축전지 사업장에서 공기 중 납 농도의 허용노출기준 초과율 변화에 관한 연구

최재욱,김남수,함정오,이병국 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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경구개법 또는 내시경하 비내 접근법으로 치료한 비인강 혈관 섬유종 3예

김진국,이민우,강성호,남태욱,김재영 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Nasopharyngeal angiofibroma is uncommon, histologically benign vascular tumor that occurs almost exclusively in adolescent males. It is clinically malignant because it has propensity for locally destructive growth and fatal hemorrhage. Treatment of angiofibroma is controversial. The two major treatment modality are surgery and radiation. Adjuvant treatment with chemotherapy or embolization can be used as well. We experienced three cases of nasopharyngeal angiofibroma that was resected by transpalatine and endoscopic endonasal approach with good result. So, we report these with review of literature.

Zn₁-xFexSe의 고유결함에 관한 연구

박남천,송재홍,채건식,오재근,김영국,손인호 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-

We studied the native defects of dilute magnetic semiconductors Zn₁-xFexSe epilayer by using SAW device. The energy gap of Zn₁-xFexSe for each epilayer(x=0.0213, 0.0915) was 2.57eV, 2.74eV at room temperature (294K). The trap level for x=0.0213, 0.0915 were calculated by measuring Transverse Acoustoelectric Voltage(TAV). Also we can calculated cross section.

자발성 뇌교출혈 환자의 예후에 관한 임상 분석

조재영,석종식,민병국,권정택,최덕영,황성남,김영백,박승원 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.1

Patients with spontaneous pontine hemorrhage very often develop setvere disturbances of consciousness,pupilary abnormalities, respiratory and motor. They have high mortality rate. Therefore, I analyzed the correlation between the Glasgow outcome scale(GOS)and clincial manifestations or computed tomographic(CT)findings in 48 patients with spontaneous pontine hemorrhage to clarify factors predicting the prognosis. I examined 48 Patients with spontaneous pontine hemorrhage; 33 males and 15 females, age 54.6±8.99(mean±S.D.;range 39 to 68)brought to our hospital between January 1995 and December 1999, retrospectively. Correlations between the clinical manifestations, CT findings and the GOS was assessed with multivariate regression analysis. The results were as follow: 1) Patients with the pontine hemorrhage were of 8.8% in those with intracerebral hemorrhage. The ratio of male and female was 33 to 15. The incidence of age is eqial to 40,50 and 60. Total mortality was 41.6%. 2) The poor prognostic factor were that; Glasgow coma scale(GCS)3∼8, irregular respiration. pupilary abnormality, quadriplegia, Brain CT typeⅠ(massive), hydrocephalus, extrapontine extension, Intraventricular hemorrhage(IVH). These clinical analysis should be useful in determining the level of care and future resuscitative efforts.

비내시경을 이용한 안와 내벽 골절 정복 2예

김진국,남태욱,임채형,김재영,김정석 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Traditional surgical approaches to orbital medial wall fractures are either extraocular skin incision or indirect bicoronal flap. However these methods can leave remarkable orbital scar or scalp alopecia with possible complications. Endoscopic intranasal visualization of the medial orbital wall and lamina papyracea is a technique familar to otolaryngologists. This endoscopic view allows confirmation of fracture of medial orbital wall and herniation of orbital contents. Good visualization of the fracture can facilitate the anatomic reduction of orbital contents and the proper placement of orbital implant. Two cases of medial orbital wall fracture repaired by intranasal endoscopy using silastic sheet are reported.

도전재 첨가량에 따른 리튬폴리머 2차 전지 MCMB 부극의 전기적 특성

김상필,정재국,남효덕 嶺南大學校 工業技術硏究所 2002 工業技術硏究所論文集 Vol.30 No.2

Anode characteristics of Lithium Polymer Batteries(LPB) were investigated by adding different contents of conducting agents. Super P Black(SPB), Vapor Carbon Grown Fiber(VGCF) and Kuraha Carbon Fiber(KCF) were used as conducting agents with active material of Mesocarbon Microbeads(MCMB). In consequence, the internal resistance of LPB was decreased by increasing the amounts of conducting agents. AS a result, the conductivity of the battery improved upto 0.27×10 exp (-3)S/㎝, 0.4×10 erxp (-3)-3S/㎝ and 0.36×10 exp (-3)S/㎝ by adding SPB, VGCF and KCF as conducting agents to the anode, compared to that of the anode without conducting agents.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

The development of the conditionally replication-competent adenovirus: replacement of E4 orf1-4 region by exogenous gene

Nam, Jae-Kook,Lee, Mi-Hyang,Seo, Hae-Hyun,Kim, Seok-Ki,Lee, Kang-Huyn,Kim, In-Hoo,Lee, Sang-Jin John Wiley Sons, Ltd. 2010 The journal of gene medicine Vol.12 No.5

