한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

HgCdTe광다이오드에서 고정전하와 계면전하가 터널링 전류에 미치는 영향

박장우 순천대학교 공업기술연구소 1995 工業技術硏究所論文集 Vol.9 No.-

In this paper, we investigate the contribution of the fixed charge in passivation layer and the HgCdTe/passivation layer interface charge to the current-voltage characteristics of HgCdTe photodiode. If there is the assumption that these charges serve as a gate of the gate-controlled diode, it can be expected that they change a depletion width and an electric field of n^+-p junction. Because the changed junction field has and effect on the tunneling current, which is sensitively dependent on electic filed, the total current, after all, is influenced by these charges, In this paper, the modeling method of these charge contribution to the current-voltage characteristics and the results are presented. The method and results proposed in this paper can't exactly describe experimental results but may be helpful in understanding the effect of these charge on the electic characteristics of the device.

화학 이론의 전통 과학적 연구

박서영,정원우,방경곤,김용수,문장수,이우붕 慶北大學校 師範大學 科學敎育硏究所 2007 科學敎育硏究誌 Vol.31 No.-

According to the system of the oriental traditional science, everything has to be harmony and interact with one another. The fundamental notions of the traditional natural philosophy are "do(doctrine)", "taegeuk(the great absolute)", "yin-yang," "five primary substance", "four events", and "eight signs for divination". Taegeuk, especially, explains the formation and the death of all things in the universe through circulation of yin-yang, and shows the balance of nature and universe. Yin-yang, relative ideas produces four events, and four events also is divided into the eight signs for divination. 'four events', 'eight signs for divination' like 'yin-yang' indicates the cycle of nature. The essential notions of the traditional science are not different from those of modern chemistry. Taegeuk which is the origin of all things in the universe means the situation of harmony and balance through ceaseless circulation and connotes dynamic equilibrium on neutralization that chemical reaction get to. A number of opponent concepts such as acid-base, oxidation-reduction, atomic nucleus-electron are given an explanation by ying-yang(the positive and negative) that reaches Taegeuk through chemical bonding or reaction over simple antagonistic relationship. 'Yin-yang', 'four-events', 'eight signs for divination' do not imply a substance or a phenomenon in itself but the properties of them. That is why it is possible to see into various chemical concepts like a relative strength of acid-base, groups of periodic table with traditional scientific philosophy. We have regretfully neglected studies in traditional science. It is time to perform the concrete work connecting theory of traditional science with that of modern science for advisable appreciating of traditional science. Moreover, It is necessary to do research and development of educational programs or teaching-learning materials using the traditional science properly. 동양 과학 철학이나 자연 철학은 태극,음양오행,사상팔괘를 이용해 우주 만물의 운동과 자연의 순환을 설명하는데 있어 그 학문적 우수성을 부인할 수 없으나 현대의 화학식이나 수식이 현상을 미시적 관점에서 구체적으로 설명할 수 있는 것과는 달리 전통 과학이론은 거시적 관점에서 그 전체적 흐름만을 나타낸다는 한계를 가지고 있다. 그럼에도 불구하고 태극,음양오행 그리고 사상팔괘론을 중심으로 한 전통 과학 이론은 현대인들에게 과학에 대한 새로운 시각을 제공함으로써 무분별하고 비윤리적인 과학 기술 활용으로 인한 전 지구적인 문제들을 해결하는데 있어 핵심적인 역할을 수행함은 물론 오늘날의 한국 과학이 한 걸음더 전진하는데 이바지 할 수 있을 것이다. 그러므로 서구 중심의 기존의 과학문명에만 머무를 것이 아니라 동양의 전통 과학 철학을 연구하여 민족의 과학 체계를 수립하고 과학의 토착화를 이루어야 한다. 이를 성공적으로 수행하기 위해서는 전통 과학과 현대 과학 사이에 다리를 놓는 구체적인 작업이 본격적으로 진행되어야 한다. 기본적인 화학 개념들을 전통 과학적 관점에서 재해석 하는 것은 물론이고 더 나아가 전통 과학의 이론을 이용하여 화학 반응 과정을 구체적으로 설명하려는 시도가 필요할 것이다.

불량행위 청소년을 중심으로 한 학교폭력 가해자의 사회인구학적 특성 및 정신병리(V)

