열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

The Risk of Rosacea According to Chronic Diseases and Medications: A 5-Year Retrospective, Multi-Institutional Case-Control Study

( Jee Hee Son ),( Bo Young Chung ),( Min Je Jung ),( Yong Won Choi ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.6

Background: Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries. Objective: To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the use of antihypertensive and antihyperlipidemic drugs in Korea. Methods: A five-year retrospective study, using hospital database, was conducted in five medical centers for five years. Totally 1,399,528 patients were evaluated. Results: The overall frequency for diagnosed rosacea was 0.18% over five years (2,536 rosacea patients). Patients with diabetes and patients with dyslipidemia were more likely to have rosacea (odd ratio [OR] 2.724, 95% confidence interval [CI] 1.295∼5.730, p=0.016; OR 1.788, 95% CI 1.445∼ 2.212, p<0.001). Patients with CVD were less likely to have rosacea (OR 0.431, 95% CI 0.244∼0.760, p=0.003). Patients with α-blocker prescriptions and patients with β-blocker prescriptions showed a tendency diagnosed with rosacea frequently (OR 1.963, 95% CI 1.200∼3.212, p=0.006; OR 3.939, 95% CI 3.512∼4.419, p<0.001). Patients with [beta]-hydroxy-[beta]-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and those with fibrate, were prone to have rosacea (OR 1.599, 95% CI 1.390∼1.839, p<0.001; OR 1.660, 95% CI 1.056∼2.609, p=0.026). As adjusted results, among the patients who took HMG-CoA reductase inhibitor without dyslipidemia, rosacea was less likely to be diagnosed (OR 0.780, 95% CI 0.620∼0.982, p=0.034). Conclusion: Rosacea is associated with chronic diseases and drugs. (Ann Dermatol 30(6) 676∼687, 2018)

Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis

Son, Jee Hee,Park, Sook Young,Cho, Yong Se,Chung, Bo Young,Kim, Hye One,Park, Chun Wook KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.12

<P>Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.</P>

FCP 10 Effect of histamine-free diet in adult patients with chronic urticaria

( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: In adult patients with chronic urticaria (CU), causal relationship between food and disease exacerbation is relatively weak compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance. Objectives: The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of histamine-free diet in adult patients with CU. Methods: Twenty-two adult patients with CU were enrolled. Foods with high amounts of histamine were prohibited to all patients for 4 weeks. Department of nutrition supplied the reference menu with histamine-free diet and consulted the patients. Severity degree of urticaria using Urticaria Severity Score (USS) and Urticaria Activity Score (UAS) were evaluated. Plasma histamine levels and diamine oxidase (DAO) activity were determined and compared between baseline and after the histamine-free diet. Results: Twenty-two adult patients were recruited and completed the 4 weeks of histamine-free diet. There was a significant difference in plasma histamine level between baseline and after the histamine free-diet (p=0.014). DAO activity did not change after the histamine-free diet (p=0.165). Likewise, both USS and UAS score significantly decreased after the histamine-free diet (p=0.010, p=0.006). Conclusion: Ingested histamine might be related with CU severity and histamine-free diet is helpful for adult patients with CU.

Immediate hypersensitivity reactions induced by triamcinolone in a 32-year-old woman with atopic dermatitis

( Jee Hee Son ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Coricosteroids are potent anti-inflammatory and antiallergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are especially considered frequent therapy for many skin diseases. Allergic reactions caused by corticosteroids, however, have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year old woman with triamcinolone induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She had atopic dermatitis (AD) since 3 years ago. She had used systemic steroid, cyclosporine and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injecting triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk and both hands. After intravenous injecting dexamethasone, her symptoms got worse. After treated with epinephrine, all symptoms resolved within two hours. We performed provocation test, skin prick test and patch test. She had a positive result only in prick test with triamcinolone and all other steroids showed negative in provocation test and patch test. Oral provocation test will be planned. Dermatologist should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.

Effects of itraconazole and tacrolimus on Aryl hydrocarbon receptor and NADPH quinine oxidoreductase 1

