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김성곤,민영기,이덕기,김미영,송영상,권도훈,고영훈,박제민,정병선 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1
목 적: 본 연구의 목적은 한국인 남자 알코올 의존 환자의 기질적 특성을 Temperament and Character Inventory(TCI)를 이용하여 조사하는 것이다. 방 법: DSM-Ⅳ 진단 기준에 맞는 알코올 의존 환자 30명과 정상인 36명을 대상으로 연구학적 특성을 조사하고, 기질적 특성을 한글판 TCI를 이용하여 조사하였다. 모든 대상자의 나이는 30~60세였다. 결 과: 1) 두 군간 평균 나이는 유의한 차이가 없었으나, 교육 정도와 결혼을 유지하고 있는 비율 및 취업률은 알코올 의존군이 정상 대조군에 비해 유의하게 낮았다. 2) 알코올 의존군에서는 정상 대조군에 비해 Harm Avoidance(HA) 점수와 Self-transcendence(ST)점수는 유의하게 높았으며, Self-directiveness(SD)점수는 유의하게 낮았다. 3) 알코올 의존군 내에서의 각 척도들 간의 상관관계는, HA와 SD 점수, HA와 Persistence(PE) 점수, ST와 SD 점수는 각각 유의한 음의 상관관계, ST와 PE 점수, SD 점수와 Cooperativeness(CO) 점수, Reward Dependence(RD)와 CO 점수는 양의 상관관계를 보였다. 결 론: 이러한 본 연구의 결과는 한국인 남성에서 수줍음을 잘 타며, 걱정도 많고, 염세적이고 쉽게 피로해지는 기질적 특성이 알코올 의존과 연관성이 있음을 의미한다. Objectives : The purpose of this study was to assess the temperament of male parients with alcohol dependence. Methods : The subjects were 30 patients who met DSM-Ⅳ criteria for alcohol dependence and 36 normal controls. All subjects completed Temperament and Character Inventory(TCI) which was developed by Cloninger. Results : 1) The educational level, marital status, and occupation in alcohol dependence group were significantly lower than those of normal control group, but there was no difference in the age between two groups. 2) Among the scores of TCI, the score of harm avoidance(HA) and self-transcendence(ST) were significantly higher in the alcohol dependence group than in the normal control group. 3) In the alcohol dependence group, a significant negative correlation among the scores of TCI was between HA and SD, HA and Persistence(PE), ST and SD, and positive correlation between ST and PE, SD and Cooperativeness(CO), Reward Dependence(RD) and CO. Conclusion : These results suggest that shy, fearful, pessimistic and fatigable temperament are related to developing alcohol dependence in Korean males.
Young Ho Kim,Jae Young Choi,Yeon Ho Je,Young Ho Koh,Si Hyeock Lee 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
Two acetylcholinesterases (AChEs; BgAChE1 and BgAChE2) from Blattella germanica were functionally expressed using the baculovirus system. Kinetic analysis demonstrated that BgAChE2 had higher catalytic efficiency but lower substrate specificity than BgAChE1. Except paraoxon, BgAChE1 was generally less sensitive to inhibitors than BgAChE2. Western blot analysis using anti-BgAChE antibodies revealed that BgAChE1 was far more abundant in all examined tissues compared to BgAChE2, which is only present in the central nervous system. Both BgAChEs existed in dimeric form, covalently connected via a disulfide bridge under native conditions. Most fractions of BgAChE1 had a glycophosphatidylinositol (GPI) anchor, but a small fraction comprised a collagenlike tail. BgAChE2 appeared to have a collagen-GPI-fused tail. Based on the kinetic and molecular properties, tissue distribution and abundance, BgAChE1 was confirmed to play a major role in postsynaptic transmission.
Carpal Tunnel Syndrome in Elderly Patients
Young San Ko,Hee-Jin Yang,Sung Bae Park,Son Young-Je,Kang Min Kim,Lee Sang Hyung,Young Seob Chung 대한말초신경학회 2018 The Nerve Vol.4 No.2
Objective Carpal tunnel syndrome (CTS) is a common entrapment neuropathy. Differences in the clinical features and treatment outcomes of CTS between elderly and young patients remain debatable. We analyzed CTS in elderly patients to assess the differences in the characteristics of CTS between elderly and younger patients. Methods We retrospectively analyzed patients who were operated for CTS between January 2010 and December 2016. Patients were diagnosed based on clinical features and neurological findings and operated owing to persistent symptoms refractory to conservative management. Nerve conduction study (NCS) and ultrasonography were performed preoperatively. Endoscopic surgery was performed under local anesthesia. Carpal tunnel pressure (CTP) was measured intraoperatively using the Spiegelberg intracranial pressure monitoring device connected to a parenchymal type catheter. Results We performed 304 operations −48 wrists operated were in patients aged ≥70 years. No significant difference was observed in the sex distribution. The Elderly group showed more severe clinical symptoms (p=0.04), a higher frequency of thenar atrophy (p=0.02), NCS grades indicative of more severe disease (p=0.001), and more prominent median nerve swelling (p=0.04). Both groups showed similar CTPs before and after division of the transverse carpal ligament. Elderly patients showed poorer outcomes than those observed in younger patients (p=0.005). Conclusion Our series demonstrated that elderly patients showed more severe clinical features and findings using supplementary tests. Considering the lack of intergroup differences in CTP, we conclude that the reaction to compression of the median nerve in elderly patients causes more severe clinical, radiological, and electrodiagnostic features.