<B>Background</B><P>Tumor or tissue specific replicative adenovirus armed with a therapeutic gene has shown a promising anti-cancer therapeutic modality. However, because the genomic packaging capacity is constrained, only a few places inside it are available for transgene insertion. In the present study, we introduce a novel strategy utilizing the early E4 region for the insertion of therapeutic gene(s).</P><B>Methods</B><P>We constructed the conditionally replication-competent adenovirus (CRAd), Ad5E4(mRFP) by: (i) replacing the E4/E1a promoter by the prostate-specific enhancer element; (ii) inserting mRFP inside the E4orf1-4 deletion region; and (iii) sub-cloning enhanced green fluorescent protein controlled by cytomegalovirus promoter in the left end of the viral genome. Subsequently, we evaluated its replication abilities and killing activities in vitro, as well as its in vivo anti-tumor efficacy in CWR22rv xenografts.</P><B>Results</B><P>When infected with Ad5E4(mRFP), the number and intensity of the mRFP gene products increased in a prostate cancer cell-specific manner as designed, suggesting that the mRFP gene and E4orfs other than E4orf1-4 were well synthesized from one transcript via alternative splicing as the recombinant adenovirus replicated. As expected from the confirmed virus replication capability, Ad5E4(mRFP) induced cell lysis as potent as the wild-type adenovirus and effectively suppressed tumor growth when tested in the CWR22rv xenografts in nude mice. Furthermore, Ad5E4(endo/angio) harboring an endostatin-angiostatin gene in E4orf1-4 was able to enhance CRAd by replacing mRFP with a therapeutic gene.</P><B>Conclusions</B><P>The approach employed in the present study for the insertion of a therapeutic transgene in CRAd should facilitate the construction of CRAd containing multiple therapeutic genes in the viral genome that may have the potential to serve as highly potent cancer therapeutic reagents. Copyright © 2010 John Wiley & Sons, Ltd.</P>

The survey of phytoparasitic nematodes in kiwifruit orchards

Sun-Nam Park,Jae-Kook Lee,Byeong-Yong Park 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10

This study was conducted to investigate occurrence and biodiversity of phytoparasitic nematodes in kiwifruit orchards in Korea. Soil samples were collected from 11 locations of Gosung, Goheung, Namhae, Bosung, Sacheon, Suncheon, Wando, Jangheung, Jeju, Jindo, Haenam from April to August, 2008. Phytoparasitic nematodes were found in 115 among 178 soil samples. The major genera of phytoparasitic nematodes on kiwifruit were Meloidogyne spp.(52.2%), Tylenchinae (42.1%), Tylenchus spp. (9.0%), Helicotylenchus spp. (9.0%) and Tylenchorhynchus spp. (6.7%). Ditylenchus spp., Hirschmaniella spp., Trichodorus spp. and Psilenchus spp. were also detected, even though their frequencies were very low. According to the cultivation period, the phytoparasitic nematodes were found as follows; 16.9% of soils under 5 years of kiwifruit cultivation, 10.7% 6~10 years, 23.0% 11~15 years, 3.9% 16~20 years and 5.6% over 21 years respectively. The frequency of phytoparasitic nematodes is higher in the open field (50.0%) than that in plastic houses (13.5%). The frequency of phytoparasitic nematodes was 36.5% in the field where vegetables were previously cultivated and 12.9% in the field where rice was previously cultivated.

The Cellular Response to Graphene Oxide and Its Related Nano-derivatives

( Jong Wook Shin ),( Chang Seok Park ),( Jae Kook Nam ),( Young Ae Baik ),( Jae Woo Jung ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byoung Whui Choi ),( Kyung Soon Choi ),( Juhyun Park ),( 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

The graphene which is an allotrope of carbon has the honeycombing structure of one-atom-thick planar sheets. it is used in modern electronic, informative technologies sensors and drug delivery system. Graphene oxide (GO) has oxygen functional groups on the graphene plane. We performed this experiment to define the cellular effect of GO. GO was prepared by the modified Hummers method using 2 g of graphite powder. After sequential procedure, GO in water was used for experiment. U-937, Raw264.7 cells and A549 cells were cultivated with GO and related nanoparticles. We checked the microscopic charac-teristics, MTT assay and Western blotting. The X-ray diffraction patterns showed that the pristine graphite had a peak centered at 2θ=26.5o (d=0.33 nm). This peak was shifted to 2θ=11.3o (d=0.78 nm) after applying the Hummers method. U937 cells aggregated sround GO. During 48 hours, modified GO with methyl group (DA-GO) and SDS-hydrazine GO(SDS-HYDrGO) diminished A549 proliferation than GO. In contrast, GO inhibited proliferation of Raw264.7 cells than DA-GO and SDS-HYD rGO. The shifting from LC3B-I to LC3B-II was minimal in GO, DA-GO, SDS-HYD rGO. In conclusion, GO in water may be phagocytosed by mononuclear cells. GO and its ligand-modified derivatives may affect differentially on proliferation or survival in airway epithelial cells and mononuclear cells. Acknowledgement: This research was supported by Mid-career Research Program (2011-0028752) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology.