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Yongjin Shin,Hyunjin Kim,J. Stuart Nelson,Sohee Park,Woonggyu Jung,Youngseop Kim,Zhongping Chen 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.II
We propose a novel application of optical coherence tomography (OCT) to monitor pit formation in laser-irradiated optical storage materials. A multilayer optical storage recordable compact disk is composed of multiple layers, each of different structure. The disks were irradiated with a Q-Switched Nd:YAG laser with an energy of 373 mJ. Post-irradiated disks were evaluated by using OCT, and the images were compared with those obtained by using optical microscopy. Our results indicate that OCT can be a useful instrument for investigating pit formation in multilayer optical storage disks and might also provide information on ways to optimize optical memory technology.
Polarization Color Imaging System for On-Line Quantitative Evaluation of Facial Skin Lesions
KANG, HEESUNG,JUNG, BYUNGJO,NELSON, J. STUART Elsevier Science, Inc 2007 Dermatologic surgery Vol.33 No.11
<P>BACKGROUND</P><P>A number of studies have been performed for accurate evaluation of chromophores in skin lesions. Qualitative methods are subjective and cause user-dependent error in evaluation. Quantitative methods have limitations for widely distributed skin lesions due to poor spatial resolution, potential skin blanching, and difficulty in relocating identical sites for subsequent measurements and analysis.</P><P>OBJECTIVE</P><P>The objective was to develop a new imaging modality that provides both qualitative and quantitative methods to evaluate widely distributed skin lesions.</P><P>METHODS</P><P>We have developed a prototype polarization color imaging system named “DermaVision,” which provides quantitative on-line image analysis of polarization color images. Herein, we describe the hardware and software of DermaVision in terms of its performance and usefulness for dermatologic applications.</P><P>RESULTS</P><P>Polarization color images were successfully acquired from patients with vascular or pigmented skin lesions. The erythema and melanin index images were successfully computed and quantitatively confirmed the degree of erythema and pigmentation in the skin lesions.</P><P>CONCLUSION</P><P>We believe that DermaVision can be a useful auxiliary tool in dermatology because it simultaneously provides both qualitative and quantitative images of skin lesions.</P>
Development of an Optical Tissue Clearing Laser Probe System
여창민,강희성,배윤진,박지훈,이경중,J. Stuart Nelson,정병조 한국광학회 2013 Current Optics and Photonics Vol.17 No.4
Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to 10℃; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region;and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at 10℃; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3)1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion,the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density
Enhancement of optical skin clearing efficacy using a microneedle roller
Yoon, Jinhee,Son, Taeyoon,Choi, Eung-ho,Choi, Bernard,Nelson, J. Stuart,Jung, Byungjo SPIE - International Society for Optical Engineeri 2008 Journal of biomedical optics Vol.13 No.2
<P>Light scattering in biological tissues can be reduced by using optical clearing agents. Various physical methods in conjunction with agents have been studied to enhance the optical clearing efficacy of skin for diagnostic and therapeutic applications. In this study, we propose a new physical method to enhance the optical clearing potential of topically applied glycerol. A microneedle roller is used to easily create numerous transdermal microchannels prior to glycerol application. The optical clearing efficacy of skin is quantitatively evaluated with the use of a modulation transfer function target placed underneath ex vivo porcine skin samples. From cross-polarized images acquired at various time points after glycerol application, we find that samples treated with the microneedle roller resulted in an approximately two-fold increase in contrast compared to control samples 30 min after glycerol application. In conclusion, our data suggest that the microneedle roller can be a good physical method to enhance transdermal delivery of optical clearing agents, and hence their optical clearing potential over large regions of skin.</P>
Thermal depth profiling of vascular lesions: automated regularization of reconstruction algorithms
Verkruysse, Wim,Choi, Bernard,Zhang, Jenny R,Kim, Jeehyun,Nelson, J Stuart Institute of Physics in association with the Ameri 2008 Physics in medicine & biology Vol.53 No.5
<P>Pulsed photo-thermal radiometry (PPTR) is a non-invasive, non-contact diagnostic technique used to locate cutaneous chromophores such as melanin (epidermis) and hemoglobin (vascular structures). Clinical utility of PPTR is limited because it typically requires trained user intervention to regularize the inversion solution. Herein, the feasibility of automated regularization was studied. A second objective of this study was to depart from modeling port wine stain PWS, a vascular skin lesion frequently studied with PPTR, as strictly layered structures since this may influence conclusions regarding PPTR reconstruction quality. Average blood vessel depths, diameters and densities derived from histology of 30 PWS patients were used to generate 15 randomized lesion geometries for which we simulated PPTR signals. Reconstruction accuracy for subjective regularization was compared with that for automated regularization methods. The objective regularization approach performed better. However, the average difference was much smaller than the variation between the 15 simulated profiles. Reconstruction quality depended more on the actual profile to be reconstructed than on the reconstruction algorithm or regularization method. Similar, or better, accuracy reconstructions can be achieved with an automated regularization procedure which enhances prospects for user friendly implementation of PPTR to optimize laser therapy on an individual patient basis.</P>
Jeon, Mansik,Kim, Jeehyun,Song, Jae-Won,Lee, Ho,Choi, Sanghoon,Nelson, J. Stuart Wiley Subscription Services, Inc., A Wiley Company 2008 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.50 No.5
<P>A simple, compact, and low cost tunable ring laser with a commercial semiconductor optical amplifier (SOA) was demonstrated. The tunable ring laser is based on an external wavelength filter cavity that is analogous with the Littman configuration with a diffraction grating, a mirror, and a simple slit. The unique structural advantage of this new system is that the slit is displaced to select a desired wavelength instead of tilting the mirror as in the Littman configuration. This allows easy control over the selected wavelength by the translating action of the slit. The full width half maximum (FWHM) wavelength turning range is 45 nm, and the wavelength resolution is about 2 pm. The demonstrated tunable ring laser has 2 mW output power. The side mode suppression ratios is 70–73 dB. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 1317–1320, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23340</P>