박지도,최현경,장우성,조동환,김정기 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 이 연구는 불량행위 청소년군과 학생군을 대상으로 학교내외에서 행하는 폭력행동의 특징을 알아보고 특히 가해자의 정신병리와 청소년의 폭력행동과의 관계를 알아봄으로써 학교폭력의 이해와 대처방법 그리고 예방프로그램의 수립에 도움이 되고자 한다. 방 법 : 불량행위 청소년(청소년 선도프로그램인 BBS참석자) 남자 331명과 남자 중고등학교생 394명을 폭력의 유형을 괴롭힘, 금품갈취, 신체적 폭력, 언어적 폭력, 위협 등의 5가지 유형으로 나눈 설문문항을 바탕으로 각 경우의 경험빈도를 5점 척도로 하여 각 문항에서 3점 이상을 가해자군으로 분류하였으며 설문지를 통한 조사와 정신병리의 측정도구로서 한국판 아동-청소년 문제행동 평가 척도표(CBCL : Child Behavior Checklist, 청소년용)및 청소년의 자기개념을 알아보기 위해 한국판 피어스-해리스 소아 자기 개념척도(Piers-Harris Children's Self-Concept Scale, Piers, 1984, 이하 자기개념척도)를 적용하였으며 Chi-square test, T-test, 그리고 Two-way ANOVA를 사용하여 비교하였다. 결 과 : 사회 인구학적 특성에서는 대부분의 요인에서 불량행위군과 학생군 그리고 가해자군과 비가해군간에 차이는 보이지 않았으나 흡연과 음주하는 비율이 불량행위군과 학생군 두 군 모두 가해자군이 비가해자군보다 의미있게 높게 나타났다. 부모의 부부싸움 빈도는 불량행위군에서는 가해자와 비가해자군간에 차이를 보이지 않았으나 학생군에서는 가해자군에서 종종 싸운다는 비율이 의미있게 높게 나타났다. 학교생활에서는 성적이나 교우관계에서는 두 군 사이와 가해여부에 따라 유의한 차이를 보이지는 않았으며 성적은 불량행위군이 학생군에 비해 낮은 반면 가해여부에 따라서는 차이가 없었다. 하지만 학생군에서는 가해자군이 비가해자군보다 성적이 낮았으며 만화방을 이용하는 빈도도 가해자군에서 높게 나타났다. 폭력물 시청 시 느낌은 불량행위군과 학생군 모두에게서 가해자군이 비가해자군에 비해 흥분된다는 비율이 높게 나타났다. CBCL(Child Behavior Checklist)척도는 불량행위군의 경우 비행, 공격성, 외현화, 사회성 척도가 학생군에 비해 유의하게 높았고 위축, 사회적 미성숙, 사고문제, 주의집중, 내재화 척도는 학생군에서 불량행위군에 비해 유의하게 높았다. 전체 대상군을 가해자군과 비가해자군으로 나누어 비교하였을 때 신체증상, 사고문제, 주의집중, 비행, 공격성, 내재화, 외현화척도에서 가해자군이 비가해자군에 비해 유의하게 높았으며 군과 가해여부의 상호작용효과 검증결과에서는 유의한 상호작용을 보이는 척도는 없었으나 각 집단의 모든 척도에서 가해자군이 비가해자군보다 높은 점수를 보여주었으며 불량행위군의 경우 가해자군일수록 비행, 공격성, 외현화 척도가 높아지는 경향을 보였으며 학생군의 경우에서도 마찬가지로 비행, 공격성, 외현화 척도에서 가해자군이 비가해자군보다 높게 나타났다. 자기개념 척도는 불량행위군의 경우 행동, 지적학업척도에서 학생군에 비해 유의하게 낮게 나타났으며 불안, 인기척도는 학생군에서 불량행위군보다 유의하게 낮게 나타났다. 전체 대상군을 가해자군과 비가해자군으로 나누어 비교하였을 때 행동, 지적학업척도는 가해자군이 비가해자군에 비해 유의하게 낮은 점수를 보여주었으며 각 군과 가해여부의 상호작용검증결과에서는 유의한 상호작용효과를 보인 것은 없었으나 두 군 모두 행동척도가 가해자군이 비가해자군에 비해 낮은 경향을 보여주었다. 결 론 : 불량행위군과 학생군에서의 폭력가해자는 사회인구학적 변인에서는 비가해자와 유사한 특징을 가지나 각자의 내재된 심리상태와 정신병리에 따라 폭력 영상물과 음주 흡연의 가능성증가 그리고 가정에서의 폭력의 학습 등 주변의 위해 요인에 가해자군이 비가해자군에 비해 영향을 많이 받는 것으로 생각된다. 이에 학교폭력에 대한 대책수립 시 결과에만 초점을 맞춘 처벌 위주의 방식에서 벗어나 이들이 가진 심리적 특징과 정신병리를 이해하고 그에 따른 예방적인 대책수립이 필요할 것으로 생각된다. Objective : The purpose of this study was to identify the characteristics of school violence, self concept, psychopathology and psychosocial characteristics of male aldolescent delinquency doing school violence. And we hoped to use this result as basic material for prevention of school violence through comparison of those of students group. Method : We surveyed 725 male adolescents including 331 deliquents from educational program called "Big Brothers and Sister" in Pusan. We used self-reporting questionnaire composed of demographic data and attitude to violence. In order to investigate the psychopathology and self-concept, we used Child Behavior Check List, Youth edit, Korean version(CBCL) and the Piers-Harris Children's Self-Concept Scale. Statistical methods employed were Chi-square, t-test, two-way ANOVA. Result : The results show that in most demographic and psychosocial factor including age, education, socio-economic condition, religion and relationship with friends, there was no significant difference between delinquent and student group. And there was no significant difference between bully and non-bully in both group. The frequency of alcohol drinking and smoking were higher in bullying groups. For the feeling of watching violent mass-media, bullying delinquents reported more excited state than non-bullying delinquents in both group. On results of CBCL, subscales of delinquent behavior, aggressive behavior, externalizing problem, social scale in delinquent group were higher than those in student group. Subscale of somatic complaints, thought problem, attention problem, delinquent behavior, aggressive behavior, internalizing problem, and externalizing problem in bullying group were higher than those in nonbullying group. In both delinquent and student group, subscale of delinquent behavior, aggressive behavior, and externalizing problem in bullying group were significantly higher than those in nonbully group. In the results of self-concept scale, subscales of behavior, intellectual and school status in delinquent group were lower than those in student group. Subscale of somatic complaints, thought problem, attention problem, delinquent behavior, aggressive behavior, internalizing problem, and externalizing problem in bullying group were higher than those in nonbully group Conclusion : In both delinquent and student groups, most psychosocial factors in bully group were not significantly different with those in nonbully group. Bully group was more influenced by internal psychic state, psychopathology and environmental factor than nonbully group.

