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李金泳,吳永南,馬在濚,曺徵 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1
한국인의 정상 남자 112명, 여자 118명 총 230명의 460足蹠에 나타난 皮紋을 분석하여 다음과 같은 결과를 얻었다. 1) 족척의 중간부의 降線 方向은 橫行(76.5%), 輕度의 비골측 近位傾斜(11.5%), 輕度의 비골측 遠位傾斜(11.1%), 뚜렷한 비골측 遠位傾斜(0.9%)의 순으로 나타났으며 중간부의 융선 배열에 대한 대칭 빈도는 63.9%로 나타났다. 2) 무지구부 紋形은 원위측 제상문(64.8%), 와상문(20.2%), 개방문(5.9%)의 순으로 나타났으며 무지구에 나타난 대칭 빈도는 83.2%이었다. 3) 趾間部 紋形은 Ⅱ지간부에서는 개방문(73.7%), 원위측 제상문(22.2%), 근위측 제상문(3.3%), 와상문(0.9%)의 순으로, Ⅲ지간부에서는 개방문(54.8%), 원위측 제상문(41.7%), 와상문(2.4%), 근위측 제상문(1.1%)의 순으로, Ⅳ지간부에서는 개방문(81.7%), 원위측 제상문(17.4%), 와상문(0.9%)의 순으로 나타났다. 4) 趾間部 降線數는 a-b 57.76, b-c 70.74, c-d 75.09이며 남녀 사이, 또는 양족 사이에는 통계적으로 유의한 차이가 없었다(P>0.01). The dermatoglyphic patterns of the hands and feet form during early fetal life and thereafter remain essentially unchanged. These traits are useful to study genetics and environmental factors that influence prenatal life and used in practice for personal identification and diagnosis of some diseases. The students of 112 male and 118 female were tested for the patterns of plantar regions. The most common patterns were open fields in the four interdigital areas and the frequency of the mirror pattern on them was 57.2%. For a-b, b-c and c-d ridge counts of the plantar interdigital areas sampled from 105 male and 109 female students, the nonsignificances were found between both sexes and between both feet.
조재금,이재연,정성목,김명철 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1
Seven-year old, castrated male pekingese was presented with sudden onset of pain and tetraparesis. He was diagnosed with multiple intervertebral disc disease (lesion: C6-7 [mild], T12-13 [mild], L2-3 [moderate] via MRI in 2006. After undergoing conservative therapy at local hospital, he had more severe symptom in December 2009 than before. In order to identify exact site, he had been taken second MRI and transferred to CNU VMTH. Definitive diagnosis is also multiple intervertebral disc disease (IVDD) with the same lesion except C3-4 (+++). The spinal cord between C3 and C4 is ventrally compressed by intervertebral disc and the compression is much more severe than other lesions. Since the symptoms were severe and took place rapidly and didn't respond to medical treatment, surgical treatment, ventral slot for new lesion(C3-4) was planned. After the ventral compression of spinal cord between C3 and C4 was achieved, he showed enhancement which is gradual return to normal neurologic response, sternal recumbency, and occasional standing. After postoperative treatment at local hospital, he fully recovered to the normal. It was considered that accurate diagnosis timely adequate treatment are essential for the cure of IVDD.
성인간호학회지 논문(1989-2000)의 내용과 경향 분석
서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4
"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.
Jae Seok Choi,Young Jun Lee,Tae Hyung Kim,Hyun Jung Lim,Mee Young Ahn,Seung Jun Kwack,Tae Seok Kang,Kui Lea Park,Jaewon Lee,Nam Deuk Kim,Tae Cheon Jeong,Sang Geum Kim,Hye Gwang Jeong,Byung Mu Lee,Hyun 한국독성학회 2011 Toxicological Research Vol.27 No.2
Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard, which makes it important to determine the mechanism of their toxicity. In the present study, dose-dependent toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male prepubertal rats (postnatal day 18) treated orally with TBBPA at 0, 125, 250 or 500 ㎎/㎏ for 30 days. There were no differences in body weight gain between the control and TBBPA-treated groups. However, absolute and relative liver weights were significantly increased in high dose of TBBPA-treated groups. TBBPA treatment led to significant induction of CYP2B1 and constitutive androstane receptor (CAR) expression in the liver. In addition, serum thyroxin (T4) concentration was significantly reduced in the TBBPA treated group. These results indicate that repeated exposure to TBBPA induces drug-metabolising enzymes in rats through the CAR signaling pathway. In particular, TBBPA efficiently produced reactive oxygen species (ROS) through CYP2B1 induction in rats. We measured 8-hydroxy-2’-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in the kidney, liver and testes of rats following TBBPA treatment. As expected, TBBPA strongly induced the production of 8-OHdG in the testis and kidney. These observations suggest that TBBPA-induced target organ toxicity may be due to ROS produced by metabolism of TBBPA in Sprague-Dawley rats.
