,Hur, Gyu Young The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.1
Background: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not widely been evaluated. Therefore, we investigated the prevalence of osteoporosis and its relationship with the clinical parameters of patients with asthma, COPD, and ACOS. Methods: This was a retrospective, cross-sectional study. Bone mineral density (BMD), lung function tests, and disease status evaluations were conducted. Results: A total of 321 patients were enrolled: 138 with asthma, 46 with ACOS, and 137 with COPD. One hundred and ninety-three patients (60.1%) were diagnosed with osteoporosis (53.6% of asthma, 65.2% of ACOS, and 65.0% of COPD). Patients with ACOS showed a significantly lower BMD and T-score than did those with asthma. In addition to age, sex, and body mass index (BMI), which were previously reported to be associated with BMD, BMD also had a negative correlation with the diagnosis of ACOS, as compared to a diagnosis of asthma, after adjusting for age, sex, BMI, smoking, and inhaled corticosteroid use (p=0.001). Among those patients with COPD and ACOS, BMD was negatively associated with the COPD Assessment Test (CAT) after adjustment (p<0.001). Inhaled corticosteroid was not associated with the prevalence of osteoporosis and BMD. Conclusion: Patients with ACOS, particularly aged and lean women, should be more carefully monitored for osteoporosis as compared to patients with asthma.
( Jee Youn Oh ),( Jae Kyeom Sim ),( Kyung Hoon Min ),( Gyu Young Hur ),( Jae Jeong Shim ),( Kyung Ho Kang ),( Sung Yong Lee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
The programmed death-1 (PD-1) mediates tumor-induced immune suppression. Expression of mutant EGFR in bronchial epithelial cells induces PD-1 ligand (PD-L1) and PD-L1 expression is reduced by EGFR inhibitors in lung cancer cell lines with activated EGFR. Thus, we compared the levels of PD-1 in peripheral blood according to stage and tyrosine kinase inhibitor(TKI) treatment response in lung cancer patients. Blood samples of lung cancer were obtained from Korea university guro hospital, and additional samples were done for patients with EGFR mutant adenocarcinoma after EGFR TKI treatment. Flow cytometry was used to detect PD-1 expression. Total 40 patients were enrolled for relationship of stage and PD-1, and among them 7 patients were EGFR mutant and treated with EGFR TKI. The expression levels of CD8+PD-1+ cells in Stage I/II patients tended to be lower than stage III/IV (0.18±0.19% vs. 0.90±1.18%, P=0.09). For patients treated with EGFR TKI, expression levels of CD8+PD-1+ cells significantly decreased after TKI treatment (1.85±1.56% vs. 0.77±0.83%, P=0.02). Post/pre TKI treatment ratio of CD8+PD-1+ cells expression was lower in partial response (n=3) than stable disease (n=4) (0.15±0.10 vs. 0.67±0.25, P=0.04). We confirmed the role of PD-1 of immune escape and tumor development by comparing levels of peripheral blood according to stage. We also verified that EGFR mutant lung tumor inhibited antitumor immunity by activating PD-1 and PD-1 expression was reduced by EGFR TKI, which was proportional to treatment response. Further large studies should be followed.
( Jee Youn Oh ),( Kyung Hoon Min ),( Jae Kyeom Sim ),( Gyu Young Hur ),( Sung Yong Lee ),( Jae Jeong Shim ),( Kyung Ho Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Smoke is a mixture of heated particles and gases, and smoke inhalation occurs when a person breathe in the products of combustion. Smoke inhalation lung injury can occur by lack of oxygen, chemical/thermal irritation, and chemical asphyxiation. We report a case of acute smoke inhalation lung injury after accidently boiling soup overnight. The patient was 34-year-old woman, and she was referred to our hospital with dyspnea and chest tightness. She was a non-smoker and had no other past medical history. The day before visit, she started boiling soup and then accidently fell asleep, so all the stuffs on the pot were burned out. She got up after 4 hours and started to feel dyspnea, chest tightness and headache. She was alert and her vital signs were stable. Breathing sounds were course with crackle on pulmonary auscultation. Initial blood gas analysis showed pH 7.44, PCO2 36.1mmHg, PO2 65.8mmHg, HCO3 24mmol/L, and SaO2 93%. Electrocardiography showed sinus tachycardia. Carbon monoxide hemoglobin level was 1.8%. Initial chest radiograph showed opacities in both lung fi elds. A chest computed tomography scan showed poorly defi ned consolidation and ground glass opacities in both upper lung, right middle lung and right lower lung fi eld. After 1 day, opacities in both lung on chest radiography decreased, and after 2 days, opacities dissapeared. In conclusion, we report a case of acute inhalation lung injury after accidently boiling soup overnight which was relieved after 2 days without any specifi c treatment except oxygen supply.
( Jee Youn Oh ),( Kyung Hoon Min ),( Jae Kyeom Sim ),( Gyu Young Hur ),( Sung Yong Lee ),( Jae Jeong Shim ),( Kyung Ho Kang ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Smoke is a mixture of heated particles and gases, and smoke inhalation occurs when a person breathe in the products of combustion. Smoke inhalation lung injury can occur by lack of oxygen, chemical/thermal irritation, and chemical asphyxiation. We report a case of acute smoke inhalation lung injury after accidently boiling soup overnight. The patient was 34-year-old woman, and she was referred to our hospital with dyspnea and chest tightness. She was a non-smoker and had no other past medical history. The day before visit, she started boiling soup and then accidently fell asleep, so all the stuffs on the pot were burned out. She got up after 4 hours and started to feel dyspnea, chest tightness and headache. She was alert and her vital signs were stable. Breathing sounds were course with crackle on pulmonary auscultation. Initial blood gas analysis showed pH 7.44, PCO2 36.1mmHg, PO2 65.8mmHg, HCO3 24mmol/L, and SaO2 93%. Electrocardiography showed sinus tachycardia. Carbon monoxide hemoglobin level was 1.8%. Initial chest radiograph showed opacities in both lung fields. A chest computed tomography scan showed poorly defined consolidation and ground glass opacities in both upper lung, right middle lung and right lower lung field. After 1 day, opacities in both lung on chest radiography decreased, and after 2 days, opacities dissapeared. In conclusion, we report a case of acute inhalation lung injury after accidently boiling soup overnight which was relieved after 2 days without any specific treatment except oxygen supply.