서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

側腦室內 Substance P가 家兎 腎臟機能에 미치는 影響

昔延鎬,黃炳斗,李載欣 충남대학교 의과대학 지역사회의학연구소 1981 충남의대잡지 Vol.8 No.2

In this study, the effects of substance P, administered intracranioventricularly, on the renal function of the rabbit were investigated. 1) Intraventricular substance P(0.01, 0.1 and 10ng) elicited antidiuresis, and decreased the renal plasma flow, glomerular filtration rate and urinary excreted amounts of sodium and potassium, but did not influence to free water clearance. 2) Correlation coefficient between changes of urine volume and of renal plasma flow, glomerular filtration rate or urinary sodium excretion was statistically significant. 3) Systemic blood pressure was not affected in a dose of 0.01ng, but increased in 0.1ng(10mmHg) or 10ng(20∼25mmHg). 4) Antidiuretic effects of intraventricular substance P were partially inhibited by the renal nerve degeneration. From the above results, it is suggested that the antidiuretic effect of intraventricular substance P is dae to renal hemodynamic changes, partially induced by renal sympathetic nerve activation.

Diphenylhydantoin이 백서뇌신경세포막의 Na^+, K^+ -ATPase에 미치는 영향

황인방,허강민,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To study the effect of diphenylhydantoin on the synaptosomal Na^+ K^+ -ATPase in the rat with Goldblatt kidney, one kidney was removed and renal artery on the other side was partially ligated (external diameter=0.38mm). One kidney was removed in the control group. Synaptosome was prepared from the control and hypertensive rat and ATPase activity (total, EGTA, Azide and ouabain sensitive) was measured in the presence or absence of saponin. The effect of diphenylhydantoin on the synaptosomal ATPase was observed in the presence of diphenylhydantoin and/or ouabain. To investigate the maximal binding of ouabain to synaptosome, ouabain binding study was also carried out. Results as follows: 1. Blood pressure was significantly increased in 1-kidney, 1-clip hypertensive rat. 2. ATPase activity(Total, EGTA and ouabain sensitive) was increased to 2 times in the presence of saponin in the hypertensive and control group. 3. Na^+, K^+ -ATPase activity in hypertensive group was significantly decreased, compared with the control group. 4. Diphenylhydantoin slightly increased the ATPase activity in the control and hypertensive group, but it was not significant. 5. Total activity of ATPase was significantly decreased in the case with dephenylhydantoin and ouabain, but there was not difference between ouabain and ouabain with diphenylhydantoin treated case. 6. In the experiment of oubain binding, diphenylhydantoin did not alter Bmax and Kd of hypertensive and control group. From the above results, it is suggested that diphenylhydantoin will decrease the intracellular sodium without dependence on the stimulation of Na^+, K^+ -ATPase-in hypertensive rat.

