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Wegener 씨 육아종 증례보고 1예 : A Case Report
정선관,임형근,정은택,노병석,김창근,원종진 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
Wegener's granulomatosis is characterized by necrotizing and granulomatous disease which involves upper, lower respiratory tract and kidney. The basic pathophysiologic mechanism of Wegener's granulomatosis is still unknown. We report a case of Wegener's granulomatosis which involved lung and pleura and was diagnosed by clinical symptoms, radiologic findings and anti-neutrophilic cytoplasmic autoantibodies.
Propylene의 氣相重合反應에서 反應因子들이 反應速度 및 立體規則性에 미치는 影響에 관한 硏究
이태형,임상윤,정석진 慶熙大學校 材料科學技術硏究所 1992 材料科學技術硏究論集 Vol.5 No.-
In order to investigate the effects of reaction factors on reaction rate, catalytic yield and stereospecific properties of polypropylene, commercial MgCl_(2) supported Ziegler-Natta catalyst was used. In the effects of reaction temperature, the polymerization rate was increased as increasing of reaction temperature until 60℃, but decreased above 60℃. This was considered as the active site of catalyst was deactivated by decomposition of transition metal-organic compound ligand at higher temperature (≥60℃) It was found that the relation between reaction pressure and catalytic yield was linear, and could derived the equation of catalytic yield with regard to reaction pressure. In the effects of cocatalyst concentration, the more cocatalyst amount, the faster polymerization rate. But reaction rate was decreased above Al/Ti mole ratio = 50. This was considered as the excess cocatalysts were adsorbed on the catalyst active sites in competition with monomers and/or reacted as a chain transfer agent which quenches the polymerization. In the effects of reaction factors on stereospecific properties, the isotactic index of polymer was increased according to temperature and has a maximum valve at 50℃. The effect of reaction pressure on isotacticity was not severe. It was commonly known that the isotactic index of polypropylene is decreased as increasing of cocatalyst concentration because the atactic site activation is increased with increasing of Al/Ti mole ratio. The electron donor(EB) was incorporated for increasing of isotactic index of polypropylene, but the more electron donor, the lower isotactic index. This was considered of isotactic site poisoning by excess electron donor.
정의식,강형모,류봉조,임경빈,고준빈,박수규 한밭대학교 산업과학기술연구소 1995 논문집 Vol.3 No.-
This paper deal with a method of detecting localized defects on taper roller bearing in main spindle of machine tool system. The statistical parameters in time-domain signal processing techniques have been calculated to extract useful features from bearing vibration signals. Emloying these features, the statiscical parameters have been established to detect defects on the rollers of bearings, respectively, and used by the input feature of an artificial neural nerwork. As a result that the proposed bearing defects monitoring system could be successfully performed by using the statistical parameters of acceleration signals.
유한세프라딘 캅셀(세프라딘 500 mg)에 대한 브로드세프 캅셀의 생물학적 동등성
조혜영,이석,강현아,오인준,임동구,문재동,이용복 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
Cepharadine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequinalence of two cepharadine capsules, Cefradine Yuhan (Yuhan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules ?? was tested using KP Ⅶ Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, 23.10±2.90 years in age and 67.69±8.04 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one capsule containing 500 ㎎ as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cepharadine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the phaemacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_t and C_max and untransformed T_max. The results showed that the differences in AUC_t, C_max and T_max between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.93)∼log(1.02) and log(0.88)∼log(1.13) for AUC_t, and C_max, respectively). the 90% confidence interval using untransformed data was within ±20% (e.g., -17.54∼7.78 for T_max). All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.
다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도
주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.
2. Financial Markets and Industries
( Hyung Joon Lim ),( Bomi Lee ),( Hyungjoon Ray Lim ),( Jong Sang Park ),( Soo Jin Lee ),( Soon Ho Lee ),( Min Kyu Song ),( Suk Ho Lee ),( Min Kee Song ) 한국금융연구원 2015 Korean Economic and Financial Review Vol.20 No.4
The interest rate is expected to continue falling during the 4th quarter of 2015, we have yet to see what will happen to the policy rate. Korean Won is likely to depreciate as Korean economy is forecast to stagnate compared to the U.S. economy. And stock price is expected to stagger as the fate of developing countries`` economy is highly uncertain. Money supply is forecast to maintain its upward trend thanks to low interest rate and housing market boom created by the government.
Joo-Hyung Kim,Min-Suk Kim,Sun-Hyung Lim,Young-Mi Kim,Jong-Yeol Lee 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
LMW-GSs represent approximately 1/3 of the total wheat gluten fraction, which have not been widely studied, even though they are important in the context of wheat end-use quality. In this study, we report on the qualitative and quantitative analysis of LMW-GS in korean wheat cultivars by 2DE in 32 cultivars of Korean wheat for the use of the basis of wheat breeding. We firstly identified spots corresponding each of Glu-3 alleles. The 2DE results for each cultivar will be used as reference map or protein marker discriminating wheat cultivars, wheat and rice, imported and Korean flour. Unexpectedly, five LMW-GS spots were found to be expressed at a common position in hexaploid wheat cultivars, and these spots might play something in glutenin biosynthesis. Total spot numbers were expressed variously between 20 and 10, and average spot number was shown 17.12. The average number of spots in Glu-A3, Glu-B3 and Glu-D3 were 3.0, 4.56 and 2.96 respectively. When the Korean wheat cultivars were compared with the Chinese spring (1.0) in the average relative expression level, Korean one’s were lower as 0.67. Especially, Gobun was the highest as 1.32 and Baekjoong was the lowest as 0.24. Also we investigated phylogenetic relationship based on frequency of HMW-GS spots and quantification value of each spot to all LMW-GS spots. As a result, the varieties of Korean wheat could be classified into five groups.
Min-Suk Kim,Joo-Hyung Kim,Sun-Hyung Lim,Young-Mi Kim,Jong-Yeol Lee 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
To evaluate expression level of HMW-GS protein qualitatively and quantitatively, we separated glutenin fractions and conducted two-dimensional electrophoresis (2DE) in 32 cultivars of Korean wheat for the use of as the basis of wheat breeding. The average spot number of HMW-GS in all Korean wheat cultivars was 11.78 which included 1.31, 5.53 and 4.94 to Glu-A1, Glu-B1 and Glu-D1 loci, respectively. Cultivars harboring 1, 2* subunits had many spots more than ones harboring null allele in Glu-A1 loci because there is no difference of spots between Glu-B1 and Glu-D1 loci. In total spot number of HMW-GS, the highest one was Jokyung as 18 and Dahong the lowest as 7. When the Korean wheat cultivars were compared with the Chinese spring in the average relative expression level, Korean one’s were lower as 0.44. Especially, Gobun was the highest as 1.11 and Eunpa was the lowest as 0.24. Also we investigated phylogenetic relationship based on both frequency of HMW-GS spots and quantification value of each spot to all HMW-GS spots. As a result, Korean the varieties of Korean wheat could be classified into six groups.