낮은 Crossover 왜곡을 갖는 Class-AB 출력단의 설계

박장우 順天大學校 1999 論文集 Vol.18 No.1

Power efficiency in the power amplifier is important. To obtain high power efficiency in the power amplifier, push-pull amplifier utilizing class-B operation has been usually used. Class-B amplifier has the high power efficiency but shows the distortion in output signal. It's distortion can be improved using the class-A amplifier, which has low power efficiency. To overcome the drawbacks of above two amplifiers, class-AB amplifier has been adapted. That is, the class-AB output amplifier shows the low crossover distortion and relatively high power efficiency. In this paper, class-AB output stage is designed, which can be used in the general purpose opamp. The output stage is designed to reduce the crossover distortion and to operate in full supply voltage range, which is needed to efficiently utilize the supply voltage. The designed output stage can be operating at 3V or below and shows the output voltage swing of 2.8V at 1㏀ load resistance and 1.5V at 100Ω

다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

자극성 물질이 첩포시험 결과에 미치는 영향에 대한 연구

박장규,이우재,김경훈,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

We studied the effects of irritants on the positive patch test sites in 6 volunteers. We firstly performed the patch test with 2, 4, 6, 8, 10% sodium lauryl sulfate on the back of 22 volunteers. Allergens (thimerosal, mercury ammonium chloride) were applied in duplicate, and 24 hours later they were removed and sodium lauryl sulfate was applied for a further 24hours to one set of patches. Response of allergen alone were measured at 24 hours, 48 hours, 72 hours, 120hours, 140hours and the degree of inflammation of the other site(allergen + irritant) was graded 30 minutes, 24, 48 and 72 hours later according to International Contact Dermatitis Research Group. The results were as follows 1. Twenty volunteers(90.9%) showed irritation sign on the patch sites with 6% sodium lauryl sulfate. 2. In the results of patch test in 6 cases with positive allergen sites, 5 cases showed the similar results with those of previous patch test (reproducibility = 83 %) 3. When we assessed the patch test results according to ICDRG, the results of patch tests after application with irritants on previous positive allergen slites did not show stronger responses than those of positive allergen alone 4. The results of patch test after application with irritants on previous negative allergen did not show erythema. It seems that the effect irritant application of lower concentration than irritant dose not influence the response to the allergen concentration than to cause erythema, on the response of allergen

충남지역 나환자에 대한 사회의학적 조사연구

박연우,오장균,이태용,심운택 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

We studied through February 1989 to August 1989 to investigate the demographic characteristics, disease status and deformity of leprosy patients registered at Chungnam provincial area on December 31, 1988. The results were as follows: 1. Older than 40 years of age occupied 83.3%, and most patients lived at his or her own home as farmer or stock breeder. 2. The infection source was more the extrafamilial than the intrafamilial source and the most common initial symptoms and signs by body site were sensory paralysis on extremities and infiltration on face and macule on trunk. 3. The deformity was higher in male than female, older the age and much more the deformity. 4. The deformity was higher in T type than L type, and more recent onset of disease and shorter the duration between the onset and the register of disease, more lighter the deformity. The settlement villiger than domiciliary and the group of patientnts being treated at health center than leprosy association, the deformity was heavier.

대전에서 연중 태양광선의 UVA와 UVB양에 대한 조사 (예비보고)

박장규,김경훈,이우재,서기범 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ultraviolet A(355 nm) and ultraviolet B(290 nm) doses were measured at Taejon from March to September, 1993, on four different weather conditions(clear, relatively clear, relatively cloudy and cloudy). And the results were compared with the doses of Kongju area measured in 1985. The followings were the summary of the findings. 1. UVA(1.98± 0.35 × 10 exp(-3) w/㎠) and UVB(17.62+ 5.72 X 10 exp(-6) w/㎠ doses were peak at noon on clear weather. 2. Average doses of UVA(2.36±0.70 × exp(-3) w/㎠) and UVB(24.28±8.83 × exp(-3) w/㎠) were peak at noon in August on clear weather. 3. The doses of UVA and UVB were influenced by yellow sand, fog and other pollutants. 4. The doses of UVA on clear weather in Daejoen were lower than Kongju about 40%, in contrast those of UVB were not different in statistical values.