Young San Ko,Hee-Jin Yang,Young-Je Son,Sung Bae Park,이상형,정영섭 대한신경손상학회 2018 Korean Journal of Neurotrauma Vol.14 No.2
Cranial nerve palsies are relatively common after trauma, but trochlear nerve palsy is relatively uncommon. Although traumatic trochlear nerve palsy is easy to diagnose clinically because of extraocular movement disturbances, radiologic evaluations of this condition are diffcult to perform because of the nerve’s small size. Here, we report the case of a patient withdelayed traumatic trochlear nerve palsy associated with a traumatic subarachnoid hemorrhage (SAH) and the related radiological fndings, as obtained with high-resolution three-dimensional (3D) magnetic resonance imaging (MRI). A 63-yearold woman was brought to the emergency room after a minor head trauma. Neurologic examinations did not reveal anyfocal neurologic defcits. Brain computed tomography showed a traumatic SAH at the left ambient cistern. The patientcomplained of vertical diplopia at 3 days post-trauma. Ophthalmologic evaluations revealed trochlear nerve palsy on theleft side. High-resolution 3D MRI, performed 20 days post-trauma, revealed continuity of the trochlear nerve and its abutted course by the posterior cerebral artery branch at the brain stem. Chemical irritation due to the SAH and the abuttingnerve course were considered causative factors. The trochlear nerve palsy completely resolved during follow-up. This caseshows the usefulness of high-resolution 3D MRI for evaluating trochlear nerve palsy
Ko, Je-Sang,Na, Doe-Sun,Lee, Young-Han,Shin, Soon-Young,Kim, Ji-Hoon,Hwang, Byung-Gil,Min, Byung-Il,Park, Dong-Suk 생화학분자생물학회 2002 Journal of biochemistry and molecular biology Vol.35 No.4
Partial nerve injury is the main cause of neuropathic pain disorders in humans. Acupuncture has long been used to relieve pain. It is known to relieve pain by controlling the activities of the autonomic nervous system. Although the mechanism of neuropathic pain and analgesic effects of electroacupuncture (EA) have been studied in a rat model system, its detailed mechanism at the molecular level remains unclear. To identify genes that might serve as either markers or explain these distinct biological functions, a cDNA microarray analysis was used to compare the expression of 8,400 genes among three sample groups. Messenger RNAs that were pooled from the spinal nerves of 7 normal. 7 neuropathic pain, and 7 EA treatment rat models were compared. Sixty-eight genes were differentially expressed more than 2-fold in the neuropathic rat model when compared to the normal, and restored to the normal expression level after the EA treatment. These genes are involved in a number of biological processes, including the signal transduction, gene expression, and nociceptive pathways. Confirmation of the differential gene expression was performed by a dot-blot analysis. Dot-blotting results showed that the opioid receptor sigma was among those genes. This indicates that opioid-signaling events are involved in neuropathic pain and the analgesic effects of EA. The potential application of these data include the identification and characterization of signaling pathways that are involved in the EA treatment, studies on the role of the opioid receptor in neuropathic pain, and further exploration on the role of selected identified genes in animal models.
Ko, Young‐,Ho,Kim, Je‐,Hyung,Jin, Li‐,Hua,Ko, Suk‐,Min,Kwon, Bong‐,Joon,Kim, Joosung,Kim, Taek,Cho, Yong‐,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45
<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>
(Je Sang Ko),(Doe Sun Na),(Young Han Lee),(Soon Young Shin),(Ji Hoon Kim),(Byung Gil Hwang),(Byung Il Min),(Dong Suk Park) 생화학분자생물학회 2002 BMB Reports Vol.35 No.4
Partial nerve injury is the main cause of neuropathic pain disorders in humans. Acupuncture has long been used to relieve pain. It is known to relieve pain by controlling the activities of the autonomic nervous system. Although the mechanism of neuropathic pain and analgesic effects of electroacupuncture (EA) have been studied in a rat model system, its detailed mechanism at the molecular level remains unclear. To identify genes that might serve as either markers or explain these distinct biological functions, a cDNA microarray analysis was used to compare the expression of 8,400 genes among three sample groups. Messenger RNAs that were pooled from the spinal nerves of 7 normal, 7 neuropathic pain, and 7 EA treatment rat models were compared. Sixty-eight genes were differentially expressed more than 2-fold in the neuropathic rat model when compared to the normal, and restored to the normal expression level after the EA treatment. These genes are involved in a number of biological processes, including the signal transduction, gene expression, and nociceptive pathways. Confirmation of the differential gene expression was performed by a dotblot analysis. Dot-blotting results showed that the opioid receptor sigma was among those genes. This indicates that opioid-signaling events are involved in neuropathic pain and the analgesic effects of EA. The potential application of these data include the identification and characterization of signaling pathways that are involved in the EA treatment, studies on the role of the opioid receptor in neuropathic pain, and further exploration on the role of selected identified genes in animal models.