살모사 교상 후에 발생한 뇌간 경색

권석범,이병철,배재천,황성희,김대훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

간경변증의 상태와 식도정맥류의 정도가 식도정맥류 결찰요법에 미치는 영향

황재석 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.2

식도 정맥류 출혈로 내원한 환자 중 결찰요법을 시행하여 정맥류가 근절된 57명을 대상으로 하여 식도 정맥류의 정도와 간경변증의 상태가 정맥류의 근절 (또는 grade 1 이하)에 미치는 영향을 알기 위해 근절 때까지 시생한 결찰요법의 횟수, 사용한 고무 밴드수를 비교하여 다음과 같은 결과를 얻었다. 1) 간경변증의 원인은 알콜성 33명 (58\%), 괴사성 24명 (42%)이었으며, Child-Pugh 분류에 의한 간경변증은 A는 16명 (28%), B는 32명 (56%), C는 9명 (16%)이었다. 2) 식도 정맥류의 크기는 (grade, G)는 정맥류의 직경이 4-6 mm (G2)는 5명, 7-10 mm (G3)는 28명, 10 mm 이상은 (G4) 24명이었다. 정맥류의 위치 (location, L)는 하부에만 있는 경우가 (L1) 5명, 하ㆍ중부에 있는 경우가 (L2) 34명, 전식도에 정맥류가 관찰되는 경우가 (L3) 18명이다. 3) 식도 정맥류의 크기와 결찰요법의 횟수를 비교하면 G2,일 때 2.2±0.8, G3일 때 2.2±0.5, G4일 때 2.8±0.7회로서 정맥류의 크기가 10 mm이상일 때 결찰요법의 횟수는 유의하게 증가하였다. (p=0.006) 식도 정맥류의 크기와 사용된 고무 밴드수를 비교하면 G2일 때 5.6±2.5, G3일 때 5.6±2.0, G4일 때 9.0±3.2개로서 정맥류의 크기가 10 mm이상일 때 사용된 고무 밴드수는 유의하게 증가하였다.(p〈0.001). 4) 식도 정맥류의 위치와 결찰요법의 횟수를 비교하면 L1일 때 1.6±0.5, L2일 때 2.3±0.6, L3일대 3.0±0.5회로서 정맥류의 위치가 전 식도에 존재할수록 결찰요법의 횟수는 유의하게 증가하였다.(p〈0.001). 식도 정맥류의 위치와 사용된 고무 밴드수를 비교하면 L1일 때 3.2±1.3, L2일 때 6.3±2.5, L3일 때 9.4±2.8개로서 정맥류의 위치가 전 식도에 존재할수록 사용된 고무 밴드수는 유의하게 증가하였다(p〈0.001). 5) Child-Pugh 분류에 의한 결찰요법의 횟수를 비교하면 A, B, C일 때 각각 2.4±0.7, 2.6±0.6, 2.2±0.8회로 유의한 차이가 없었다. Child-Pugh 분류에 의한 사용된 고무 밴드수를 비교하면 A, B, C일 때 각각 7.1±3.3, 7.1±2.7, 6.6±4.3개로서 역시 유의한 차이가 없었다. 이상의 결과를 볼 때 식도 정맥류의 결찰요법에서 식도 정맥류의 위치가 전 식도에 존재할수록, 또한 정맥류의 크기가 클수록 정맥류 근치에 필요한 내시경 시술횟수는 증가하고 사용된 고무 밴드수도 증가하는 것으로 나타났다. 그러나 간경변증의 심한 정도는 영향을 미치지 못하는 것으로 사료된다. EVL is a newly developed alternative technique to sclerotherapy. This technique consists of mechanical ligation and thrombosis of varices using elastic "O" rings. Fifty-seven bleeding patients were selected for evaluation. These patients had varices that were eradicated by EVL. They were analysed based on the severity of varices and liver cirrhosis that affected eradication of varices. We compared the ligation time and the number of bands used for eradication of varices. 1. Among 57 liver cirrhosis patients, 33 (58%) patients were due to alcoholics, while 24 (42%) patients were due to postviral infection. According to Child- Pugh classification, 16 (28%) patients were A, 32 (56%) patients B, and 9 (16%) patients C. 2. The severity of varices is classified by grade (G) and location (L) as follows: Five patients with G2 (varix diameter between 4-6 mm), 28 with G3(7-10mm), and 24 with G4 (over 10mm) ; 5 patients with L1 (inferior), 34 with L2 (inferior and middle), and 18 with L3 (entire portion). 3. The ligation time and the number of bands used for eradication of varices by grade were 2.2 and 5.6 for G2 and G3, and 2.8 and 9.0 for G4 respectively. 4. The ligation time and the number of bands used for eradication of varices by location were 1.6 and 3.2 for L1, 2.3 and 6.3 for L2, 3.0 and 9.4 for L3 respectively. 5. According to Child-Pugh classification, the ligation time and the number of bands used for eradication were not significantly different. In conclusion, the ligation time and the number of bands used for eradication of varices were increased as the size of varix and location of the lesion became more involved. However, the severity of cirrhosis did not affect procedures.

應力과 캐비테이션 下에서의 應力腐蝕 擧動에 관한 硏究

황재호,임우재,안석환 釜山水産大學校 1994 釜山水産大學 硏究報告 Vol.34 No.1

In this paper, stress corrosion cracking behavior, and stress corrosion cracking behavior under cavitation-erosion of water injection were investigated. Main result obtained were as follows 1) The weight loss of stress corrosion under stress is less susceptive than that of stress corrosion under stress and cavitation environment. 2) Cracking growth rate of stress corrosion under stress and cavitation is faster than that of stress corrosion under stress. 3) Corrosion potential of stress corrosion under stress and cavitation is less noble than that of stress corrosion under stress. And corrosion current density under stress and cavitation is higher than that of stress corrosion under stress.

排卵湯이 白鼠의 排卵에 미치는 影響

황태원,박재웅,위석,조한백,유심근 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

Baelantang(BLT) is used in female infertility caused by ovulation disorder. An attempt was to evaluate the influences, of BLT on the serum concentrations of FSH, LH, estradiol(E_(2)) and progesterone, the histological and optical changes of ovary, ovary weight of rats. The results of the study were as follows : 1. Blood FSH level increased experimental group as compared with control group on 7th day, which showed no efficacy. 2. Blood LH level increased in experimental group as compared with control group on 7th day and decreased 14th day, which showed no efficacy. 3. Blood E_(2) level decreased in experimental group as compared with control group on 7th day and increased 14th day, which showed no efficacy. 4. Blood progesterone level increased in experimental group as compared with control group on 7th day and decreased 14th day, which showed no efficacy. 5. In histological observations of ovary, ovulation increased in experimental group as compared control group on 7th day and on 14th day, which showed no efficacy. 6. In optically observations of ovary, weight of ovary increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. According to these results, BLT did not influence on the ovulation and ovary of rats.