Screening of Plants with Inhibitory Activity on Cellular Senescence
Lee, Seung-Eun,Kim, Jae-Ryong,Noh, Hyung-Jun,Kim, Geum-Sook,Lee, Jeong-Hoon,Choi, Jehun,Lee, Dae-Young,Kim, Seung-Yu The Plant Resources Society of Korea 2014 한국자원식물학회지 Vol.27 No.6
In this study, the effect of plant extract on the senescence action and cell survival rate in two types of cells, in which aging was derived by adriamycin, was analyzed to find the materials for suppressing cell senescence from natural resources. The results are as follows. For human umbilical vein endothelial cells (HUVECs), the fruit of Physalis angulata L. and the aerial part of Synurus deltoides (Aiton) Nakai showed excellent cell-senescence inhibition activities in a treatment concentration-dependent manner, demonstrating the high possibility for utilization as a material for prevention and treatment for vascular diseases. The water extract from the root of Polygonatum odoratum var. pluriflorum for variegatum Y. N. Lee showed potent cell-senescence inhibitory effect for human dermal fibroblasts (HDFs). Thus it is considered that the additional study on the plant needs for elucidating the possible utilization as material for skin health improvement.
Lee, Jae-Chul,Park, Joon Ha,Yan, Bing Chun,Kim, In Hye,Cho, Geum-Sil,Jeoung, Dooil,Kwon, Young-Geun,Kim, Young-Myeong,Lee, Yun Lyul,Shin, Hyung-Cheul,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2013 Neurochem Res Vol.38 No.1
<P>DNA methylation is a key epigenetic modification of DNA that is catalyzed by DNA methyltransferases (Dnmt). Increasing evidences suggest that DNA methylation in neurons regulates synaptic plasticity as well as neuronal network activity. In the present study, we investigated the changes in DNA methyltransferases 1 (Dnmt1) immunoreactivity and its protein levels in the gerbil hippocampal CA1 region after 5 min of transient global cerebral ischemia. CA1 pyramidal neurons were well stained with NeuN (a neuron-specific soluble nuclear antigen) antibody in the sham-group, Four days after ischemia-reperfusion (I-R), NeuN-positive ((+)) cells were significantly decreased in the stratum pyramidale (SP) of the CA1 region, and many Fluro-Jade B (a marker for neuronal degeneration)(+) cells were observed in the SP. Dnmt1 immunoreactivity was well detected in all the layers of the sham-group. Dnmt1 immunoreactivity was hardly detected only in the stratum pyramidale of the CA1 region from 4 days post-ischemia; however, at these times, Dnmt1 immunoreactivity was newly expressed in GABAergic interneurons or astrocytes in the ischemic CA1 region. In addition, the level of Dnmt1 was lowest at 4 days post-ischemia. In brief, both the Dnmt1 immunoreactivity and protein levels were distinctively decreased in the ischemic CA1 region 4 days after transient cerebral ischemia. These results indicate that the decrease of Dnmt1 expression at 4 days post-ischemia may be related to ischemia-induced delayed neuronal death.</P>
Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4
LEE, JAE-CHUL,CHEN, BAI HUI,CHO, JEONG-HWI,KIM, IN HYE,AHN, JI HYEON,PARK, JOON HA,TAE, HYUN-JIN,CHO, GEUM-SIL,YAN, BING CHUN,KIM, DAE WON,HWANG, IN KOO,PARK, JINSEU,LEE, YUN LYUL,CHOI, SOO YOUNG,WON, SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.4
<P>Inhibitors of DNA-binding/differentiation (ID) proteins bind to basic helix-loop-helix (bHLH) transcription factors, including those that regulate differentiation and cell-cycle progression during development, and regulate gene transcription. However, little is known about the role of ID proteins in the brain under transient cerebral ischemic conditions. In the present study, we examined the effects of ischemia-reperfusion (I-R) injury on the immunoreactivity and protein levels of IDs 1–4 in the gerbil hippocampus proper <I>Cornu Ammonis</I> regions CA1–3 following 5 min of transient cerebral ischemia. Strong ID1 immunoreactivity was detected in the nuclei of pyramidal neurons in the hippocampal CA1–3 regions; immunoreactivity was significantly changed following I-R in the CA1 region, but not in the CA2/3 region. Five days following I-R, ID1 immunoreactivity was not detected in the CA1 pyramidal neurons. ID1 immunoreactivity was detected only in GABAergic interneurons in the ischemic CA1 region. Weak ID4 immunoreactivity was detected in non-pyramidal cells, and immunoreactivity was again only changed in the ischemic CA1 region. Five days following I-R, strong ID4 immunoreactivity was detected in non-pyramidal cells, which were identified as microglia, and not astrocytes, in the ischemic CA1 region. Furthermore, changes in the protein levels of ID1 and ID4 in the ischemic CA1 region studied by western blot were consistent with patterns of immunoreactivity. In summary, these results indicate that immunoreactivity and protein levels of ID1 and ID4 are distinctively altered following transient cerebral ischemia only in the CA1 region, and that the changes in ID1 and ID4 expression may relate to the ischemia-induced delayed neuronal death.</P>