현장계측용 변위계의 환경영향 특성연구

이한준,최만용,박정학,임재학 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The sensor and measuring instrument that are used for the infrastructure is discussed the reliability problem from the various environment factors. In the domestic infrastructure, the low reliability products are produced, because of lack of the pertinent test methods and equipments. To improve the practical use and accuracy of the sensor, it raises the measurement reliability about the sensor and measurement instrument. In this study, the variance of the displacement value according to temperature was investigated using the LVDT for the infrastructure. The experimental results showed that a sensor is affected by environment factor such as temperature.

28세 여성에서 Epinephrine 국소 주사 후 발생한 스트레스성 심근병증 1예

임주견,곽성동,박재영,천재홍,최성열,차태준,이준상 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Stress induced cardiomyopathy is characterized by transient left ventricular dysfunction with typical regional wall motion abnormality of basal segment hyperkinesia and apical hypokinesia after physical or psychological stress. Stress induced cardiomyopathy mimics acute myocardial infarction but coronary angiography shows normal and usually recovers rapidly. Stress induced cardiomyopathy appears to occur almost exclusively in old females. Only a few cases have been reported in younger women but not yet in korea. The pathogenesis is not well known. Currently, it is thought that catecholamine may play important role. Especially, epinephrine may be most important catecholamine in the pathogenesis of steress induced cardiomyopathy. We report a case of stress induced cardiomyopathy occurred in young female after local epinephrine injection for hemostasis during tonsillectomy. 스트레스성 심근병증은 고령의 여성에서 주로 발생하며 카테콜라민 중 특히 epinephrine이 병리기전의 주요한 원인의 하나로 생각되어지고 있다. 저자들은 28세의 젊은 여성에서 편도절제술 도중 지혈을 목적으로 epinephrine을 국소 주사한 후 발생한 스트레스성 심근병증 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

Update in the diagnosis and treatment of pulmonary tuberculosis

( Jae-joon Yim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

In 2018, 10 million people developed tuberculosis (TB) worldwide, of which 5.7 million were men, 3.2 million were women and 1.1 million were children. In addition, TB caused 1.5 million deaths among HIV-negative people and an additional 251,000 deaths among HIV-positive people. Early and accurate detection of TB is important for the timely initiation of treatment and prevention of TB transmission. Furthermore, early detection of drug resistance is crucial for early treatment of multi-drug resistant (MDR) TB. Conventional methods for the diagnosis of TB have limitations in terms of early as well as accurate detection. Acid-fast bacilli smears show short turnaround times and high specificity, but lower and variable sensitivity. Confirmation of mycobacterial culture takes a few weeks and conventional drug susceptibility tests based on culture takes another few weeks. To overcome the shortcomings of culture-based TB diagnosis, several methods of molecular diagnosis, which could provide a rapid diagnosis of TB as well as drug susceptibility profiling, was introduced and being adopted more frequently. Among them, the Xpert MTB/RIF assay is being used most frequently. It is an automated, single- cartridge-based nucleic acid amplification test using reverse transcription-polymerase chain reaction detection of the TB-specific rpoB gene. Xpert MTB/RIF assay represents an important advance in the field of rapid molecular diagnosis of TB and drug resistance. The test enables simultaneous identification and detection of TB and rifampicin- resistance to be completed within 2 hours. As rifampicin-resistant M. tuberculosis is also likely to be resistant to isoniazid, the early detection of rifampicin resistance using Xpert MTB/RIF assay prompts the initiation of management of MDR-TB. For the molecular detection of resistance to 2nd line anti-TB drugs, line-probe assay (eg. MTBDRsl assay) is available and the newer version of Xpert MTB/RIF assay (‘ultra’) has been tested. In addition, rapid, reliable, and increasingly affordable whole-genome sequencing of TB bacilli is becoming an option of diagnosis of drug resistance and source investigation of TB outbreak. For the treatment of TB, several repurposed drugs (eg, fluoroquinolones, linezolid) and newly developed anti- TB drugs (eg, bedaquiline, delamanid) became available. To shorten the treatment duration of drug-susceptible pulmonary TB, several 4-month regimens adopting fluoroquinolones instead of isoniazid or ethambutol have been tried. Unfortunately, none of those 4-month treatment regimens showed non-inferiority to the current 6-month regimen. A recent phase 2 trial using linezolid instead of ethambutol failed to show higher rates of culture conversion at 8 weeks of treatment. Several trials testing shorter regimens with high dose rifamycins or new drugs including pretomanid are ongoing. Meanwhile, almost 20 TB vaccine candidates are at different stages of the clinical trial pipeline. In addition, several host-directed therapies to enhance anti-TB immunity have been tested and some of them showed promising results.