수술로 절제된 간의 국소 결절성 증식의 임상적 특징

황남철,최문석,이준혁,고광철,백승운,유병철,이종철,이광웅,조재원,박철근 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2

목적: 간의 국소 결정성 과형성은 일반적으로 특별한 치료가 필요 없는 양성 종양이다. 그러나 드물지만 합병증이 발생한 경우와 진단이 불확실한 경우에는 수술을 시행하게 된다. 이에 저자들은 간절제술을 시행한 국소 결절성 과형성의 임상적, 영상학적 특징들을 알아보고자 하였다. 대상과 방법: 1995년부터 2003년까지 수술을 시행하여 조직을 확인한 국소 결절성 과형성 환자 10명을 대상으로 연령, 성별, 실험실 검사 및 영상 소견과 조직 소견을 분석하였다. 결과: 연령의 중앙값은 37.5세, 남녀 비는 1.5:1이었다. 5예에서는 간세포선종이나 간세포암종을 감별할 수 없어서 수술을 시행하였으며, 수술 후 우연히 진단된 예는 4예이었다. 간세포암종의 위험 인자를 가지고 있었던 예는 4예(B형 간염 바이러스 보유자 3예, 간경변 2예)이었다. CT검사가 시행되었던 6예 중 5예는 동맥기에서 조영 증강을 보였고 문맥기 및 지연기로 감에 따라 주변과 동일(4예)한 또는 감소(2예)되는 양상을 보여 간세포암종과의 감별이 어려웠다. 크기는 3.2±2.2㎝이었으며 위치는 간우엽의 후하구역(S6)에 가장 많았다(30.0%). 4예에서 수술 전 침생검을 시행하였으나 고분화 간세포암종이나 간세포선종과의 감별이 어려웠다. 결론: 임상상, 영상검사 및 간침생검으로도 간세포암종이나 간세포선종과의 감별이 어려운 경우 수술을 시행하였으며 수술 전에는 발견하지 못하였지만 다른 질환으로 인한 수술시 우연히 발견된 경우도 있어 국소 결절성 과형성의 수술 전 진단이 어려운 경우가 적지 않음을 알 수 있었다. Background/Aims: Focal nodular hyperplasia (FNH) is a benign hepatic tumor with few serious complications and no malignant transformation. However, differential diagnosis between FNH and other liver tumors, especially hepatocellular carcinoma, is often difficult. Methods: Clinical features of surgically resected FNH were reviewed. From January, 1995 to February, 2003, 10 patients with surgically resected FNH were enrolled. Their age, sex, results of laboratory examination, imaging studies and pathologic findings were evaluated. Results: Median age was 37.5 years and sex ratio (male:female) was 1.5:1. In 5 cases, resection to exclude hepatic adenoma or HCC was performed. Four cases were diagnosed incidentally after surgery. Four patients had risk factors for HCC, such as hepatitis B virus infection, liver cirrhosis or both. The size of FNH was 3.2 2.2 cm. The most common site of the tumor was segment 6 (30.0%). Differential diagnosis with HCC was difficult in 5 of six cases in whom CT was performed. Although needle biopsies were performed preoperatively in 4 cases, it was difficult to distinguish FNH from hepatic adenoma or HCC. Conclusions: FNH was resected due to uncertainty of diagnosis, or incidentally during hepatectomy in patients with other liver disease. In the former, differential diagnosis with hepatic adenoma or HCC was a major problem despite extensive work-up including dynamic CT or biopsy. (Korean J Hepatol 2004;10:135-141)

골격근 근형질세망의 ATP유도 ^45Ca-uptake에 대한 Thapsigargin및 Vanillylnonanamide의 영향

황의강,배소현,홍장희,허강민,김진회,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

To investigate the effect of thapsigargin(THP) and vanillylnonanamide(VN), derivative of capsaicin, on the ATP-induced ^45Ca-uptake in the sarcoplasmic reticulum(SR) of the skeletal muscle, the SR vesicles were prepared from the back muscle of the rabbit, and ^45Ca-uptake was carried out. The results as follows: ATP-induced ^45Ca-uptake of skeletal muscular SR was significantly increased by 1 mM ATP. It was significantly blocked by 5 μM THP, but slightly decreased by 20 μM VN. The combined effect of THP and VN on the 45Ca-uptake of the SR vesicles was much potentiated than the sum of each effect of them. The above results suggest that the action of VN, being slightly influential to ATP-induced Ca-uptake but potentiating the effect of THP on the Ca-uptake, might be related with direct perturbation of the SR membrane or exposure of the THP-binding site.