( Jee Hee Son ),( Sook Young Park ),( Yong Se Cho ),( Yun Sun Byun ),( Yoon Seok Yang ),( Bo Young Chung ),( Hee Jin Cho ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Aryl hydrocarbon receptor (AhR) is a ligand-inducible transcription factor responding to halogenated aromatic hydrocarbons. AhR regulates nuclear factor-erythroid 2- related factor-2 (Nrf2), a key molecule for cell protection. Itraconazole (ICZ) and tacrolimus exhibit anti-inflammatory effects, but underlying molecular mechanism remains unclear, especially on AhR-Nrf2 pathway. Objectives: To evaluate the influence of ICZ and tacrolimus on AhR pathway, especially AhR-Nrf2 pathway. Methods: Normal human epidermal keratinocytes (NHEK) were treated with 2,3,7,8-tetrachlrodibenzo-p-dioxin TCDD), 6-Formylindolo[3,2-b]carbazole (FICZ), Indirubin, ICZ and tacrolimus. Then, RT-PCR and Western blot analysis were performed. Results: The expression levels of the AhR, Arylhydrocarbon receptor nuclear translocator (ARNT), Cytochrome P450 1A1 (CYP1A1) and NADPH quinine oxidoreductase 1 (NQO1) mRNA were higher when treated with TCDD, FICZ, and Indirubin, especially in 12 hours. However, with ICZ and tacrolimus, there was no significant difference from control. When analyzing protein expressions of NHEKs with Western blot, the levels of AhR, CYP1A1, and NQO1 were higher after treatment with TCDD, FICZ, and Indirubin. With ICZ and tacrolilmus, there was no significant difference Conclusion: ICZ and tacrolimus did not effect on mRNA and protein levels of AhR-related factors. This suggests ICZ and tacrolimus exhibit different pathway from AhR.

Two Cases of Successful Treatment of Refractory Chronic Inflammatory Skin Disease, Atopic Dermatitis and Psoriasis with Oral Alitretinoin

( Jee Hee Son ),( Sook Young Park ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hee Jin Cho ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4

Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset

Son, Jee Hee,Chung, Bo Young,Kim, Hye One,Park, Chun Wook The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.8

<P>Few studies of atopic dermatitis (AD) in adult patients have evaluated differences in clinical features of AD according to onset age. We aimed to characterize the clinical features of AD in adult patients according to age of onset. Subjects with AD outpatient visiting the Department of Dermatology at Kangnam Sacred Heart Hospital were recruited for this study. A dermatologist conducted clinical evaluation, a survey of demographics, and onset of AD-associated signs and symptoms for each participant. Total immunoglobulin E (IgE) was also tested. A total of 280 adult AD patients were enrolled, among which 232 patients (82.86%) showed pre-adult-onset (age < 18 years) and 48 patients (17.14%) had adult-onset (age ≥ 18 years) of AD. There were significant differences between the 2 groups in the area of initial involvement (<I>P</I> = 0.017) and in treatment history (<I>P</I> = 0.010). Interestingly, patients with body mass index (BMI) ≥ 25 showed significantly higher Eczema Area and Severity Index (EASI) scores than did patients with BMI < 25 in the pre-adult-onset adult AD group (<I>P</I> = 0.048). On the other hand, there were no significant differences in sex, family history, BMI, EASI, and total IgE between patients with pre-adult-onset AD and patients with adult-onset AD. Our findings suggest that, even though many common features exist, there are significant differences between the clinical characteristics of pre-adult-onset and adult-onset AD subgroups, in adult patients with AD.</P>

P036 The correlation between rosacea and cardiovascular diseases, antihypertensive and antihyperlipidemic drugs

( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hee Jin Cho ),( Chun Wook Park ),( Hye One Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Rosacea is a chronic inflammatory recurrent facial disorder of unclear origin. It has been associated with chronic systemic disease, but researches on this association are lacking. Objectives: The aim of this study is to evaluate the association between rosacea and systemic comorbidities, related with cardiovascular diseases, and the use of antihypertensive and antihyperlipidemic drugs. Methods: A cross-sectional study was conducted in five different hospitals of Hallym University. Rosacea patients and patients with cardiovascular risk factors such as diabetes mellitus, hypertension, hyperlipidemia and peripheral vascular disease were extracted from hospitals’ database. In addition, patients, who were prescribed certain drugs including antihypertensive and antihyperlipidemic drugs, were evaluated. Incidence rates of rosacea were calculated using the Poisson regression analysis. Associations between rosacea and other systemic disease or drugs, were analyzed using the chi-square test. Results: Presence of diseases such as diabetes mellitus and dyslipidemia and use of alpha-blocker, beta-blocker, and HMG-CoA reductase inhibitor increased the prevalence of rosacea. Cerebrovascular attack was statistically related to lower risk of rosacea. Conclusion: Rosacea is associated with numerous chronic systemic diseases and also associated with drugs, especially antihypertensive and antihyperlipidemic drugs. Physicians should be aware of these associations to provide comprehensive care.

Herpes Zoster Duplex Unilateralis: Two Cases and Brief Literature Review

( Jee Hee Son ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.6

Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection. A 33-year-old woman presented with painful erythematous grouped vesicles and crust on her left forehead and neck (Lt. V1, Lt. C5). Both patients were treated with oral administration of famcyclovir 750 mg/day for seven days. (Ann Dermatol 28(6) 757∼761, 2016)