NTM Pulmonary Disease in Korea: An Observational, Multicenter, Prospective, Cohort Study (NTM-KOREA)

( Jae-joon Yim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Comparison of Daily Norfloxacin versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Controlled Trial

( Hyung Joon Yim ),( Sang Jun Suh ),( Young Kul Jung ),( Sun Young Yim ),( Yeon Seok Seo ),( Soo Young Park ),( Jae Young Jang ),( Young Seok Kim ),( Hong Soo Kim ),( Byung Ik Kim ),( Kwang-hyub Han ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: For the prevention of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, norfloxacin 400mg per day is a standard regimen. However, ciprofloxacin 750 mg per week is also known to be effective. In addition, ciprofloxacin once weekly administration is more convenient and less costly. This study aims to prove that ciprofloxacin once weekly administration is as effective as norfloxacin once daily administration for the prevention of SBP. Methods: Liver cirrhosis patients with ascites between 20-75 years old were screened, and enrolled in this randomized controlled trial if 1) ascitic polymorphonucleated cell count < 250/mm3 2) ascitic protein is equal or less than 1.5 g/dL or 3) the presence of history of SBP. Patients were randomly assigned into norfloxacin daily or ciprofloxacin weekly group, and followed-up for 12 months. Primary end point was the prevention rate of SBP, and the secondary end points were 1 year mortality, incidence of infectious events, hepatorenal syndrome, and hepatic encephalopathy. Results: 124 patients were enrolled and allocated into each group by 1:1 ratio (62:62). Male patients were 90% and the mean age was 55.2 ± 10.1. The mean Model for End stage Liver Disease (MELD) score was 14.6 ± 4.8. There was no difference in baseline characteristics between the groups. SBP developed in 2 patient of ciprofloxacin group, and in 3 patients of norfloxacin group (3.2% vs. 4.8%, P = 0.643). Cumulative transplant free survival rate were comparable between the groups (80.6% vs. 82.3%, P = 0.863). Incidence of infectious complication, hepatorenal syndrome, hepatic encephalopathy, and variceal bleeding rates were not significantly different (all P = ns). The only factor related to survival was underlying liver function MELD, P = 0.001). Conclusions: Once weekly ciprofloxacin was as effective as daily norfloxacin for the prevention of SBP in cirrhotic patients with ascites. NCT01542801]

전신성 홍반성 낭창 환자에서 발생한 Mycobacterium abscessus에 의한 폐렴

임재준 ( Jae Joon Yim ),오명돈 ( Myoung Don Oh ),유철규 ( Chul Gyu Yoo ),송영욱 ( Yeong Wook Song ),김영환 ( Young Whan Kim ),서정욱 ( Jung Wook Seo ),한성구 ( Sung Gu Han ),최강원 ( Kang Won Choe ),심영수 ( Young Soo Shim ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.1

신종 감염병의 최신 지견 ; 내성 결핵균의 실태 및 치료

임재준 ( Jae Joon Yim ) 대한내과학회 2009 대한내과학회지 Vol.77 No.2

Drug-resistant tuberculosis (TB), especially multidrug-resistant (MDR)-TB and extensively drug resistant (XDR)-TB, poses a serious threat to global health because it requires treatment for a long duration and frequent hospitalization, and results in a considerable number of mortalities. In South Korea, MDR is observed in 2.7% of newly diagnosed TB cases and in 14% of re-treatment cases. In addition, 5~20% of MDR-TB could be categorized as XDR-TB. Treatment regimen for MDR or XDR-TB should include 4~5 drugs susceptible to isolated tuberculous bacilli and should be maintained at least 18 months after culture conversion. Pertinent combination of anti-TB drugs and solid compliance are the basis of successful treatment for MDR and XDR-TB patients. (Korean J Med 77:152-156, 2009)

결핵성 흉막염의 진단과 치료

임재준 ( Jae Joon Yim ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2

Tuberculous (TB) pleuritis is the second most common form of extrapulmonary tuberculosis. Because the yield of pleural fluid mycobacterial culture is as low as 20% and the pleural biopsy is rather invasive, the measurement of adenosine deaminase (ADA) has been a cornerstone of the diagnosis of TB pleuritis. If the ADA level of pleural fluid is higher than 70 IU/L, the diagnosis of TB pleuritis can be made safely. The treatment is based on a standard short course anti-TB treatment starting with isoniazid, rifampicin, ethambutol, and pyrazinamide. Although systemic steroids and drainage of pleural fluid have been tried to reduce the residualpleural thickening, the results are contradicting. (Korean J Med 2011;81:150-153)

증례 : 순환기 ; 임시형 심박조율기 삽입 후 발생한 조율 허용성 다형 심실빈맥 1예

박재영 ( Jae Young Park ),곽성동 ( Seong Dong Kwak ),임주견 ( Ju Kyeon Yim ),정재식 ( Jae Shik Jeong ),천재홍 ( Jae Hong Chun ),최성열 ( Sung Yeol Choi ),정준훈 ( Joon Hoon Jeong ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S

저자들은 하벽의 급성 심근경색증 환자에서 VVI 방식의 임시형 심박조율기를 삽입한 후 심박조율기 오작동으로 인한 조율 허용성 다형 심실빈맥을 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. A 74-year-old man was admitted with sudden-onset chest pain. Electrocardiography showed ST segment elevation in leads II, III, and aVF; in addition, the levels of several cardiac enzymes were elevated. The patient received a VVI temporary pacemaker due to bradycardia (45 beats/min) and was subjected to primary percutaneous coronary intervention. After percutaneous coronary intervention for the RCA infarction, the patient was admitted to the coronary care unit. Six hours later, polymorphic ventricular tachycardia occurred following a short-long-short sequence. This is the first case of temporary pacemaker-permitted ventricular tachycardia in Korea. Here we present a case of pacemaker-permitted polymorphic ventricular tachycardia in a patient with inferior acute myocardial infarction. (Korean J Med 77:S1157-S1161, 2009)