Determination of Hemispheric Language Dominance Using Functional MRI : Comparison of Visual and Auditory Stimuli

Yoo, Ie Ryung,Ahn, Kook Jin,Kim, Tae,Lee, Jae Mun 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-

Purpose : To assess the difference between auditory and visual stimuli when determining hemispheric language dominance by using functional MRI. Materials and Methods : In ten healthy adult volunteers (8 right-handed, 1 left-handed, 1 ambidextrous), motor language activation in axial slices of frontal lobe was mapped on a Simens 1.5T Vision Plus system using single-shot EPI. Series of 120 consecutive images per section were acquired during three cycles of task activation and rest. During each activation, a series of four syllables was delivered by either of visual or auditory method, and the volunteers were asked to mentally generate words starting with each syllable. In both inferior frontal gyri and whole frontal lobes, lateralization indices were calculated from the activated pixels. We determined the language dominant hemisphere, and compared the results of the visual method and the auditory method. Results : Seven right-handed persons were left-hemisphere dominant, and one left-hand-ed and one ambidextrous person were right-hemisphere dominant. Five of nine persons demonstrated large lateralization indices with the auditory method than the visual method, while the remaining four showed larger lateralization indices with the visual method. No statistically significant difference was notes when comparing the results of the two method (p<0.05). Conclusion : When determining hemispheric language dominance using functional MRI, the two methods are equally appropriate. (Journal of the Korean Radiological Society 41(6):1085-1090, 1999)

Bone SPECT/CT of the Foot and Ankle: Potential Clinical Application for Chronic Foot Pain

Ie Ryung Yoo 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.1

Diseases of the foot and ankle are common but relatively difficult to diagnose because of the complexity of the anatomy and the frequent occurrence of multiple diseases at the same time. For these reasons, management of chronic foot pain is often clinically challenging. MRI is the imaging modality of choice in many types of diseases causing chronic foot pain, due to high resolution and excellent soft tissue contrast. However, in the postoperative state, the use of MRI can be limited by artifact from metallic devices, and it may be difficult to confirm whether the pathology detected on the MRI is the actual cause of the pain. As bone scintigraphy provides metabolic information, it can help to find the origin of pain, and SPECT/CT can further improve the specificity by adding anatomical information. In daily clinical practice for management of foot and ankle pathologies, the use of bone SPECT/CT is gradually increasing. However, there has been limited evidence of usefulness of SPECT/CT in evaluating chronic foot pain. In this review article, the potential application of bone SPECT/CT for chronic foot pain is illustrated, and the role of SPECT/CT in the management of the foot and ankle diseases in clinical practice is described.

위장관 간질 종양(Gastrointestinal stromal tumor)에서 18F-fluorodeoxyglucose positron emission tomography의 역할

유이령 ( Ie Ryung Yoo ) 대한핵의학회 2008 핵의학 분자영상 Vol.42 No.-

후두 편평상피암종의 림프절 피막외 침범에 대한 FDG PET/CT 영상의 유용성

주영훈(Young-Hoon Joo)유이령(Ie-Ryung Yoo),조광재(Kwang-Jae Cho),송지남(Jee-Nam Song),유동준(Dong-Joon Yoo),이호석(Ho-Suk Lee),김민식(Min-Sik Kim) 대한두경부종양학회 2012 대한두경부 종양학회지 Vol.28 No.2

Backgrounds:To evaluated the use of FDG PET/CT for the identification of extracapsular spread(ECS) with histologic correlation in laryngeal cancer. Methods:We reviewed 79 medical records of patients who under-went of FDG PET/CT for laryngeal cancer before surgery. Results:ECS was present in 41.9%(18/43) dis-sected necks and in 34.5%(20/58) dissected cervical levels. There was a significant difference in the SUVmax between cervical lymph nodes with ECS and without ECS(6.39±4.53 vs. 1.19±1.64, p<0.001). The cut-off value for the SUVmax for differentiating with ECS from without ECS was 2.8 with the sensitivity of 85.7% and the specificity of 85.6%. Conclusion:The median SUVmax cut-off values of FDG PET/CT higher than 2.8 was associated with greater risk cervical lymph node metastasis with ECS in patients with laryngeal cancer.

Prognostic Value of Pre- and Post-Treatment FDG PET/CT Parameters in Small Cell Lung Cancer Patients

Kim, Hyoungwoo,Yoo, Ie Ryung,Boo, Sun Ha,Park, Hye Lim,O, Joo Hyun,Kim, Sung Hoon 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.1

Purpose To evaluate the prognostic value of PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC. Methods Fifty-nine patients with initially diagnosed SCLC from 2009 to 2014 were included and had chemotherapy and/or concurrent chemoradiotherapy. FDG PET/CT examinations were performed before (PET1) and after (PET2) treatment to evaluate treatment response. A region of interest was placed over the primary lesion and metastatic lymph nodes within the thoracic cavity. PET parameters including change from PET1 to PET2 (${\Delta}$ in %) were acquired: SUVmax, SUVpeak, MTV2.5, TLG, ${\Delta}SUVmax$, ${\Delta}SUVpeak$, ${\Delta}MTV$ and ${\Delta}TLG$. Patient characteristics including staging, age, sex, LDH and response evaluation by RECIST were surveyed. Statistical analysis was done using Kaplan-Meier method and Cox regression analysis with respect to OS and PFS. Results The median follow-up was 9.6 months (2.5-80.5 months). 27 patients were LD and 32 were ED. Forty-six patients (78.0%) had died, and median OS was 8.6 months; 51 patients (86%) showed disease progression, and median PFS was 2.5 months. On univariate analysis, patients with ED, high interval change (${\Delta}SUVmax$ and ${\Delta}SUVpeak$) and low PET2 parameters showed longer OS and PFS. Multivariate analyses demonstrated that ${\Delta}SUVpeak$ (HR 2.6, P = 0.002) was an independent prognostic factors for OS, and MTV2.5 of PET2 (HR 2.8, P = 0.001), disease stage (HR 2.7, P = 0.003) and RECIST (HR 2.0, P = 0.023) were independent prognostic factors for PFS. Conclusions Metabolic and volumetric PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC have significant prognostic information.

Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma

Hye Lim Park,Ie Ryung Yoo,Sung Hoon Kim,Sohee Lee 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.6

The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). She underwent total parathyroidectomy with video-assisted thoracoscopic surgery on an anterior mediastinal mass. Anterior mediastinal parathyroid adenoma in MEN1 patients is rare. Precise localization of an ectopic parathyroid gland with Tc-99m sestamibi SPECT/CT can lead to successful treatment of hyperparathyroidism. This is the first reported case in the literature of mediastinal parathyroid adenoma in MEN1 patient visualized by Tc-99m sestamibi SPECT/CT.

Prognostic Value of Metabolic Tumor Volume Measured by $^{18}F$-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi, Kyu-Ho,Yoo, Ie-Ryung,Han, Eun-Ji,Kim, Yeon-Sil,Kim, Gi-Won,Na, Sae-Jung,Sun, Dong-Il,Jung, So-Lyung,Jung, Chan-Kwon,Kim, Min-Sik,Lee, So-Yeon,Kim, Sung-Hoon The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.1

Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using$^{18}F$-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). $Methods$ We retrospectively reviewed 56 patients (51 men, five women; mean age $56.0{\pm}8.8$years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value ($SUV_{peak}$) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared $SUV_{peak}$, MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median $SUV_{peak}$ was 7.8 (range, 1.8-19.0) and MTV was17.0 $cm^3$ (range, 0.1-131.0 $cm^3$). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of $SUV_{peak}$ 6.2 and MTV 20.7 $cm^3$ were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.

Value of Surveillance $^{18}F$-FDG PET/CT in Colorectal Cancer: Comparison with Conventional Imaging Studies

Choi, Eun Kyoung,Yoo, Ie Ryung,Park, Hye Lim,Choi, Hyun Su,Han, Eun Ji,Kim, Sung Hoon,Chung, Soo Kyo,O, Joo Hyun The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.3

Purpose To assess the value of PET/CT for detecting local or distant recurrence in patients who undergo surgery for colorectal cancer (CRC) and to compare the accuracy of PET/CT to that of conventional imaging studies (CIS). Methods Tumor surveillance PET/CT scans done between March 2005 and December 2009 of disease-free patients after surgery with or without adjuvant chemotherapy for CRC were retrospectively studied. CIS (serial enhanced CT from lung base to pelvis and plain chest radiograph) were performed within 1 month of PET/CT. We excluded patients with distant metastasis on initial staging, a known recurrent tumor, and a lack of follow-up imaging. The final diagnosis was based on at least 6 months of follow-up with colonoscopy, biopsy, and serial imaging studies in combination with carcinoembryonic antigen levels. Results A total of 262 PET/CT scans of 245 patients were included. Local and distant recurrences were detected in 27 cases (10.3%). On case-based analysis, the overall sensitivity, specificity, and accuracy were 100, 97.0, and 97.3% for PET/CT and 85.1, 97.0, and 95.8% for CIS, respectively. On lesion-based analysis, PET/CT detected more lesions compared to CIS in local recurrence and lung metastasis. PET/CT and CIS detected the same number of lesions in abdominal lymph nodes, hepatic metastasis, and peritoneal carcinomatosis. PET/CT detected two more metachronous tumors than did CIS in the lung and thyroid gland. Conclusion PET/CT detected more recurrences in patients who underwent surgery for CRC than did CIS and had the additional advantage of evaluating the entire body during a single scan.

Radiation nephritis: 99mTc hydroxydiphosphonate bone scan, 99mTc dimercaptosuccinic acid renal scan, and 18F-FDG PET/CT findings

Hye Lim Park,Ie Ryung Yoo,Yeon Sil Kim,Jin-Hyoung Kang,Ji Eun Lee 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4

Clinical Significance of F-18 FP-CIT Dual Time Point PET Imaging in Idiopathic Parkinson's Disease

Oh, Jin-Kyoung,Yoo, Ik-Dong,Seo, Ye-Young,Chung, Yong-An,Yoo, Ie-Ryung,Kim, Sung-Hoon,Song, In-Uk The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.4

Purpose The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD). Materials and Methods Twenty-four patients with PD (mean age 69.6) and 18 healthy people (mean age 70.26) underwent two sequential PET/CT scans (dual time point imaging) at 90 and 210 min after F-18 FPCIT injection. Tracer activity of region of interest was measured in the caudate, putamen and a reference region in the brain from both time points. The outcome parameter was the striatooccipital ratio (SOR). Normal SOR values were obtained in the control group. The percent change in tracer activity between 90- and 210- min images was calculated. The SOR values and the percent change in tracer activity were compared between the patients and healthy control group. Results The SOR values for the caudate, anterior and posterior putamen at both 90- and 210-min images were significantly reduced in the patients with PD. The lowest P value was obtained for the anterior and posterior putamen (p<0.001) at both time points. There were significant differences of the percent change in tracer activity for the anterior and posterior putamen in the two groups (p=0.01). Conclusions F-18 FP-CIT PET scans at 90 and 210 min after injection are both able to diagnose PD. Therefore, the 90-min image by itself is sufficient for diagnosing PD.